iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-091909

Ensembl Protein ID

ENSPANP00000005258.1

UniProt Accession

A0A096MZ67; A0A096MZ67_PAPAN

Genbank Protein ID

ENSPANP00000005258

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01033828

Gene Name

TBL1X

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000016547.1	ENSPANT00000010003.1	ENSPANP00000005258.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.70e-53	175.6	503	541
UBD/Beta-Prp	1.70e-79	267.2	287	574

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g+l++s
   Q: 503  HQEPVYSVAFsPDgKYLASGSFDKCVHIWNTQSGNLVHS 541
           9**********999********************99886 PP

UBD/Beta-Prp

   S: 13   itcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlsls 101
           +t++++  +++llatgs+dg  ++w  ++g+l ++l +h++++ a+k++++g+++++++ D+t  +wd  tg+  + +  h++ +l+++
   Q: 287  VTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVD 374
           677999*******************5.777*********************************************************** PP
   S: 102  fspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfds 190
           ++  + +++s s d  i+v  l  +  ++ t++gh+  vn ++++p+g ll+s+s+D t+++W++k++ ++++l+  h++ +y +++++
   Q: 375  WQN-NTTFASCSTDMCIHVCRLGCDRPVK-TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQA-HNKEIYTIKWSP 460
           *99.899**********************.*********************************************8.************ PP
   S: 191  ng............kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssv 267
           +g             +l+s+s d+tv+lwd+++g c++tl+ h+++v+sv+fsp++++l+sgs D+ + iW+++sg+l++++ ++    
   Q: 461  TGpatsnpnsnimlASLASASFDSTVRLWDIERGVCIHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG--G 547
           *********************************************************************************99965..2 PP
   S: 268  isvavlsfgdnvlvlgsedskvniwkl 294
           i   +++  + ++ + ++d++v +++l
   Q: 548  IFEVCWNARGDKVGASASDGSVCVLDL 574
           222333444444444444566666665 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MTELAGASSS CCHRPAGRGA MQSVLHHFQR LRGREGGSHF INTSSPRGEA KMSITSDEVN 60
FLVYRYLQES GFSHSAFTFG IESHISQSNI NGTLVPPAAL ISILQKGLQY VEAEISINED 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACATCCTGGA AGGTGAGCGT CAAAGCAGGT GAATGGCTGG CTCTCGGATT CAAGCTTCCC 60
TGATCCTCTC CAGAAGTGTA TCCTTCTCCT TTAAGAGAAG TCATGGCAGA ATTTTTAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005876--C:spindle microtubule
GO:0005667--C:transcription factor complex
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0045444--P:fat cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043627--P:response to estrogen
GO:0048545--P:response to steroid hormone
GO:0007605--P:sensory perception of sound

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001450	Ailuropoda melanoleuca	89.72	0.00e+00	999.00
IUUC-Apl-003232	Anas platyrhynchos	92.59	0.00e+00	974.00
IUUC-Aca-005035	Anolis carolinensis	91.57	0.00e+00	983.00
IUUC-Bta-013202	Bos taurus	92.66	0.00e+00	988.00
IUUC-Cja-019281	Callithrix jacchus	91.49	0.00e+00	1063.00
IUUC-Cfa-020929	Canis familiaris	92.82	0.00e+00	980.00
IUUC-Csa-023943	Chlorocebus sabaeus	97.22	0.00e+00	1114.00
IUUC-Dno-028926	Dasypus novemcinctus	91.51	0.00e+00	969.00
IUUC-Ete-032822	Echinops telfairi	83.65	0.00e+00	837.00
IUUC-Eca-033897	Equus caballus	93.01	0.00e+00	984.00
IUUC-Fca-036462	Felis catus	93.02	0.00e+00	980.00
IUUC-Fal-037388	Ficedula albicollis	93.35	0.00e+00	984.00
IUUC-Gga-040671	Gallus gallus	93.54	0.00e+00	984.00
IUUC-Gac-041851	Gasterosteus aculeatus	88.57	0.00e+00	926.00
IUUC-Ggo-045373	Gorilla gorilla	97.07	0.00e+00	1117.00
IUUC-Hsa-045841	Homo sapiens	97.24	0.00e+00	1124.00
IUUC-Itr-048236	Ictidomys tridecemlineatus	95.47	0.00e+00	757.00
IUUC-Lch-050535	Latimeria chalumnae	90.86	0.00e+00	960.00
IUUC-Laf-054071	Loxodonta africana	92.48	0.00e+00	986.00
IUUC-Mcc-055233	Macaca mulatta	97.01	0.00e+00	1100.00
IUUC-Mtr-058624	Medicago truncatula	46.83	4.00e-141	494.00
IUUC-Mga-059895	Meleagris gallopavo	93.17	0.00e+00	984.00
IUUC-Mmr-061286	Microcebus murinus	93.25	0.00e+00	992.00
IUUC-Mmu-063447	Mus musculus	93.40	0.00e+00	985.00
IUUC-Mac-065508	Musa acuminata	45.61	6.00e-106	377.00
IUUC-Nle-069151	Nomascus leucogenys	97.23	0.00e+00	1120.00
IUUC-Ont-072252	Oreochromis niloticus	88.19	0.00e+00	943.00
IUUC-Oan-073562	Ornithorhynchus anatinus	93.02	0.00e+00	985.00
IUUC-Oba-075618	Oryza barthii	48.21	2.00e-144	506.00
IUUC-Ogl-077302	Oryza glaberrima	50.00	9.00e-156	543.00
IUUC-Ogu-078718	Oryza glumaepatula	50.00	7.00e-156	543.00
IUUC-Oin-079515	Oryza indica	44.57	4.00e-97	349.00
IUUC-Ome-081696	Oryza meridionalis	48.92	1.00e-150	526.00
IUUC-Oni-082137	Oryza nivara	50.00	7.00e-156	543.00
IUUC-Opu-083505	Oryza punctata	47.85	3.00e-143	501.00
IUUC-Oru-085276	Oryza rufipogon	50.00	4.00e-156	544.00
IUUC-Osa-085791	Oryza sativa	50.00	7.00e-156	543.00
IUUC-Oar-089506	Ovis aries	93.14	0.00e+00	985.00
IUUC-Ptr-090793	Pan troglodytes	89.56	0.00e+00	934.00
IUUC-Psi-093358	Pelodiscus sinensis	89.16	0.00e+00	942.00
IUUC-Pma-094105	Petromyzon marinus	62.03	7.00e-102	363.00
IUUC-Pfo-097214	Poecilia formosa	86.86	0.00e+00	910.00
IUUC-Pab-098317	Pongo abelii	97.02	0.00e+00	1103.00
IUUC-Rno-105857	Rattus norvegicus	93.40	0.00e+00	985.00
IUUC-Sha-107326	Sarcophilus harrisii	92.19	0.00e+00	991.00
IUUC-Stu-112786	Solanum tuberosum	47.84	3.00e-141	494.00
IUUC-Ssc-115646	Sus scrofa	93.05	0.00e+00	1014.00
IUUC-Tgu-116898	Taeniopygia guttata	92.78	0.00e+00	976.00
IUUC-Tru-117862	Takifugu rubripes	88.80	0.00e+00	938.00
IUUC-Tni-119656	Tetraodon nigroviridis	88.89	0.00e+00	938.00
IUUC-Tae-125368	Triticum aestivum	49.55	2.00e-154	539.00
IUUC-Tur-126856	Triticum urartu	42.65	4.00e-77	282.00
IUUC-Ttr-128826	Tursiops truncatus	91.52	0.00e+00	926.00
IUUC-Uma-129469	Ustilago maydis	43.14	9.00e-59	221.00
IUUC-Xma-133591	Xiphophorus maculatus	87.10	0.00e+00	917.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence