iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	18803400; 19759827
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	18803400; 19759827

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.20e-53	176.9	504	542
UBD/Beta-Prp	4.60e-63	214.8	376	575

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g+l++s
   Q: 504  HQEPVYSVAFsPDgKYLASGSFDKCVHIWNTQSGNLVHS 542
           9**********999********************99886 PP

UBD/Beta-Prp

   S: 15   cvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp.. 104
           +v++ ++++ +a+ s+d +i v ++     +++++gh++ev+a+k++p+g +l+++s+D+t+k+w++++  c+h l++h+++++++++sp  
   Q: 376  DVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPtg 466
           3333.444445555555555555555555555555555555555555555555555555555555555555555555555555555554444 PP
   S: 105  .......sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfd 189
                  s+  l+s+s d+t+r+wd+e g c + tl++h++ v +v+++pdg++l+sGs D++v +W+ ++g+l++  +g  t+ +  + ++
   Q: 467  patsnpnSNIMLASASFDSTVRLWDIERGVCTH-TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG--TGGIFEVCWN 555
           433333222345555555555555555555555.5555555555555555555555555555555555555555555554..5555555555 PP
   S: 190  sngkelvsgsldgtvklwdl 209
             g  + + + dg+v + dl
   Q: 556  ARGDKVGASASDGSVCVLDL 575
           55555555555555554444 PP

Organism

Homo sapiens

Functional Description
(View)

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.

Protein Sequence
(Fasta)

MTELAGASSS CCHRPAGRGA MQSVLHHFQR LRGREGGSHF INTSSPRGEA KMSITSDEVN 60
FLVYRYLQES GFSHSAFTFG IESHISQSNI NGTLVPPAAL ISILQKGLQY VEAEISINED 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTGCATGTA ATACCTCAGC ATCAGTCTGC ACAAGCCCAG GGAGCCCAGG AGCAACGAAG 60
GGCAGGCTCA AGGGAAGGCC CCACCATGTC CTTCTGGGGG GCCTTGAATG GCAACTGATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0209--Deafness
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0008013--F:beta-catenin binding
GO:0042393--F:histone binding
GO:0008022--F:protein C-terminus binding
GO:0019904--F:protein domain specific binding
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0044255--P:cellular lipid metabolic process
GO:0016575--P:histone deacetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis
GO:0007605--P:sensory perception of sound
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:6907

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001450	Ailuropoda melanoleuca	89.74	0.00e+00	1000.00
IUUC-Apl-003232	Anas platyrhynchos	93.35	0.00e+00	974.00
IUUC-Aca-005035	Anolis carolinensis	92.09	0.00e+00	987.00
IUUC-Bta-013202	Bos taurus	94.51	0.00e+00	989.00
IUUC-Cja-019281	Callithrix jacchus	91.68	0.00e+00	1065.00
IUUC-Cfa-020929	Canis familiaris	93.92	0.00e+00	986.00
IUUC-Csa-023943	Chlorocebus sabaeus	97.40	0.00e+00	1119.00
IUUC-Dno-028926	Dasypus novemcinctus	92.60	0.00e+00	971.00
IUUC-Dme-031939	Drosophila melanogaster	80.38	3.00e-174	605.00
IUUC-Ete-032822	Echinops telfairi	83.11	0.00e+00	838.00
IUUC-Eca-033897	Equus caballus	95.06	0.00e+00	989.00
IUUC-Fca-036462	Felis catus	93.74	0.00e+00	983.00
IUUC-Fal-037388	Ficedula albicollis	93.73	0.00e+00	984.00
IUUC-Gga-040671	Gallus gallus	93.54	0.00e+00	984.00
IUUC-Gac-041851	Gasterosteus aculeatus	88.40	0.00e+00	925.00
IUUC-Ggo-045373	Gorilla gorilla	98.44	0.00e+00	1129.00
IUUC-Itr-048236	Ictidomys tridecemlineatus	95.97	0.00e+00	760.00
IUUC-Lch-050535	Latimeria chalumnae	90.11	0.00e+00	962.00
IUUC-Laf-054071	Loxodonta africana	93.57	0.00e+00	986.00
IUUC-Mcc-055233	Macaca mulatta	97.37	0.00e+00	1105.00
IUUC-Mga-059895	Meleagris gallopavo	94.11	0.00e+00	984.00
IUUC-Mvi-060557	Microbotryum violaceum	37.30	2.00e-70	260.00
IUUC-Mmr-061286	Microcebus murinus	94.15	0.00e+00	993.00
IUUC-Mmu-063447	Mus musculus	93.93	0.00e+00	986.00
IUUC-Nle-069151	Nomascus leucogenys	97.57	0.00e+00	1127.00
IUUC-Ont-072252	Oreochromis niloticus	88.02	0.00e+00	943.00
IUUC-Oan-073562	Ornithorhynchus anatinus	94.12	0.00e+00	988.00
IUUC-Oba-075618	Oryza barthii	48.29	6.00e-144	504.00
IUUC-Ogl-077302	Oryza glaberrima	50.09	3.00e-155	541.00
IUUC-Ogu-078718	Oryza glumaepatula	50.09	2.00e-155	542.00
IUUC-Oin-079515	Oryza indica	44.34	3.00e-95	343.00
IUUC-Ome-081696	Oryza meridionalis	49.01	5.00e-150	524.00
IUUC-Oni-082137	Oryza nivara	50.09	2.00e-155	542.00
IUUC-Opu-083505	Oryza punctata	48.29	1.00e-143	503.00
IUUC-Oru-085276	Oryza rufipogon	50.09	1.00e-155	543.00
IUUC-Osa-085791	Oryza sativa	50.09	2.00e-155	542.00
IUUC-Oar-089506	Ovis aries	92.40	0.00e+00	985.00
IUUC-Pan-091909	Papio anubis	97.24	0.00e+00	1124.00
IUUC-Psi-093358	Pelodiscus sinensis	89.56	0.00e+00	944.00
IUUC-Pma-094105	Petromyzon marinus	62.19	3.00e-102	364.00
IUUC-Pfo-097214	Poecilia formosa	86.50	0.00e+00	909.00
IUUC-Pab-098317	Pongo abelii	99.47	0.00e+00	1115.00
IUUC-Ppe-101572	Prunus persica	50.81	1.00e-142	499.00
IUUC-Rno-105857	Rattus norvegicus	93.93	0.00e+00	986.00
IUUC-Sha-107326	Sarcophilus harrisii	91.44	0.00e+00	991.00
IUUC-Ssc-115646	Sus scrofa	93.93	0.00e+00	1014.00
IUUC-Tgu-116898	Taeniopygia guttata	93.54	0.00e+00	976.00
IUUC-Tru-117862	Takifugu rubripes	88.45	0.00e+00	938.00
IUUC-Tni-119656	Tetraodon nigroviridis	88.53	0.00e+00	937.00
IUUC-Tae-125368	Triticum aestivum	50.36	1.00e-155	543.00
IUUC-Tur-126856	Triticum urartu	43.38	6.00e-77	281.00
IUUC-Ttr-128826	Tursiops truncatus	91.72	0.00e+00	927.00
IUUC-Uma-129469	Ustilago maydis	43.14	9.00e-59	222.00
IUUC-Vvi-131193	Vitis vinifera	59.26	3.00e-129	455.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence