iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045831

Ensembl Protein ID

ENSP00000266269.5

UniProt Accession

Q9HBE1; Q9HBE2; Q9HBE3; Q9P1A9; Q9UDU0; Q9Y529; PATZ1_HUMAN

Genbank Protein ID

AAF32518.1; AAG09031.1; AAG09032.1; AAG09033.1; AAG09034.1; AAK19024.1; CAB51404.1; CAG30499.1; AAF01349.1; AAH21091.1

Protein Name

POZ-, AT hook-, and zinc finger-containing protein 1; BTB/POZ domain zinc finger transcription factor; Protein kinase A RI subunit alpha-associated protein; Zinc finger and BTB domain-containing protein 19; Zinc finger protein 278; Zinc finger sarcoma gene protein

Genbank Nucleotide ID

AF119256; AF254082; AF254083; AF254084; AF254085; AY028384; AL096880; CR456613; AC005003; BC021091

Gene Name

PATZ1; PATZ; RIAZ; ZBTB19; ZNF278; ZSG

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000100105.17	ENST00000266269.9	ENSP00000266269.5
ENSG00000100105.17	ENST00000405309.7	ENSP00000384173.3
ENSG00000100105.17	ENST00000351933.8	ENSP00000337520.4
ENSG00000100105.17	ENST00000215919.3	ENSP00000215919.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	HINT	Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	2.90e-13	51.6	41	126

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmelees......................ksklmveikdvqpevfrallkFlYtgkl 65
           +Dv+l vg+e f+ah++vLaa+S++F++ f+ +l ++                        + + e++ ++ +vf ++l+F Yt+++
   Q: 41   CDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGgaadggpadvggataapgggagG-SRELEMHTISSKVFGDILDFAYTSRI 126
           8**********************************999********************54.8899999****************997 PP

Organism

Homo sapiens

Functional Description
(View)

Transcriptional repressor.

Protein Sequence
(Fasta)

MERVNDASCG PSGCYTYQVS RHSTEMLHNL NQQRKNGGRF CDVLLRVGDE SFPAHRAVLA 60
ACSEYFESVF SAQLGDGGAA DGGPADVGGA TAAPGGGAGG SRELEMHTIS SKVFGDILDF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCCAGCCG CCGCCGCCGC CGCCACCGCC CTCCAGGCTC CGGGACCCGG CCCGCGCCAC 60
CGCCCCCGTG CGCGCCCCGC CGCCGCCGCC TTCGCCTTCG CCTTTTGTTT CCTCCGCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR000637--HMGI/Y_DNA-bd_CS
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00354--HMGI_Y
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008584--P:male gonad development
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007283--P:spermatogenesis
GO:0030217--P:T cell differentiation

KEGG

hsa:23598

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001393	Ailuropoda melanoleuca	99.13	0.00e+00	1273.00
IUUC-Ame-010861	Astyanax mexicanus	58.56	0.00e+00	710.00
IUUC-Bta-012647	Bos taurus	99.13	0.00e+00	1271.00
IUUC-Cja-019987	Callithrix jacchus	99.42	0.00e+00	1248.00
IUUC-Cfa-020091	Canis familiaris	99.27	0.00e+00	1273.00
IUUC-Cpo-021731	Cavia porcellus	98.40	0.00e+00	1260.00
IUUC-Csa-023323	Chlorocebus sabaeus	96.56	0.00e+00	944.00
IUUC-Cho-024339	Choloepus hoffmanni	96.64	7.00e-104	371.00
IUUC-Dre-028776	Danio rerio	54.30	0.00e+00	651.00
IUUC-Dno-028988	Dasypus novemcinctus	98.55	0.00e+00	1169.00
IUUC-Eca-034224	Equus caballus	92.58	0.00e+00	1164.00
IUUC-Fca-035834	Felis catus	92.72	0.00e+00	1159.00
IUUC-Gmo-038564	Gadus morhua	54.67	0.00e+00	671.00
IUUC-Gga-040923	Gallus gallus	88.20	0.00e+00	1145.00
IUUC-Gac-042115	Gasterosteus aculeatus	56.35	0.00e+00	732.00
IUUC-Ggo-045483	Gorilla gorilla	99.85	0.00e+00	1285.00
IUUC-Itr-048966	Ictidomys tridecemlineatus	99.13	0.00e+00	1274.00
IUUC-Lch-050298	Latimeria chalumnae	70.69	0.00e+00	904.00
IUUC-Laf-053714	Loxodonta africana	98.54	0.00e+00	1276.00
IUUC-Mcc-055844	Macaca mulatta	82.53	0.00e+00	753.00
IUUC-Mmr-061004	Microcebus murinus	96.24	0.00e+00	1224.00
IUUC-Mdo-061816	Monodelphis domestica	83.71	0.00e+00	972.00
IUUC-Mmu-063774	Mus musculus	98.98	0.00e+00	1271.00
IUUC-Mpu-066238	Mustela putorius furo	96.37	0.00e+00	937.00
IUUC-Mlu-068149	Myotis lucifugus	98.98	0.00e+00	1270.00
IUUC-Opr-071017	Ochotona princeps	88.33	0.00e+00	752.00
IUUC-Ont-072352	Oreochromis niloticus	55.17	0.00e+00	704.00
IUUC-Oan-073423	Ornithorhynchus anatinus	93.18	0.00e+00	1208.00
IUUC-Ocu-074291	Oryctolagus cuniculus	95.99	0.00e+00	939.00
IUUC-Oga-088646	Otolemur garnettii	99.27	0.00e+00	1268.00
IUUC-Oar-089847	Ovis aries	88.65	0.00e+00	1093.00
IUUC-Ptr-091669	Pan troglodytes	99.85	0.00e+00	1285.00
IUUC-Pfo-097307	Poecilia formosa	53.18	0.00e+00	657.00
IUUC-Pab-097693	Pongo abelii	99.56	0.00e+00	1282.00
IUUC-Pca-100274	Procavia capensis	83.50	2.00e-143	503.00
IUUC-Pva-102261	Pteropus vampyrus	99.42	0.00e+00	1273.00
IUUC-Ptt-103895	Puccinia triticina	38.10	8.00e-06	44.70
IUUC-Rno-105339	Rattus norvegicus	92.43	0.00e+00	1155.00
IUUC-Ssc-116429	Sus scrofa	91.99	0.00e+00	1148.00
IUUC-Tgu-116916	Taeniopygia guttata	82.43	0.00e+00	972.00
IUUC-Tru-117811	Takifugu rubripes	57.68	0.00e+00	751.00
IUUC-Tni-120697	Tetraodon nigroviridis	52.78	0.00e+00	642.00
IUUC-Ttr-128276	Tursiops truncatus	99.13	0.00e+00	1271.00
IUUC-Xtr-131778	Xenopus tropicalis	71.45	0.00e+00	892.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence