iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013202

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Transducin beta-like 1

Genbank Nucleotide ID

DAAA02075574

Gene Name

TBL1Y; TBL1X

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000018112.5	ENSBTAT00000024105.5	ENSBTAP00000024105.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.20e-54	177.1	455	493
UBD/Beta-Prp	1.20e-64	218.4	325	527

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g l++s
   Q: 455  HQEPVYSVAFsPDgKYLASGSFDKCVHIWNTQSGSLVHS 493
           9**********999******************9999875 PP

UBD/Beta-Prp

   S: 13   itcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlsls 101
             +v++ ++++ +a+ s+d +i v ++     +++++gh++ev+a+k++p+g +l+++s+D+t+k+w++++ +cvh l++h++++++++
   Q: 325  ALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDTCVHDLQAHSKEIYTIK 412
           444555.6667777777777777777777777778888888888888888877778888888888888888888888888888888877 PP
   S: 102  fsp.........sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           +sp         s+  l+s+s d+t+r+wd+e g cl+ tl++h++ v +v+++pdg++l+sGs D++v +W+ ++g+l++  +g  t+
   Q: 413  WSPtgpatsnpnSSIMLASASFDSTVRLWDVERGVCLH-TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYRG--TG 498
           77755555544333567777788888888888888887.7888888888888888778888888888888888888888888877..77 PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlq 210
            +  + ++  g  + + + dg+v + dl+
   Q: 499  GIFEVCWNARGDKVGASASDGSVCVLDLR 527
           77777777777777777777777777765 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPAALI SILQKGLQYV 60
EAEISINEDG TVFDGRPIES LSLIDAVMPD VVQTRQQAFR EKLAQQQAAA AAAAAAAAAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCATTA CCAGTGACGA GGTGAACTTC CTGGTGTACC GATATCTCCA GGAGTCAGGT 60
AAGAAGCCGG CTTCCTGCCC GGAGCGGCAA AAAAAACACC TTCCAACACG CCACCTGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR008207--Sig_transdc_His_kin_Hpt_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005876--C:spindle microtubule
GO:0005667--C:transcription factor complex
GO:0017053--C:transcriptional repressor complex
GO:0008013--F:beta-catenin binding
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0045444--P:fat cell differentiation
GO:0016575--P:histone deacetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0043627--P:response to estrogen
GO:0048545--P:response to steroid hormone
GO:0007605--P:sensory perception of sound

KEGG

bta:515972

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001450	Ailuropoda melanoleuca	92.42	0.00e+00	994.00
IUUC-Apl-003232	Anas platyrhynchos	95.83	0.00e+00	998.00
IUUC-Aca-005035	Anolis carolinensis	94.51	0.00e+00	999.00
IUUC-Aly-005622	Arabidopsis lyrata	56.10	2.00e-119	423.00
IUUC-Ath-007137	Arabidopsis thaliana	59.50	7.00e-121	427.00
IUUC-Bdi-014315	Brachypodium distachyon	61.19	2.00e-134	472.00
IUUC-Cja-019281	Callithrix jacchus	91.48	0.00e+00	980.00
IUUC-Cfa-020929	Canis familiaris	96.78	0.00e+00	1005.00
IUUC-Cre-022979	Chlamydomonas reinhardtii	61.98	3.00e-132	465.00
IUUC-Csa-023943	Chlorocebus sabaeus	93.18	0.00e+00	981.00
IUUC-Cin-025704	Ciona intestinalis	72.09	0.00e+00	793.00
IUUC-Dno-028926	Dasypus novemcinctus	96.40	0.00e+00	997.00
IUUC-Dme-031939	Drosophila melanogaster	81.47	3.00e-176	611.00
IUUC-Ete-032822	Echinops telfairi	84.66	0.00e+00	846.00
IUUC-Eca-033897	Equus caballus	97.35	0.00e+00	1009.00
IUUC-Fca-036462	Felis catus	97.54	0.00e+00	1007.00
IUUC-Fal-037388	Ficedula albicollis	96.02	0.00e+00	1006.00
IUUC-Gga-040671	Gallus gallus	95.83	0.00e+00	1006.00
IUUC-Gac-041851	Gasterosteus aculeatus	88.64	0.00e+00	935.00
IUUC-Ggo-045373	Gorilla gorilla	93.94	0.00e+00	989.00
IUUC-Hsa-045841	Homo sapiens	94.51	0.00e+00	989.00
IUUC-Itr-048236	Ictidomys tridecemlineatus	98.92	0.00e+00	779.00
IUUC-Lch-050535	Latimeria chalumnae	91.67	0.00e+00	981.00
IUUC-Laf-054071	Loxodonta africana	96.79	0.00e+00	1006.00
IUUC-Mcc-055233	Macaca mulatta	92.71	0.00e+00	965.00
IUUC-Mga-059895	Meleagris gallopavo	96.40	0.00e+00	1006.00
IUUC-Mvi-060557	Microbotryum violaceum	37.30	2.00e-70	260.00
IUUC-Mmr-061286	Microcebus murinus	96.60	0.00e+00	1013.00
IUUC-Mmu-063447	Mus musculus	97.35	0.00e+00	1009.00
IUUC-Mac-065508	Musa acuminata	61.42	1.00e-91	330.00
IUUC-Nle-069151	Nomascus leucogenys	93.18	0.00e+00	985.00
IUUC-Ont-072252	Oreochromis niloticus	89.39	0.00e+00	959.00
IUUC-Oan-073562	Ornithorhynchus anatinus	96.97	0.00e+00	1010.00
IUUC-Opu-083505	Oryza punctata	48.47	9.00e-144	503.00
IUUC-Oar-089506	Ovis aries	95.27	0.00e+00	1013.00
IUUC-Ptr-090793	Pan troglodytes	92.23	0.00e+00	954.00
IUUC-Pan-091909	Papio anubis	93.60	0.00e+00	988.00
IUUC-Psi-093358	Pelodiscus sinensis	91.44	0.00e+00	957.00
IUUC-Ppa-095868	Physcomitrella patens	66.30	2.00e-139	489.00
IUUC-Pfo-097214	Poecilia formosa	87.69	0.00e+00	926.00
IUUC-Pab-098317	Pongo abelii	94.21	0.00e+00	968.00
IUUC-Pop-098989	Populus trichocarpa	58.15	1.00e-129	456.00
IUUC-Ppe-101572	Prunus persica	63.97	4.00e-128	451.00
IUUC-Rno-105857	Rattus norvegicus	97.35	0.00e+00	1009.00
IUUC-Sha-107326	Sarcophilus harrisii	94.32	0.00e+00	1013.00
IUUC-Ssc-115646	Sus scrofa	97.54	0.00e+00	1017.00
IUUC-Tgu-116898	Taeniopygia guttata	96.02	0.00e+00	1000.00
IUUC-Tru-117862	Takifugu rubripes	89.58	0.00e+00	946.00
IUUC-Tni-119656	Tetraodon nigroviridis	90.34	0.00e+00	946.00
IUUC-Tca-121739	Theobroma cacao	54.55	8.00e-125	441.00
IUUC-Tae-125368	Triticum aestivum	59.38	6.00e-135	474.00
IUUC-Ttr-128826	Tursiops truncatus	96.09	0.00e+00	922.00
IUUC-Uma-129469	Ustilago maydis	43.53	1.00e-58	221.00
IUUC-Vvi-131193	Vitis vinifera	57.39	4.00e-130	458.00
IUUC-Xma-133591	Xiphophorus maculatus	87.88	0.00e+00	927.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence