iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000104881.15	ENST00000360957.9	ENSP00000354218.4
ENSG00000104881.15	ENST00000589371.1	ENSP00000466555.1
ENSG00000104881.15	ENST00000591986.1	ENSP00000466939.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.10e-10	40.8	762	814

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlvi.ekeeqdegWlkgvkelegkrGlfPenF 58
            v +l+dy+a+  deL++++G+ v+v+  +  ++ +W+ +   l+g++G +P n+
   Q: 762  AVYALWDYSAEFGDELSFREGESVTVLrRDGPEETDWWWA--ALHGQEGYVPRNY 814
           5889***********************8777788999999..8***********9 PP

Organism

Homo sapiens

Functional Description
(View)

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.

Protein Sequence
(Fasta)

MDSEAFQSAR DFLDMNFQSL AMKHMDLKQM ELDTAAAKVD ELTKQLESLW SDSPAPPGPQ 60
AGPPSRPPRY SSSSIPEPFG SRGSPRKAAT DGADTPFGRS ESAPTLHPYS PLSPKGRPSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCCTAAGC CTTAAAGAGA CAGGACGGTC GATTGGTCTG AAATTCTTGA AGAGACAGGT 60
AAGAATACTA GTTAGTAGGG CTGTGCTTTC TGTGTTAAAT GTCTTCTGGG GAGGCCCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0040--ANK repeat
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0728--SH3 domain
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR028320--iASPP
IPR001452--SH3_domain

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50002--SH3

Pfam

PF12796--Ank_2
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00248--ANK
SM00326--SH3

Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0045171--C:intercellular bridge
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0045296--F:cadherin binding
GO:0042802--F:identical protein binding
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0006915--P:apoptotic process
GO:0060048--P:cardiac muscle contraction
GO:0003215--P:cardiac right ventricle morphogenesis
GO:0031076--P:embryonic camera-type eye development
GO:0042633--P:hair cycle
GO:0035264--P:multicellular organism growth
GO:0048871--P:multicellular organismal homeostasis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045597--P:positive regulation of cell differentiation
GO:0009791--P:post-embryonic development
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0006351--P:transcription, DNA-templated
GO:0003229--P:ventricular cardiac muscle tissue development

KEGG

hsa:10848

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001236	Ailuropoda melanoleuca	90.31	8.00e-179	620.00
IUUC-Aca-004907	Anolis carolinensis	79.70	5.00e-99	355.00
IUUC-Bta-012555	Bos taurus	86.23	0.00e+00	1050.00
IUUC-Cfa-020223	Canis familiaris	90.00	3.00e-174	605.00
IUUC-Cpo-022180	Cavia porcellus	77.44	0.00e+00	1064.00
IUUC-Csa-023984	Chlorocebus sabaeus	98.27	8.00e-167	580.00
IUUC-Dre-027600	Danio rerio	48.17	2.00e-91	330.00
IUUC-Dno-029486	Dasypus novemcinctus	86.94	0.00e+00	724.00
IUUC-Dor-030334	Dipodomys ordii	87.78	2.00e-152	533.00
IUUC-Eca-033590	Equus caballus	85.31	0.00e+00	662.00
IUUC-Gac-041648	Gasterosteus aculeatus	51.46	4.00e-96	345.00
IUUC-Itr-048093	Ictidomys tridecemlineatus	85.10	0.00e+00	1028.00
IUUC-Lch-049426	Latimeria chalumnae	55.52	7.00e-95	342.00
IUUC-Laf-054593	Loxodonta africana	88.43	0.00e+00	1061.00
IUUC-Mcc-055896	Macaca mulatta	96.87	0.00e+00	1192.00
IUUC-Mmr-061007	Microcebus murinus	82.20	0.00e+00	976.00
IUUC-Mmu-063188	Mus musculus	88.41	0.00e+00	1134.00
IUUC-Mac-065548	Musa acuminata	34.52	2.00e-05	44.30
IUUC-Mpu-066381	Mustela putorius furo	90.50	4.00e-174	605.00
IUUC-Nle-069627	Nomascus leucogenys	99.72	2.00e-174	605.00
IUUC-Ont-071459	Oreochromis niloticus	49.18	9.00e-92	331.00
IUUC-Ocu-074924	Oryctolagus cuniculus	74.86	4.00e-119	421.00
IUUC-Obr-076350	Oryza brachyantha	32.97	1.40e-02	34.30
IUUC-Olo-080981	Oryza longistaminata	32.97	2.00e-02	33.90
IUUC-Ola-087294	Oryzias latipes	50.45	3.00e-94	340.00
IUUC-Oga-088356	Otolemur garnettii	90.40	0.00e+00	1113.00
IUUC-Oar-089777	Ovis aries	92.57	4.00e-156	545.00
IUUC-Ptr-090843	Pan troglodytes	99.64	0.00e+00	1217.00
IUUC-Pfo-096934	Poecilia formosa	50.00	3.00e-96	346.00
IUUC-Pab-098564	Pongo abelii	99.16	5.00e-174	603.00
IUUC-Pca-100382	Procavia capensis	81.64	0.00e+00	861.00
IUUC-Pva-102159	Pteropus vampyrus	91.76	4.00e-163	568.00
IUUC-Rno-106055	Rattus norvegicus	87.73	0.00e+00	1120.00
IUUC-Tru-117623	Takifugu rubripes	51.58	3.00e-95	343.00
IUUC-Tni-120255	Tetraodon nigroviridis	54.00	4.00e-94	338.00
IUUC-Xtr-132435	Xenopus tropicalis	70.80	1.00e-90	327.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence