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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045676
Ensembl Protein ID ENSP00000489189.1
UniProt Accession Q99933; O75315; Q14414; Q53H32; Q5VZE8; Q5VZE9; Q5VZF0; Q96TG2; Q9Y2V4; BAG1_HUMAN
Genbank Protein ID CAA84624.1; AAD11467.1; AAC34258.1; AAD25045.1; BAD96469.1; CAH72516.1; CAH72516.1; CAH72517.1; CAH72517.1; CAH72518.1; CAH72518.1; CAH72741.1; CAH72741.1; CAH72742.1; CAH72742.1; CAH72743.1; CAH72743.1; EAW58514.1; EAW58515.1; AAH01936.2; AAH14774.2
Protein Name BAG family molecular chaperone regulator 1; Bcl-2-associated athanogene 1
Genbank Nucleotide ID Z35491; U46917; AF022224; AF116273; AK222749; AL161445; AL356472; AL161445; AL356472; AL161445; AL356472; AL356472; AL161445; AL356472; AL161445; AL356472; AL161445; CH471071; CH471071; BC001936; BC014774
Gene Name BAG1; HAP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000107262.17 ENST00000634734.1 ENSP00000489189.1
ENSG00000107262.17 ENST00000379707.7 ENSP00000369029.2
ENSG00000107262.17 ENST00000473464.2 ENSP00000489401.1
ENSG00000107262.17 ENST00000473781.1 ENSP00000419092.1
ENSG00000107262.17 ENST00000635077.1 ENSP00000488937.1
ENSG00000107262.17 ENST00000488499.1 ENSP00000417576.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
AREsitecircRNADbCircNetmiRTarBase
microRNATRANSFACRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
DrugBankPDTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UBQ/UBQ_PIM UBQ_PIM 10671488; 10675567; 11278763; 11520069; 14978028; 12874020; 2156268
Classification
Family E-value Score Start End
ULD/UDP/UBQ/UBQ_PIM 5.40e-19 69.6 144 223
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UBQ/UBQ_PIM
   S: 1    mkltvktlkgke...fel.evseddtveelKekiakesgvppeqqkLIyaGkiL.kDdttLselgikdgsvvhlvvkksk 75
           +++tv+++++k+   ++  ++s++  v++l + +++++gvp+++qkLI++Gk L +++t+Ls+lgi+dg+ v+l++kk++
   Q: 144  LTVTVTHSNEKHdlhVTSqQGSSEPVVQDLAQVVEEVIGVPQSFQKLIFKGKSLkEMETPLSALGIQDGCRVMLIGKKNS 223
           58***********9955559**********************************99*********************986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631).
 Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631).
Protein Sequence
(Fasta)
LAQRGGARRP RGDRERLGSR LRALRPGREP RQSEPPAQRG PPPSGRPPAR STASGHDRPT 60
RGAAAGARRP RMKKKTRRRS TRSEELTRSE ELTLSEEATW SEEATQSEEA TQGEEMNRSQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045676|ULD,UBQ_PIM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGCCGGGGC GGGGCTGGGA AGTAGTCGGG CGGGGTTGTG AGACGCCGCG CTCAGCTTCC 60
ATCGCTGGGC GGTCAACAAG TGCGGGCCTG GCTCAGCGCG GGGGGGCGCG GAGACCGCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045676|ULD,UBQ_PIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0024--Alternative initiation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR003103--BAG_domain
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
PROSITE

PS51035--BAG
PS50053--UBIQUITIN_2
Pfam

PF02179--BAG
PF00240--ubiquitin
SMART

SM00264--BAG
SM00213--UBQ
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000774--F:adenyl-nucleotide exchange factor activity
GO:0005057--F:signal transducer activity, downstream of receptor
GO:0006915--P:apoptotic process
GO:0007166--P:cell surface receptor signaling pathway
GO:0070389--P:chaperone cofactor-dependent protein refolding
GO:0043066--P:negative regulation of apoptotic process
GO:1900034--P:regulation of cellular response to heat
KEGG hsa:573
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002280 Ailuropoda melanoleuca 89.95 5.00e-98 350.00
IUUC-Apl-003205 Anas platyrhynchos 68.56 7.00e-69 253.00
IUUC-Aly-005847 Arabidopsis lyrata 22.22 2.00e-04 39.70
IUUC-Ath-006745 Arabidopsis thaliana 21.62 1.00e-03 37.00
IUUC-Ame-010788 Astyanax mexicanus 57.49 3.00e-59 221.00
IUUC-Bta-013367 Bos taurus 89.37 1.00e-97 348.00
IUUC-Bol-015349 Brassica oleracea 23.50 5.00e-06 45.10
IUUC-Bra-017646 Brassica rapa 23.50 4.00e-05 42.00
IUUC-Cel-018648 Caenorhabditis elegans 30.34 1.00e-07 49.70
IUUC-Cja-019611 Callithrix jacchus 87.08 1.00e-136 479.00
IUUC-Cfa-021242 Canis familiaris 86.19 4.00e-105 374.00
IUUC-Cpo-022338 Cavia porcellus 66.89 2.00e-95 342.00
IUUC-Csa-023516 Chlorocebus sabaeus 93.04 6.00e-150 523.00
IUUC-Cho-024494 Choloepus hoffmanni 63.48 4.00e-98 350.00
IUUC-Cin-025141 Ciona intestinalis 30.38 2.00e-16 78.60
IUUC-Cne-026989 Cryptococcus neoformans 32.10 2.00e-04 40.00
IUUC-Dre-027358 Danio rerio 58.94 4.00e-67 247.00
IUUC-Dno-029553 Dasypus novemcinctus 68.70 9.00e-97 347.00
IUUC-Dor-030921 Dipodomys ordii 57.88 4.00e-78 284.00
IUUC-Ete-032795 Echinops telfairi 65.40 2.00e-96 345.00
IUUC-Eca-033827 Equus caballus 91.13 4.00e-99 353.00
IUUC-Eeu-035301 Erinaceus europaeus 80.93 2.00e-70 258.00
IUUC-Fca-035448 Felis catus 85.84 2.00e-100 357.00
IUUC-Fal-037005 Ficedula albicollis 67.18 1.00e-75 275.00
IUUC-Gmo-039387 Gadus morhua 56.52 8.00e-63 233.00
IUUC-Gga-040291 Gallus gallus 68.90 3.00e-75 274.00
IUUC-Gac-041491 Gasterosteus aculeatus 55.56 4.00e-65 240.00
IUUC-Gma-043584 Glycine max 26.03 5.30e-02 31.60
IUUC-Ggo-044781 Gorilla gorilla 94.30 6.00e-133 466.00
IUUC-Itr-048938 Ictidomys tridecemlineatus 82.43 8.00e-100 356.00
IUUC-Lch-049883 Latimeria chalumnae 59.69 9.00e-66 242.00
IUUC-Loc-052923 Lepisosteus oculatus 58.37 6.00e-62 229.00
IUUC-Laf-053603 Loxodonta africana 69.84 2.00e-97 348.00
IUUC-Meu-056205 Macropus eugenii 71.13 1.00e-79 288.00
IUUC-Mga-060089 Meleagris gallopavo 69.39 4.00e-72 263.00
IUUC-Mmr-060978 Microcebus murinus 90.91 2.00e-102 365.00
IUUC-Mdo-061923 Monodelphis domestica 71.50 2.00e-85 308.00
IUUC-Mmu-063817 Mus musculus 69.08 1.00e-100 359.00
IUUC-Mlu-067465 Myotis lucifugus 71.21 2.00e-104 372.00
IUUC-Nle-069902 Nomascus leucogenys 86.96 4.00e-122 431.00
IUUC-Ont-072564 Oreochromis niloticus 56.52 1.00e-66 246.00
IUUC-Ocu-073948 Oryctolagus cuniculus 74.55 1.00e-96 346.00
IUUC-Ola-087199 Oryzias latipes 54.59 1.00e-62 232.00
IUUC-Olu-087829 Ostreococcus lucimarinus 46.43 1.20e-01 30.40
IUUC-Oga-088813 Otolemur garnettii 77.33 1.00e-125 442.00
IUUC-Oar-089897 Ovis aries 79.63 6.00e-110 390.00
IUUC-Ptr-091308 Pan troglodytes 99.59 5.00e-116 409.00
IUUC-Pan-092194 Papio anubis 95.38 5.00e-132 464.00
IUUC-Psi-093848 Pelodiscus sinensis 70.05 1.00e-62 232.00
IUUC-Pma-094330 Petromyzon marinus 47.52 8.00e-45 173.00
IUUC-Pfo-096498 Poecilia formosa 57.00 3.00e-59 221.00
IUUC-Pab-098046 Pongo abelii 96.81 2.00e-134 472.00
IUUC-Pop-100023 Populus trichocarpa 22.40 7.00e-03 34.70
IUUC-Pca-100703 Procavia capensis 67.28 1.00e-68 253.00
IUUC-Pva-102461 Pteropus vampyrus 69.29 4.00e-49 188.00
IUUC-Pyt-104698 Pyrenophora triticirepentis 38.89 2.30e-02 33.50
IUUC-Rno-105172 Rattus norvegicus 67.83 2.00e-99 355.00
IUUC-Sha-107413 Sarcophilus harrisii 71.50 9.00e-86 309.00
IUUC-Sja-107708 Schizosaccharomyces japonicus 27.66 9.00e-03 33.50
IUUC-Spo-108138 Schizosaccharomyces pombe 28.38 8.00e-03 36.20
IUUC-Sar-113726 Sorex araneus 81.48 4.00e-34 138.00
IUUC-Ssc-116295 Sus scrofa 86.47 2.00e-93 335.00
IUUC-Tgu-117415 Taeniopygia guttata 67.53 6.00e-68 249.00
IUUC-Tru-117989 Takifugu rubripes 51.79 1.00e-61 229.00
IUUC-Tni-120123 Tetraodon nigroviridis 58.33 1.00e-62 232.00
IUUC-Tca-121714 Theobroma cacao 27.27 2.00e-04 39.30
IUUC-Tre-121995 Trichoderma reesei 36.67 2.60e-01 29.30
IUUC-Tvi-122372 Trichoderma virens 36.67 6.80e-01 28.10
IUUC-Tbe-127702 Tupaia belangeri 75.29 2.00e-84 305.00
IUUC-Ttr-128319 Tursiops truncatus 80.75 1.00e-107 382.00
IUUC-Uma-129429 Ustilago maydis 32.20 1.00e-04 40.40
IUUC-Vda-129722 Verticillium dahliae 33.33 5.30e-02 32.30
IUUC-Xtr-132825 Xenopus tropicalis 69.33 4.00e-47 180.00
Created Date 25-Jun-2017

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