iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000103404.14	ENST00000219689.11	ENSP00000219689.7
ENSG00000103404.14	ENST00000567975.1	ENSP00000461621.1
ENSG00000103404.14	ENST00000563525.2	ENSP00000481339.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
iRefIndex	Mentha
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-93	315.4	129	765

Active Site

Position(s)	Description	Evidence
137	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
723	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp.........kepkgellkslqklfeelwkskkkavsprell 74
           Gl+N+gNtC+mN++LQcLsn++ ++e+l            +         p          + +ge++++l++l+++lw+ + +    r+++
   Q: 129  GLRNHGNTCFMNATLQCLSNTELFAEYLALgqyragrpepS---------PdpeqpagrgAQGQGEVTEQLAHLVRALWTLEYTPQHSRDFK 211
           9***************************9954444333330.........133334444456666*************************** PP
   S: 75   kalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssre 166
           ++++k a +++g++q+DaqEfl +lld+++e+l++ + k+  +   +  se++++ e       ++++++lFq q++s+++c++c+++s+++
   Q: 212  TIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNH-SVKQSGQPPLKPPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQSNTF 302
           *********************************65.33333333334445566667777778888*************************** PP
   S: 167  epfldlslpvpgkeetkke......................................................................... 185
           +pfl +slp+p  +++ ++                                                                         
   Q: 303  DPFLCISLPIPLPHTR-PLyvtvvyqgkcshcmrigvavplsgtvarlreavsmetkiptdqivltemyydgfhrsfcdtddletvhesdci 393
           ***********87755.34689********************************************************************** PP
   S: 186  ............................................................................................ 185
                                                                                                       
   Q: 394  fafetpeifrpegilsqrgihlnnnlnhlkfgldyhrlssptqtaakqgkmdsptsragsdkivllvcnractgqqgkrfglpfvlhlekti 485
           ******************************************************************************************** PP
   S: 186  ............................................................................................ 185
                                                                                                       
   Q: 486  awdllqkeilekmkyflrptvciqvcpfslrvvsvvgityllpqeeqplchpiveralkscgpggtahvklvvewdketrdflfvntedeyi 577
           ******************************************************************************************** PP
   S: 186  ...................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple 258
                              +l++c++ +tkee+l  ++++ c++ck++q+ + +l+l++lP+vLi+hLkRf  ++e+++r k+++ v+fpl+
   Q: 578  pdaesvrlqrerhhqpqtcTLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRF--RQEGDRRMKLQNMVKFPLT 667
           ***********************************************************************..99***************** PP
   S: 259  .Ldlspfctspeekqke...................kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgst 329
            Ld++p+++++++++ +                   +++Y+L+av++H+G++++GHY+ay+kn+ ++ W++fdDs V++++e+ev++   +t
   Q: 668  gLDMTPHVVKRSQSSWSlpshwspwrrpyglgrdpeDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGlWYCFDDSDVQQLSEDEVCT---QT 756
           *********977666559999999999999999999***************************87777*******************...** PP
   S: 330  aYvlfYkrr 338
           aY+lfY+rr
   Q: 757  AYILFYQRR 765
           *******96 PP

Organism

Homo sapiens

Functional Description
(View)

May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MSKVTAPGSG PPAAASGKEK RSFSKRLFRS GRAGGGGAGG PGASGPAAPS SPSSPSSARS 60
VGSFMSRVLK TLSTLSHLSS EGAAPDRGGL RSCFPPGPAA APTPPPCPPP PASPAPPACA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCAAGG TAACGGCGCC TGGGTCCGGG CCGCCGGCGG CGGCGAGCGG GAAGGAGAAG 60
CGCTCCTTCA GCAAGCGGCT GTTTCGGAGC GGCCGCGCTG GCGGCGGCGG CGCGGGGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:57478

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001207	Ailuropoda melanoleuca	92.99	0.00e+00	1976.00
IUUC-Apl-003186	Anas platyrhynchos	77.45	0.00e+00	1442.00
IUUC-Aca-004949	Anolis carolinensis	67.59	0.00e+00	1400.00
IUUC-Ame-010968	Astyanax mexicanus	66.80	0.00e+00	1112.00
IUUC-Bta-013271	Bos taurus	93.89	0.00e+00	1619.00
IUUC-Cja-019663	Callithrix jacchus	96.24	0.00e+00	1799.00
IUUC-Cfa-021258	Canis familiaris	93.00	0.00e+00	1984.00
IUUC-Csa-024188	Chlorocebus sabaeus	98.45	0.00e+00	1644.00
IUUC-Cho-024813	Choloepus hoffmanni	86.85	0.00e+00	1580.00
IUUC-Csv-026086	Ciona savignyi	38.65	2.00e-133	469.00
IUUC-Dre-027372	Danio rerio	70.50	0.00e+00	1024.00
IUUC-Dno-029964	Dasypus novemcinctus	90.38	0.00e+00	1807.00
IUUC-Dor-030448	Dipodomys ordii	84.20	0.00e+00	1174.00
IUUC-Ete-032975	Echinops telfairi	77.04	0.00e+00	1461.00
IUUC-Eca-034030	Equus caballus	93.62	0.00e+00	1924.00
IUUC-Eeu-034629	Erinaceus europaeus	75.94	0.00e+00	1179.00
IUUC-Fca-035788	Felis catus	92.96	0.00e+00	1869.00
IUUC-Fal-036874	Ficedula albicollis	84.10	0.00e+00	1283.00
IUUC-Gmo-039479	Gadus morhua	59.12	0.00e+00	1192.00
IUUC-Gga-041092	Gallus gallus	73.26	0.00e+00	1563.00
IUUC-Gac-041609	Gasterosteus aculeatus	70.96	0.00e+00	1132.00
IUUC-Ggo-044782	Gorilla gorilla	97.35	0.00e+00	825.00
IUUC-Itr-048158	Ictidomys tridecemlineatus	92.99	0.00e+00	1773.00
IUUC-Lch-050332	Latimeria chalumnae	65.20	0.00e+00	1312.00
IUUC-Loc-051953	Lepisosteus oculatus	60.81	0.00e+00	1263.00
IUUC-Mcc-055398	Macaca mulatta	97.91	0.00e+00	2070.00
IUUC-Meu-056822	Macropus eugenii	77.74	0.00e+00	1459.00
IUUC-Mga-060115	Meleagris gallopavo	74.93	0.00e+00	1416.00
IUUC-Mmr-061150	Microcebus murinus	95.53	0.00e+00	1937.00
IUUC-Mdo-062700	Monodelphis domestica	80.41	0.00e+00	1813.00
IUUC-Mmu-063512	Mus musculus	89.66	0.00e+00	1850.00
IUUC-Mpu-066059	Mustela putorius furo	91.00	0.00e+00	1722.00
IUUC-Mlu-067870	Myotis lucifugus	86.40	0.00e+00	1724.00
IUUC-Nle-069898	Nomascus leucogenys	98.77	0.00e+00	2016.00
IUUC-Opr-070338	Ochotona princeps	81.23	0.00e+00	889.00
IUUC-Ont-072469	Oreochromis niloticus	68.49	0.00e+00	1107.00
IUUC-Oan-073175	Ornithorhynchus anatinus	86.26	0.00e+00	1357.00
IUUC-Ola-087303	Oryzias latipes	70.53	0.00e+00	1098.00
IUUC-Oga-089021	Otolemur garnettii	94.78	0.00e+00	1924.00
IUUC-Oar-090016	Ovis aries	95.67	0.00e+00	1627.00
IUUC-Ptr-090864	Pan troglodytes	99.33	0.00e+00	2095.00
IUUC-Pan-092370	Papio anubis	97.94	0.00e+00	1957.00
IUUC-Psi-093881	Pelodiscus sinensis	75.77	0.00e+00	1441.00
IUUC-Pfo-097427	Poecilia formosa	69.80	0.00e+00	1113.00
IUUC-Pab-098104	Pongo abelii	95.71	0.00e+00	2006.00
IUUC-Pca-100640	Procavia capensis	97.73	2.00e-130	460.00
IUUC-Pva-102287	Pteropus vampyrus	82.91	0.00e+00	1528.00
IUUC-Rno-106033	Rattus norvegicus	91.28	0.00e+00	1811.00
IUUC-Sha-107041	Sarcophilus harrisii	84.51	0.00e+00	1648.00
IUUC-Ssc-116412	Sus scrofa	85.12	0.00e+00	749.00
IUUC-Tgu-116889	Taeniopygia guttata	76.68	0.00e+00	1442.00
IUUC-Tru-118340	Takifugu rubripes	70.40	0.00e+00	1113.00
IUUC-Tsy-118887	Tarsius syrichta	90.09	0.00e+00	1742.00
IUUC-Tni-120463	Tetraodon nigroviridis	70.52	0.00e+00	1116.00
IUUC-Tbe-127491	Tupaia belangeri	94.08	4.00e-134	473.00
IUUC-Ttr-128210	Tursiops truncatus	89.26	0.00e+00	1547.00
IUUC-Vpa-130222	Vicugna pacos	82.62	0.00e+00	813.00
IUUC-Xtr-132509	Xenopus tropicalis	63.69	0.00e+00	1335.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence