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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045941
UUCD1 version UUC-HoS-00047
Ensembl Protein ID ENSP00000429084.1
UniProt Accession O95071; B2RP24; J3KMW7; O94970; Q9NPL3; UBR5_HUMAN
Genbank Protein ID AAD01259.2; AAF88143.1; BAA74919.3; AAI37235.1
Protein Name E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase, HECT domain-containing 1; HECT-type E3 ubiquitin transferase UBR5; Hyperplastic discs protein homolog; Progestin-induced protein
Genbank Nucleotide ID AF006010; U95000; AB020703; AP002907
Gene Name UBR5; EDD; EDD1; HYD; KIAA0896
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000104517.12 ENST00000520539.5 ENSP00000429084.1
ENSG00000104517.12 ENST00000220959.8 ENSP00000220959.4
ENSG00000104517.12 ENST00000521922.5 ENSP00000427819.1
ENSG00000104517.12 ENST00000520898.5 ENSP00000429127.1
ENSG00000104517.12 ENST00000519365.1 ENSP00000428138.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 18073532; 21127351; 21118991; 16601676; 16554297
E3 activity/N-recognin/UBR-box UBR 18073532; 21127351; 21118991; 16601676; 16554297
Classification
Family E-value Score Start End
E3 activity/HECT 4.30e-80 271.3 2474 2798
Active Site
Position(s) Description Evidence
2768 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 15   gEegldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklll 101
           ++e+ + +G++r ++++ ++++ + d  ++lf +  +++ +t +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k ll
   Q: 2474 QQENRKRHGSSRSVVDMDLDDTDDGDdnAPLFyQPGKRGFYTPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLL 2559
           56778888***************999878888334444777777777775....89********************************** PP
   S: 102  gkklsledleevdpelyks.lkeikena..esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegike 188
           g+k++++d++ +dp +y+s  + i++++  ++d   +++dl+f ++ ++ +   ++eL+p+G nipVt +N +eYv++++e+r+    ++
   Q: 2560 GRKVNWHDFAFFDPVMYESlRQLILASQssDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQ 2649
           *******************5556666655556888999**************************************************** PP
   S: 189  qveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLqFvTgssrl 274
            ++a+r+G+ +v+p+++l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    +wFw+++e++s++er++++ F+T+s++l
   Q: 2650 PLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRWFWSIVEKMSMTERQDLVYFWTSSPSL 2739
           ***********************************************9999999999989999*************************** PP
   S: 275  Pl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           P+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2740 PAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2798
           **999******..799999.99**********************************9.99875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
Protein Sequence
(Fasta)
MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNLNSHPPL NVLEQATIKQ CVVGPNHAAF 60
LLEDGRVCRI GFSVQPDRLE LGKPDNNDGS KLNSNSGAGR TSRPGRTSDS PWFLSGSETL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045941|E3,HECT;E3,UBR-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGGGGGCCT TGCCGCCCGT TTCCCGGAGC CCCGCCTCTC GCCGCCGCGC CCCCGCCCGC 60
CGGTCTCCTC CCTCCTCCTC CTCCCGTTTG CCCCTCCCCC GCCGCTCCGG AGCGGAGCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045941|E3,HECT;E3,UBR-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR
PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR
Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP
SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1
Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0035413--P:positive regulation of catenin import into nucleus
GO:0010628--P:positive regulation of gene expression
GO:0033160--P:positive regulation of protein import into nucleus, translocation
GO:0050847--P:progesterone receptor signaling pathway
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:51366
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002217 Ailuropoda melanoleuca 98.68 0.00e+00 4574.00
IUUC-Apl-004165 Anas platyrhynchos 97.13 0.00e+00 4489.00
IUUC-Aca-004577 Anolis carolinensis 95.98 0.00e+00 3915.00
IUUC-Ame-010702 Astyanax mexicanus 84.67 0.00e+00 2487.00
IUUC-Bta-012313 Bos taurus 99.36 0.00e+00 4653.00
IUUC-Cel-018165 Caenorhabditis elegans 35.31 2.00e-69 259.00
IUUC-Cja-019858 Callithrix jacchus 99.64 0.00e+00 4655.00
IUUC-Cfa-020973 Canis familiaris 99.36 0.00e+00 4653.00
IUUC-Cpo-022108 Cavia porcellus 97.88 0.00e+00 1948.00
IUUC-Csa-023985 Chlorocebus sabaeus 99.57 0.00e+00 4705.00
IUUC-Cho-025034 Choloepus hoffmanni 89.06 0.00e+00 986.00
IUUC-Cin-025715 Ciona intestinalis 40.61 0.00e+00 949.00
IUUC-Csv-026088 Ciona savignyi 40.20 1.00e-161 563.00
IUUC-Dre-027730 Danio rerio 88.34 0.00e+00 4061.00
IUUC-Dno-029123 Dasypus novemcinctus 96.29 0.00e+00 4446.00
IUUC-Dor-030757 Dipodomys ordii 94.62 0.00e+00 2910.00
IUUC-Dme-032192 Drosophila melanogaster 51.98 2.00e-174 608.00
IUUC-Ete-032292 Echinops telfairi 96.20 0.00e+00 2198.00
IUUC-Eca-034347 Equus caballus 99.03 0.00e+00 4544.00
IUUC-Eeu-034873 Erinaceus europaeus 94.74 0.00e+00 4379.00
IUUC-Fca-036485 Felis catus 97.88 0.00e+00 4484.00
IUUC-Fal-037071 Ficedula albicollis 97.80 0.00e+00 4507.00
IUUC-Gmo-039589 Gadus morhua 88.83 0.00e+00 3981.00
IUUC-Gga-041195 Gallus gallus 96.53 0.00e+00 4440.00
IUUC-Gac-042538 Gasterosteus aculeatus 88.84 0.00e+00 4010.00
IUUC-Ggo-045351 Gorilla gorilla 99.14 0.00e+00 4693.00
IUUC-Itr-048635 Ictidomys tridecemlineatus 99.24 0.00e+00 4601.00
IUUC-Lch-050480 Latimeria chalumnae 94.23 0.00e+00 4338.00
IUUC-Loc-052664 Lepisosteus oculatus 89.91 0.00e+00 4152.00
IUUC-Laf-053935 Loxodonta africana 98.66 0.00e+00 1600.00
IUUC-Mcc-054703 Macaca mulatta 99.57 0.00e+00 4701.00
IUUC-Meu-056431 Macropus eugenii 87.62 0.00e+00 802.00
IUUC-Mga-059289 Meleagris gallopavo 97.25 0.00e+00 3600.00
IUUC-Mmr-061737 Microcebus murinus 98.92 0.00e+00 4540.00
IUUC-Mdo-062499 Monodelphis domestica 98.02 0.00e+00 4529.00
IUUC-Mmu-063273 Mus musculus 98.21 0.00e+00 4556.00
IUUC-Mpu-066907 Mustela putorius furo 99.06 0.00e+00 4229.00
IUUC-Mlu-067942 Myotis lucifugus 98.78 0.00e+00 4590.00
IUUC-Nle-069527 Nomascus leucogenys 99.78 0.00e+00 4687.00
IUUC-Opr-070626 Ochotona princeps 87.19 0.00e+00 1464.00
IUUC-Ont-071951 Oreochromis niloticus 87.60 0.00e+00 3990.00
IUUC-Oan-072958 Ornithorhynchus anatinus 98.20 0.00e+00 4179.00
IUUC-Ocu-074503 Oryctolagus cuniculus 96.72 0.00e+00 4532.00
IUUC-Ola-086757 Oryzias latipes 89.18 0.00e+00 4099.00
IUUC-Oga-088781 Otolemur garnettii 99.32 0.00e+00 4651.00
IUUC-Oar-089274 Ovis aries 99.06 0.00e+00 4572.00
IUUC-Ptr-090669 Pan troglodytes 99.83 0.00e+00 4083.00
IUUC-Pan-092226 Papio anubis 99.50 0.00e+00 4677.00
IUUC-Psi-093502 Pelodiscus sinensis 98.10 0.00e+00 4516.00
IUUC-Pma-094454 Petromyzon marinus 77.51 0.00e+00 736.00
IUUC-Pfo-096173 Poecilia formosa 88.58 0.00e+00 3752.00
IUUC-Pab-098355 Pongo abelii 97.66 0.00e+00 3364.00
IUUC-Pca-100570 Procavia capensis 98.95 0.00e+00 1177.00
IUUC-Pva-102572 Pteropus vampyrus 95.08 0.00e+00 1366.00
IUUC-Rno-104916 Rattus norvegicus 96.47 0.00e+00 3992.00
IUUC-Sha-106653 Sarcophilus harrisii 98.11 0.00e+00 4563.00
IUUC-Sar-113517 Sorex araneus 90.95 0.00e+00 1284.00
IUUC-Ssc-115470 Sus scrofa 99.37 0.00e+00 2535.00
IUUC-Tgu-116932 Taeniopygia guttata 97.55 0.00e+00 4489.00
IUUC-Tru-117682 Takifugu rubripes 87.96 0.00e+00 2583.00
IUUC-Tsy-119417 Tarsius syrichta 94.84 0.00e+00 2481.00
IUUC-Tni-120442 Tetraodon nigroviridis 84.47 0.00e+00 3638.00
IUUC-Tbe-127456 Tupaia belangeri 86.69 0.00e+00 2140.00
IUUC-Ttr-128606 Tursiops truncatus 95.55 0.00e+00 1608.00
IUUC-Vpa-130112 Vicugna pacos 96.55 0.00e+00 3756.00
IUUC-Xtr-131929 Xenopus tropicalis 94.29 0.00e+00 4446.00
Created Date 25-Jun-2017

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