iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-37	126.7	271	305

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrtg 33
           Ht++v+cl+f   s+ +l++Gs D+t+ +WDlr  
   Q: 271  HTAEVNCLSFnpySEFILATGSADKTVALWDLRNL 305
           **********96554568*************9875 PP

Organism

Rattus norvegicus

Functional Description
(View)

Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity).

Protein Sequence
(Fasta)

MASKEMFEDT VEERVINEEY KIWKKNTPFL YDLVMTHALQ WPSLTVQWLP EVTKPEGKDY 60
ALHWLVLGTH TSDEQNHLVV ARVHIPNDDA QFDASHCDSD KGEFGGFGSV TGKIECEIKI 120

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Nucleotide Sequence
(Fasta)

GGGCTGAGAG GCGCGGGTTG AAAAGTCTCG TTCCAAGTTT GGAGAGAGGG AGAGAGAGGA 60
GAGCGTCTCA GACCTCGCTA CCCGCAAGCG GGGAGGAGGC AGAAGAGAAG ATCGCGGCGT 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0143--Chaperone
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0235--DNA replication
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR022052--Histone-bd_RBBP4_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12265--CAF1C_H4-bd
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0035098--C:ESC/E(Z) complex
GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0003723--F:RNA binding
GO:0070370--P:cellular heat acclimation
GO:0016569--P:covalent chromatin modification
GO:0006260--P:DNA replication
GO:0030308--P:negative regulation of cell growth
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048545--P:response to steroid hormone
GO:0006351--P:transcription, DNA-templated

KEGG

rno:83712

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001256	Ailuropoda melanoleuca	99.05	0.00e+00	867.00
IUUC-Apl-003357	Anas platyrhynchos	92.07	0.00e+00	809.00
IUUC-Bta-013455	Bos taurus	99.53	0.00e+00	877.00
IUUC-Cja-019957	Callithrix jacchus	99.29	0.00e+00	868.00
IUUC-Cfa-020917	Canis familiaris	99.05	0.00e+00	869.00
IUUC-Cpo-022173	Cavia porcellus	100.00	0.00e+00	881.00
IUUC-Csa-023738	Chlorocebus sabaeus	100.00	0.00e+00	881.00
IUUC-Dno-029206	Dasypus novemcinctus	99.76	0.00e+00	879.00
IUUC-Dor-030733	Dipodomys ordii	86.02	0.00e+00	737.00
IUUC-Eca-034138	Equus caballus	99.05	0.00e+00	868.00
IUUC-Fca-035977	Felis catus	99.05	0.00e+00	868.00
IUUC-Fal-037538	Ficedula albicollis	90.05	0.00e+00	797.00
IUUC-Gga-040764	Gallus gallus	93.65	0.00e+00	828.00
IUUC-Hsa-045677	Homo sapiens	100.00	0.00e+00	881.00
IUUC-Itr-048060	Ictidomys tridecemlineatus	100.00	0.00e+00	868.00
IUUC-Kpa-049258	Komagataella pastoris	36.65	8.00e-71	260.00
IUUC-Laf-053973	Loxodonta africana	98.83	0.00e+00	869.00
IUUC-Mcc-055687	Macaca mulatta	100.00	0.00e+00	881.00
IUUC-Mga-059209	Meleagris gallopavo	90.82	0.00e+00	795.00
IUUC-Mmr-061008	Microcebus murinus	99.29	0.00e+00	870.00
IUUC-Mdo-062817	Monodelphis domestica	96.24	0.00e+00	850.00
IUUC-Mmu-063773	Mus musculus	99.76	0.00e+00	879.00
IUUC-Mpu-066722	Mustela putorius furo	99.05	0.00e+00	867.00
IUUC-Mlu-067813	Myotis lucifugus	99.05	0.00e+00	868.00
IUUC-Nle-070023	Nomascus leucogenys	99.29	0.00e+00	869.00
IUUC-Oan-073579	Ornithorhynchus anatinus	95.29	0.00e+00	842.00
IUUC-Ocu-074778	Oryctolagus cuniculus	99.76	0.00e+00	879.00
IUUC-Oga-088987	Otolemur garnettii	92.20	0.00e+00	785.00
IUUC-Oar-090250	Ovis aries	98.82	0.00e+00	862.00
IUUC-Ptr-091598	Pan troglodytes	99.76	0.00e+00	869.00
IUUC-Pan-092412	Papio anubis	100.00	0.00e+00	881.00
IUUC-Psi-093162	Pelodiscus sinensis	95.13	0.00e+00	773.00
IUUC-Pab-097865	Pongo abelii	100.00	0.00e+00	881.00
IUUC-Pva-102369	Pteropus vampyrus	99.05	0.00e+00	869.00
IUUC-Sha-107575	Sarcophilus harrisii	95.29	0.00e+00	840.00
IUUC-Sar-113236	Sorex araneus	90.84	0.00e+00	768.00
IUUC-Ssc-116352	Sus scrofa	99.05	0.00e+00	870.00
IUUC-Tsy-118854	Tarsius syrichta	99.29	0.00e+00	869.00
IUUC-Tbe-128010	Tupaia belangeri	88.15	0.00e+00	762.00
IUUC-Ttr-128558	Tursiops truncatus	87.38	0.00e+00	743.00
IUUC-Vpa-130664	Vicugna pacos	99.29	0.00e+00	865.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence