iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000089775.11	ENST00000555220.5	ENSP00000450718.1
ENSG00000089775.11	ENST00000555424.1	ENSP00000451046.1
ENSG00000089775.11	ENST00000608382.5	ENSP00000476746.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.30e-11	46.4	24	84

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik..dvqpevfrallkFlYtgk 64
           +D+++ +g+++f+ah++vLaa S +F+  f ++ +e      ++i+  d+qp+ f+ ll+ +Ytgk
   Q: 24   CDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQTSEC-----IKIQptDIQPDIFSYLLHIMYTGK 84
           8*****************************9987775.....7777769****************8 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MDTASHSLVL LQQLNMQREF GFLCDCTVAI GDVYFKAHRA VLAAFSNYFK MIFIHQTSEC 60
IKIQPTDIQP DIFSYLLHIM YTGKGPKQIV DHSRLEEGIR FLHADYLSHI ATEMNQVFSP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAGAAGGTA ACTAATTTGG GAACTAGTCT CCGTAGGGGC TTCGCCTCCG ACTCAGGGAG 60
GCCGCACGCC CGGGACCTGA CGCGCCGGCA ACAAGCAGGC GGCCTGGCAG CCGCCCGTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0010467--P:gene expression
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:7597

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001351	Ailuropoda melanoleuca	94.25	0.00e+00	835.00
IUUC-Apl-003334	Anas platyrhynchos	69.16	2.00e-165	575.00
IUUC-Aca-004964	Anolis carolinensis	69.93	0.00e+00	628.00
IUUC-Bta-012769	Bos taurus	94.71	0.00e+00	824.00
IUUC-Cja-018836	Callithrix jacchus	97.47	0.00e+00	884.00
IUUC-Cfa-020444	Canis familiaris	94.48	0.00e+00	823.00
IUUC-Cpo-021628	Cavia porcellus	88.28	0.00e+00	802.00
IUUC-Csa-023058	Chlorocebus sabaeus	97.01	0.00e+00	852.00
IUUC-Dre-027659	Danio rerio	41.33	7.00e-80	291.00
IUUC-Dno-029861	Dasypus novemcinctus	94.48	0.00e+00	852.00
IUUC-Dor-030291	Dipodomys ordii	91.49	0.00e+00	833.00
IUUC-Ete-033178	Echinops telfairi	85.09	0.00e+00	728.00
IUUC-Eca-033467	Equus caballus	96.32	0.00e+00	837.00
IUUC-Eeu-034718	Erinaceus europaeus	92.64	0.00e+00	802.00
IUUC-Fca-036324	Felis catus	93.56	0.00e+00	824.00
IUUC-Fal-037537	Ficedula albicollis	71.88	2.00e-178	619.00
IUUC-Gga-040945	Gallus gallus	66.21	3.00e-157	548.00
IUUC-Gac-041897	Gasterosteus aculeatus	40.49	9.00e-74	270.00
IUUC-Ggo-044413	Gorilla gorilla	99.77	0.00e+00	873.00
IUUC-Itr-048633	Ictidomys tridecemlineatus	94.25	0.00e+00	851.00
IUUC-Lch-050677	Latimeria chalumnae	57.47	3.00e-134	471.00
IUUC-Loc-052804	Lepisosteus oculatus	54.47	6.00e-104	371.00
IUUC-Laf-053352	Loxodonta africana	92.69	0.00e+00	733.00
IUUC-Mcc-055704	Macaca mulatta	97.58	0.00e+00	721.00
IUUC-Mga-059603	Meleagris gallopavo	68.41	1.00e-145	509.00
IUUC-Mmr-061175	Microcebus murinus	96.67	3.00e-31	125.00
IUUC-Mdo-063040	Monodelphis domestica	87.04	0.00e+00	638.00
IUUC-Mmu-063587	Mus musculus	90.89	0.00e+00	804.00
IUUC-Mpu-066137	Mustela putorius furo	93.79	0.00e+00	851.00
IUUC-Mlu-068132	Myotis lucifugus	93.33	0.00e+00	819.00
IUUC-Nle-069753	Nomascus leucogenys	98.73	2.00e-177	615.00
IUUC-Opr-071048	Ochotona princeps	78.21	6.00e-129	454.00
IUUC-Ont-072048	Oreochromis niloticus	41.25	1.00e-77	283.00
IUUC-Oan-072845	Ornithorhynchus anatinus	75.74	0.00e+00	635.00
IUUC-Ocu-074564	Oryctolagus cuniculus	71.26	5.00e-172	597.00
IUUC-Ola-087233	Oryzias latipes	41.18	1.00e-74	273.00
IUUC-Oga-088508	Otolemur garnettii	92.18	0.00e+00	836.00
IUUC-Oar-089268	Ovis aries	95.40	0.00e+00	830.00
IUUC-Ptr-091072	Pan troglodytes	99.77	0.00e+00	873.00
IUUC-Pan-092136	Papio anubis	97.24	0.00e+00	846.00
IUUC-Psi-093721	Pelodiscus sinensis	75.74	0.00e+00	662.00
IUUC-Pfo-096731	Poecilia formosa	40.40	2.00e-74	273.00
IUUC-Pab-097737	Pongo abelii	99.31	0.00e+00	868.00
IUUC-Pca-100695	Procavia capensis	91.72	0.00e+00	824.00
IUUC-Pva-103115	Pteropus vampyrus	94.02	0.00e+00	848.00
IUUC-Rno-105648	Rattus norvegicus	89.04	0.00e+00	781.00
IUUC-Sha-107219	Sarcophilus harrisii	88.24	0.00e+00	657.00
IUUC-Sar-112990	Sorex araneus	92.41	0.00e+00	827.00
IUUC-Tgu-117413	Taeniopygia guttata	71.43	1.00e-178	619.00
IUUC-Tru-118484	Takifugu rubripes	41.18	5.00e-73	268.00
IUUC-Tbe-127785	Tupaia belangeri	94.94	0.00e+00	861.00
IUUC-Ttr-128226	Tursiops truncatus	85.98	0.00e+00	766.00
IUUC-Vpa-130406	Vicugna pacos	93.33	0.00e+00	802.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence