iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020756

Ensembl Protein ID

ENSCAFP00000009209.3

UniProt Accession

E2R427; E2R427_CANLF

Genbank Protein ID

ENSCAFP00000009209

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03013396

Gene Name

ARHGEF7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000006116.3	ENSCAFT00000009923.3	ENSCAFP00000009209.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.50e-15	54.8	87	141

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL+++kGdv++v     +++gW++g  + +gk G fP+n+v++++
   Q: 87   VVRAKFNFQQTNEDELSFTKGDVIHVT--RVEEGGWWEG--THNGKTGWFPSNYVREMK 141
           78999*********************7..999*******..8*************9975 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

FSFQTFDAND LYQGQNFNKV LSSLVTLNKV TADIGLGSDS VCARPSSHRI KSFDSLGAQP 60
SHSRTSKLFQ GQYRSLDMTD NSNSQLVVRA KFNFQQTNED ELSFTKGDVI HVTRVEEGGW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTCTTTTC AGACATTTGA TGCAAATGAT TTGTATCAGG GGCAGAATTT TAACAAGGTC 60
CTCAGTTCCT TAGTGACTCT AAACAAAGTA ACAGCAGGTA AGAATTTTCT ATTGAACTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0000322--C:storage vacuole
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:0060124--P:positive regulation of growth hormone secretion
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0032092--P:positive regulation of protein binding
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001259	Ailuropoda melanoleuca	97.78	0.00e+00	1180.00
IUUC-Aca-004591	Anolis carolinensis	90.63	0.00e+00	1061.00
IUUC-Ame-010759	Astyanax mexicanus	75.20	0.00e+00	922.00
IUUC-Bta-013328	Bos taurus	93.80	0.00e+00	1135.00
IUUC-Cja-018742	Callithrix jacchus	94.30	0.00e+00	1140.00
IUUC-Cpo-021284	Cavia porcellus	93.81	0.00e+00	1112.00
IUUC-Csa-023162	Chlorocebus sabaeus	94.29	0.00e+00	1141.00
IUUC-Cho-024736	Choloepus hoffmanni	73.14	2.00e-173	602.00
IUUC-Cin-025535	Ciona intestinalis	40.31	5.00e-95	341.00
IUUC-Cgl-026676	Colletotrichum gloeosporioides	42.86	1.00e-11	65.90
IUUC-Cne-026866	Cryptococcus neoformans	49.21	1.00e-12	69.30
IUUC-Dre-028646	Danio rerio	65.18	0.00e+00	933.00
IUUC-Dno-029461	Dasypus novemcinctus	94.92	0.00e+00	1154.00
IUUC-Dor-030623	Dipodomys ordii	83.76	0.00e+00	979.00
IUUC-Dse-031165	Dothistroma septosporum	37.66	2.00e-11	65.10
IUUC-Dme-032219	Drosophila melanogaster	45.99	1.00e-101	364.00
IUUC-Ete-032236	Echinops telfairi	80.24	0.00e+00	813.00
IUUC-Eca-034137	Equus caballus	96.50	0.00e+00	1165.00
IUUC-Fca-035742	Felis catus	98.33	0.00e+00	1332.00
IUUC-Fal-037205	Ficedula albicollis	92.25	0.00e+00	978.00
IUUC-Gmo-039475	Gadus morhua	75.14	0.00e+00	1008.00
IUUC-Gga-040539	Gallus gallus	93.50	0.00e+00	1155.00
IUUC-Gac-042615	Gasterosteus aculeatus	71.55	0.00e+00	934.00
IUUC-Ggo-044470	Gorilla gorilla	94.46	0.00e+00	1147.00
IUUC-Hsa-046398	Homo sapiens	93.99	0.00e+00	1133.00
IUUC-Loc-052146	Lepisosteus oculatus	83.89	0.00e+00	1031.00
IUUC-Laf-053891	Loxodonta africana	94.62	0.00e+00	1196.00
IUUC-Mcc-055483	Macaca mulatta	93.99	0.00e+00	1136.00
IUUC-Mga-059410	Meleagris gallopavo	91.93	0.00e+00	1120.00
IUUC-Mmr-060758	Microcebus murinus	95.56	0.00e+00	1110.00
IUUC-Mdo-061900	Monodelphis domestica	94.17	0.00e+00	1310.00
IUUC-Mmu-063849	Mus musculus	93.49	0.00e+00	1099.00
IUUC-Mpu-065876	Mustela putorius furo	97.92	0.00e+00	1353.00
IUUC-Mlu-067970	Myotis lucifugus	95.87	0.00e+00	1161.00
IUUC-Nle-069685	Nomascus leucogenys	92.26	0.00e+00	1207.00
IUUC-Opr-071132	Ochotona princeps	60.51	0.00e+00	642.00
IUUC-Ont-071815	Oreochromis niloticus	67.47	0.00e+00	975.00
IUUC-Oan-073057	Ornithorhynchus anatinus	92.25	0.00e+00	986.00
IUUC-Ola-086663	Oryzias latipes	74.09	0.00e+00	856.00
IUUC-Oga-088103	Otolemur garnettii	94.30	0.00e+00	1103.00
IUUC-Ptr-091162	Pan troglodytes	94.30	0.00e+00	1139.00
IUUC-Pan-092093	Papio anubis	81.38	0.00e+00	993.00
IUUC-Pma-094261	Petromyzon marinus	65.93	4.00e-125	441.00
IUUC-Pfo-096736	Poecilia formosa	74.03	0.00e+00	1025.00
IUUC-Pab-097641	Pongo abelii	95.01	0.00e+00	1318.00
IUUC-Pva-102819	Pteropus vampyrus	91.75	0.00e+00	1093.00
IUUC-Rno-106099	Rattus norvegicus	93.33	0.00e+00	1102.00
IUUC-Sha-106845	Sarcophilus harrisii	93.50	0.00e+00	1306.00
IUUC-Ssc-116036	Sus scrofa	94.05	0.00e+00	1305.00
IUUC-Tgu-117498	Taeniopygia guttata	92.22	0.00e+00	1121.00
IUUC-Tru-118278	Takifugu rubripes	73.82	0.00e+00	872.00
IUUC-Tsy-118990	Tarsius syrichta	94.30	0.00e+00	978.00
IUUC-Tni-120852	Tetraodon nigroviridis	73.62	0.00e+00	1014.00
IUUC-Ttr-128922	Tursiops truncatus	90.13	0.00e+00	1060.00
IUUC-Xtr-132012	Xenopus tropicalis	82.31	0.00e+00	919.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence