iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000105982.16	ENST00000317955.9	ENSP00000315950.5
ENSG00000105982.16	ENST00000311822.12	ENSP00000308894.8
ENSG00000105982.16	ENST00000392741.6	ENSP00000376497.2
ENSG00000105982.16	ENST00000392747.6	ENSP00000376503.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb	OMIM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.80e-15	58.2	127	169

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf.kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC+e+f  ++ ++l+C Hvfh+ Clq++     +  ++ +CPlCr
   Q: 127  CPICKEEFeLRPQVLLSCSHVFHKACLQAF----EKFTNKKTCPLCR 169
           ********64445569***********999....66788889****8 PP

Organism

Homo sapiens

Functional Description
(View)

May play a role in sperm formation.

Protein Sequence
(Fasta)

MLKNKGHSSK KDNLAVNAVA LQDHILHDLQ LRNLSVADHS KTQVQKKENK SLKRDTKAII 60
DTGLKKTTQC PKLEDSEKEY VLDPKPPPLT LAQKLGLIGP PPPPLSSDEW EKVKQRSLLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAACGGGAA CGACCACAGC CACCGCAGGG AAACAACCGG GGCCCAGGCC CAGGTGGGCG 60
GGCGGCTGAG GAGCGTGGCT GCGCCCACAA AGCCGCCGGG GGCTGCGGAC TACAGCGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000048--IQ_motif_EF-hand-BS
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50096--IQ
PS50089--ZF_RING_2

Pfam

PF00612--IQ
PF13639--zf-RING_2
PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0016235--C:aggresome
GO:0005768--C:endosome
GO:0008270--F:zinc ion binding

KEGG

hsa:140545

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001847	Ailuropoda melanoleuca	78.60	6.00e-106	376.00
IUUC-Apl-003532	Anas platyrhynchos	60.92	3.00e-126	444.00
IUUC-Aca-004730	Anolis carolinensis	62.15	2.00e-127	448.00
IUUC-Bta-013281	Bos taurus	75.89	8.00e-152	529.00
IUUC-Cja-019187	Callithrix jacchus	91.71	0.00e+00	671.00
IUUC-Cfa-020665	Canis familiaris	80.93	6.00e-173	600.00
IUUC-Cpo-021578	Cavia porcellus	73.00	5.00e-150	523.00
IUUC-Cre-022693	Chlamydomonas reinhardtii	40.17	6.00e-40	157.00
IUUC-Csa-023950	Chlorocebus sabaeus	96.13	0.00e+00	700.00
IUUC-Cho-024664	Choloepus hoffmanni	68.61	3.00e-74	271.00
IUUC-Cin-025108	Ciona intestinalis	43.24	7.00e-87	314.00
IUUC-Dre-027402	Danio rerio	46.33	2.00e-86	312.00
IUUC-Dno-029767	Dasypus novemcinctus	80.49	2.00e-171	594.00
IUUC-Dor-031061	Dipodomys ordii	89.29	2.00e-56	212.00
IUUC-Ete-032881	Echinops telfairi	69.23	7.00e-137	480.00
IUUC-Eca-033638	Equus caballus	79.12	1.00e-167	582.00
IUUC-Fca-035506	Felis catus	79.40	1.00e-170	592.00
IUUC-Gmo-039580	Gadus morhua	44.26	1.00e-76	280.00
IUUC-Gga-040567	Gallus gallus	58.13	2.00e-116	412.00
IUUC-Gac-041432	Gasterosteus aculeatus	49.17	2.00e-90	325.00
IUUC-Ggo-045089	Gorilla gorilla	98.34	0.00e+00	720.00
IUUC-Itr-048933	Ictidomys tridecemlineatus	79.01	4.00e-166	577.00
IUUC-Lch-049581	Latimeria chalumnae	59.93	4.00e-95	341.00
IUUC-Loc-051928	Lepisosteus oculatus	52.35	3.00e-102	365.00
IUUC-Laf-054012	Loxodonta africana	71.43	3.00e-139	488.00
IUUC-Mcc-055205	Macaca mulatta	96.40	0.00e+00	705.00
IUUC-Meu-055979	Macropus eugenii	62.69	1.00e-44	173.00
IUUC-Mga-059261	Meleagris gallopavo	60.22	1.00e-119	422.00
IUUC-Mmr-060786	Microcebus murinus	83.65	2.00e-170	591.00
IUUC-Mdo-062161	Monodelphis domestica	64.40	7.00e-128	450.00
IUUC-Mmu-063832	Mus musculus	76.36	7.00e-150	523.00
IUUC-Mpu-065870	Mustela putorius furo	82.07	2.00e-172	598.00
IUUC-Mlu-066948	Myotis lucifugus	76.31	4.00e-163	567.00
IUUC-Nle-069688	Nomascus leucogenys	95.86	0.00e+00	707.00
IUUC-Opr-070529	Ochotona princeps	83.04	1.00e-109	388.00
IUUC-Ont-072412	Oreochromis niloticus	45.30	3.00e-85	308.00
IUUC-Oan-073689	Ornithorhynchus anatinus	65.67	4.00e-122	431.00
IUUC-Ocu-074486	Oryctolagus cuniculus	82.07	7.00e-160	556.00
IUUC-Ola-087246	Oryzias latipes	44.07	2.00e-75	275.00
IUUC-Oga-088111	Otolemur garnettii	81.23	1.00e-167	582.00
IUUC-Oar-089709	Ovis aries	75.89	3.00e-158	550.00
IUUC-Ptr-090644	Pan troglodytes	99.45	0.00e+00	692.00
IUUC-Pan-092906	Papio anubis	94.46	0.00e+00	692.00
IUUC-Psi-093361	Pelodiscus sinensis	63.37	4.00e-126	444.00
IUUC-Pab-097850	Pongo abelii	99.17	0.00e+00	726.00
IUUC-Pca-100576	Procavia capensis	80.77	6.00e-126	443.00
IUUC-Pva-102371	Pteropus vampyrus	78.39	8.00e-161	559.00
IUUC-Rno-105726	Rattus norvegicus	77.38	1.00e-156	546.00
IUUC-Sha-106873	Sarcophilus harrisii	66.76	1.00e-136	479.00
IUUC-Smo-109589	Selaginella moellendorffii	42.31	8.00e-21	91.70
IUUC-Ssc-115709	Sus scrofa	73.02	3.00e-144	504.00
IUUC-Tru-118508	Takifugu rubripes	46.70	4.00e-89	321.00
IUUC-Tsy-118862	Tarsius syrichta	82.51	2.00e-170	591.00
IUUC-Tni-119760	Tetraodon nigroviridis	46.03	4.00e-83	301.00
IUUC-Ttr-128727	Tursiops truncatus	65.11	1.00e-124	439.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence