iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045688

Ensembl Protein ID

ENSP00000358789.4

UniProt Accession

Q5TCZ1; D3DR98; O43302; Q5TCZ2; Q5TDQ8; SPD2A_HUMAN

Genbank Protein ID

BAA24848.2; CAI13961.1; CAI13961.1; CAI13962.1; CAI13962.1; CAI13963.1; CAI15351.1; CAI15351.1; CAI15352.1; CAI15352.1; EAW49623.1; EAW49624.1

Protein Name

SH3 and PX domain-containing protein 2A; Adapter protein TKS5; Five SH3 domain-containing protein; SH3 multiple domains protein 1; Tyrosine kinase substrate with five SH3 domains

Genbank Nucleotide ID

AB007878; AL121929; AL133355; AL121929; AL133355; AL121929; AL133355; AL121929; AL133355; AL121929; CH471066; CH471066

Gene Name

SH3PXD2A; FISH; KIAA0418; SH3MD1; TKS5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000107957.16	ENST00000369774.8	ENSP00000358789.4
ENSG00000107957.16	ENST00000420222.1	ENSP00000395781.1
ENSG00000107957.16	ENST00000355946.6	ENSP00000348215.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.30e-24	86.8	172	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
            v  +y+ q++ eL+l++G+vv+vi  e+++ gW+     +++ +G +P+ + e
   Q: 172  VVVSNYKKQENSELSLQAGEVVDVI--EKNESGWWFV--STSEEQGWVPATYLE 221
           55668999*****************..9999****87..89********99976 PP

Organism

Homo sapiens

Functional Description
(View)

Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.

Protein Sequence
(Fasta)

MLAYCVQDAT VVDVEKRRNP SKHYVYIINV TWSDSTSQTI YRRYSKFFDL QMQLLDKFPI 60
EGGQKDPKQR IIPFLPGKIL FRRSHIRDVA VKRLKPIDEY CRALVRLPPH ISQCDEVFRF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGAGCGGGC GAGCGCAGCG CGGCGGCCGC GCGGGAGTGA AGGGGCGCGC GGCAGGCCGG 60
CGGGGAGTCC CCCGGGGCGC ACGGAGCCCG CGCGCCCTCC GGGACCCTCC CCCGTCCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain

Interpro

IPR001683--Phox
IPR001452--SH3_domain

PROSITE

PS50195--PX
PS50002--SH3

Pfam

PF00787--PX
PF00018--SH3_1

SMART

SM00312--PX
SM00326--SH3

Gene Ontology

GO:0030054--C:cell junction
GO:0042995--C:cell projection
GO:0005737--C:cytoplasm
GO:0002102--C:podosome
GO:0035091--F:phosphatidylinositol binding
GO:0016176--F:superoxide-generating NADPH oxidase activator activity
GO:0072675--P:osteoclast fusion
GO:0055114--P:oxidation-reduction process
GO:0071800--P:podosome assembly
GO:0006801--P:superoxide metabolic process

KEGG

hsa:9644

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002151	Ailuropoda melanoleuca	88.70	0.00e+00	1463.00
IUUC-Apl-003703	Anas platyrhynchos	74.51	0.00e+00	1290.00
IUUC-Aca-004457	Anolis carolinensis	81.91	0.00e+00	627.00
IUUC-Ago-007743	Ashbya gossypii	33.06	6.00e-12	65.90
IUUC-Acl-008171	Aspergillus clavatus	34.17	3.00e-14	73.60
IUUC-Afl-008719	Aspergillus flavus	35.00	3.00e-14	73.60
IUUC-Afu-008915	Aspergillus fumigatus	35.00	4.00e-15	76.60
IUUC-Ani-009427	Aspergillus nidulans	35.00	7.00e-15	75.90
IUUC-Ang-009708	Aspergillus niger	33.33	1.00e-13	71.60
IUUC-Aor-010013	Aspergillus oryzae	35.00	3.00e-14	73.60
IUUC-Ate-010261	Aspergillus terreus	33.33	2.00e-13	71.20
IUUC-Ame-011457	Astyanax mexicanus	64.10	0.00e+00	761.00
IUUC-Bta-013479	Bos taurus	88.13	0.00e+00	1492.00
IUUC-Cja-019155	Callithrix jacchus	93.65	0.00e+00	1766.00
IUUC-Cfa-020490	Canis familiaris	92.33	0.00e+00	1718.00
IUUC-Cpo-021684	Cavia porcellus	90.82	0.00e+00	1796.00
IUUC-Csa-023923	Chlorocebus sabaeus	96.17	0.00e+00	1670.00
IUUC-Dre-028235	Danio rerio	64.77	0.00e+00	764.00
IUUC-Dno-029730	Dasypus novemcinctus	90.79	0.00e+00	1378.00
IUUC-Dor-030418	Dipodomys ordii	85.06	0.00e+00	1586.00
IUUC-Dse-031199	Dothistroma septosporum	32.79	2.00e-13	70.90
IUUC-Eca-034227	Equus caballus	93.90	0.00e+00	1782.00
IUUC-Eeu-034576	Erinaceus europaeus	85.64	0.00e+00	811.00
IUUC-Fca-036401	Felis catus	90.10	0.00e+00	1319.00
IUUC-Fal-037241	Ficedula albicollis	75.25	0.00e+00	1406.00
IUUC-Gmo-038635	Gadus morhua	65.57	0.00e+00	716.00
IUUC-Gga-040247	Gallus gallus	76.25	0.00e+00	1549.00
IUUC-Gac-042274	Gasterosteus aculeatus	68.45	0.00e+00	819.00
IUUC-Ggo-044416	Gorilla gorilla	99.65	0.00e+00	2030.00
IUUC-Itr-048267	Ictidomys tridecemlineatus	90.31	0.00e+00	1537.00
IUUC-Lch-049929	Latimeria chalumnae	67.74	0.00e+00	1368.00
IUUC-Loc-052462	Lepisosteus oculatus	63.92	0.00e+00	1231.00
IUUC-Lma-053176	Leptosphaeria maculans	33.65	1.00e-13	72.40
IUUC-Laf-053739	Loxodonta africana	93.24	0.00e+00	1829.00
IUUC-Mcc-055016	Macaca mulatta	99.21	0.00e+00	2018.00
IUUC-Meu-056030	Macropus eugenii	81.84	0.00e+00	1712.00
IUUC-Mga-059413	Meleagris gallopavo	75.30	0.00e+00	1276.00
IUUC-Mvi-060253	Microbotryum violaceum	28.91	3.00e-11	64.30
IUUC-Mmr-061087	Microcebus murinus	95.06	0.00e+00	1924.00
IUUC-Mdo-062381	Monodelphis domestica	82.54	0.00e+00	1692.00
IUUC-Mmu-063918	Mus musculus	91.09	0.00e+00	1820.00
IUUC-Mpu-065765	Mustela putorius furo	91.17	0.00e+00	1816.00
IUUC-Mlu-067569	Myotis lucifugus	93.11	0.00e+00	1707.00
IUUC-Nfi-068447	Neosartorya fischeri	35.00	4.00e-15	76.60
IUUC-Ncr-068701	Neurospora crassa	34.62	1.00e-14	75.10
IUUC-Nle-069525	Nomascus leucogenys	98.94	0.00e+00	1953.00
IUUC-Opr-070295	Ochotona princeps	91.01	0.00e+00	1827.00
IUUC-Ont-071453	Oreochromis niloticus	65.77	0.00e+00	754.00
IUUC-Oan-073433	Ornithorhynchus anatinus	70.33	0.00e+00	1150.00
IUUC-Ocu-074937	Oryctolagus cuniculus	90.82	0.00e+00	1706.00
IUUC-Ola-087466	Oryzias latipes	65.05	0.00e+00	749.00
IUUC-Oga-088137	Otolemur garnettii	93.62	0.00e+00	1712.00
IUUC-Oar-089419	Ovis aries	87.66	0.00e+00	1528.00
IUUC-Pan-092312	Papio anubis	98.86	0.00e+00	1519.00
IUUC-Psi-093083	Pelodiscus sinensis	79.16	0.00e+00	687.00
IUUC-Pma-094308	Petromyzon marinus	54.51	1.00e-148	521.00
IUUC-Pno-095129	Phaeosphaeria nodorum	31.73	5.00e-12	66.20
IUUC-Pfo-096570	Poecilia formosa	65.85	0.00e+00	769.00
IUUC-Pab-098178	Pongo abelii	95.94	0.00e+00	1947.00
IUUC-Pca-100175	Procavia capensis	86.67	0.00e+00	909.00
IUUC-Pva-102477	Pteropus vampyrus	90.59	0.00e+00	1842.00
IUUC-Pte-104254	Pyrenophora teres	34.31	1.00e-13	71.60
IUUC-Pyt-104756	Pyrenophora triticirepentis	33.65	9.00e-14	72.00
IUUC-Rno-105320	Rattus norvegicus	90.29	0.00e+00	1821.00
IUUC-Sha-106782	Sarcophilus harrisii	82.12	0.00e+00	1639.00
IUUC-Sja-107854	Schizosaccharomyces japonicus	32.54	6.00e-12	65.90
IUUC-Ssc-116136	Sus scrofa	93.30	0.00e+00	1607.00
IUUC-Tgu-116879	Taeniopygia guttata	73.45	0.00e+00	1231.00
IUUC-Tru-117609	Takifugu rubripes	65.15	0.00e+00	774.00
IUUC-Tni-119718	Tetraodon nigroviridis	64.54	0.00e+00	727.00
IUUC-Tbe-128042	Tupaia belangeri	86.94	0.00e+00	1063.00
IUUC-Ttr-129158	Tursiops truncatus	86.42	0.00e+00	971.00
IUUC-Xtr-132901	Xenopus tropicalis	68.19	0.00e+00	1291.00
IUUC-Xma-133284	Xiphophorus maculatus	66.72	0.00e+00	797.00
IUUC-Yli-134532	Yarrowia lipolytica	32.17	6.00e-12	66.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence