iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046058

UUCD1 version

UUC-HoS-01191

Ensembl Protein ID

ENSP00000264552.8

UniProt Accession

Q16763; Q9BTC1; UBE2S_HUMAN

Genbank Protein ID

AAA58446.1; BAB93484.1; AAH04236.1; AAH07554.1; AAH65364.1

Protein Name

Ubiquitin-conjugating enzyme E2 S; E2 ubiquitin-conjugating enzyme S; E2-EPF; Ubiquitin carrier protein S; Ubiquitin-conjugating enzyme E2-24 kDa; Ubiquitin-conjugating enzyme E2-EPF5; Ubiquitin-protein ligase S

Genbank Nucleotide ID

M91670; AB062397; AC020922; BC007554; BC065364

Gene Name

UBE2S; E2EPF; OK/SW-cl.73

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000108106.13	ENST00000264552.13	ENSP00000264552.8
ENSG00000108106.13	ENST00000587845.5	ENSP00000467409.1
ENSG00000108106.13	ENST00000589978.1	ENSP00000466388.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20498703; 20622874; 21281817

Classification

Family	E-value	Score	Start	End
E2/UBC	6.00e-40	137.9	17	149

Active Site

Position(s)	Description	Evidence
95	Glycyl thioester intermediate	N/A

Domain Profile

E2/UBC

   S: 3    kkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWsp 94
           +ke+++l++dpp+gi++ p++e dlt+++v+i+Gpe+tpY+gg+F++++ + +d+P++PPk  fltkifhPnv +nG++C+++lk  ++W++
   Q: 17   YKEVTTLTADPPDGIKVFPNEE-DLTDLQVTIEGPEGTPYAGGLFRMKLLLGKDFPASPPKGYFLTKIFHPNVGANGEICVNVLK--RDWTA 105
           79********************.9************************************************************9..***** PP
   S: 95   alsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
            l +++vll+i+ ll +pnpes+lneea +ll +n eey  ++r
   Q: 106  ELGIRHVLLTIKCLLIHPNPESALNEEAGRLLLENYEEYAARAR 149
           ***************************************99876 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.

Protein Sequence
(Fasta)

MNSNVENLPP HIIRLVYKEV TTLTADPPDG IKVFPNEEDL TDLQVTIEGP EGTPYAGGLF 60
RMKLLLGKDF PASPPKGYFL TKIFHPNVGA NGEICVNVLK RDWTAELGIR HVLLTIKCLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGGGCACC GGGGCGGCGG GTTGGTCTAC GCTGTGCGCG GCGGACGTCG GAGGCAGCGG 60
GGAGCGGAGC GGGGCCGCCG GGGCCTCTCC AGGGCCGCAG CGGCAGCAGT TGGGCCCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0006464--P:cellular protein modification process
GO:0010458--P:exit from mitosis
GO:0010994--P:free ubiquitin chain polymerization
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0070979--P:protein K11-linked ubiquitination
GO:0044314--P:protein K27-linked ubiquitination
GO:0035519--P:protein K29-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination

KEGG

hsa:27338

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000818	Aegilops tauschii	59.30	2.00e-49	189.00
IUUC-Aml-001979	Ailuropoda melanoleuca	93.10	7.00e-92	329.00
IUUC-Atr-002706	Amborella trichopoda	59.09	4.00e-48	184.00
IUUC-Aca-004432	Anolis carolinensis	77.11	8.00e-87	312.00
IUUC-Aly-005779	Arabidopsis lyrata	64.10	2.00e-58	218.00
IUUC-Ath-007162	Arabidopsis thaliana	64.74	1.00e-58	219.00
IUUC-Acl-008107	Aspergillus clavatus	50.40	3.00e-34	139.00
IUUC-Afl-008578	Aspergillus flavus	45.40	3.00e-35	142.00
IUUC-Afu-009034	Aspergillus fumigatus	52.34	5.00e-35	142.00
IUUC-Ani-009151	Aspergillus nidulans	51.94	4.00e-36	145.00
IUUC-Ang-009649	Aspergillus niger	50.77	4.00e-36	145.00
IUUC-Ame-010836	Astyanax mexicanus	60.24	3.00e-79	287.00
IUUC-Bta-012740	Bos taurus	100.00	4.00e-89	320.00
IUUC-Bdi-014057	Brachypodium distachyon	59.66	2.00e-50	192.00
IUUC-Bol-016481	Brassica oleracea	65.38	2.00e-58	219.00
IUUC-Bra-016867	Brassica rapa	64.74	1.00e-58	219.00
IUUC-Cja-019763	Callithrix jacchus	98.51	3.00e-106	377.00
IUUC-Cfa-020216	Canis familiaris	93.60	4.00e-94	337.00
IUUC-Cpo-021720	Cavia porcellus	90.10	4.00e-96	343.00
IUUC-Cre-022676	Chlamydomonas reinhardtii	60.93	4.00e-56	210.00
IUUC-Csa-023751	Chlorocebus sabaeus	99.01	1.00e-106	378.00
IUUC-Cho-024620	Choloepus hoffmanni	98.23	1.00e-63	234.00
IUUC-Cin-025632	Ciona intestinalis	61.33	1.00e-64	239.00
IUUC-Csv-025984	Ciona savignyi	65.45	1.00e-63	235.00
IUUC-Cne-026844	Cryptococcus neoformans	54.05	7.00e-48	183.00
IUUC-Cme-027294	Cyanidioschyzon merolae	57.69	2.00e-51	195.00
IUUC-Dre-027674	Danio rerio	62.70	6.00e-81	293.00
IUUC-Dno-029886	Dasypus novemcinctus	100.00	4.00e-89	320.00
IUUC-Dor-030440	Dipodomys ordii	93.60	1.00e-95	342.00
IUUC-Dse-031211	Dothistroma septosporum	47.06	3.00e-31	126.00
IUUC-Dme-031888	Drosophila melanogaster	67.53	4.00e-63	233.00
IUUC-Ete-032365	Echinops telfairi	80.35	3.00e-70	257.00
IUUC-Eca-033733	Equus caballus	94.58	9.00e-94	335.00
IUUC-Eeu-035342	Erinaceus europaeus	96.75	3.00e-86	310.00
IUUC-Fca-035964	Felis catus	100.00	1.00e-62	232.00
IUUC-Gmo-039357	Gadus morhua	80.49	5.00e-77	280.00
IUUC-Gga-040261	Gallus gallus	87.23	6.00e-47	179.00
IUUC-Gac-042593	Gasterosteus aculeatus	77.71	8.00e-77	279.00
IUUC-Gma-043597	Glycine max	57.95	2.00e-58	219.00
IUUC-Ggo-044626	Gorilla gorilla	99.35	6.00e-77	279.00
IUUC-Hvu-047281	Hordeum vulgare	64.24	4.00e-49	187.00
IUUC-Itr-048739	Ictidomys tridecemlineatus	90.59	9.00e-95	339.00
IUUC-Lch-049415	Latimeria chalumnae	70.25	4.00e-57	213.00
IUUC-Lpe-050956	Leersia perrieri	48.30	2.00e-33	135.00
IUUC-Lma-052996	Leptosphaeria maculans	52.29	3.00e-32	132.00
IUUC-Laf-053337	Loxodonta africana	93.56	2.00e-90	324.00
IUUC-Mcc-055485	Macaca mulatta	88.55	4.00e-103	367.00
IUUC-Meu-056123	Macropus eugenii	97.40	4.00e-87	313.00
IUUC-Mtr-058300	Medicago truncatula	57.95	3.00e-56	211.00
IUUC-Mla-059060	Melampsora laricipopulina	50.92	7.00e-50	189.00
IUUC-Mmr-061005	Microcebus murinus	93.56	6.00e-91	326.00
IUUC-Mdo-062979	Monodelphis domestica	97.60	1.00e-69	255.00
IUUC-Mmu-063778	Mus musculus	92.54	5.00e-94	337.00
IUUC-Mac-064575	Musa acuminata	59.09	6.00e-58	218.00
IUUC-Mpu-065829	Mustela putorius furo	96.06	9.00e-101	359.00
IUUC-Mlu-067498	Myotis lucifugus	95.45	2.00e-81	294.00
IUUC-Nfi-068520	Neosartorya fischeri	52.34	7.00e-35	141.00
IUUC-Nle-069727	Nomascus leucogenys	99.01	2.00e-106	378.00
IUUC-Opr-071066	Ochotona princeps	98.25	1.00e-63	234.00
IUUC-Ont-072363	Oreochromis niloticus	79.27	2.00e-75	275.00
IUUC-Oan-073383	Ornithorhynchus anatinus	92.73	4.00e-57	213.00
IUUC-Ocu-074599	Oryctolagus cuniculus	98.50	3.00e-75	273.00
IUUC-Oba-075186	Oryza barthii	59.09	3.00e-51	195.00
IUUC-Obr-076104	Oryza brachyantha	59.09	1.00e-49	189.00
IUUC-Ogl-077835	Oryza glaberrima	60.59	3.00e-51	194.00
IUUC-Ogu-078690	Oryza glumaepatula	60.59	3.00e-51	194.00
IUUC-Oin-080215	Oryza indica	59.09	3.00e-51	195.00
IUUC-Olo-080816	Oryza longistaminata	59.09	3.00e-51	195.00
IUUC-Ome-081657	Oryza meridionalis	59.09	6.00e-51	194.00
IUUC-Oni-082601	Oryza nivara	59.09	3.00e-51	195.00
IUUC-Opu-083367	Oryza punctata	59.66	7.00e-51	193.00
IUUC-Oru-084477	Oryza rufipogon	59.09	2.00e-51	195.00
IUUC-Osa-086119	Oryza sativa	59.09	3.00e-51	195.00
IUUC-Ola-086702	Oryzias latipes	80.37	9.00e-78	282.00
IUUC-Olu-087576	Ostreococcus lucimarinus	54.61	3.00e-47	181.00
IUUC-Oga-088946	Otolemur garnettii	94.55	3.00e-97	347.00
IUUC-Oar-089564	Ovis aries	94.55	1.00e-92	332.00
IUUC-Ptr-090620	Pan troglodytes	99.50	2.00e-106	377.00
IUUC-Pan-092382	Papio anubis	88.55	4.00e-103	367.00
IUUC-Psi-093891	Pelodiscus sinensis	89.47	5.00e-61	225.00
IUUC-Pma-094344	Petromyzon marinus	82.35	3.00e-75	274.00
IUUC-Ppa-095452	Physcomitrella patens	55.56	4.00e-48	184.00
IUUC-Pfo-097288	Poecilia formosa	81.21	4.00e-79	287.00
IUUC-Pab-098506	Pongo abelii	99.01	2.00e-106	378.00
IUUC-Pop-098882	Populus trichocarpa	57.39	1.00e-57	216.00
IUUC-Pca-100749	Procavia capensis	92.61	2.00e-92	331.00
IUUC-Ppe-102084	Prunus persica	57.95	2.00e-57	215.00
IUUC-Pva-102755	Pteropus vampyrus	95.07	2.00e-95	341.00
IUUC-Pgr-103394	Puccinia graminis	51.52	2.00e-48	186.00
IUUC-Ptt-103750	Puccinia triticina	54.30	3.00e-48	184.00
IUUC-Pte-104240	Pyrenophora teres	49.23	2.00e-31	130.00
IUUC-Pyt-104483	Pyrenophora triticirepentis	48.46	6.00e-31	128.00
IUUC-Rno-105739	Rattus norvegicus	93.60	1.00e-100	358.00
IUUC-Smo-108939	Selaginella moellendorffii	58.33	2.00e-46	179.00
IUUC-Sit-109881	Setaria italica	60.47	5.00e-50	191.00
IUUC-Sly-111764	Solanum lycopersicum	62.25	2.00e-57	215.00
IUUC-Stu-111968	Solanum tuberosum	62.25	2.00e-57	215.00
IUUC-Sar-113093	Sorex araneus	61.27	3.00e-56	211.00
IUUC-Sbi-114015	Sorghum bicolor	59.09	3.00e-50	191.00
IUUC-Sre-115036	Sporisorium reilianum	43.37	7.00e-34	137.00
IUUC-Tru-117716	Takifugu rubripes	81.82	5.00e-79	287.00
IUUC-Tni-120210	Tetraodon nigroviridis	81.21	1.00e-78	285.00
IUUC-Tca-121315	Theobroma cacao	57.95	6.00e-58	217.00
IUUC-Tae-124474	Triticum aestivum	59.30	2.00e-49	188.00
IUUC-Tur-126669	Triticum urartu	60.74	6.00e-49	187.00
IUUC-Tme-127125	Tuber melanosporum	48.45	7.00e-40	157.00
IUUC-Tbe-128157	Tupaia belangeri	94.12	2.00e-89	321.00
IUUC-Ttr-128593	Tursiops truncatus	94.58	7.00e-100	356.00
IUUC-Uma-129592	Ustilago maydis	48.37	6.00e-41	160.00
IUUC-Vvi-131716	Vitis vinifera	57.95	3.00e-58	218.00
IUUC-Xtr-132592	Xenopus tropicalis	74.13	5.00e-84	303.00
IUUC-Xma-133064	Xiphophorus maculatus	77.98	1.00e-70	259.00
IUUC-Yli-134575	Yarrowia lipolytica	49.31	6.00e-38	150.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence