iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035742

Ensembl Protein ID

ENSFCAP00000013482.3

UniProt Accession

M3WKV7; M3WKV7_FELCA

Genbank Protein ID

ENSFCAP00000013482

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02107853

Gene Name

ARHGEF7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000014533.3	ENSFCAT00000014537.3	ENSFCAP00000013482.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.40e-15	55.4	105	159

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL+++kGd+++v     +++gW++g  + +g+ G fP+n+v++++
   Q: 105  VVRAKFNFQQTNEDELSFTKGDIIHVT--RVEEGGWWEG--THNGRTGWFPSNYVREVK 159
           78999*********************7..999*******..8**************996 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MCWCISLVSL GVPRCPRCQG GQTFDANDLY QGQNFNKVLS SLVTLNKVTA DIGLGSDSVC 60
ARPSSHRIKS FDSLGAQPSH SRTSKLFQGQ YRSLDMTDNS NSQLVVRAKF NFQQTNEDEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGGCTGCG GGGCTGCCCT TCCTCTTATG TGCTGGTGTA TTTCCCTCGT GAGCCTTGGG 60
GTGCCGCGGT GTCCACGCTG TCAGGGTGGA CAGGTGAGTG GGAGGGAGGG CTGGGCTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0000322--C:storage vacuole
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:0060124--P:positive regulation of growth hormone secretion
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0032092--P:positive regulation of protein binding
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001259	Ailuropoda melanoleuca	97.77	0.00e+00	1169.00
IUUC-Aca-004591	Anolis carolinensis	88.72	0.00e+00	1056.00
IUUC-Ame-010759	Astyanax mexicanus	76.27	0.00e+00	919.00
IUUC-Bta-013328	Bos taurus	93.24	0.00e+00	1136.00
IUUC-Cja-018742	Callithrix jacchus	95.23	0.00e+00	1138.00
IUUC-Cfa-020756	Canis familiaris	98.33	0.00e+00	1358.00
IUUC-Cpo-021284	Cavia porcellus	91.65	0.00e+00	1109.00
IUUC-Csa-023162	Chlorocebus sabaeus	93.20	0.00e+00	1149.00
IUUC-Cho-024736	Choloepus hoffmanni	73.14	7.00e-173	600.00
IUUC-Cin-025535	Ciona intestinalis	39.92	8.00e-95	340.00
IUUC-Cgl-026676	Colletotrichum gloeosporioides	41.43	1.00e-11	65.50
IUUC-Cne-026866	Cryptococcus neoformans	52.38	3.00e-13	71.20
IUUC-Dre-028646	Danio rerio	65.34	0.00e+00	928.00
IUUC-Dno-029461	Dasypus novemcinctus	93.04	0.00e+00	1153.00
IUUC-Dor-030623	Dipodomys ordii	83.92	0.00e+00	980.00
IUUC-Dme-032219	Drosophila melanogaster	45.74	4.00e-102	366.00
IUUC-Ete-032236	Echinops telfairi	80.24	0.00e+00	809.00
IUUC-Eca-034137	Equus caballus	96.34	0.00e+00	1160.00
IUUC-Fal-037205	Ficedula albicollis	92.25	0.00e+00	972.00
IUUC-Gmo-039475	Gadus morhua	76.08	0.00e+00	1008.00
IUUC-Gga-040539	Gallus gallus	93.65	0.00e+00	1151.00
IUUC-Gac-042615	Gasterosteus aculeatus	73.99	0.00e+00	936.00
IUUC-Ggo-044470	Gorilla gorilla	95.39	0.00e+00	1145.00
IUUC-Hsa-046398	Homo sapiens	95.08	0.00e+00	1138.00
IUUC-Loc-052146	Lepisosteus oculatus	84.60	0.00e+00	1033.00
IUUC-Laf-053891	Loxodonta africana	95.22	0.00e+00	1190.00
IUUC-Mcc-055483	Macaca mulatta	95.22	0.00e+00	1138.00
IUUC-Mla-059044	Melampsora laricipopulina	26.96	1.00e-19	92.00
IUUC-Mga-059410	Meleagris gallopavo	89.95	0.00e+00	1110.00
IUUC-Mmr-060758	Microcebus murinus	93.20	0.00e+00	1103.00
IUUC-Mdo-061900	Monodelphis domestica	92.41	0.00e+00	1307.00
IUUC-Mmu-063849	Mus musculus	91.50	0.00e+00	1098.00
IUUC-Mpu-065876	Mustela putorius furo	96.84	0.00e+00	1345.00
IUUC-Mlu-067970	Myotis lucifugus	95.71	0.00e+00	1157.00
IUUC-Nle-069685	Nomascus leucogenys	93.50	0.00e+00	1215.00
IUUC-Opr-071132	Ochotona princeps	60.99	0.00e+00	646.00
IUUC-Ont-071815	Oreochromis niloticus	68.04	0.00e+00	974.00
IUUC-Oan-073057	Ornithorhynchus anatinus	92.07	0.00e+00	979.00
IUUC-Ola-086663	Oryzias latipes	75.32	0.00e+00	856.00
IUUC-Oga-088103	Otolemur garnettii	93.96	0.00e+00	1090.00
IUUC-Ptr-091162	Pan troglodytes	95.23	0.00e+00	1138.00
IUUC-Pan-092093	Papio anubis	80.49	0.00e+00	998.00
IUUC-Pma-094261	Petromyzon marinus	66.25	1.00e-125	442.00
IUUC-Pfo-096736	Poecilia formosa	74.83	0.00e+00	1025.00
IUUC-Pab-097641	Pongo abelii	96.11	0.00e+00	1325.00
IUUC-Pva-102819	Pteropus vampyrus	89.49	0.00e+00	1087.00
IUUC-Pgr-103400	Puccinia graminis	27.00	4.00e-19	90.90
IUUC-Rno-106099	Rattus norvegicus	91.50	0.00e+00	1103.00
IUUC-Sha-106845	Sarcophilus harrisii	93.77	0.00e+00	1303.00
IUUC-Ssc-116036	Sus scrofa	94.72	0.00e+00	1301.00
IUUC-Tgu-117498	Taeniopygia guttata	90.26	0.00e+00	1116.00
IUUC-Tru-118278	Takifugu rubripes	75.04	0.00e+00	873.00
IUUC-Tsy-118990	Tarsius syrichta	94.91	0.00e+00	980.00
IUUC-Tni-120852	Tetraodon nigroviridis	74.10	0.00e+00	1012.00
IUUC-Ttr-128922	Tursiops truncatus	89.65	0.00e+00	1051.00
IUUC-Xtr-132012	Xenopus tropicalis	83.02	0.00e+00	913.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence