iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000107372.12	ENST00000376962.9	ENSP00000366161.5
ENSG00000107372.12	ENST00000376956.3	ENSP00000366155.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/ZnF_A20	ZnF_A20	21923101

Classification

Family	E-value	Score	Start	End
UBD/ZnF/ZnF_A20	2.70e-20	73.6	8	42

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkkgCgfYGnpetngyCSkCyreelrrrr 35
           +p+++lC++gCgfYGnp+tng+CS+Cy+e+l+r++
   Q: 8    TPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQQ 42
           69*******************************96 PP

Organism

Homo sapiens

Functional Description
(View)

Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.

Protein Sequence
(Fasta)

MAQETNQTPG PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QQNSGRMSPM GTASGSNSPT 60
SDSASVQRAD TSLNNCEGAA GSTSEKSRNV PVAALPVTQQ MTEMSISRED KITTPKTEVS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGCCCGGG CGCCGGGCGG CGAGTGCGTT AGTCGGCCGG GACGCGGAGC TGTGTGCATC 60
TCCTACGCGG GCTCGCTCGC TCCCGGGAGC CGCGCAGCTT CCCCGGCGGT GGCAGGAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002653--Znf_A20
IPR000058--Znf_AN1

PROSITE

PS51036--ZF_A20
PS51039--ZF_AN1

Pfam

PF01754--zf-A20
PF01428--zf-AN1

SMART

SM00259--ZnF_A20
SM00154--ZnF_AN1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0003677--F:DNA binding
GO:0008270--F:zinc ion binding
GO:0060324--P:face development
GO:0010761--P:fibroblast migration
GO:0001701--P:in utero embryonic development
GO:0048008--P:platelet-derived growth factor receptor signaling pathway
GO:0003016--P:respiratory system process
GO:0048705--P:skeletal system morphogenesis
GO:0048745--P:smooth muscle tissue development
GO:0001944--P:vasculature development

KEGG

hsa:7763

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001163	Aegilops tauschii	32.37	4.00e-27	114.00
IUUC-Aml-002088	Ailuropoda melanoleuca	99.53	1.00e-103	369.00
IUUC-Atr-002750	Amborella trichopoda	66.13	1.00e-22	99.00
IUUC-Apl-003370	Anas platyrhynchos	92.06	4.00e-99	353.00
IUUC-Aca-004848	Anolis carolinensis	91.55	6.00e-92	329.00
IUUC-Aly-006499	Arabidopsis lyrata	29.06	2.00e-21	95.10
IUUC-Ath-006840	Arabidopsis thaliana	33.00	1.00e-24	105.00
IUUC-Ame-011611	Astyanax mexicanus	67.29	3.00e-59	221.00
IUUC-Bta-012511	Bos taurus	98.59	7.00e-102	362.00
IUUC-Bdi-014584	Brachypodium distachyon	35.68	1.00e-30	125.00
IUUC-Cel-018374	Caenorhabditis elegans	36.45	4.00e-32	130.00
IUUC-Cja-019481	Callithrix jacchus	100.00	1.00e-102	365.00
IUUC-Cfa-020427	Canis familiaris	100.00	5.00e-103	366.00
IUUC-Cpo-021969	Cavia porcellus	100.00	4.00e-103	367.00
IUUC-Csa-024124	Chlorocebus sabaeus	100.00	5.00e-103	366.00
IUUC-Cho-024982	Choloepus hoffmanni	88.73	5.00e-97	346.00
IUUC-Cin-025685	Ciona intestinalis	42.93	5.00e-37	147.00
IUUC-Dre-028143	Danio rerio	62.84	2.00e-75	275.00
IUUC-Dno-029194	Dasypus novemcinctus	98.12	1.00e-101	362.00
IUUC-Dor-031104	Dipodomys ordii	99.06	2.00e-102	364.00
IUUC-Ete-032527	Echinops telfairi	97.65	2.00e-101	361.00
IUUC-Eca-034160	Equus caballus	99.53	1.00e-102	365.00
IUUC-Eeu-034800	Erinaceus europaeus	98.12	8.00e-88	316.00
IUUC-Fca-035481	Felis catus	100.00	5.00e-103	366.00
IUUC-Fal-036728	Ficedula albicollis	90.14	8.00e-109	385.00
IUUC-Gmo-039236	Gadus morhua	67.14	9.00e-76	276.00
IUUC-Gga-040753	Gallus gallus	81.78	7.00e-84	303.00
IUUC-Gac-042356	Gasterosteus aculeatus	65.89	3.00e-68	250.00
IUUC-Gma-043085	Glycine max	35.92	7.00e-27	113.00
IUUC-Ggo-044975	Gorilla gorilla	99.53	4.00e-102	363.00
IUUC-Hvu-047179	Hordeum vulgare	36.27	2.00e-28	118.00
IUUC-Itr-047997	Ictidomys tridecemlineatus	96.71	2.00e-98	351.00
IUUC-Lch-049431	Latimeria chalumnae	83.33	6.00e-88	316.00
IUUC-Lpe-051068	Leersia perrieri	33.49	8.00e-28	116.00
IUUC-Loc-051838	Lepisosteus oculatus	71.89	3.00e-83	300.00
IUUC-Laf-054572	Loxodonta africana	99.06	8.00e-109	386.00
IUUC-Meu-056305	Macropus eugenii	96.97	2.00e-93	334.00
IUUC-Mtr-058809	Medicago truncatula	35.78	4.00e-28	117.00
IUUC-Mga-059903	Meleagris gallopavo	80.37	2.00e-82	298.00
IUUC-Mdo-062494	Monodelphis domestica	97.18	5.00e-104	370.00
IUUC-Mmu-063632	Mus musculus	98.59	5.00e-102	363.00
IUUC-Mac-064854	Musa acuminata	32.69	2.00e-26	111.00
IUUC-Mpu-065918	Mustela putorius furo	99.53	1.00e-103	369.00
IUUC-Mlu-067594	Myotis lucifugus	99.53	5.00e-103	366.00
IUUC-Nle-069326	Nomascus leucogenys	97.65	2.00e-112	397.00
IUUC-Opr-071113	Ochotona princeps	96.71	2.00e-100	358.00
IUUC-Ont-071860	Oreochromis niloticus	66.20	2.00e-72	265.00
IUUC-Oan-073601	Ornithorhynchus anatinus	92.02	4.00e-88	317.00
IUUC-Ocu-073952	Oryctolagus cuniculus	99.06	2.00e-101	361.00
IUUC-Oba-075600	Oryza barthii	32.06	2.00e-28	118.00
IUUC-Obr-076269	Oryza brachyantha	33.33	3.00e-28	118.00
IUUC-Ogl-077456	Oryza glaberrima	32.06	2.00e-28	118.00
IUUC-Ogu-078105	Oryza glumaepatula	32.06	2.00e-28	118.00
IUUC-Oin-079326	Oryza indica	32.06	2.00e-28	118.00
IUUC-Olo-081039	Oryza longistaminata	32.06	2.00e-28	118.00
IUUC-Ome-081197	Oryza meridionalis	32.06	4.00e-28	117.00
IUUC-Oni-082851	Oryza nivara	32.06	3.00e-28	118.00
IUUC-Opu-083820	Oryza punctata	31.58	2.00e-28	118.00
IUUC-Oru-084563	Oryza rufipogon	32.06	2.00e-28	118.00
IUUC-Osa-085931	Oryza sativa	32.06	2.00e-28	118.00
IUUC-Ola-087109	Oryzias latipes	68.22	3.00e-79	287.00
IUUC-Oga-088394	Otolemur garnettii	99.06	2.00e-103	367.00
IUUC-Oar-089649	Ovis aries	98.59	7.00e-102	362.00
IUUC-Pan-092692	Papio anubis	100.00	5.00e-103	366.00
IUUC-Psi-093090	Pelodiscus sinensis	93.43	6.00e-88	316.00
IUUC-Pma-094271	Petromyzon marinus	51.97	7.00e-58	216.00
IUUC-Pfo-096087	Poecilia formosa	66.36	1.00e-69	255.00
IUUC-Pab-098585	Pongo abelii	100.00	5.00e-103	366.00
IUUC-Pop-099528	Populus trichocarpa	37.02	8.00e-28	116.00
IUUC-Pca-100951	Procavia capensis	100.00	6.00e-89	319.00
IUUC-Ppe-101886	Prunus persica	33.50	7.00e-29	119.00
IUUC-Pva-102118	Pteropus vampyrus	99.53	6.00e-102	363.00
IUUC-Pyt-104769	Pyrenophora triticirepentis	33.33	1.00e-03	37.70
IUUC-Rno-105890	Rattus norvegicus	98.12	9.00e-102	362.00
IUUC-Sha-106942	Sarcophilus harrisii	97.65	1.00e-114	405.00
IUUC-Smo-109137	Selaginella moellendorffii	58.02	2.00e-23	102.00
IUUC-Sit-110684	Setaria italica	34.93	8.00e-31	126.00
IUUC-Sly-111440	Solanum lycopersicum	37.02	1.00e-29	122.00
IUUC-Stu-112819	Solanum tuberosum	36.76	3.00e-26	111.00
IUUC-Sar-113241	Sorex araneus	98.59	3.00e-101	360.00
IUUC-Sbi-114497	Sorghum bicolor	36.67	2.00e-28	118.00
IUUC-Ssc-115824	Sus scrofa	99.53	2.00e-102	364.00
IUUC-Tgu-116588	Taeniopygia guttata	93.43	5.00e-116	409.00
IUUC-Tru-118060	Takifugu rubripes	65.12	5.00e-73	266.00
IUUC-Tsy-119054	Tarsius syrichta	91.55	2.00e-87	315.00
IUUC-Tni-120082	Tetraodon nigroviridis	65.73	7.00e-77	280.00
IUUC-Tca-121832	Theobroma cacao	36.06	2.00e-26	111.00
IUUC-Tae-123386	Triticum aestivum	36.27	1.00e-28	119.00
IUUC-Tur-126864	Triticum urartu	33.33	1.00e-27	116.00
IUUC-Tbe-127974	Tupaia belangeri	98.86	1.00e-91	328.00
IUUC-Ttr-129163	Tursiops truncatus	99.06	7.00e-101	360.00
IUUC-Vpa-130351	Vicugna pacos	99.53	4.00e-102	363.00
IUUC-Vvi-131696	Vitis vinifera	35.12	4.00e-28	117.00
IUUC-Xtr-132723	Xenopus tropicalis	88.26	7.00e-93	333.00
IUUC-Xma-134104	Xiphophorus maculatus	67.14	2.00e-72	264.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence