iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035967

Ensembl Protein ID

ENSFCAP00000004739.3

UniProt Accession

M3W3H7; M3W3H7_FELCA

Genbank Protein ID

ENSFCAP00000004739

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AANG02047603

Gene Name

ABL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000005115.3	ENSFCAT00000005116.3	ENSFCAP00000004739.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.80e-14	52.9	82	139

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++++++W+++  ++++ +G +P+n+++ ++
   Q: 82   PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNHNGEWCEA--QTKNGQGWVPSNYITPVN 139
           68899************************.***********..79999**********997 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MGQQPGKVLG DQRRPSLPAL HFIKGAGKKE SSRHGGPHCN VFVEHEALQR PVASDFEPQG 60
LSEAARWNSK ENLLAGPSEN DPNLFVALYD FVASGDNTLS ITKGEKLRVL GYNHNGEWCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGCAGC AGCCTGGAAA AGTTCTTGGG GACCAGAGGA GGCCAAGCTT GCCTGCCCTG 60
CACTTTATCA AAGGAGCAGG GAAGAAGGAG TCATCGAGGC ACGGGGGTCC GCACTGCAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR033221--ABL1
IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0031252--C:cell leading edge
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0090135--P:actin filament branching
GO:0050798--P:activated T cell proliferation
GO:1990051--P:activation of protein kinase C activity
GO:0046632--P:alpha-beta T cell differentiation
GO:0002322--P:B cell proliferation involved in immune response
GO:0050853--P:B cell receptor signaling pathway
GO:0001922--P:B-1 B cell homeostasis
GO:0060020--P:Bergmann glial cell differentiation
GO:0072358--P:cardiovascular system development
GO:0030154--P:cell differentiation
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071222--P:cellular response to lipopolysaccharide
GO:0021587--P:cerebellum morphogenesis
GO:0048668--P:collateral sprouting
GO:0006975--P:DNA damage induced protein phosphorylation
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0045184--P:establishment of protein localization
GO:0045087--P:innate immune response
GO:0030035--P:microspike assembly
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0022408--P:negative regulation of cell-cell adhesion
GO:2000773--P:negative regulation of cellular senescence
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045930--P:negative regulation of mitotic cell cycle
GO:1900275--P:negative regulation of phospholipase C activity
GO:0071901--P:negative regulation of protein serine/threonine kinase activity
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0001843--P:neural tube closure
GO:0060563--P:neuroepithelial cell differentiation
GO:0050885--P:neuromuscular process controlling balance
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0006909--P:phagocytosis
GO:0035791--P:platelet-derived growth factor receptor-beta signaling pathway
GO:1904531--P:positive regulation of actin filament binding
GO:0043065--P:positive regulation of apoptotic process
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902715--P:positive regulation of interferon-gamma secretion
GO:1900042--P:positive regulation of interleukin-2 secretion
GO:1904528--P:positive regulation of microtubule binding
GO:0045931--P:positive regulation of mitotic cell cycle
GO:1901216--P:positive regulation of neuron death
GO:0033690--P:positive regulation of osteoblast proliferation
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:2000096--P:positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:0009791--P:post-embryonic development
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0030516--P:regulation of axon extension
GO:0042127--P:regulation of cell proliferation
GO:1903053--P:regulation of extracellular matrix organization
GO:0031113--P:regulation of microtubule polymerization
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0042770--P:signal transduction in response to DNA damage
GO:0048536--P:spleen development
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0048538--P:thymus development
GO:0002333--P:transitional one stage B cell differentiation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001550	Ailuropoda melanoleuca	95.74	0.00e+00	1964.00
IUUC-Apl-003452	Anas platyrhynchos	81.74	0.00e+00	1660.00
IUUC-Aca-005312	Anolis carolinensis	80.63	0.00e+00	1266.00
IUUC-Ame-011903	Astyanax mexicanus	84.68	0.00e+00	1093.00
IUUC-Bta-012351	Bos taurus	90.88	0.00e+00	1796.00
IUUC-Cja-019491	Callithrix jacchus	90.79	0.00e+00	1934.00
IUUC-Cfa-021256	Canis familiaris	95.22	0.00e+00	1999.00
IUUC-Cpo-022046	Cavia porcellus	91.43	0.00e+00	1587.00
IUUC-Csa-023046	Chlorocebus sabaeus	90.78	0.00e+00	1863.00
IUUC-Dre-028190	Danio rerio	65.89	0.00e+00	1259.00
IUUC-Dno-029853	Dasypus novemcinctus	90.18	0.00e+00	1883.00
IUUC-Dor-030635	Dipodomys ordii	83.09	0.00e+00	1707.00
IUUC-Dme-032098	Drosophila melanogaster	75.32	0.00e+00	778.00
IUUC-Eca-033720	Equus caballus	93.76	0.00e+00	1864.00
IUUC-Eeu-035173	Erinaceus europaeus	90.40	0.00e+00	1506.00
IUUC-Fal-036723	Ficedula albicollis	82.01	0.00e+00	1652.00
IUUC-Gmo-039550	Gadus morhua	75.96	0.00e+00	1136.00
IUUC-Gga-040481	Gallus gallus	82.28	0.00e+00	1613.00
IUUC-Gac-041643	Gasterosteus aculeatus	67.23	0.00e+00	1308.00
IUUC-Ggo-045299	Gorilla gorilla	90.93	0.00e+00	1961.00
IUUC-Hsa-047033	Homo sapiens	100.00	1.00e-41	160.00
IUUC-Itr-047935	Ictidomys tridecemlineatus	90.43	0.00e+00	1755.00
IUUC-Lch-050530	Latimeria chalumnae	77.25	0.00e+00	1588.00
IUUC-Loc-052430	Lepisosteus oculatus	86.37	0.00e+00	1043.00
IUUC-Laf-053609	Loxodonta africana	90.61	0.00e+00	1857.00
IUUC-Mcc-055654	Macaca mulatta	91.23	0.00e+00	1981.00
IUUC-Meu-056488	Macropus eugenii	78.16	0.00e+00	1619.00
IUUC-Mga-059270	Meleagris gallopavo	82.08	0.00e+00	1661.00
IUUC-Mmr-060593	Microcebus murinus	89.82	0.00e+00	1845.00
IUUC-Mdo-062227	Monodelphis domestica	91.48	0.00e+00	1359.00
IUUC-Mmu-064002	Mus musculus	86.30	0.00e+00	1835.00
IUUC-Mpu-066197	Mustela putorius furo	95.30	0.00e+00	1967.00
IUUC-Mlu-067255	Myotis lucifugus	93.48	0.00e+00	1845.00
IUUC-Nle-069977	Nomascus leucogenys	89.37	0.00e+00	1425.00
IUUC-Opr-070327	Ochotona princeps	81.72	0.00e+00	1563.00
IUUC-Ont-072307	Oreochromis niloticus	66.32	0.00e+00	1281.00
IUUC-Oan-073100	Ornithorhynchus anatinus	84.39	0.00e+00	1697.00
IUUC-Ocu-074892	Oryctolagus cuniculus	83.29	0.00e+00	1597.00
IUUC-Ola-087389	Oryzias latipes	67.65	0.00e+00	1092.00
IUUC-Oga-088145	Otolemur garnettii	90.50	0.00e+00	1823.00
IUUC-Oar-090432	Ovis aries	93.41	0.00e+00	1471.00
IUUC-Ptr-090800	Pan troglodytes	91.31	0.00e+00	1962.00
IUUC-Psi-093078	Pelodiscus sinensis	81.56	0.00e+00	1712.00
IUUC-Pma-094420	Petromyzon marinus	78.52	0.00e+00	901.00
IUUC-Pfo-096979	Poecilia formosa	70.04	0.00e+00	1087.00
IUUC-Pca-100874	Procavia capensis	99.74	0.00e+00	772.00
IUUC-Pva-102415	Pteropus vampyrus	92.96	0.00e+00	1900.00
IUUC-Rno-105682	Rattus norvegicus	86.56	0.00e+00	1831.00
IUUC-Sha-106711	Sarcophilus harrisii	83.57	0.00e+00	1701.00
IUUC-Ssc-115472	Sus scrofa	92.78	0.00e+00	1876.00
IUUC-Tgu-117037	Taeniopygia guttata	83.23	0.00e+00	1770.00
IUUC-Tru-118324	Takifugu rubripes	58.94	0.00e+00	1110.00
IUUC-Tsy-119216	Tarsius syrichta	97.62	0.00e+00	1184.00
IUUC-Tni-119950	Tetraodon nigroviridis	77.92	0.00e+00	987.00
IUUC-Ttr-128209	Tursiops truncatus	94.09	0.00e+00	2000.00
IUUC-Xtr-132477	Xenopus tropicalis	74.27	0.00e+00	1079.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence