iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000100897.17	ENST00000559115.5	ENSP00000452898.1
ENSG00000100897.17	ENST00000557802.5	ENSP00000453462.1
ENSG00000100897.17	ENST00000560901.5	ENSP00000453132.1
ENSG00000100897.17	ENST00000558706.5	ENSP00000453803.1
ENSG00000100897.17	ENST00000558914.5	ENSP00000453035.1
ENSG00000100897.17	ENST00000396941.8	ENSP00000380146.4
ENSG00000100897.17	ENST00000396936.5	ENSP00000380142.1
ENSG00000100897.17	ENST00000559144.1	ENSP00000453115.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	16964240

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.40e-25	88.7	482	514
UBD/Beta-Prp	1.40e-46	160.7	270	516

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           H++ v+++++   +  +vs+s+Dg++++W +r+
   Q: 482  HKACVRDVSWhpFEEKIVSSSWDGNLRLWQYRQ 514
           9999******965599*************9775 PP

UBD/Beta-Prp

   S: 15   cvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.....tgkcvhtlkghedsvlsl 100
           ++++s d++ ++ g  dg++ v+d ++     ++++he+ v+av f + ++ il +g++D++ kvwd +     ++k+v +l gh+d ++ +
   Q: 270  SIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSqILFSGGDDAICKVWDRRtmredDPKPVGALAGHQDGITFI 361
           47889999999****************9999999**********99875545**************8877778899**************** PP
   S: 101  sfspsgdklvsGshdrtirvwdletgqclee.....................................tlsghdgvvncvv.....vhpdg. 149
           ++  +  +l+s s+d+ti++wd++  +  e                                      t +gh  + + ++     +h++g 
   Q: 362  DSKGDARYLISNSKDQTIKLWDIRRFSSREGmeasrqaatqqnwdyrwqqvpkkawrklklpgdsslmTYRGHGVLHTLIRcrfspIHSTGq 453
           ****99*****************9999887789999*******************************9888886655555433344799999 PP
   S: 150  nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtge 213
           + + sG+  ++v ++dl +g ++++lt  h+  v+ +s+++  + +vs s dg ++lw++++ e
   Q: 454  QFIYSGCSTGKVVVYDLLSGHIVKKLTN-HKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAE 516
           9999**********************97.******************************99554 PP

Organism

Homo sapiens

Functional Description
(View)

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Protein Sequence
(Fasta)

MGSRNSSSAG SGSGDPSEGL PRRGAGLRRS EEEEEEDEDV DLAQVLAYLL RRGQVRLVQG 60
GGAANLQFIQ ALLDSEEEND RAWDGRLGDR YNPPVDATPD TRELEFNEIK TQVELATGQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAAGACGCG TGTATTAGGG AACGTCTGCA AAGACCGCGG CGGAAAGCCA GGGATTGTCT 60
TAAAAAATTG TCAGACCGGA TAAAGGGAGG TCTAAAAGGG GACCGTCCCA AGAGCAAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR017399--DCAF11/LEC14B
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005654--C:nucleoplasm
GO:0016567--P:protein ubiquitination

KEGG

hsa:80344

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000659	Aegilops tauschii	42.36	1.00e-65	244.00
IUUC-Aml-001732	Ailuropoda melanoleuca	95.27	0.00e+00	968.00
IUUC-Atr-002856	Amborella trichopoda	42.82	2.00e-79	289.00
IUUC-Aca-005081	Anolis carolinensis	80.20	0.00e+00	839.00
IUUC-Aly-006571	Arabidopsis lyrata	42.24	1.00e-91	330.00
IUUC-Ath-007313	Arabidopsis thaliana	42.72	2.00e-92	333.00
IUUC-Acl-008126	Aspergillus clavatus	36.10	2.00e-58	220.00
IUUC-Afl-008513	Aspergillus flavus	34.88	1.00e-60	228.00
IUUC-Afu-008765	Aspergillus fumigatus	32.08	3.00e-57	216.00
IUUC-Ani-009456	Aspergillus nidulans	36.80	7.00e-64	238.00
IUUC-Ang-009781	Aspergillus niger	33.16	2.00e-52	201.00
IUUC-Aor-010093	Aspergillus oryzae	34.88	1.00e-60	228.00
IUUC-Ate-010456	Aspergillus terreus	35.45	3.00e-60	226.00
IUUC-Ame-011825	Astyanax mexicanus	70.12	1.00e-175	608.00
IUUC-Bgr-012310	Blumeria graminis	33.70	3.00e-57	216.00
IUUC-Bta-013043	Bos taurus	95.09	0.00e+00	964.00
IUUC-Bci-013758	Botrytis cinerea	36.36	5.00e-60	226.00
IUUC-Bdi-014294	Brachypodium distachyon	46.69	7.00e-88	317.00
IUUC-Bol-016186	Brassica oleracea	44.05	5.00e-86	312.00
IUUC-Bra-018035	Brassica rapa	44.05	6.00e-86	311.00
IUUC-Cel-018145	Caenorhabditis elegans	42.59	2.00e-86	313.00
IUUC-Cja-018940	Callithrix jacchus	97.62	0.00e+00	995.00
IUUC-Cfa-020064	Canis familiaris	95.84	0.00e+00	967.00
IUUC-Cpo-022220	Cavia porcellus	93.17	0.00e+00	977.00
IUUC-Cre-022728	Chlamydomonas reinhardtii	50.84	1.00e-65	242.00
IUUC-Csa-023158	Chlorocebus sabaeus	99.01	0.00e+00	1004.00
IUUC-Cho-024797	Choloepus hoffmanni	75.42	2.00e-94	339.00
IUUC-Cgl-026444	Colletotrichum gloeosporioides	37.77	5.00e-62	232.00
IUUC-Cne-026917	Cryptococcus neoformans	36.72	7.00e-51	195.00
IUUC-Cme-027273	Cyanidioschyzon merolae	29.89	1.00e-44	175.00
IUUC-Dre-028711	Danio rerio	69.09	0.00e+00	717.00
IUUC-Dno-029851	Dasypus novemcinctus	94.31	0.00e+00	954.00
IUUC-Dor-030952	Dipodomys ordii	85.80	0.00e+00	830.00
IUUC-Dse-031288	Dothistroma septosporum	31.41	2.00e-57	217.00
IUUC-Dme-031925	Drosophila melanogaster	36.78	2.00e-80	293.00
IUUC-Ete-032983	Echinops telfairi	87.02	0.00e+00	843.00
IUUC-Eca-033499	Equus caballus	95.65	0.00e+00	996.00
IUUC-Eeu-035179	Erinaceus europaeus	89.86	0.00e+00	763.00
IUUC-Fca-035615	Felis catus	96.83	0.00e+00	946.00
IUUC-Fox-037867	Fusarium oxysporum	37.53	8.00e-57	214.00
IUUC-Fso-038274	Fusarium solani	36.03	8.00e-58	218.00
IUUC-Gmo-038731	Gadus morhua	67.57	0.00e+00	708.00
IUUC-Ggr-039861	Gaeumannomyces graminis	33.41	4.00e-57	216.00
IUUC-Gac-041615	Gasterosteus aculeatus	68.88	0.00e+00	712.00
IUUC-Gma-043167	Glycine max	40.85	1.00e-89	323.00
IUUC-Hvu-047177	Hordeum vulgare	56.16	9.00e-62	229.00
IUUC-Itr-048985	Ictidomys tridecemlineatus	94.84	0.00e+00	965.00
IUUC-Lch-050257	Latimeria chalumnae	55.73	5.00e-156	544.00
IUUC-Lpe-051521	Leersia perrieri	44.79	1.00e-85	310.00
IUUC-Lma-053067	Leptosphaeria maculans	36.01	8.00e-54	205.00
IUUC-Laf-054259	Loxodonta africana	96.86	0.00e+00	973.00
IUUC-Mcc-054958	Macaca mulatta	98.94	0.00e+00	978.00
IUUC-Meu-056889	Macropus eugenii	84.66	0.00e+00	879.00
IUUC-Mor-057196	Magnaporthe oryzae	35.92	3.00e-58	219.00
IUUC-Mpo-057340	Magnaporthe poae	32.03	5.00e-54	206.00
IUUC-Mtr-058464	Medicago truncatula	41.51	9.00e-90	324.00
IUUC-Mla-058873	Melampsora laricipopulina	30.21	2.00e-50	194.00
IUUC-Mvi-060439	Microbotryum violaceum	34.45	2.00e-63	237.00
IUUC-Mmr-061329	Microcebus murinus	92.73	0.00e+00	967.00
IUUC-Mdo-062123	Monodelphis domestica	82.64	0.00e+00	863.00
IUUC-Mmu-063616	Mus musculus	93.49	0.00e+00	953.00
IUUC-Mac-064473	Musa acuminata	42.60	4.00e-81	295.00
IUUC-Mpu-066351	Mustela putorius furo	96.24	0.00e+00	847.00
IUUC-Mlu-067043	Myotis lucifugus	96.85	0.00e+00	945.00
IUUC-Nfi-068552	Neosartorya fischeri	34.76	7.00e-57	215.00
IUUC-Ncr-068715	Neurospora crassa	36.68	3.00e-57	216.00
IUUC-Nle-070052	Nomascus leucogenys	99.05	0.00e+00	1024.00
IUUC-Opr-070605	Ochotona princeps	83.74	0.00e+00	880.00
IUUC-Ont-072411	Oreochromis niloticus	69.33	0.00e+00	698.00
IUUC-Ocu-074078	Oryctolagus cuniculus	95.89	0.00e+00	941.00
IUUC-Oba-075901	Oryza barthii	43.23	4.00e-85	308.00
IUUC-Obr-076556	Oryza brachyantha	44.13	1.00e-84	306.00
IUUC-Ogl-077227	Oryza glaberrima	43.49	1.00e-85	310.00
IUUC-Ogu-078264	Oryza glumaepatula	42.31	6.00e-81	295.00
IUUC-Oin-079655	Oryza indica	43.49	8.00e-86	310.00
IUUC-Olo-080362	Oryza longistaminata	41.03	5.00e-74	271.00
IUUC-Ome-081712	Oryza meridionalis	43.46	6.00e-86	311.00
IUUC-Oni-083108	Oryza nivara	43.49	8.00e-86	310.00
IUUC-Opu-084070	Oryza punctata	43.49	6.00e-84	304.00
IUUC-Oru-085194	Oryza rufipogon	43.23	6.00e-85	308.00
IUUC-Osa-086287	Oryza sativa	41.88	1.00e-84	306.00
IUUC-Ola-086329	Oryzias latipes	68.32	0.00e+00	712.00
IUUC-Oga-088779	Otolemur garnettii	94.84	0.00e+00	970.00
IUUC-Oar-089262	Ovis aries	95.09	0.00e+00	963.00
IUUC-Ptr-091346	Pan troglodytes	95.07	0.00e+00	1007.00
IUUC-Pan-092716	Papio anubis	99.21	0.00e+00	1007.00
IUUC-Pma-094148	Petromyzon marinus	73.08	5.00e-129	453.00
IUUC-Pno-095116	Phaeosphaeria nodorum	35.22	1.00e-52	201.00
IUUC-Ppa-095260	Physcomitrella patens	44.56	1.00e-92	334.00
IUUC-Pfo-096424	Poecilia formosa	67.21	0.00e+00	707.00
IUUC-Pab-098091	Pongo abelii	94.88	0.00e+00	973.00
IUUC-Pop-099095	Populus trichocarpa	42.86	5.00e-89	321.00
IUUC-Pca-100153	Procavia capensis	96.07	0.00e+00	958.00
IUUC-Ppe-102075	Prunus persica	40.95	1.00e-88	320.00
IUUC-Pva-102598	Pteropus vampyrus	94.52	0.00e+00	957.00
IUUC-Pgr-103327	Puccinia graminis	34.22	5.00e-53	202.00
IUUC-Ptt-103861	Puccinia triticina	26.54	6.00e-28	118.00
IUUC-Pte-104286	Pyrenophora teres	35.12	3.00e-62	233.00
IUUC-Pyt-104745	Pyrenophora triticirepentis	38.31	2.00e-52	200.00
IUUC-Rno-104890	Rattus norvegicus	93.89	0.00e+00	956.00
IUUC-Sha-106540	Sarcophilus harrisii	84.49	0.00e+00	867.00
IUUC-Ssl-108528	Sclerotinia sclerotiorum	32.72	7.00e-49	188.00
IUUC-Smo-109019	Selaginella moellendorffii	41.32	5.00e-84	305.00
IUUC-Sit-110726	Setaria italica	39.69	1.00e-87	317.00
IUUC-Sly-110856	Solanum lycopersicum	43.33	3.00e-92	332.00
IUUC-Stu-112589	Solanum tuberosum	41.27	3.00e-81	295.00
IUUC-Sar-113742	Sorex araneus	93.75	0.00e+00	947.00
IUUC-Sbi-114505	Sorghum bicolor	44.05	3.00e-71	261.00
IUUC-Sre-115073	Sporisorium reilianum	35.66	4.00e-53	202.00
IUUC-Ssc-116019	Sus scrofa	93.57	0.00e+00	950.00
IUUC-Tru-118536	Takifugu rubripes	68.28	0.00e+00	706.00
IUUC-Tsy-119518	Tarsius syrichta	96.15	0.00e+00	991.00
IUUC-Tni-120264	Tetraodon nigroviridis	68.26	0.00e+00	705.00
IUUC-Tca-121554	Theobroma cacao	42.64	1.00e-87	317.00
IUUC-Tre-122144	Trichoderma reesei	35.31	1.00e-56	214.00
IUUC-Tvi-122472	Trichoderma virens	34.31	4.00e-59	223.00
IUUC-Tae-124083	Triticum aestivum	45.98	2.00e-84	306.00
IUUC-Tur-126714	Triticum urartu	37.61	2.00e-73	270.00
IUUC-Tme-127050	Tuber melanosporum	33.98	4.00e-69	256.00
IUUC-Tbe-127495	Tupaia belangeri	96.63	0.00e+00	982.00
IUUC-Ttr-128553	Tursiops truncatus	95.27	0.00e+00	977.00
IUUC-Uma-129557	Ustilago maydis	37.92	6.00e-54	206.00
IUUC-Vda-129951	Verticillium dahliae	35.10	2.00e-59	223.00
IUUC-Vpa-130542	Vicugna pacos	83.19	5.00e-102	364.00
IUUC-Vvi-131266	Vitis vinifera	43.88	3.00e-90	325.00
IUUC-Xtr-132525	Xenopus tropicalis	74.34	0.00e+00	719.00
IUUC-Xma-133165	Xiphophorus maculatus	67.61	0.00e+00	712.00
IUUC-Yli-134635	Yarrowia lipolytica	26.42	5.00e-22	99.80
IUUC-Zma-135833	Zea mays	42.94	5.00e-81	295.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence