iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000103994.16	ENST00000263805.8	ENSP00000263805.4
ENSG00000103994.16	ENST00000565380.5	ENSP00000455674.1
ENSG00000103994.16	ENST00000565500.5	ENSP00000456604.1
ENSG00000103994.16	ENST00000569648.5	ENSP00000456191.1
ENSG00000103994.16	ENST00000567772.2	ENSP00000475881.1
ENSG00000103994.16	ENST00000564754.5	ENSP00000456845.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.20e-19	69.9	1569	1609
UBD/Beta-Prp	2.60e-43	150.0	1669	1803

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtl...lvsGsdDgtikvWDlrtgvll 36
           gHt++v+cl     s+     l +Gs D+ti+++++++  ++
   Q: 1569 GHTSKVNCLLVtqtSG-KnaaLYTGSSDHTIRCYNVKSRECV 1609
           8*******95587533.24579**************988876 PP

UBD/Beta-Prp

   S: 21   dksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklv 110
            ++ll++gs+d ti v d+++g llr+l+gh++++ ++k  +d  +  +gs+D+ ++  ++ tg+ v+++kgh++ v+ +++    +++v
   Q: 1669 ARKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNILG--KVMV 1754
           5689***************************************..9*************************************9..**** PP
   S: 111  sGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvr 162
           ++  d+ +rv++l++   l+ +  gh+++++c+++h+  +++ +G++D+ ++
   Q: 1755 TACLDKFVRVYELQSHDRLQ-VYGGHKDMIMCMTIHK--SMIYTGCYDGSIQ 1803
           ********************.****************..**********997 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MPVGRIECPS SPSFPRDISH ECRVCGVTEV GLSAYAKHIS GQLHKDNVDA QEREDDGKGE 60
EEEEDYFDKE LIQLIKQRKE QSRQDEPSNS NQEINSDDRR PQWRREDRIP YQDRESYSQP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGCGGCT GTGGCGGGGC CCGGCGGGGA GCGGGTCCGG AGCAGGCTCC CGGACCCAAA 60
ACTGAAGGGG GCGTCTGAGG CGTCAGGGAG CTCCCTCGCC TGGCTCTCGG CGGCCTGATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR013087--Znf_C2H2_type

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS00028--ZINC_FINGER_C2H2_1

Pfam

PF00400--WD40

SMART

SM00320--WD40
SM00355--ZnF_C2H2

Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0046872--F:metal ion binding
GO:0003723--F:RNA binding
GO:0017124--F:SH3 domain binding
GO:0008286--P:insulin receptor signaling pathway

KEGG

hsa:64397

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001928	Ailuropoda melanoleuca	88.21	0.00e+00	3183.00
IUUC-Apl-003674	Anas platyrhynchos	57.05	0.00e+00	1715.00
IUUC-Aca-005018	Anolis carolinensis	53.91	0.00e+00	1647.00
IUUC-Ame-011431	Astyanax mexicanus	68.95	0.00e+00	684.00
IUUC-Bta-013436	Bos taurus	87.80	0.00e+00	3082.00
IUUC-Cfa-020278	Canis familiaris	87.36	0.00e+00	2626.00
IUUC-Cpo-022278	Cavia porcellus	80.21	0.00e+00	2799.00
IUUC-Csa-023115	Chlorocebus sabaeus	95.89	0.00e+00	2092.00
IUUC-Cho-024829	Choloepus hoffmanni	82.44	0.00e+00	2226.00
IUUC-Dre-028112	Danio rerio	65.18	0.00e+00	666.00
IUUC-Dno-029127	Dasypus novemcinctus	84.97	0.00e+00	2967.00
IUUC-Dor-030367	Dipodomys ordii	81.18	0.00e+00	1207.00
IUUC-Ete-032500	Echinops telfairi	73.41	0.00e+00	1278.00
IUUC-Eca-034319	Equus caballus	89.53	0.00e+00	3128.00
IUUC-Eeu-034754	Erinaceus europaeus	77.13	0.00e+00	2421.00
IUUC-Fca-036181	Felis catus	88.85	0.00e+00	3102.00
IUUC-Fal-036865	Ficedula albicollis	56.21	0.00e+00	1609.00
IUUC-Gmo-039227	Gadus morhua	64.00	3.00e-175	608.00
IUUC-Gga-041178	Gallus gallus	57.25	0.00e+00	1743.00
IUUC-Gac-042209	Gasterosteus aculeatus	58.07	7.00e-169	587.00
IUUC-Ggo-044636	Gorilla gorilla	97.65	0.00e+00	3513.00
IUUC-Itr-048628	Ictidomys tridecemlineatus	88.97	0.00e+00	3164.00
IUUC-Lch-049753	Latimeria chalumnae	50.10	0.00e+00	1439.00
IUUC-Loc-052333	Lepisosteus oculatus	69.14	0.00e+00	728.00
IUUC-Laf-053530	Loxodonta africana	83.61	0.00e+00	3010.00
IUUC-Mcc-054664	Macaca mulatta	97.24	0.00e+00	3445.00
IUUC-Meu-056609	Macropus eugenii	67.04	0.00e+00	1231.00
IUUC-Mga-059632	Meleagris gallopavo	57.41	0.00e+00	1706.00
IUUC-Mmr-060742	Microcebus murinus	89.38	0.00e+00	3172.00
IUUC-Mdo-061831	Monodelphis domestica	82.21	0.00e+00	1330.00
IUUC-Mmu-064055	Mus musculus	76.76	0.00e+00	2573.00
IUUC-Mpu-066458	Mustela putorius furo	92.26	0.00e+00	1579.00
IUUC-Mlu-067767	Myotis lucifugus	84.92	0.00e+00	2962.00
IUUC-Nle-069728	Nomascus leucogenys	97.93	0.00e+00	3506.00
IUUC-Opr-070914	Ochotona princeps	80.01	0.00e+00	2790.00
IUUC-Ont-072462	Oreochromis niloticus	56.96	3.00e-163	568.00
IUUC-Ocu-073827	Oryctolagus cuniculus	87.47	0.00e+00	2997.00
IUUC-Ola-087573	Oryzias latipes	68.23	1.00e-162	566.00
IUUC-Oga-088664	Otolemur garnettii	89.65	0.00e+00	1870.00
IUUC-Oar-090256	Ovis aries	84.68	0.00e+00	2389.00
IUUC-Ptr-090884	Pan troglodytes	97.59	0.00e+00	2986.00
IUUC-Pan-091779	Papio anubis	96.06	0.00e+00	2100.00
IUUC-Psi-093267	Pelodiscus sinensis	93.09	2.00e-165	574.00
IUUC-Pma-094414	Petromyzon marinus	43.84	3.00e-59	223.00
IUUC-Pfo-097009	Poecilia formosa	63.99	4.00e-159	556.00
IUUC-Pca-100820	Procavia capensis	78.92	0.00e+00	2215.00
IUUC-Pva-103044	Pteropus vampyrus	80.39	0.00e+00	1233.00
IUUC-Rno-105960	Rattus norvegicus	71.53	0.00e+00	2358.00
IUUC-Sar-113018	Sorex araneus	75.87	0.00e+00	1367.00
IUUC-Ssc-115278	Sus scrofa	88.18	0.00e+00	3118.00
IUUC-Tgu-117231	Taeniopygia guttata	55.44	0.00e+00	1637.00
IUUC-Tru-118472	Takifugu rubripes	55.34	4.00e-165	576.00
IUUC-Tsy-118877	Tarsius syrichta	85.89	0.00e+00	2108.00
IUUC-Tni-119881	Tetraodon nigroviridis	56.67	3.00e-177	616.00
IUUC-Tbe-127499	Tupaia belangeri	80.36	0.00e+00	1619.00
IUUC-Ttr-128962	Tursiops truncatus	88.74	0.00e+00	3092.00
IUUC-Vpa-130089	Vicugna pacos	82.42	0.00e+00	1354.00
IUUC-Xtr-132940	Xenopus tropicalis	59.30	0.00e+00	886.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence