iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	microRNA
TRANSFAC	TargetScan	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	HINT	Mentha	InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.70e-50	166.0	451	489
UBD/Beta-Prp	7.30e-62	210.9	321	494

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g l++s
   Q: 451  HQEPVYSVAFsPDgKYLASGSFDKYVHIWNTQSGSLVHS 489
           9**********999******************9999875 PP

UBD/Beta-Prp

   S: 97   vlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsf 188
           +l+++++  + +++s s d  i+v  l  +  ++ t++gh+  vn ++++p+g ll+s+s+D t+++W++k++ ++++l+  h + +y +++
   Q: 321  ALDVDWQN-NMTFASCSTDMCIHVCRLGCDHPVK-TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQA-HSKEIYTIKW 409
           33333333.3444444444444444444444444.4444444444444444444444444444444444444444444443.4444444444 PP
   S: 189  dsng.........kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn 264
           +++g           l+s+s d+tv+lwd+++g c +tl  h+++v+sv+fsp++++l+sgs D+ + iW+++sg l++++q++ 
   Q: 410  SPTGpatsnpnssIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTG 494
           4444444444444444444444444444444444444444444444444444444444444444444444444444444444432 PP

Organism

Homo sapiens

Functional Description
(View)

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).

Protein Sequence
(Fasta)

MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPSALI SILQKGLQYV 60
EAEISINKDG TVFDSRPIES LSLIVAVIPD VVQMRQQAFG EKLTQQQASA AATEASAMAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGTGCCCC CAATTCGCGC TCGGGAGTGA GGAGCCGCCA ACACCCCAGC TCCGCTGCTG 60
CCGCCACCGC AGTGCTCTCT AGTCGCCATT GGTTACCTAA ACTTTCCAGT ACCCGCGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0045444--P:fat cell differentiation
GO:0016575--P:histone deacetylation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0043627--P:response to estrogen
GO:0048545--P:response to steroid hormone
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:90665

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Mcc-055124	Macaca mulatta	91.88	0.00e+00	947.00
IUUC-Olu-087589	Ostreococcus lucimarinus	52.37	5.00e-156	544.00
IUUC-Ptr-090793	Pan troglodytes	96.93	0.00e+00	977.00
IUUC-Stu-112786	Solanum tuberosum	48.31	6.00e-142	497.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence