iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000006191.3	ENSMMUT00000054153.1	ENSMMUP00000057883.1
ENSMMUG00000006191.3	ENSMMUT00000008662.3	ENSMMUP00000008141.3
ENSMMUG00000006191.3	ENSMMUT00000077126.1	ENSMMUP00000056346.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.70e-50	167.2	496	534
UBD/Beta-Prp	4.00e-62	211.2	376	538

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g+l++s
   Q: 496  HQEPVYSVAFsPDgRYLASGSFDKCVHIWNTQSGNLVHS 534
           9**********999********************99886 PP

UBD/Beta-Prp

   S: 108  klvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng.... 192
           +++s s d  i+v  l  +  ++ t++gh+  vn ++++p+g ll+s+s+D t+++W++k++ ++++l+  h++ +y ++++++g    
   Q: 376  TFASCSTDMCIHVCRLGCDRPVK-TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQA-HNKEIYTIKWSPTGpats 462
           45555556666666666666665.6666666666666666666666666666666666666666666655.666666666555555555 PP
   S: 193  .....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlh 263
                  l+s+s d+tv+lwd+++g c +tl+ h+++v+sv+fsp++ +l+sgs D+ + iW+++sg+l++++ ++
   Q: 463  npnsnIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQSGNLVHSYRGT 538
           5555555566666666666666666666666666666666666666666666666666666666666666555443 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MTELAGASSS CCHRPAGRGA MQSVLHHFQR LRGREGGSHF INTSSPRGEA KMSITSDEVN 60
FLVYRYLQES GFSHSAFTFG IESHISQSNI NGTLVPPAAL ISILQKGLQY VEAEISINED 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAGGAGGG AGTCAGATGT GTTTTGCAAA CGATGGAAAC TGAAACGTGA GTACCAGGAC 60
CATATGGTGT TCAGAAACTT TTATCATAAC TACAGTGAAT AAATAAAGTG CTTGACAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0016575--P:histone deacetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006508--P:proteolysis
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0007605--P:sensory perception of sound

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001450	Ailuropoda melanoleuca	90.40	0.00e+00	984.00
IUUC-Apl-003232	Anas platyrhynchos	92.05	0.00e+00	957.00
IUUC-Aca-005035	Anolis carolinensis	91.03	0.00e+00	970.00
IUUC-Bta-013202	Bos taurus	91.75	0.00e+00	972.00
IUUC-Cja-019281	Callithrix jacchus	92.35	0.00e+00	1049.00
IUUC-Cfa-020929	Canis familiaris	91.71	0.00e+00	963.00
IUUC-Csa-023943	Chlorocebus sabaeus	96.64	0.00e+00	1102.00
IUUC-Dno-028926	Dasypus novemcinctus	90.77	0.00e+00	952.00
IUUC-Ete-032822	Echinops telfairi	83.98	0.00e+00	830.00
IUUC-Eca-033897	Equus caballus	92.87	0.00e+00	967.00
IUUC-Fca-036462	Felis catus	92.31	0.00e+00	964.00
IUUC-Fal-037388	Ficedula albicollis	93.02	0.00e+00	968.00
IUUC-Gga-040671	Gallus gallus	93.02	0.00e+00	968.00
IUUC-Ggo-045373	Gorilla gorilla	97.02	0.00e+00	1105.00
IUUC-Hsa-045841	Homo sapiens	97.37	0.00e+00	1112.00
IUUC-Itr-048236	Ictidomys tridecemlineatus	95.07	0.00e+00	741.00
IUUC-Lch-050535	Latimeria chalumnae	91.19	0.00e+00	946.00
IUUC-Laf-054071	Loxodonta africana	92.34	0.00e+00	969.00
IUUC-Mga-059895	Meleagris gallopavo	93.04	0.00e+00	968.00
IUUC-Mmr-061286	Microcebus murinus	92.93	0.00e+00	976.00
IUUC-Mmu-063447	Mus musculus	92.50	0.00e+00	968.00
IUUC-Nle-069151	Nomascus leucogenys	97.01	0.00e+00	1108.00
IUUC-Oan-073562	Ornithorhynchus anatinus	92.69	0.00e+00	969.00
IUUC-Oba-075618	Oryza barthii	48.27	8.00e-141	493.00
IUUC-Ogl-077302	Oryza glaberrima	50.09	3.00e-152	531.00
IUUC-Ogu-078718	Oryza glumaepatula	50.09	3.00e-152	531.00
IUUC-Oin-079515	Oryza indica	44.34	4.00e-95	342.00
IUUC-Ome-081696	Oryza meridionalis	49.00	8.00e-147	513.00
IUUC-Oni-082137	Oryza nivara	50.09	3.00e-152	531.00
IUUC-Opu-083505	Oryza punctata	48.09	3.00e-140	491.00
IUUC-Oru-085276	Oryza rufipogon	50.09	2.00e-152	532.00
IUUC-Osa-085791	Oryza sativa	50.09	3.00e-152	531.00
IUUC-Oar-089506	Ovis aries	93.15	0.00e+00	969.00
IUUC-Pan-091909	Papio anubis	97.01	0.00e+00	1109.00
IUUC-Psi-093358	Pelodiscus sinensis	89.84	0.00e+00	929.00
IUUC-Pma-094105	Petromyzon marinus	62.82	3.00e-102	364.00
IUUC-Pab-098317	Pongo abelii	97.18	0.00e+00	1107.00
IUUC-Rno-105857	Rattus norvegicus	92.50	0.00e+00	968.00
IUUC-Sha-107326	Sarcophilus harrisii	92.56	0.00e+00	976.00
IUUC-Ssc-115646	Sus scrofa	92.36	0.00e+00	997.00
IUUC-Tgu-116898	Taeniopygia guttata	92.25	0.00e+00	959.00
IUUC-Tae-125368	Triticum aestivum	49.82	5.00e-151	527.00
IUUC-Tur-126856	Triticum urartu	43.14	1.00e-75	276.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence