iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-136373

Ensembl Protein ID

ENSP00000219313.4

UniProt Accession

P51665; D3DWS9; Q6PKI2; Q96E97; PSMD7_HUMAN

Genbank Protein ID

D50063; CH471166; CH471166; BC000338; BC012606

Protein Name

26S proteasome non-ATPase regulatory subunit 7;26S proteasome regulatory subunit RPN8;26S proteasome regulatory subunit S12;Mov34 protein homolog;Proteasome subunit p40

Genbank Nucleotide ID

BAA08780.1; EAW59162.1; EAW59163.1; AAH00338.1; AAH12606.1

Gene Name

PSMD7;MOV34L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000103035.10	ENST00000219313.8	ENSP00000219313.4
ENSG00000103035.10	ENST00000568717.1	ENSP00000455953.1
ENSG00000103035.10	ENST00000567958.5	ENSP00000457244.1
ENSG00000103035.10	ENST00000568615.2	ENSP00000454999.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/JAMM	JAMM	22298430

Organism

Homo sapiens

Functional Description
(View)

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Protein Sequence
(Fasta)

MPELAVQKVV VHPLVLLSVV DHFNRIGKVG NQKRVVGVLL GSWQKKVLDV SNSFAVPFDE 60
DDKDDSVWFL DHDYLENMYG MFKKVNARER IVGWYHTGPK LHKNDIAINE LMKRYCPNSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAGCGGAA GAAGGAGGCC GCGCGAGGGC TGACGAACCG GAAGAAGAGG AACTGGGCCT 60
GAAAGGGTAC CGGTGACCGC TACTGCTGCC GGTGTTTGCG TGTGGCAGGG AGCCAGGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR000555--JAMM/MPN+_dom
IPR033858--MPN_RPN7_8
IPR024969--Rpn11/EIF3F_C

Pfam

PF01398--JAB
PF13012--MitMem_reg

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005576--C:extracellular region
GO:1904813--C:ficolin-1-rich granule lumen
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0005838--C:proteasome regulatory particle
GO:0034774--C:secretory granule lumen
GO:0042803--F:protein homodimerization activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0000165--P:MAPK cascade
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0010972--P:negative regulation of G2/M transition of mitotic cell cycle
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0043312--P:neutrophil degranulation
GO:0038061--P:NIK/NF-kappaB signaling
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043687--P:post-translational protein modification
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006521--P:regulation of cellular amino acid metabolic process
GO:0043488--P:regulation of mRNA stability
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway
GO:0055085--P:transmembrane transport
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
GO:0060071--P:Wnt signaling pathway, planar cell polarity pathway

KEGG

hsa:5713

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence