iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000102178.12	ENST00000369660.8	ENSP00000358674.4
ENSG00000102178.12	ENST00000421431.1	ENSP00000396237.1
ENSG00000102178.12	ENST00000369653.8	ENSP00000358667.4
ENSG00000102178.12	ENST00000417913.1	ENSP00000397223.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	15571810

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	4.20e-19	69.8	1	72

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 1    vqvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           +q+tvk l+g+e++l+v++++ V++LK+ +++kl++p++qqrL++kGk L d+k L+dy + ++s++ l++k
   Q: 1    MQLTVKALQGRECSLQVPEDELVSTLKQLVSEKLNVPVRQQRLLFKGKALADGKRLSDYSIGPNSKLNLVVK 72
           79*******************************************************************987 PP

Organism

Homo sapiens

Functional Description
(View)

As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).

Protein Sequence
(Fasta)

MQLTVKALQG RECSLQVPED ELVSTLKQLV SEKLNVPVRQ QRLLFKGKAL ADGKRLSDYS 60
IGPNSKLNLV VKPLEKVLLE EGEAQRLADS PPPQVWQLIS KVLARHFSAA DASRVLEQLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTCCAGCG CGCGCCCGGG GCGGCGGCGC GCGGCGGGGG GTGGTTGGGG TGCGCGCCGG 60
CCCGAGTGGA CGCCGTCGCG ACCGCCATGC AGCTGACGGT GAAGGCGCTG CAGGGCCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

PRINTS

PR00348--UBIQUITIN

SMART

SM00213--UBQ

Gene Ontology

GO:0071818--C:BAT3 complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0051087--F:chaperone binding
GO:0019787--F:ubiquitin-like protein transferase activity
GO:0006464--P:cellular protein modification process
GO:0071816--P:tail-anchored membrane protein insertion into ER membrane
GO:0006810--P:transport

KEGG

hsa:8266

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001829	Ailuropoda melanoleuca	86.81	3.00e-56	210.00
IUUC-Aca-005306	Anolis carolinensis	69.03	1.00e-55	208.00
IUUC-Ame-010823	Astyanax mexicanus	58.49	5.00e-45	173.00
IUUC-Bta-013094	Bos taurus	86.79	7.00e-65	239.00
IUUC-Cja-018762	Callithrix jacchus	96.38	2.00e-62	231.00
IUUC-Cfa-020432	Canis familiaris	76.73	5.00e-61	226.00
IUUC-Cpo-021312	Cavia porcellus	88.61	7.00e-66	243.00
IUUC-Csa-023983	Chlorocebus sabaeus	99.36	2.00e-76	277.00
IUUC-Dre-028189	Danio rerio	62.82	1.00e-49	188.00
IUUC-Dno-029589	Dasypus novemcinctus	83.19	2.00e-37	147.00
IUUC-Dor-030848	Dipodomys ordii	92.09	1.00e-68	252.00
IUUC-Ete-032719	Echinops telfairi	84.67	5.00e-54	203.00
IUUC-Eca-033402	Equus caballus	89.51	5.00e-69	252.00
IUUC-Eeu-034802	Erinaceus europaeus	78.16	2.00e-33	133.00
IUUC-Fca-035600	Felis catus	77.99	3.00e-60	224.00
IUUC-Gmo-038655	Gadus morhua	58.33	7.00e-46	176.00
IUUC-Gga-040933	Gallus gallus	49.65	7.00e-29	120.00
IUUC-Gac-041809	Gasterosteus aculeatus	56.17	8.00e-46	176.00
IUUC-Ggo-044574	Gorilla gorilla	99.28	9.00e-65	239.00
IUUC-Itr-048284	Ictidomys tridecemlineatus	94.90	1.00e-71	261.00
IUUC-Loc-051925	Lepisosteus oculatus	61.29	1.00e-48	184.00
IUUC-Laf-053420	Loxodonta africana	79.14	6.00e-70	256.00
IUUC-Mcc-055841	Macaca mulatta	97.84	3.00e-74	270.00
IUUC-Mmr-061224	Microcebus murinus	97.20	5.00e-65	239.00
IUUC-Mdo-062067	Monodelphis domestica	67.09	5.00e-46	176.00
IUUC-Mmu-063667	Mus musculus	89.81	2.00e-67	248.00
IUUC-Mpu-066384	Mustela putorius furo	86.11	4.00e-50	190.00
IUUC-Mlu-067611	Myotis lucifugus	87.42	4.00e-65	240.00
IUUC-Nle-069287	Nomascus leucogenys	96.12	1.00e-42	165.00
IUUC-Opr-070425	Ochotona princeps	90.44	1.00e-64	238.00
IUUC-Oan-073168	Ornithorhynchus anatinus	61.90	6.00e-27	113.00
IUUC-Ocu-074452	Oryctolagus cuniculus	93.63	5.00e-81	292.00
IUUC-Ola-086473	Oryzias latipes	58.86	6.00e-47	179.00
IUUC-Oga-088650	Otolemur garnettii	94.90	2.00e-71	260.00
IUUC-Oar-089593	Ovis aries	81.94	1.00e-48	185.00
IUUC-Ptr-090659	Pan troglodytes	99.28	1.00e-64	239.00
IUUC-Pan-092760	Papio anubis	98.73	2.00e-86	311.00
IUUC-Psi-092996	Pelodiscus sinensis	62.86	9.00e-32	128.00
IUUC-Pfo-096839	Poecilia formosa	61.29	9.00e-48	182.00
IUUC-Pab-098410	Pongo abelii	100.00	7.00e-68	249.00
IUUC-Pca-100665	Procavia capensis	76.47	7.00e-25	105.00
IUUC-Rno-104898	Rattus norvegicus	88.54	3.00e-66	243.00
IUUC-Sha-107088	Sarcophilus harrisii	62.76	5.00e-37	146.00
IUUC-Ssc-116266	Sus scrofa	77.99	1.00e-60	225.00
IUUC-Tru-117619	Takifugu rubripes	55.76	2.00e-45	174.00
IUUC-Xtr-131815	Xenopus tropicalis	56.13	1.00e-41	161.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence