iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000105821.14	ENST00000249270.11	ENSP00000249270.7
ENSG00000105821.14	ENST00000379263.7	ENSP00000368565.3
ENSG00000105821.14	ENST00000426036.6	ENSP00000412611.2
ENSG00000105821.14	ENST00000379257.7	ENSP00000368559.3
ENSG00000105821.14	ENST00000412522.1	ENSP00000406275.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Other/Other	UBD/Other/Other	21179169; 25665097

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
UBD/Other/Other	94.20	0.00e+00	926.00	IUUC-Mmu-063361

Organism

Homo sapiens

Functional Description
(View)

Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.

Protein Sequence
(Fasta)

MLLLPSAADG RGTAITHALT SASTLCQVEP VGRWFEAFVK RRNRNASASF QELEDKKELS 60
EESEDEELQL EEFPMLKTLD PKDWKNQDHY AVLGLGHVRY KATQRQIKAA HKAMVLKHHP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCCGGATCT CAGTCAGTAT AGAACTAGGT TACCGCACAC GTTGGCGGGG GTGGGAGGGT 60
GTGAGACTGG CCTCCACACC ACGAAAGATC CATCCCGGAA GTGCTTACTG GTCGTCTCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0143--Chaperone
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR001623--DnaJ_domain
IPR018253--DnaJ_domain_CS
IPR009057--Homeobox-like
IPR032003--RAC_head
IPR001005--SANT/Myb
IPR017884--SANT_dom

PROSITE

PS00636--DNAJ_1
PS50076--DNAJ_2
PS51293--SANT

Pfam

PF00226--DnaJ
PF00249--Myb_DNA-binding
PF16717--RAC_head

SMART

SM00271--DnaJ
SM00717--SANT

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0001671--F:ATPase activator activity
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0042393--F:histone binding
GO:0030544--F:Hsp70 protein binding
GO:0003723--F:RNA binding
GO:0043130--F:ubiquitin binding
GO:0051083--P:'de novo' cotranslational protein folding
GO:0016569--P:covalent chromatin modification
GO:0006260--P:DNA replication
GO:2000279--P:negative regulation of DNA biosynthetic process
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:1900034--P:regulation of cellular response to heat
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:27000

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000523	Aegilops tauschii	48.02	6.00e-51	195.00
IUUC-Aml-001384	Ailuropoda melanoleuca	97.58	0.00e+00	944.00
IUUC-Atr-002863	Amborella trichopoda	49.02	3.00e-52	199.00
IUUC-Apl-004102	Anas platyrhynchos	90.08	1.00e-122	433.00
IUUC-Aca-004586	Anolis carolinensis	87.52	0.00e+00	842.00
IUUC-Aly-006535	Arabidopsis lyrata	47.32	2.00e-48	187.00
IUUC-Ath-007402	Arabidopsis thaliana	47.80	4.00e-50	192.00
IUUC-Afl-008435	Aspergillus flavus	48.66	4.00e-57	215.00
IUUC-Afu-008810	Aspergillus fumigatus	46.97	2.00e-56	213.00
IUUC-Ani-009141	Aspergillus nidulans	48.28	3.00e-56	213.00
IUUC-Aor-010002	Aspergillus oryzae	48.66	4.00e-57	215.00
IUUC-Ame-011909	Astyanax mexicanus	82.73	1.00e-115	410.00
IUUC-Bta-012870	Bos taurus	97.91	0.00e+00	994.00
IUUC-Bci-013889	Botrytis cinerea	45.86	3.00e-54	206.00
IUUC-Bdi-014225	Brachypodium distachyon	48.51	5.00e-52	199.00
IUUC-Bol-015562	Brassica oleracea	47.80	2.00e-50	194.00
IUUC-Bra-017547	Brassica rapa	47.80	3.00e-51	196.00
IUUC-Cel-018685	Caenorhabditis elegans	41.67	4.00e-79	288.00
IUUC-Cja-019293	Callithrix jacchus	98.39	0.00e+00	974.00
IUUC-Cfa-020528	Canis familiaris	90.11	0.00e+00	887.00
IUUC-Cpo-022171	Cavia porcellus	84.47	0.00e+00	847.00
IUUC-Cre-022887	Chlamydomonas reinhardtii	48.72	4.00e-48	186.00
IUUC-Csa-023129	Chlorocebus sabaeus	98.87	0.00e+00	998.00
IUUC-Cho-025056	Choloepus hoffmanni	80.57	0.00e+00	756.00
IUUC-Cin-025527	Ciona intestinalis	60.29	6.00e-68	251.00
IUUC-Cgl-026448	Colletotrichum gloeosporioides	43.98	2.00e-43	170.00
IUUC-Cme-027325	Cyanidioschyzon merolae	37.37	9.00e-29	122.00
IUUC-Dre-028808	Danio rerio	75.99	0.00e+00	753.00
IUUC-Dno-029938	Dasypus novemcinctus	97.11	0.00e+00	934.00
IUUC-Dor-030802	Dipodomys ordii	76.92	2.00e-95	343.00
IUUC-Dme-031862	Drosophila melanogaster	60.49	2.00e-74	273.00
IUUC-Ete-032900	Echinops telfairi	95.65	5.00e-103	368.00
IUUC-Eca-034311	Equus caballus	97.58	0.00e+00	956.00
IUUC-Eeu-034969	Erinaceus europaeus	80.00	4.00e-115	408.00
IUUC-Fca-036146	Felis catus	98.55	0.00e+00	961.00
IUUC-Fal-036866	Ficedula albicollis	87.58	0.00e+00	812.00
IUUC-Fox-038071	Fusarium oxysporum	41.55	5.00e-45	175.00
IUUC-Gmo-039191	Gadus morhua	72.35	0.00e+00	723.00
IUUC-Gga-040158	Gallus gallus	87.88	0.00e+00	814.00
IUUC-Gac-041990	Gasterosteus aculeatus	76.89	0.00e+00	753.00
IUUC-Gma-043759	Glycine max	47.80	1.00e-51	197.00
IUUC-Ggo-045049	Gorilla gorilla	99.26	7.00e-139	487.00
IUUC-Hvu-047309	Hordeum vulgare	47.50	4.00e-50	192.00
IUUC-Itr-048875	Ictidomys tridecemlineatus	97.99	0.00e+00	874.00
IUUC-Kpa-049255	Komagataella pastoris	41.07	1.00e-47	184.00
IUUC-Lch-049756	Latimeria chalumnae	85.05	0.00e+00	805.00
IUUC-Lpe-051235	Leersia perrieri	45.77	5.00e-47	182.00
IUUC-Loc-052580	Lepisosteus oculatus	72.36	4.00e-83	301.00
IUUC-Laf-054095	Loxodonta africana	97.26	0.00e+00	990.00
IUUC-Mcc-054797	Macaca mulatta	94.35	0.00e+00	941.00
IUUC-Meu-056077	Macropus eugenii	96.45	7.00e-89	321.00
IUUC-Mpo-057559	Magnaporthe poae	45.83	6.00e-52	198.00
IUUC-Mtr-058690	Medicago truncatula	48.76	2.00e-50	194.00
IUUC-Mga-059854	Meleagris gallopavo	87.03	0.00e+00	800.00
IUUC-Mmr-061638	Microcebus murinus	97.75	0.00e+00	992.00
IUUC-Mdo-062704	Monodelphis domestica	90.71	1.00e-134	473.00
IUUC-Mmu-063361	Mus musculus	94.20	0.00e+00	993.00
IUUC-Mac-065182	Musa acuminata	48.42	1.00e-48	187.00
IUUC-Mpu-065792	Mustela putorius furo	98.87	0.00e+00	969.00
IUUC-Mlu-067874	Myotis lucifugus	98.07	0.00e+00	953.00
IUUC-Nle-069392	Nomascus leucogenys	99.36	0.00e+00	941.00
IUUC-Opr-070583	Ochotona princeps	98.45	6.00e-130	457.00
IUUC-Ont-071387	Oreochromis niloticus	79.35	8.00e-111	394.00
IUUC-Oan-073081	Ornithorhynchus anatinus	89.02	2.00e-133	469.00
IUUC-Ocu-074901	Oryctolagus cuniculus	98.55	0.00e+00	981.00
IUUC-Oba-075416	Oryza barthii	48.28	9.00e-51	195.00
IUUC-Obr-076383	Oryza brachyantha	48.00	3.00e-50	193.00
IUUC-Ogl-077602	Oryza glaberrima	25.00	8.00e-14	70.90
IUUC-Ogu-078774	Oryza glumaepatula	48.00	4.00e-51	196.00
IUUC-Oin-079255	Oryza indica	44.25	2.00e-20	94.40
IUUC-Olo-080628	Oryza longistaminata	48.00	6.00e-51	195.00
IUUC-Ome-081488	Oryza meridionalis	48.00	5.00e-51	196.00
IUUC-Oni-082149	Oryza nivara	47.13	1.00e-40	161.00
IUUC-Opu-083627	Oryza punctata	47.50	1.00e-50	194.00
IUUC-Oru-084567	Oryza rufipogon	48.00	7.00e-51	195.00
IUUC-Osa-086150	Oryza sativa	24.21	2.00e-13	69.30
IUUC-Ola-086782	Oryzias latipes	80.13	4.00e-69	253.00
IUUC-Olu-087582	Ostreococcus lucimarinus	41.54	4.00e-33	134.00
IUUC-Oga-089051	Otolemur garnettii	96.78	0.00e+00	937.00
IUUC-Oar-090356	Ovis aries	98.07	0.00e+00	994.00
IUUC-Ptr-090858	Pan troglodytes	99.68	0.00e+00	976.00
IUUC-Pan-091826	Papio anubis	98.87	0.00e+00	996.00
IUUC-Psi-094066	Pelodiscus sinensis	88.21	0.00e+00	816.00
IUUC-Ppa-095598	Physcomitrella patens	48.48	2.00e-48	187.00
IUUC-Pfo-097101	Poecilia formosa	80.29	9.00e-114	404.00
IUUC-Pab-098089	Pongo abelii	98.71	0.00e+00	949.00
IUUC-Pop-099771	Populus trichocarpa	47.76	9.00e-52	198.00
IUUC-Pca-100615	Procavia capensis	86.97	0.00e+00	680.00
IUUC-Ppe-101366	Prunus persica	48.77	3.00e-52	199.00
IUUC-Pva-102536	Pteropus vampyrus	96.67	1.00e-135	476.00
IUUC-Pgr-103582	Puccinia graminis	52.43	1.00e-53	203.00
IUUC-Ptt-103970	Puccinia triticina	51.48	3.00e-45	176.00
IUUC-Pte-104323	Pyrenophora teres	46.90	2.00e-53	203.00
IUUC-Rno-105279	Rattus norvegicus	93.72	0.00e+00	993.00
IUUC-Sha-107457	Sarcophilus harrisii	92.14	3.00e-136	478.00
IUUC-Sja-107842	Schizosaccharomyces japonicus	43.77	2.00e-44	173.00
IUUC-Spo-108041	Schizosaccharomyces pombe	48.15	1.00e-54	207.00
IUUC-Ssl-108474	Sclerotinia sclerotiorum	44.78	1.00e-43	171.00
IUUC-Smo-109454	Selaginella moellendorffii	52.28	2.00e-54	207.00
IUUC-Sit-110667	Setaria italica	48.51	7.00e-51	195.00
IUUC-Sly-111760	Solanum lycopersicum	44.25	1.00e-41	164.00
IUUC-Stu-112803	Solanum tuberosum	45.81	2.00e-50	193.00
IUUC-Sar-113066	Sorex araneus	72.30	0.00e+00	699.00
IUUC-Sbi-114777	Sorghum bicolor	48.00	4.00e-50	192.00
IUUC-Ssc-115941	Sus scrofa	98.39	0.00e+00	998.00
IUUC-Tgu-116799	Taeniopygia guttata	89.05	0.00e+00	800.00
IUUC-Tru-118137	Takifugu rubripes	80.71	3.00e-107	382.00
IUUC-Tsy-118984	Tarsius syrichta	97.42	0.00e+00	966.00
IUUC-Tni-120898	Tetraodon nigroviridis	80.22	4.00e-114	405.00
IUUC-Tca-120925	Theobroma cacao	47.29	1.00e-51	197.00
IUUC-Tvi-122560	Trichoderma virens	43.40	4.00e-54	205.00
IUUC-Tae-123257	Triticum aestivum	48.02	7.00e-51	195.00
IUUC-Tur-126859	Triticum urartu	48.02	2.00e-50	194.00
IUUC-Tme-127035	Tuber melanosporum	39.31	3.00e-62	232.00
IUUC-Tbe-127978	Tupaia belangeri	87.86	2.00e-122	432.00
IUUC-Ttr-128247	Tursiops truncatus	90.34	0.00e+00	865.00
IUUC-Uma-129601	Ustilago maydis	55.88	5.00e-55	208.00
IUUC-Vda-129704	Verticillium dahliae	44.15	6.00e-49	188.00
IUUC-Vpa-130249	Vicugna pacos	88.48	0.00e+00	825.00
IUUC-Vvi-131626	Vitis vinifera	48.28	9.00e-53	201.00
IUUC-Xtr-132927	Xenopus tropicalis	80.90	5.00e-127	448.00
IUUC-Xma-133433	Xiphophorus maculatus	78.46	0.00e+00	717.00
IUUC-Zma-135295	Zea mays	49.01	1.00e-51	197.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence