iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.00e-12	47.9	359	389

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWD 29
           H+ +v+cl f   +  +++s s+Dgt+++ D
   Q: 359  HSQPVSCLYFspaNPAHILSLSYDGTLRCGD 389
           9**********963399**********9855 PP

Organism

Homo sapiens

Functional Description
(View)

Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

Protein Sequence
(Fasta)

MSRSGAAAEK ADSRQRPQMK VNEYKENQNI AYVSLRPAQT TVLIKTAKVY LAPFSLSNYQ 60
LDQLMCPKSL SEKNSNNEVA CKKTKIKKTC RRIIPPKMKN TSSKAESTLQ NSSSAVHTES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGGACCCGC CCCTCCCGGC CTCCCGCCGC AATCTTGGCG GGAAGGCGCC GGCCGCTAAG 60
AAGCCGAAAG ATGTCCAGGT CGGGCGCGGC GGCTGAGAAG GCGGACTCCA GACAGCGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR033052--Cmr1/WDR76
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

SMART

SM00320--WD40

Gene Ontology

GO:0006974--P:cellular response to DNA damage stimulus

KEGG

hsa:79968

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002605	Amborella trichopoda	26.90	6.00e-25	108.00
IUUC-Apl-003441	Anas platyrhynchos	53.32	1.00e-141	496.00
IUUC-Aca-004241	Anolis carolinensis	57.76	6.00e-150	523.00
IUUC-Aly-005444	Arabidopsis lyrata	26.96	1.00e-27	118.00
IUUC-Ath-007550	Arabidopsis thaliana	26.57	6.00e-27	115.00
IUUC-Ago-007715	Ashbya gossypii	23.87	3.00e-15	76.60
IUUC-Acl-008370	Aspergillus clavatus	25.26	2.00e-31	130.00
IUUC-Afl-008586	Aspergillus flavus	27.32	9.00e-36	144.00
IUUC-Afu-008907	Aspergillus fumigatus	26.53	3.00e-33	136.00
IUUC-Ani-009415	Aspergillus nidulans	26.40	3.00e-30	126.00
IUUC-Ang-009597	Aspergillus niger	24.86	2.00e-11	64.30
IUUC-Aor-010197	Aspergillus oryzae	27.32	6.00e-36	145.00
IUUC-Ate-010280	Aspergillus terreus	25.99	3.00e-33	136.00
IUUC-Bgr-012236	Blumeria graminis	24.80	8.00e-24	105.00
IUUC-Bta-013059	Bos taurus	79.01	0.00e+00	945.00
IUUC-Bci-013796	Botrytis cinerea	26.72	4.00e-29	122.00
IUUC-Bdi-015040	Brachypodium distachyon	28.74	2.00e-20	93.60
IUUC-Bol-015202	Brassica oleracea	26.40	7.00e-24	105.00
IUUC-Bra-018032	Brassica rapa	25.62	3.00e-23	103.00
IUUC-Cja-019043	Callithrix jacchus	92.50	0.00e+00	1096.00
IUUC-Cfa-021103	Canis familiaris	81.05	0.00e+00	957.00
IUUC-Cpo-021508	Cavia porcellus	73.29	0.00e+00	885.00
IUUC-Cre-022967	Chlamydomonas reinhardtii	35.35	3.00e-10	60.50
IUUC-Csa-023555	Chlorocebus sabaeus	95.66	0.00e+00	976.00
IUUC-Cho-024931	Choloepus hoffmanni	64.39	2.00e-146	513.00
IUUC-Cin-025651	Ciona intestinalis	32.45	2.00e-61	230.00
IUUC-Cgl-026604	Colletotrichum gloeosporioides	24.10	1.00e-27	118.00
IUUC-Cne-027093	Cryptococcus neoformans	24.32	2.00e-19	90.50
IUUC-Cme-027238	Cyanidioschyzon merolae	27.39	2.00e-21	97.80
IUUC-Dre-027441	Danio rerio	35.83	1.00e-88	320.00
IUUC-Dno-029575	Dasypus novemcinctus	79.45	0.00e+00	957.00
IUUC-Dor-030554	Dipodomys ordii	73.36	0.00e+00	664.00
IUUC-Dse-031299	Dothistroma septosporum	26.26	3.00e-31	129.00
IUUC-Ete-032716	Echinops telfairi	62.80	0.00e+00	662.00
IUUC-Eca-034027	Equus caballus	80.92	0.00e+00	818.00
IUUC-Eeu-035234	Erinaceus europaeus	84.08	2.00e-79	290.00
IUUC-Fca-035892	Felis catus	81.62	0.00e+00	952.00
IUUC-Fal-036986	Ficedula albicollis	51.28	2.00e-124	439.00
IUUC-Fox-037750	Fusarium oxysporum	24.51	3.00e-27	116.00
IUUC-Fso-038198	Fusarium solani	23.64	2.00e-20	94.00
IUUC-Gga-040479	Gallus gallus	51.08	7.00e-104	370.00
IUUC-Gac-042043	Gasterosteus aculeatus	43.52	1.00e-93	337.00
IUUC-Gma-043913	Glycine max	26.48	7.00e-34	138.00
IUUC-Ggo-045290	Gorilla gorilla	98.56	0.00e+00	1189.00
IUUC-Hvu-047193	Hordeum vulgare	29.07	3.00e-17	82.80
IUUC-Itr-047914	Ictidomys tridecemlineatus	79.97	0.00e+00	968.00
IUUC-Kpa-049275	Komagataella pastoris	22.69	3.00e-19	90.10
IUUC-Lch-049718	Latimeria chalumnae	56.20	2.00e-150	526.00
IUUC-Lpe-051708	Leersia perrieri	27.57	4.00e-16	79.30
IUUC-Loc-052565	Lepisosteus oculatus	47.22	1.00e-115	410.00
IUUC-Lma-053276	Leptosphaeria maculans	26.10	1.00e-31	131.00
IUUC-Laf-053970	Loxodonta africana	76.39	0.00e+00	912.00
IUUC-Mcc-054740	Macaca mulatta	95.38	0.00e+00	999.00
IUUC-Meu-056546	Macropus eugenii	65.42	2.00e-75	276.00
IUUC-Mtr-058451	Medicago truncatula	25.95	4.00e-34	139.00
IUUC-Mla-059117	Melampsora laricipopulina	26.46	1.00e-23	104.00
IUUC-Mga-059328	Meleagris gallopavo	47.75	4.00e-105	375.00
IUUC-Mvi-060555	Microbotryum violaceum	26.98	5.00e-22	99.40
IUUC-Mmr-061520	Microcebus murinus	81.80	0.00e+00	1004.00
IUUC-Mdo-062812	Monodelphis domestica	60.36	0.00e+00	687.00
IUUC-Mmu-064011	Mus musculus	69.48	0.00e+00	700.00
IUUC-Mpu-066486	Mustela putorius furo	80.29	0.00e+00	948.00
IUUC-Mlu-067721	Myotis lucifugus	77.08	0.00e+00	767.00
IUUC-Nfi-068314	Neosartorya fischeri	26.91	6.00e-33	135.00
IUUC-Ncr-068896	Neurospora crassa	26.34	3.00e-28	120.00
IUUC-Nle-069369	Nomascus leucogenys	97.77	0.00e+00	1199.00
IUUC-Opr-070975	Ochotona princeps	75.29	0.00e+00	838.00
IUUC-Ont-072528	Oreochromis niloticus	42.32	2.00e-101	363.00
IUUC-Oan-072955	Ornithorhynchus anatinus	60.73	3.00e-145	508.00
IUUC-Ocu-074561	Oryctolagus cuniculus	80.81	0.00e+00	923.00
IUUC-Oba-074982	Oryza barthii	27.81	8.00e-22	99.00
IUUC-Ogl-077685	Oryza glaberrima	27.27	4.00e-22	99.40
IUUC-Ogu-078331	Oryza glumaepatula	27.27	4.00e-22	99.40
IUUC-Oin-079507	Oryza indica	27.41	1.00e-21	98.20
IUUC-Olo-080604	Oryza longistaminata	29.20	5.00e-17	82.40
IUUC-Ome-081816	Oryza meridionalis	26.16	2.00e-20	94.00
IUUC-Oni-082051	Oryza nivara	27.27	8.00e-22	98.60
IUUC-Opu-083372	Oryza punctata	26.92	7.00e-20	92.00
IUUC-Oru-084578	Oryza rufipogon	27.27	4.00e-22	99.40
IUUC-Osa-086177	Oryza sativa	27.27	4.00e-22	99.40
IUUC-Ola-087208	Oryzias latipes	42.61	2.00e-96	345.00
IUUC-Olu-087680	Ostreococcus lucimarinus	29.72	1.00e-33	137.00
IUUC-Oga-088104	Otolemur garnettii	82.04	0.00e+00	983.00
IUUC-Oar-090157	Ovis aries	80.32	0.00e+00	957.00
IUUC-Ptr-091615	Pan troglodytes	98.40	0.00e+00	1186.00
IUUC-Pan-092212	Papio anubis	96.65	0.00e+00	1097.00
IUUC-Psi-092950	Pelodiscus sinensis	52.91	2.00e-166	578.00
IUUC-Pma-094625	Petromyzon marinus	33.22	6.00e-31	127.00
IUUC-Pno-094824	Phaeosphaeria nodorum	27.05	5.00e-36	145.00
IUUC-Pfo-096922	Poecilia formosa	41.60	1.00e-104	374.00
IUUC-Pab-097591	Pongo abelii	98.41	0.00e+00	1184.00
IUUC-Pop-099337	Populus trichocarpa	24.86	3.00e-27	116.00
IUUC-Pca-101025	Procavia capensis	65.46	0.00e+00	734.00
IUUC-Ppe-101256	Prunus persica	25.13	1.00e-19	91.30
IUUC-Pva-102453	Pteropus vampyrus	74.00	0.00e+00	831.00
IUUC-Pgr-103436	Puccinia graminis	25.06	5.00e-18	86.30
IUUC-Ptt-103899	Puccinia triticina	28.14	1.00e-18	88.20
IUUC-Pte-104258	Pyrenophora teres	27.45	5.00e-36	145.00
IUUC-Pyt-104625	Pyrenophora triticirepentis	27.99	8.00e-37	148.00
IUUC-Rno-104843	Rattus norvegicus	69.55	0.00e+00	803.00
IUUC-Sce-106189	Saccharomyces cerevisiae	25.81	1.00e-19	91.70
IUUC-Sha-106672	Sarcophilus harrisii	61.22	0.00e+00	703.00
IUUC-Smo-109176	Selaginella moellendorffii	29.63	1.00e-25	110.00
IUUC-Sit-109704	Setaria italica	25.69	5.00e-20	92.40
IUUC-Sly-111853	Solanum lycopersicum	24.94	3.00e-29	123.00
IUUC-Stu-112482	Solanum tuberosum	24.08	3.00e-25	110.00
IUUC-Sar-113537	Sorex araneus	57.11	1.00e-99	357.00
IUUC-Sbi-114517	Sorghum bicolor	27.81	5.00e-17	82.80
IUUC-Sre-114960	Sporisorium reilianum	28.47	2.00e-09	57.80
IUUC-Ssc-115568	Sus scrofa	83.33	0.00e+00	1003.00
IUUC-Tgu-117276	Taeniopygia guttata	49.37	1.00e-119	423.00
IUUC-Tru-117559	Takifugu rubripes	51.20	1.00e-35	141.00
IUUC-Tsy-119234	Tarsius syrichta	64.66	0.00e+00	719.00
IUUC-Tni-120358	Tetraodon nigroviridis	42.11	2.00e-98	352.00
IUUC-Tca-121273	Theobroma cacao	24.72	6.00e-26	112.00
IUUC-Tre-121932	Trichoderma reesei	26.17	1.00e-31	131.00
IUUC-Tvi-122567	Trichoderma virens	26.72	8.00e-34	138.00
IUUC-Tae-123506	Triticum aestivum	26.27	2.00e-14	73.60
IUUC-Tme-126958	Tuber melanosporum	25.35	1.00e-15	77.40
IUUC-Tbe-127425	Tupaia belangeri	85.20	0.00e+00	761.00
IUUC-Ttr-129123	Tursiops truncatus	72.34	0.00e+00	813.00
IUUC-Uma-129495	Ustilago maydis	32.14	2.00e-11	64.70
IUUC-Vda-129981	Verticillium dahliae	26.30	3.00e-29	123.00
IUUC-Vpa-130437	Vicugna pacos	75.59	0.00e+00	857.00
IUUC-Vvi-131430	Vitis vinifera	23.46	2.00e-25	110.00
IUUC-Xtr-132670	Xenopus tropicalis	52.89	3.00e-135	475.00
IUUC-Xma-133375	Xiphophorus maculatus	41.61	5.00e-102	364.00
IUUC-Yli-134341	Yarrowia lipolytica	24.67	3.00e-20	93.20
IUUC-Zma-135413	Zea mays	28.65	3.00e-21	96.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence