iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000010103.5	ENSBTAT00000045179.3	ENSBTAP00000042592.3
ENSBTAG00000010103.5	ENSBTAT00000013346.5	ENSBTAP00000013346.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	9.60e-06	26.2	10	131

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw.pglknssskefr............................................... 41
           C++C + +++ p++lpC H +++ C  ++ ++ + s+s++ r                                               
   Q: 10   CPVCGSFYRE-PIILPCSHNICQACARNIlVQTPESESPQSRrasgsgvsdydyldldkmslyseadsgygsyggfasapttpcqkspn 97
           ****888877.**************9777788887888777767777777888888888888888888888888888888888777777 PP
   S: 42   ..............................CPlC 45
                                         CP C
   Q: 98   gvrvfppampppathlspalasvprnscitCPQC 131
           7777777777777777777777777777777777 PP

Organism

Bos taurus

Functional Description
(View)

E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.

Protein Sequence
(Fasta)

MEEMEEELKC PVCGSFYREP IILPCSHNIC QACARNILVQ TPESESPQSR RASGSGVSDY 60
DYLDLDKMSL YSEADSGYGS YGGFASAPTT PCQKSPNGVR VFPPAMPPPA THLSPALASV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAGCGCCT CGCAGGGAGT CGGCGCCTAA GCGACGCGGG AAGGCGCCAC TGCCAAAACC 60
ACCGCCGCCA CTGCTGGCCA AGGTGCTGGA CACGACAGGC CAGCCGGCCA CCTCGTCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0965--Cell junction
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003649--Bbox_C
IPR013320--ConA-like_dom
IPR017903--COS_domain
IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS51262--COS
PS50853--FN3
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00041--fn3
PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00502--BBC
SM00336--BBOX
SM00060--FN3
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0030425--C:dendrite
GO:0008021--C:synaptic vesicle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

KEGG

bta:767615

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002033	Ailuropoda melanoleuca	97.71	0.00e+00	898.00
IUUC-Apl-004004	Anas platyrhynchos	91.72	0.00e+00	1144.00
IUUC-Aca-004773	Anolis carolinensis	65.31	0.00e+00	979.00
IUUC-Ame-011429	Astyanax mexicanus	61.92	0.00e+00	920.00
IUUC-Cel-018432	Caenorhabditis elegans	36.15	2.00e-133	469.00
IUUC-Cja-019517	Callithrix jacchus	66.34	0.00e+00	981.00
IUUC-Cfa-020744	Canis familiaris	99.44	0.00e+00	1089.00
IUUC-Cpo-021775	Cavia porcellus	98.69	0.00e+00	1045.00
IUUC-Csa-024085	Chlorocebus sabaeus	98.69	0.00e+00	1081.00
IUUC-Cho-024738	Choloepus hoffmanni	87.31	5.00e-128	451.00
IUUC-Cin-025387	Ciona intestinalis	42.42	1.00e-171	597.00
IUUC-Csv-025851	Ciona savignyi	45.44	0.00e+00	649.00
IUUC-Dre-027691	Danio rerio	83.94	0.00e+00	1285.00
IUUC-Dno-029047	Dasypus novemcinctus	98.87	0.00e+00	1456.00
IUUC-Dor-030823	Dipodomys ordii	81.46	0.00e+00	814.00
IUUC-Dme-031822	Drosophila melanogaster	46.20	3.00e-168	585.00
IUUC-Ete-032674	Echinops telfairi	57.80	0.00e+00	854.00
IUUC-Eca-034107	Equus caballus	67.79	0.00e+00	974.00
IUUC-Eeu-034494	Erinaceus europaeus	97.92	0.00e+00	786.00
IUUC-Fca-036046	Felis catus	94.24	0.00e+00	1013.00
IUUC-Fal-036997	Ficedula albicollis	76.31	0.00e+00	791.00
IUUC-Gmo-039639	Gadus morhua	77.72	0.00e+00	1173.00
IUUC-Gga-040951	Gallus gallus	90.83	0.00e+00	1328.00
IUUC-Gac-041390	Gasterosteus aculeatus	79.27	0.00e+00	1213.00
IUUC-Ggo-045059	Gorilla gorilla	98.31	0.00e+00	1079.00
IUUC-Hsa-046503	Homo sapiens	97.75	0.00e+00	1442.00
IUUC-Itr-049084	Ictidomys tridecemlineatus	97.95	0.00e+00	1040.00
IUUC-Lch-049521	Latimeria chalumnae	93.45	0.00e+00	1008.00
IUUC-Loc-052213	Lepisosteus oculatus	83.24	0.00e+00	1234.00
IUUC-Laf-054442	Loxodonta africana	98.45	0.00e+00	1450.00
IUUC-Mcc-054887	Macaca mulatta	98.03	0.00e+00	1444.00
IUUC-Meu-056251	Macropus eugenii	88.58	0.00e+00	941.00
IUUC-Mga-059961	Meleagris gallopavo	76.34	0.00e+00	770.00
IUUC-Mmr-061677	Microcebus murinus	98.31	0.00e+00	1451.00
IUUC-Mdo-062987	Monodelphis domestica	96.82	0.00e+00	1053.00
IUUC-Mmu-063314	Mus musculus	92.08	0.00e+00	1337.00
IUUC-Mpu-066785	Mustela putorius furo	99.44	0.00e+00	1089.00
IUUC-Mlu-067137	Myotis lucifugus	98.59	0.00e+00	1455.00
IUUC-Nle-070127	Nomascus leucogenys	98.17	0.00e+00	1446.00
IUUC-Opr-070763	Ochotona princeps	94.19	0.00e+00	1050.00
IUUC-Ont-071416	Oreochromis niloticus	84.74	0.00e+00	1296.00
IUUC-Oan-072901	Ornithorhynchus anatinus	92.61	7.00e-139	487.00
IUUC-Ocu-074241	Oryctolagus cuniculus	98.88	0.00e+00	1084.00
IUUC-Ola-086349	Oryzias latipes	79.72	1.00e-104	371.00
IUUC-Oga-088969	Otolemur garnettii	98.69	0.00e+00	1083.00
IUUC-Oar-089807	Ovis aries	99.15	0.00e+00	1451.00
IUUC-Ptr-090952	Pan troglodytes	97.57	0.00e+00	1065.00
IUUC-Pan-092565	Papio anubis	89.39	0.00e+00	1400.00
IUUC-Psi-093885	Pelodiscus sinensis	92.57	0.00e+00	934.00
IUUC-Pfo-096684	Poecilia formosa	84.49	0.00e+00	1296.00
IUUC-Pab-097638	Pongo abelii	98.17	0.00e+00	1440.00
IUUC-Pca-101102	Procavia capensis	98.31	0.00e+00	1075.00
IUUC-Pva-103204	Pteropus vampyrus	97.69	4.00e-147	515.00
IUUC-Rno-105306	Rattus norvegicus	97.61	0.00e+00	1402.00
IUUC-Sha-106771	Sarcophilus harrisii	75.57	0.00e+00	789.00
IUUC-Sar-113631	Sorex araneus	97.75	0.00e+00	1068.00
IUUC-Sbi-114403	Sorghum bicolor	26.89	4.00e-05	42.00
IUUC-Ssc-115634	Sus scrofa	99.15	0.00e+00	1459.00
IUUC-Tgu-117319	Taeniopygia guttata	71.82	0.00e+00	889.00
IUUC-Tru-117583	Takifugu rubripes	84.37	0.00e+00	1280.00
IUUC-Tsy-119427	Tarsius syrichta	96.54	5.00e-146	511.00
IUUC-Tni-120847	Tetraodon nigroviridis	84.34	0.00e+00	1283.00
IUUC-Tbe-127239	Tupaia belangeri	96.77	0.00e+00	675.00
IUUC-Ttr-129238	Tursiops truncatus	96.15	5.00e-142	497.00
IUUC-Vpa-130241	Vicugna pacos	96.04	0.00e+00	996.00
IUUC-Xtr-131998	Xenopus tropicalis	89.78	0.00e+00	1321.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence