iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.40e-14	55.4	294	345

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
            +++lyd+e++n++eL +k+Gd++++   ++ de+W +g   l+g +G+fP n+ve
   Q: 294  CCRALYDFEPENEGELGFKEGDIITLT--NQIDENWYEG--MLHGHSGFFPINYVE 345
           699***********************7..99********..8*************8 PP

Organism

Homo sapiens

Functional Description
(View)

Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.

Protein Sequence
(Fasta)

MSVAGLKKQF HKATQKVSEK VGGAEGTKLD DDFKEMERKV DVTSRAVMEI MTKTIEYLQP 60
NPASRAKLSM INTMSKIRGQ EKGPGYPQAE ALLAEAMLKF GRELGDDCNF GPALGEVGEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAAGAGCCC GTGTCCCGCT AGGCTCCGCG CCCTCGCGCC CATAGCCCCG GCGGCGGCAC 60
GACCAGAGGC GGCCAGGGGA GCGCGCCGCC CCGCTCGGCC CTCCAGTCCC CCTCCGCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR011511--SH3_2
IPR001452--SH3_domain
IPR013315--Spectrin_alpha_SH3

PROSITE

PS51021--BAR
PS50002--SH3

Pfam

PF03114--BAR
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN
PR01887--SPECTRNALPHA

SMART

SM00721--BAR
SM00326--SH3

Gene Ontology

GO:0030669--C:clathrin-coated endocytic vesicle membrane
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0000139--C:Golgi membrane
GO:0005886--C:plasma membrane
GO:0045202--C:synapse
GO:0042802--F:identical protein binding
GO:0008289--F:lipid binding
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:1990416--P:cellular response to brain-derived neurotrophic factor stimulus
GO:0007417--P:central nervous system development
GO:0097484--P:dendrite extension
GO:0061024--P:membrane organization
GO:0007018--P:microtubule-based movement
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0031175--P:neuron projection development
GO:0002090--P:regulation of receptor internalization
GO:0007165--P:signal transduction
GO:0016191--P:synaptic vesicle uncoating

KEGG

hsa:6456

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001915	Ailuropoda melanoleuca	98.22	0.00e+00	684.00
IUUC-Apl-003760	Anas platyrhynchos	83.51	0.00e+00	638.00
IUUC-Aca-004816	Anolis carolinensis	89.46	0.00e+00	654.00
IUUC-Ame-011714	Astyanax mexicanus	77.56	4.00e-166	577.00
IUUC-Bta-012465	Bos taurus	98.30	0.00e+00	715.00
IUUC-Cja-019054	Callithrix jacchus	100.00	0.00e+00	727.00
IUUC-Cfa-020276	Canis familiaris	98.11	0.00e+00	645.00
IUUC-Cpo-021492	Cavia porcellus	97.93	0.00e+00	686.00
IUUC-Csa-023432	Chlorocebus sabaeus	99.37	0.00e+00	656.00
IUUC-Cho-024348	Choloepus hoffmanni	96.31	0.00e+00	704.00
IUUC-Dre-028301	Danio rerio	75.00	3.00e-155	540.00
IUUC-Dno-029915	Dasypus novemcinctus	97.68	1.00e-177	615.00
IUUC-Dor-030855	Dipodomys ordii	89.02	4.00e-177	613.00
IUUC-Ete-032686	Echinops telfairi	89.32	2.00e-177	614.00
IUUC-Eca-033814	Equus caballus	98.52	0.00e+00	689.00
IUUC-Eeu-034924	Erinaceus europaeus	97.16	0.00e+00	705.00
IUUC-Fca-035895	Felis catus	98.22	0.00e+00	685.00
IUUC-Fal-037607	Ficedula albicollis	92.05	0.00e+00	677.00
IUUC-Gga-041254	Gallus gallus	90.37	0.00e+00	667.00
IUUC-Gac-041419	Gasterosteus aculeatus	76.63	3.00e-151	527.00
IUUC-Ggo-045606	Gorilla gorilla	100.00	0.00e+00	727.00
IUUC-Lch-049520	Latimeria chalumnae	76.66	2.00e-137	481.00
IUUC-Loc-052760	Lepisosteus oculatus	80.12	2.00e-156	544.00
IUUC-Mcc-055545	Macaca mulatta	99.41	0.00e+00	697.00
IUUC-Meu-056119	Macropus eugenii	95.74	0.00e+00	700.00
IUUC-Mmr-061111	Microcebus murinus	96.54	0.00e+00	686.00
IUUC-Mdo-062217	Monodelphis domestica	95.74	0.00e+00	699.00
IUUC-Mmu-063284	Mus musculus	98.86	0.00e+00	718.00
IUUC-Mpu-066706	Mustela putorius furo	97.45	0.00e+00	638.00
IUUC-Mlu-067212	Myotis lucifugus	89.43	0.00e+00	673.00
IUUC-Ont-072622	Oreochromis niloticus	79.60	6.00e-169	586.00
IUUC-Oan-073674	Ornithorhynchus anatinus	94.67	0.00e+00	663.00
IUUC-Ocu-074005	Oryctolagus cuniculus	98.30	0.00e+00	716.00
IUUC-Ola-086840	Oryzias latipes	74.65	2.00e-151	528.00
IUUC-Oga-089025	Otolemur garnettii	95.14	0.00e+00	685.00
IUUC-Oar-089614	Ovis aries	98.22	0.00e+00	686.00
IUUC-Ptr-090943	Pan troglodytes	100.00	0.00e+00	727.00
IUUC-Pan-091990	Papio anubis	99.41	0.00e+00	697.00
IUUC-Psi-093052	Pelodiscus sinensis	90.91	0.00e+00	672.00
IUUC-Pva-102745	Pteropus vampyrus	97.44	0.00e+00	713.00
IUUC-Rno-105095	Rattus norvegicus	98.58	0.00e+00	718.00
IUUC-Sha-106694	Sarcophilus harrisii	93.45	0.00e+00	679.00
IUUC-Sar-113540	Sorex araneus	92.58	0.00e+00	643.00
IUUC-Ssc-116180	Sus scrofa	89.19	2.00e-173	601.00
IUUC-Tgu-117366	Taeniopygia guttata	91.76	0.00e+00	676.00
IUUC-Tru-118509	Takifugu rubripes	78.19	2.00e-166	578.00
IUUC-Vpa-130032	Vicugna pacos	84.03	2.00e-152	531.00
IUUC-Xtr-131877	Xenopus tropicalis	79.02	2.00e-161	561.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence