iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000100266.18	ENST00000507586.1	ENSP00000422788.1
ENSG00000100266.18	ENST00000263246.7	ENSP00000263246.3
ENSG00000100266.18	ENST00000407585.5	ENSP00000385952.1
ENSG00000100266.18	ENST00000634914.1	ENSP00000489297.1
ENSG00000100266.18	ENST00000453643.5	ENSP00000398573.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.90e-16	59.4	430	486

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++lydye+q+ deL++k+Gd ++ + ++e ++gW+kg + ++g+ Gl P+n+ve ++
   Q: 430  RVRALYDYEGQEHDELSFKAGDELTKM-EDEDEQGWCKG-RLDNGQVGLYPANYVEAIQ 486
           799***********************9.9**********.59*************9885 PP

Organism

Homo sapiens

Functional Description
(View)

Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.

Protein Sequence
(Fasta)

MSVTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCSD LMNCLHERAR IEKAYAQQLT 60
EWARRWRQLV EKGPQYGTVE KAWMAFMSEA ERVSELHLEV KASLMNDDFE KIKNWQKEAF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCCGCAG GGGTCTGGGC AGGGCTGGGC AGTGCTGCCG GAGCAAAAGC GGTAGCGGGA 60
GCCCGGCCGG AGCTGGGTCT GGAGACGCCG TGGCAGCCTG AACGGAGTGT GCGACGGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR031160--F_BAR
IPR001060--FCH_dom
IPR028521--PACSIN2
IPR001452--SH3_domain

PROSITE

PS51741--F_BAR
PS50002--SH3

Pfam

PF00611--FCH
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00055--FCH
SM00326--SH3

Gene Ontology

GO:0005901--C:caveola
GO:0005911--C:cell-cell junction
GO:0005737--C:cytoplasm
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0019898--C:extrinsic component of membrane
GO:0005925--C:focal adhesion
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016607--C:nuclear speck
GO:0005886--C:plasma membrane
GO:0055038--C:recycling endosome membrane
GO:0032587--C:ruffle membrane
GO:0045296--F:cadherin binding
GO:0042802--F:identical protein binding
GO:0070300--F:phosphatidic acid binding
GO:0005215--F:transporter activity
GO:0030036--P:actin cytoskeleton organization
GO:0070836--P:caveola assembly
GO:0072584--P:caveolin-mediated endocytosis
GO:0048858--P:cell projection morphogenesis
GO:0061024--P:membrane organization
GO:0045806--P:negative regulation of endocytosis
GO:0097320--P:plasma membrane tubulation
GO:0036010--P:protein localization to endosome
GO:0030100--P:regulation of endocytosis

KEGG

hsa:11252

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001887	Ailuropoda melanoleuca	93.83	0.00e+00	861.00
IUUC-Apl-003574	Anas platyrhynchos	87.47	0.00e+00	775.00
IUUC-Aca-004251	Anolis carolinensis	80.62	0.00e+00	743.00
IUUC-Ame-011756	Astyanax mexicanus	66.21	0.00e+00	665.00
IUUC-Bta-013193	Bos taurus	90.12	0.00e+00	802.00
IUUC-Cel-018168	Caenorhabditis elegans	31.92	8.00e-61	228.00
IUUC-Cja-018756	Callithrix jacchus	97.12	0.00e+00	865.00
IUUC-Cfa-020545	Canis familiaris	94.03	0.00e+00	892.00
IUUC-Cpo-022000	Cavia porcellus	89.30	0.00e+00	893.00
IUUC-Csa-024030	Chlorocebus sabaeus	98.43	0.00e+00	794.00
IUUC-Cin-025707	Ciona intestinalis	42.54	5.00e-106	378.00
IUUC-Csv-026244	Ciona savignyi	42.11	3.00e-54	204.00
IUUC-Dre-028104	Danio rerio	63.20	1.00e-161	562.00
IUUC-Dno-029429	Dasypus novemcinctus	92.73	0.00e+00	786.00
IUUC-Dor-030122	Dipodomys ordii	87.45	0.00e+00	786.00
IUUC-Dme-032120	Drosophila melanogaster	42.69	1.00e-104	373.00
IUUC-Eca-033367	Equus caballus	91.77	0.00e+00	838.00
IUUC-Eeu-034821	Erinaceus europaeus	76.75	0.00e+00	670.00
IUUC-Fca-036079	Felis catus	94.44	0.00e+00	861.00
IUUC-Fal-036682	Ficedula albicollis	87.23	0.00e+00	772.00
IUUC-Gmo-039681	Gadus morhua	64.49	2.00e-155	542.00
IUUC-Gga-040717	Gallus gallus	87.45	0.00e+00	774.00
IUUC-Gac-042262	Gasterosteus aculeatus	63.93	2.00e-169	588.00
IUUC-Ggo-044841	Gorilla gorilla	99.38	0.00e+00	857.00
IUUC-Itr-049063	Ictidomys tridecemlineatus	94.86	0.00e+00	838.00
IUUC-Loc-051975	Lepisosteus oculatus	70.23	0.00e+00	683.00
IUUC-Laf-053839	Loxodonta africana	89.77	0.00e+00	815.00
IUUC-Mcc-055783	Macaca mulatta	98.97	0.00e+00	854.00
IUUC-Mga-060087	Meleagris gallopavo	81.91	0.00e+00	709.00
IUUC-Mmr-060827	Microcebus murinus	95.06	0.00e+00	873.00
IUUC-Mmu-064109	Mus musculus	93.83	0.00e+00	862.00
IUUC-Mpu-066591	Mustela putorius furo	94.24	0.00e+00	868.00
IUUC-Mlu-067826	Myotis lucifugus	93.42	0.00e+00	860.00
IUUC-Nle-069797	Nomascus leucogenys	99.38	0.00e+00	857.00
IUUC-Oan-073076	Ornithorhynchus anatinus	84.06	4.00e-153	533.00
IUUC-Ocu-074425	Oryctolagus cuniculus	93.83	0.00e+00	839.00
IUUC-Ola-087556	Oryzias latipes	64.84	2.00e-161	562.00
IUUC-Oga-089009	Otolemur garnettii	85.66	0.00e+00	786.00
IUUC-Oar-089806	Ovis aries	90.53	0.00e+00	806.00
IUUC-Ptr-091111	Pan troglodytes	99.18	0.00e+00	854.00
IUUC-Pan-091749	Papio anubis	96.27	0.00e+00	840.00
IUUC-Psi-093704	Pelodiscus sinensis	87.02	0.00e+00	788.00
IUUC-Pfo-096680	Poecilia formosa	62.96	4.00e-166	578.00
IUUC-Pab-098584	Pongo abelii	99.68	3.00e-169	587.00
IUUC-Pva-102649	Pteropus vampyrus	93.00	0.00e+00	836.00
IUUC-Rno-105431	Rattus norvegicus	93.24	0.00e+00	874.00
IUUC-Sha-106641	Sarcophilus harrisii	89.48	0.00e+00	808.00
IUUC-Sar-113461	Sorex araneus	81.69	0.00e+00	724.00
IUUC-Ssc-115349	Sus scrofa	93.61	0.00e+00	829.00
IUUC-Tgu-116876	Taeniopygia guttata	87.45	0.00e+00	772.00
IUUC-Tru-118306	Takifugu rubripes	67.20	2.00e-174	605.00
IUUC-Tsy-118901	Tarsius syrichta	84.18	4.00e-151	528.00
IUUC-Tni-120120	Tetraodon nigroviridis	67.62	8.00e-178	616.00
IUUC-Xtr-132925	Xenopus tropicalis	80.29	0.00e+00	740.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence