iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000101138.11	ENST00000217109.8	ENSP00000217109.4
ENSG00000101138.11	ENST00000493039.5	ENSP00000477958.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Beta-Prp	Beta-Prp	21070969

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-27	95.6	172	202
UBD/Beta-Prp	5.10e-73	247.5	102	429

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H d+vtclaf ++  +l+sGs+D t+k++D+
   Q: 172  HVDEVTCLAFhPTeQILASGSRDYTLKLFDY 202
           9**********77799**************7 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl.......................lrslsgheaevtavkfspdgkilvtgse 72
           ++ ++hk+++++ ++s+d++l+atgs+d++ik+ d++++ +                       +r+l++h +evt++ f+p+++il++gs+
   Q: 102  CYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAksampievmmnetaqqnmenhpvIRTLYDHVDEVTCLAFHPTEQILASGSR 193
           67889*********************************988*************************************************** PP
   S: 73   Drtikvwdlstgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvsGslDrt 160
           D+t+k++d+s+++  +++k  ++ ++++s+sf+psgd++++G+++ t+r++d++t qc+ +  ++++h++++++v++++++n++v+Gs+D++
   Q: 194  DYTLKLFDYSKPSAKRAFKyiQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVScnPQDQHTDAICSVNYNSSANMYVTGSKDGC 285
           **************99999999***************************************99***************************** PP
   S: 161  vrlWdlktgkllrtltgghtdsvysls.fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs....pnderlvsgssDgsir 247
           ++lWd  ++++++t++++h+++  + + f++n+k+++s ++d+  klw+++tg+++++++g     ++v+ +    +++e +v   ++++i+
   Q: 286  IKLWDGVSNRCITTFEKAHDGAEVCSAiFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTqavfNHTEDYVLLPDERTIS 377
           ***************9999998777666***********************************99999888877789**************9 PP
   S: 248  i..Wdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkn 297
           +  Wd+r+ +  + l+l +++++ + v+s++++ ++++s+d ++++w  +++
   Q: 378  LccWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRST 429
           888********************************************98765 PP

Organism

Homo sapiens

Functional Description
(View)

Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts directly with CSTF3. Interacts with BARD1.

Protein Sequence
(Fasta)

MYRTKVGLKD RQQLYKLIIS QLLYDGYISI ANGLINEIKP QSVCAPSEQL LHLIKLGMEN 60
DDTAVQYAIG RSDTVAPGTG IDLEFDADVQ TMSPEASEYE TCYVTSHKGP CRVATYSRDG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGAACCCGG AAGTGGTGGA GCCAACGGCC AGCCAGACCT GTGGCAGTCC CAGCCCCAGG 60
GTGCTCTCCG CGGTCGGCCA TTTATCGGTG AAGCAACAGC CCCTTGACGT CAAGCTTGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0507--mRNA processing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR032028--CSTF1_dimer
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF16699--CSTF1_dimer
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0003723--F:RNA binding
GO:0031124--P:mRNA 3'-end processing
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006369--P:termination of RNA polymerase II transcription

KEGG

hsa:1477

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002163	Ailuropoda melanoleuca	99.77	0.00e+00	905.00
IUUC-Atr-002687	Amborella trichopoda	38.44	5.00e-68	251.00
IUUC-Apl-003438	Anas platyrhynchos	98.38	0.00e+00	896.00
IUUC-Aca-005178	Anolis carolinensis	97.45	0.00e+00	892.00
IUUC-Aly-005791	Arabidopsis lyrata	37.50	3.00e-80	292.00
IUUC-Ath-006689	Arabidopsis thaliana	38.68	6.00e-81	294.00
IUUC-Ame-011217	Astyanax mexicanus	91.55	5.00e-162	563.00
IUUC-Bta-012619	Bos taurus	99.54	0.00e+00	903.00
IUUC-Bdi-014515	Brachypodium distachyon	43.43	2.00e-79	289.00
IUUC-Bra-017450	Brassica rapa	36.73	5.00e-75	275.00
IUUC-Cel-018151	Caenorhabditis elegans	52.20	9.00e-134	469.00
IUUC-Cja-019304	Callithrix jacchus	100.00	0.00e+00	907.00
IUUC-Cfa-020208	Canis familiaris	99.77	0.00e+00	905.00
IUUC-Cpo-022245	Cavia porcellus	99.77	0.00e+00	905.00
IUUC-Csa-023066	Chlorocebus sabaeus	100.00	0.00e+00	907.00
IUUC-Cho-024770	Choloepus hoffmanni	99.73	0.00e+00	787.00
IUUC-Cin-025621	Ciona intestinalis	57.38	3.00e-152	531.00
IUUC-Csv-026071	Ciona savignyi	60.14	2.00e-162	565.00
IUUC-Dre-028254	Danio rerio	90.02	0.00e+00	830.00
IUUC-Dno-029903	Dasypus novemcinctus	99.77	0.00e+00	905.00
IUUC-Dor-030423	Dipodomys ordii	99.54	0.00e+00	905.00
IUUC-Dme-031993	Drosophila melanogaster	55.11	3.00e-132	464.00
IUUC-Ete-032689	Echinops telfairi	98.66	2.00e-82	299.00
IUUC-Eca-033316	Equus caballus	99.54	0.00e+00	904.00
IUUC-Eeu-035001	Erinaceus europaeus	94.66	0.00e+00	860.00
IUUC-Fca-036447	Felis catus	99.77	0.00e+00	905.00
IUUC-Fal-037601	Ficedula albicollis	98.38	0.00e+00	896.00
IUUC-Gmo-038531	Gadus morhua	88.45	0.00e+00	803.00
IUUC-Gga-040869	Gallus gallus	98.14	0.00e+00	894.00
IUUC-Gac-042380	Gasterosteus aculeatus	89.40	0.00e+00	820.00
IUUC-Gma-043478	Glycine max	39.05	1.00e-83	303.00
IUUC-Ggo-045302	Gorilla gorilla	100.00	0.00e+00	907.00
IUUC-Hvu-047301	Hordeum vulgare	43.92	3.00e-81	295.00
IUUC-Itr-048259	Ictidomys tridecemlineatus	99.77	0.00e+00	905.00
IUUC-Lch-050319	Latimeria chalumnae	94.43	0.00e+00	865.00
IUUC-Lpe-051440	Leersia perrieri	40.76	4.00e-67	248.00
IUUC-Loc-052035	Lepisosteus oculatus	91.65	0.00e+00	840.00
IUUC-Laf-054275	Loxodonta africana	99.77	0.00e+00	905.00
IUUC-Mcc-055857	Macaca mulatta	86.77	0.00e+00	754.00
IUUC-Meu-056194	Macropus eugenii	99.37	4.00e-92	331.00
IUUC-Mtr-058667	Medicago truncatula	38.08	5.00e-76	278.00
IUUC-Mga-059710	Meleagris gallopavo	98.14	0.00e+00	894.00
IUUC-Mmr-060604	Microcebus murinus	99.77	0.00e+00	905.00
IUUC-Mdo-062953	Monodelphis domestica	99.07	0.00e+00	900.00
IUUC-Mmu-064292	Mus musculus	99.54	0.00e+00	905.00
IUUC-Mac-064568	Musa acuminata	44.14	1.00e-78	286.00
IUUC-Mpu-066294	Mustela putorius furo	67.79	5.00e-163	567.00
IUUC-Mlu-067995	Myotis lucifugus	98.84	0.00e+00	895.00
IUUC-Nle-069322	Nomascus leucogenys	100.00	0.00e+00	907.00
IUUC-Opr-070580	Ochotona princeps	99.30	0.00e+00	902.00
IUUC-Ont-072554	Oreochromis niloticus	91.88	0.00e+00	843.00
IUUC-Oan-072856	Ornithorhynchus anatinus	98.61	0.00e+00	897.00
IUUC-Ocu-074150	Oryctolagus cuniculus	87.73	0.00e+00	763.00
IUUC-Oba-075585	Oryza barthii	36.82	6.00e-70	258.00
IUUC-Obr-076069	Oryza brachyantha	41.84	2.00e-75	276.00
IUUC-Ogl-077045	Oryza glaberrima	40.26	3.00e-80	292.00
IUUC-Ogu-078697	Oryza glumaepatula	40.26	5.00e-76	280.00
IUUC-Oin-080119	Oryza indica	40.26	3.00e-80	292.00
IUUC-Olo-081093	Oryza longistaminata	32.15	9.00e-45	176.00
IUUC-Ome-081718	Oryza meridionalis	33.33	8.00e-57	215.00
IUUC-Oni-082072	Oryza nivara	36.82	6.00e-70	258.00
IUUC-Opu-084080	Oryza punctata	35.29	3.00e-57	215.00
IUUC-Oru-085070	Oryza rufipogon	37.38	2.00e-69	258.00
IUUC-Osa-086149	Oryza sativa	40.26	3.00e-80	292.00
IUUC-Ola-086697	Oryzias latipes	91.42	0.00e+00	842.00
IUUC-Oga-088697	Otolemur garnettii	99.77	0.00e+00	905.00
IUUC-Oar-089774	Ovis aries	99.77	0.00e+00	906.00
IUUC-Ptr-090924	Pan troglodytes	100.00	0.00e+00	907.00
IUUC-Pan-092373	Papio anubis	100.00	0.00e+00	906.00
IUUC-Psi-094001	Pelodiscus sinensis	98.14	0.00e+00	895.00
IUUC-Pma-094274	Petromyzon marinus	73.89	0.00e+00	693.00
IUUC-Ppa-095562	Physcomitrella patens	35.94	1.00e-80	293.00
IUUC-Pfo-097235	Poecilia formosa	91.42	0.00e+00	840.00
IUUC-Pab-098608	Pongo abelii	100.00	0.00e+00	907.00
IUUC-Pca-100268	Procavia capensis	99.54	0.00e+00	903.00
IUUC-Ppe-101425	Prunus persica	41.81	4.00e-83	301.00
IUUC-Pva-103183	Pteropus vampyrus	99.77	0.00e+00	905.00
IUUC-Rno-105097	Rattus norvegicus	99.54	0.00e+00	905.00
IUUC-Sha-107642	Sarcophilus harrisii	99.07	0.00e+00	900.00
IUUC-Smo-108680	Selaginella moellendorffii	36.43	7.00e-78	284.00
IUUC-Sit-110471	Setaria italica	41.15	2.00e-82	300.00
IUUC-Sly-111143	Solanum lycopersicum	33.89	2.00e-33	136.00
IUUC-Stu-111926	Solanum tuberosum	45.34	1.00e-33	135.00
IUUC-Sar-112947	Sorex araneus	99.65	5.00e-174	603.00
IUUC-Sbi-113769	Sorghum bicolor	43.03	1.00e-79	290.00
IUUC-Ssc-115736	Sus scrofa	99.77	0.00e+00	905.00
IUUC-Tgu-117457	Taeniopygia guttata	98.38	0.00e+00	896.00
IUUC-Tru-117760	Takifugu rubripes	91.18	0.00e+00	840.00
IUUC-Tsy-118943	Tarsius syrichta	98.84	0.00e+00	890.00
IUUC-Tni-120081	Tetraodon nigroviridis	91.88	0.00e+00	844.00
IUUC-Tca-121190	Theobroma cacao	40.65	9.00e-87	313.00
IUUC-Tae-125535	Triticum aestivum	44.81	4.00e-84	305.00
IUUC-Tur-126329	Triticum urartu	44.81	9.00e-84	304.00
IUUC-Tbe-127878	Tupaia belangeri	98.35	0.00e+00	878.00
IUUC-Ttr-128985	Tursiops truncatus	99.77	0.00e+00	905.00
IUUC-Vpa-130147	Vicugna pacos	99.54	0.00e+00	903.00
IUUC-Vvi-130935	Vitis vinifera	39.53	9.00e-86	310.00
IUUC-Xtr-132482	Xenopus tropicalis	95.13	0.00e+00	867.00
IUUC-Xma-133929	Xiphophorus maculatus	91.42	0.00e+00	840.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence