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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018220
Ensembl Protein ID F41H10.6a
UniProt Accession Q20296; Q9BI90; Q9BI91; HDA6_CAEEL
Genbank Protein ID CCD71098.1; CCD71099.1
Protein Name Histone deacetylase 6
Genbank Nucleotide ID FO081367; FO081367
Gene Name hda-6; F41H10.6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00018319 F41H10.6a F41H10.6a
WBGene00018319 F41H10.6b F41H10.6b
WBGene00018319 F41H10.6c F41H10.6c
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMapRAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/ZnF/ZnF_UBP 38.46 5.00e-144 509.00 IUUC-Hsa-046904
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Probable histone deacetylase. Histone deacetylases are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
 Probable histone deacetylase. Histone deacetylases are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
Protein Sequence
(Fasta)
MLFEDRQKNR STGPTLIGFN QTQNEHENTV CPTHPESSDR ILKIKEALTK TKILEKCTVL 60
TNFLEIDDAD LEVTHDKSMV KDLMESEKKT QEDINSQCEK YDSVFMTENS MKVAKDGVAC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018220|UBD,ZnF_UBP|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTTTTAGACT TTTAGCGGTT ATTCAAACAT TTATCGTTTA GTTTTCCATG CTTTTCGAAG 60
ATAGGCAGAA AAATCGATCA ACGGTAAGAA AAGTATATGT TCGTACAATC ATATAATCTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018220|UBD,ZnF_UBP|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50271--ZF_UBP
Pfam

PF00850--Hist_deacetyl
PF02148--zf-UBP
PRINTS

PR01270--HDASUPER
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0005634--C:nucleus
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558--F:protein deacetylase activity
GO:0008270--F:zinc ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG cel:CELE_F41H10.6
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000749 Aegilops tauschii 43.49 5.00e-60 224.00
IUUC-Aml-002087 Ailuropoda melanoleuca 37.25 1.00e-148 520.00
IUUC-Atr-002745 Amborella trichopoda 38.75 5.00e-71 260.00
IUUC-Apl-003250 Anas platyrhynchos 38.44 8.00e-68 251.00
IUUC-Aca-004303 Anolis carolinensis 38.12 1.00e-156 546.00
IUUC-Aly-006432 Arabidopsis lyrata 38.21 5.00e-73 267.00
IUUC-Ath-007355 Arabidopsis thaliana 39.47 2.00e-74 272.00
IUUC-Ago-007972 Ashbya gossypii 41.21 4.00e-76 277.00
IUUC-Acl-008187 Aspergillus clavatus 37.65 1.00e-74 273.00
IUUC-Afl-008399 Aspergillus flavus 44.44 3.00e-44 171.00
IUUC-Afu-008954 Aspergillus fumigatus 37.60 1.00e-62 232.00
IUUC-Ani-009142 Aspergillus nidulans 40.98 5.00e-68 251.00
IUUC-Ang-009522 Aspergillus niger 36.93 7.00e-22 97.80
IUUC-Aor-010069 Aspergillus oryzae 39.06 2.00e-67 248.00
IUUC-Ate-010291 Aspergillus terreus 39.01 6.00e-76 277.00
IUUC-Ame-010780 Astyanax mexicanus 35.67 4.00e-125 441.00
IUUC-Bta-013052 Bos taurus 37.42 6.00e-141 494.00
IUUC-Bci-013789 Botrytis cinerea 38.56 3.00e-68 251.00
IUUC-Bdi-014007 Brachypodium distachyon 42.22 2.00e-71 262.00
IUUC-Bol-015468 Brassica oleracea 40.32 7.00e-75 273.00
IUUC-Bra-016680 Brassica rapa 40.32 7.00e-75 273.00
IUUC-Cja-019473 Callithrix jacchus 38.39 2.00e-142 499.00
IUUC-Cfa-020263 Canis familiaris 37.93 3.00e-147 515.00
IUUC-Cpo-021691 Cavia porcellus 37.79 4.00e-150 524.00
IUUC-Cre-022561 Chlamydomonas reinhardtii 45.79 3.00e-49 186.00
IUUC-Csa-024223 Chlorocebus sabaeus 37.78 6.00e-148 517.00
IUUC-Cho-025033 Choloepus hoffmanni 30.99 1.00e-02 34.70
IUUC-Csv-026359 Ciona savignyi 40.71 8.00e-56 209.00
IUUC-Cgl-026709 Colletotrichum gloeosporioides 38.16 8.00e-65 240.00
IUUC-Cne-026978 Cryptococcus neoformans 44.86 1.00e-83 303.00
IUUC-Dre-028820 Danio rerio 38.90 2.00e-150 525.00
IUUC-Dno-029160 Dasypus novemcinctus 36.42 6.00e-122 431.00
IUUC-Dor-030859 Dipodomys ordii 39.48 6.00e-153 533.00
IUUC-Dse-031186 Dothistroma septosporum 38.50 6.00e-66 244.00
IUUC-Dme-031963 Drosophila melanogaster 38.98 2.00e-155 542.00
IUUC-Ete-032279 Echinops telfairi 37.69 1.00e-60 227.00
IUUC-Eca-033842 Equus caballus 38.19 1.00e-151 530.00
IUUC-Eeu-034487 Erinaceus europaeus 47.39 5.00e-62 231.00
IUUC-Fca-036430 Felis catus 42.06 9.00e-83 300.00
IUUC-Fox-038067 Fusarium oxysporum 37.57 1.00e-61 229.00
IUUC-Fso-038263 Fusarium solani 38.10 5.00e-66 244.00
IUUC-Gmo-038473 Gadus morhua 45.82 1.00e-64 240.00
IUUC-Ggr-040062 Gaeumannomyces graminis 37.67 2.00e-65 242.00
IUUC-Gga-040501 Gallus gallus 38.44 9.00e-68 250.00
IUUC-Gac-042335 Gasterosteus aculeatus 39.84 2.00e-67 249.00
IUUC-Gma-043738 Glycine max 36.31 2.00e-68 251.00
IUUC-Ggo-045022 Gorilla gorilla 38.09 2.00e-148 519.00
IUUC-Hsa-046904 Homo sapiens 38.09 2.00e-148 519.00
IUUC-Hvu-047285 Hordeum vulgare 41.90 4.00e-70 256.00
IUUC-Itr-048484 Ictidomys tridecemlineatus 37.52 3.00e-149 521.00
IUUC-Kpa-049281 Komagataella pastoris 39.67 1.00e-70 259.00
IUUC-Lch-050330 Latimeria chalumnae 37.62 7.00e-120 424.00
IUUC-Lpe-051214 Leersia perrieri 37.77 5.00e-72 264.00
IUUC-Loc-052231 Lepisosteus oculatus 38.62 9.00e-67 247.00
IUUC-Lma-053263 Leptosphaeria maculans 41.48 6.00e-74 271.00
IUUC-Laf-053386 Loxodonta africana 38.32 5.00e-147 514.00
IUUC-Mcc-055530 Macaca mulatta 37.97 2.00e-147 515.00
IUUC-Meu-056442 Macropus eugenii 41.60 1.00e-80 292.00
IUUC-Mor-057095 Magnaporthe oryzae 40.48 1.00e-71 263.00
IUUC-Mpo-057389 Magnaporthe poae 40.67 1.00e-62 233.00
IUUC-Mtr-058463 Medicago truncatula 42.49 9.00e-75 273.00
IUUC-Mla-059143 Melampsora laricipopulina 37.24 2.00e-74 272.00
IUUC-Mmr-060637 Microcebus murinus 37.80 9.00e-143 500.00
IUUC-Mdo-062198 Monodelphis domestica 39.92 1.00e-153 535.00
IUUC-Mmu-063346 Mus musculus 40.18 9.00e-156 543.00
IUUC-Mac-064630 Musa acuminata 38.02 6.00e-73 267.00
IUUC-Mpu-065884 Mustela putorius furo 36.87 4.00e-148 518.00
IUUC-Mlu-068117 Myotis lucifugus 39.61 8.00e-142 496.00
IUUC-Nfi-068404 Neosartorya fischeri 39.78 1.00e-72 266.00
IUUC-Ncr-068672 Neurospora crassa 36.10 1.00e-65 243.00
IUUC-Nle-069868 Nomascus leucogenys 43.97 4.00e-73 268.00
IUUC-Opr-071074 Ochotona princeps 42.09 2.00e-84 305.00
IUUC-Ont-072246 Oreochromis niloticus 39.27 4.00e-150 524.00
IUUC-Oan-072911 Ornithorhynchus anatinus 42.09 4.00e-58 218.00
IUUC-Ocu-074627 Oryctolagus cuniculus 38.42 4.00e-153 534.00
IUUC-Oba-075489 Oryza barthii 40.56 8.00e-71 260.00
IUUC-Obr-076150 Oryza brachyantha 41.80 1.00e-73 269.00
IUUC-Ogl-077437 Oryza glaberrima 37.77 1.00e-71 263.00
IUUC-Ogu-078370 Oryza glumaepatula 38.04 2.00e-72 265.00
IUUC-Oin-079210 Oryza indica 38.32 2.00e-72 266.00
IUUC-Olo-080971 Oryza longistaminata 44.73 2.00e-65 242.00
IUUC-Oni-082031 Oryza nivara 38.32 2.00e-72 265.00
IUUC-Opu-083471 Oryza punctata 40.25 8.00e-71 260.00
IUUC-Oru-084755 Oryza rufipogon 38.04 2.00e-72 265.00
IUUC-Osa-085447 Oryza sativa 38.04 2.00e-72 265.00
IUUC-Ola-087031 Oryzias latipes 40.32 3.00e-69 256.00
IUUC-Oga-089155 Otolemur garnettii 37.92 7.00e-149 520.00
IUUC-Oar-089620 Ovis aries 36.44 4.00e-141 494.00
IUUC-Ptr-090812 Pan troglodytes 37.37 6.00e-121 426.00
IUUC-Pan-092340 Papio anubis 37.97 2.00e-147 515.00
IUUC-Psi-093734 Pelodiscus sinensis 38.22 1.00e-67 250.00
IUUC-Pma-094386 Petromyzon marinus 39.16 6.00e-135 474.00
IUUC-Pno-095131 Phaeosphaeria nodorum 44.84 4.00e-67 247.00
IUUC-Ppa-095550 Physcomitrella patens 38.81 8.00e-70 257.00
IUUC-Pfo-096110 Poecilia formosa 41.16 8.00e-140 489.00
IUUC-Pab-098422 Pongo abelii 37.45 4.00e-138 484.00
IUUC-Pop-099174 Populus trichocarpa 38.96 2.00e-73 268.00
IUUC-Pca-100833 Procavia capensis 37.58 1.00e-149 522.00
IUUC-Ppe-101644 Prunus persica 35.54 1.00e-68 253.00
IUUC-Pva-102410 Pteropus vampyrus 38.20 4.00e-114 404.00
IUUC-Ptt-103841 Puccinia triticina 35.15 4.00e-66 244.00
IUUC-Pte-104383 Pyrenophora teres 40.17 5.00e-72 264.00
IUUC-Pyt-104427 Pyrenophora triticirepentis 41.00 2.00e-73 268.00
IUUC-Rno-105131 Rattus norvegicus 39.50 2.00e-155 542.00
IUUC-Sce-106274 Saccharomyces cerevisiae 40.77 2.00e-71 262.00
IUUC-Sha-106661 Sarcophilus harrisii 33.33 4.00e-100 358.00
IUUC-Sja-107915 Schizosaccharomyces japonicus 40.37 3.00e-78 285.00
IUUC-Spo-108300 Schizosaccharomyces pombe 40.16 2.00e-75 275.00
IUUC-Smo-109615 Selaginella moellendorffii 41.16 4.00e-73 268.00
IUUC-Sit-110160 Setaria italica 40.17 5.00e-66 244.00
IUUC-Sly-111164 Solanum lycopersicum 39.94 1.00e-75 276.00
IUUC-Stu-112685 Solanum tuberosum 36.56 1.00e-65 242.00
IUUC-Sar-113692 Sorex araneus 39.74 2.00e-59 223.00
IUUC-Sbi-114301 Sorghum bicolor 40.62 8.00e-66 243.00
IUUC-Sre-115013 Sporisorium reilianum 40.11 5.00e-72 264.00
IUUC-Ssc-115724 Sus scrofa 39.33 9.00e-137 479.00
IUUC-Tgu-116605 Taeniopygia guttata 43.34 3.00e-69 255.00
IUUC-Tru-117614 Takifugu rubripes 40.93 5.00e-160 557.00
IUUC-Tsy-118807 Tarsius syrichta 33.82 4.00e-78 285.00
IUUC-Tni-119809 Tetraodon nigroviridis 42.13 5.00e-153 534.00
IUUC-Tca-121312 Theobroma cacao 38.03 1.00e-71 263.00
IUUC-Tre-121930 Trichoderma reesei 39.52 1.00e-66 246.00
IUUC-Tvi-122373 Trichoderma virens 39.79 5.00e-65 241.00
IUUC-Tae-123064 Triticum aestivum 37.25 1.00e-63 235.00
IUUC-Tme-127027 Tuber melanosporum 37.16 2.00e-60 225.00
IUUC-Tbe-127675 Tupaia belangeri 38.61 2.00e-19 90.50
IUUC-Ttr-128411 Tursiops truncatus 34.79 8.00e-141 493.00
IUUC-Uma-129408 Ustilago maydis 45.33 7.00e-68 250.00
IUUC-Vda-129994 Verticillium dahliae 37.67 4.00e-66 244.00
IUUC-Vpa-130525 Vicugna pacos 64.29 8.00e-19 87.80
IUUC-Vvi-131038 Vitis vinifera 40.19 5.00e-71 260.00
IUUC-Xtr-132618 Xenopus tropicalis 39.45 9.00e-160 556.00
IUUC-Xma-133730 Xiphophorus maculatus 36.49 3.00e-126 445.00
IUUC-Yli-134680 Yarrowia lipolytica 39.19 2.00e-72 266.00
IUUC-Zma-135110 Zea mays 40.56 1.00e-65 243.00
Created Date 25-Jun-2017

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