iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005035

UUCD1 version

UUC-AnC-00456

Ensembl Protein ID

ENSACAP00000000557.2

UniProt Accession

G1K8M3; G1K8M3_ANOCA

Protein Name

Uncharacterized protein

Gene Name

TBL1X

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000000539.3	ENSACAT00000000576.3	ENSACAP00000000557.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-53	176.7	458	496
UBD/Beta-Prp	4.30e-64	216.5	328	530

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g+l++s
   Q: 458  HQEPVYSVAFsPDgKYLASGSFDKCVHIWNTQSGTLVHS 496
           9**********999*******************999876 PP

UBD/Beta-Prp

   S: 13   itcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlsls 101
             +v++ ++++ +a+ s+d +i v ++     +++++gh++ev+a+k++p+g +l+++s+D+t+k+w++++ +cvh l++h++++++++
   Q: 328  ALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDTCVHDLQAHNKEIYTIK 415
           445555.6677788888888888888888777888888888888888888888888888888888888888888888888888888888 PP
   S: 102  fsp.........sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           +sp         s+  l+s+s d+t+r+wd++ g c + tl++h++ v +v+++pdg++l+sGs D++v +W+ ++g+l++  +g  t+
   Q: 416  WSPtgpgttnpsSNIMLASASFDSTVRLWDVDRGVCTH-TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGTLVHSYRG--TG 501
           88766666555334567888888888888888888888.8888888888888888888888888888888888888888888877..88 PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlq 210
            +  + ++  g  + + + dg+v + dl+
   Q: 502  GIFEVCWNARGDKVGASASDGSVCVLDLR 530
           88888888888888888888888777765 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

GGAKMSITSD EVNFLVYRYL QESGFSHSAF TFGIESHISQ SNINGTLVPP AALISILQKG 60
LQYVEAEISI NEDGTVFDGR PIESLSLIDA VMPDVVQTRQ QAFKEKLAQQ QASAAPAIVT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGGGGCTA AGATGAGCAT AACCAGTGAC GAAGTGAATT TCTTGGTGTA TCGCTATCTT 60
CAGGAATCAG GTAATGTGTT TTATGTTACA ATATTATGCG TCATTTAGAA TGTTTTCACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0045444--P:fat cell differentiation
GO:0016575--P:histone deacetylation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0043627--P:response to estrogen
GO:0048545--P:response to steroid hormone

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001450	Ailuropoda melanoleuca	91.90	0.00e+00	990.00
IUUC-Apl-003232	Anas platyrhynchos	95.45	0.00e+00	999.00
IUUC-Bta-013202	Bos taurus	94.51	0.00e+00	999.00
IUUC-Cja-019281	Callithrix jacchus	90.21	0.00e+00	974.00
IUUC-Cfa-020929	Canis familiaris	94.31	0.00e+00	993.00
IUUC-Cre-022979	Chlamydomonas reinhardtii	60.88	3.00e-131	461.00
IUUC-Csa-023943	Chlorocebus sabaeus	91.53	0.00e+00	978.00
IUUC-Cin-025704	Ciona intestinalis	71.85	0.00e+00	791.00
IUUC-Cne-026946	Cryptococcus neoformans	38.46	1.00e-30	128.00
IUUC-Dno-028926	Dasypus novemcinctus	94.12	0.00e+00	985.00
IUUC-Dme-031939	Drosophila melanogaster	80.93	9.00e-175	606.00
IUUC-Ete-032822	Echinops telfairi	82.39	0.00e+00	842.00
IUUC-Eca-033897	Equus caballus	94.88	0.00e+00	996.00
IUUC-Fca-036462	Felis catus	95.83	0.00e+00	999.00
IUUC-Fal-037388	Ficedula albicollis	95.83	0.00e+00	1009.00
IUUC-Gga-040671	Gallus gallus	96.02	0.00e+00	1009.00
IUUC-Gac-041851	Gasterosteus aculeatus	88.80	0.00e+00	930.00
IUUC-Ggo-045373	Gorilla gorilla	92.47	0.00e+00	991.00
IUUC-Hsa-045841	Homo sapiens	92.09	0.00e+00	986.00
IUUC-Itr-048236	Ictidomys tridecemlineatus	97.58	0.00e+00	764.00
IUUC-Lch-050535	Latimeria chalumnae	91.84	0.00e+00	977.00
IUUC-Laf-054071	Loxodonta africana	95.27	0.00e+00	1003.00
IUUC-Mcc-055233	Macaca mulatta	90.84	0.00e+00	962.00
IUUC-Mga-059895	Meleagris gallopavo	95.45	0.00e+00	1009.00
IUUC-Mmr-061286	Microcebus murinus	95.09	0.00e+00	1004.00
IUUC-Mmu-063447	Mus musculus	94.88	0.00e+00	997.00
IUUC-Nle-069151	Nomascus leucogenys	92.66	0.00e+00	982.00
IUUC-Ont-072252	Oreochromis niloticus	88.80	0.00e+00	952.00
IUUC-Oan-073562	Ornithorhynchus anatinus	95.83	0.00e+00	1009.00
IUUC-Oba-075618	Oryza barthii	47.75	3.00e-141	495.00
IUUC-Ogl-077302	Oryza glaberrima	49.91	2.00e-153	535.00
IUUC-Ogu-078718	Oryza glumaepatula	49.91	2.00e-153	535.00
IUUC-Oin-079515	Oryza indica	43.67	5.00e-93	335.00
IUUC-Ome-081696	Oryza meridionalis	48.83	4.00e-148	517.00
IUUC-Oni-082137	Oryza nivara	49.91	2.00e-153	535.00
IUUC-Oru-085276	Oryza rufipogon	49.91	1.00e-153	536.00
IUUC-Osa-085791	Oryza sativa	49.91	2.00e-153	535.00
IUUC-Oar-089506	Ovis aries	93.17	0.00e+00	994.00
IUUC-Ptr-090793	Pan troglodytes	90.89	0.00e+00	944.00
IUUC-Pan-091909	Papio anubis	91.57	0.00e+00	983.00
IUUC-Psi-093358	Pelodiscus sinensis	90.72	0.00e+00	955.00
IUUC-Pfo-097214	Poecilia formosa	87.86	0.00e+00	922.00
IUUC-Pab-098317	Pongo abelii	91.94	0.00e+00	965.00
IUUC-Rno-105857	Rattus norvegicus	94.88	0.00e+00	997.00
IUUC-Sha-107326	Sarcophilus harrisii	93.55	0.00e+00	1010.00
IUUC-Ssc-115646	Sus scrofa	95.12	0.00e+00	1009.00
IUUC-Tgu-116898	Taeniopygia guttata	95.64	0.00e+00	1002.00
IUUC-Tru-117862	Takifugu rubripes	89.22	0.00e+00	950.00
IUUC-Tni-119656	Tetraodon nigroviridis	89.41	0.00e+00	944.00
IUUC-Tur-126856	Triticum urartu	54.70	5.00e-62	231.00
IUUC-Ttr-128826	Tursiops truncatus	94.27	0.00e+00	915.00
IUUC-Uma-129469	Ustilago maydis	43.92	9.00e-59	221.00
IUUC-Xma-133591	Xiphophorus maculatus	87.71	0.00e+00	926.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence