iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000108395.13	ENST00000585287.5	ENSP00000464666.1
ENSG00000108395.13	ENST00000583945.5	ENSP00000462778.1
ENSG00000108395.13	ENST00000393066.7	ENSP00000376785.3
ENSG00000108395.13	ENST00000577554.5	ENSP00000462340.1
ENSG00000108395.13	ENST00000393065.6	ENSP00000376784.2
ENSG00000108395.13	ENST00000581468.1	ENSP00000462863.1
ENSG00000108395.13	ENST00000580973.5	ENSP00000464590.1
ENSG00000108395.13	ENST00000580122.5	ENSP00000464688.1
ENSG00000108395.13	ENST00000584889.3	ENSP00000464263.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16306379

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 activity/RING/RING	92.44	0.00e+00	1579.00	IUUC-Mmu-064161

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).

Protein Sequence
(Fasta)

MDEQSVESIA EVFRCFICME KLRDARLCPH CSKLCCFSCI RRWLTEQRAQ CPHCRAPLQL 60
RELVNCRWAE EVTQQLDTLQ LCSLTKHEEN EKDKCENHHE KLSVFCWTCK KCICHQCALW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCCTTTCC CCTCCCACAG CGTCCTGCGC GCATGCGCTT CGCAGCTTCT CTCGCCGCCG 60
CGCCCCCAGC TGCTCTGGTT ACGGTTGGTG TTTGCGAATT CTCTGCGGCA CCTTCTTCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0242--Dwarfism
KW-0479--Metal-binding
KW-0576--Peroxisome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003649--Bbox_C
IPR002083--MATH/TRAF_dom
IPR008974--TRAF-like
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50144--MATH
PS50119--ZF_BBOX
PS50089--ZF_RING_2

Pfam

PF00917--MATH
PF00643--zf-B_box

SMART

SM00502--BBC
SM00336--BBOX
SM00061--MATH

Gene Ontology

GO:0016235--C:aggresome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0048471--C:perinuclear region of cytoplasm
GO:0005777--C:peroxisome
GO:0003682--F:chromatin binding
GO:0042803--F:protein homodimerization activity
GO:0005164--F:tumor necrosis factor receptor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0070842--P:aggresome assembly
GO:0035518--P:histone H2A monoubiquitination
GO:0036353--P:histone H2A-K119 monoubiquitination
GO:0046600--P:negative regulation of centriole replication
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051865--P:protein autoubiquitination
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:4591

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002402	Ailuropoda melanoleuca	95.54	0.00e+00	1635.00
IUUC-Apl-003421	Anas platyrhynchos	79.12	0.00e+00	1283.00
IUUC-Aca-004895	Anolis carolinensis	76.03	0.00e+00	1233.00
IUUC-Aly-005536	Arabidopsis lyrata	30.00	4.00e-08	52.80
IUUC-Ath-007082	Arabidopsis thaliana	29.46	1.00e-08	54.30
IUUC-Ame-011010	Astyanax mexicanus	70.78	0.00e+00	993.00
IUUC-Bta-012395	Bos taurus	92.95	0.00e+00	1486.00
IUUC-Bol-016312	Brassica oleracea	31.01	5.00e-08	52.80
IUUC-Cja-019077	Callithrix jacchus	97.41	0.00e+00	1678.00
IUUC-Cfa-020944	Canis familiaris	94.72	0.00e+00	1575.00
IUUC-Cpo-021701	Cavia porcellus	90.06	0.00e+00	1540.00
IUUC-Csa-023468	Chlorocebus sabaeus	98.76	0.00e+00	1700.00
IUUC-Cho-024941	Choloepus hoffmanni	84.93	0.00e+00	788.00
IUUC-Cin-025184	Ciona intestinalis	71.73	9.00e-172	596.00
IUUC-Csv-026304	Ciona savignyi	64.94	9.00e-60	222.00
IUUC-Dre-027580	Danio rerio	61.95	0.00e+00	993.00
IUUC-Dno-029665	Dasypus novemcinctus	92.40	0.00e+00	1439.00
IUUC-Dor-030509	Dipodomys ordii	67.84	0.00e+00	668.00
IUUC-Ete-032665	Echinops telfairi	73.97	2.00e-164	573.00
IUUC-Eca-034388	Equus caballus	95.03	0.00e+00	1594.00
IUUC-Eeu-034530	Erinaceus europaeus	68.72	4.00e-49	190.00
IUUC-Fca-035842	Felis catus	94.82	0.00e+00	1630.00
IUUC-Fal-037490	Ficedula albicollis	91.67	0.00e+00	936.00
IUUC-Gmo-039700	Gadus morhua	97.47	4.00e-94	338.00
IUUC-Gga-040199	Gallus gallus	77.81	0.00e+00	1270.00
IUUC-Gac-041724	Gasterosteus aculeatus	73.74	0.00e+00	923.00
IUUC-Gma-043466	Glycine max	30.43	6.00e-08	51.20
IUUC-Ggo-045389	Gorilla gorilla	97.26	0.00e+00	1539.00
IUUC-Itr-048382	Ictidomys tridecemlineatus	92.04	0.00e+00	1566.00
IUUC-Lch-049653	Latimeria chalumnae	70.21	0.00e+00	1075.00
IUUC-Loc-051900	Lepisosteus oculatus	62.45	0.00e+00	1002.00
IUUC-Laf-053606	Loxodonta africana	95.45	0.00e+00	1620.00
IUUC-Mcc-054607	Macaca mulatta	98.86	0.00e+00	1702.00
IUUC-Meu-056746	Macropus eugenii	91.19	0.00e+00	787.00
IUUC-Mga-060028	Meleagris gallopavo	78.64	0.00e+00	1271.00
IUUC-Mmr-061345	Microcebus murinus	95.64	0.00e+00	1615.00
IUUC-Mdo-062615	Monodelphis domestica	83.50	0.00e+00	1394.00
IUUC-Mmu-064161	Mus musculus	92.44	0.00e+00	1572.00
IUUC-Mac-065602	Musa acuminata	28.26	3.00e-07	49.30
IUUC-Mpu-066437	Mustela putorius furo	94.31	0.00e+00	1594.00
IUUC-Mlu-068208	Myotis lucifugus	92.24	0.00e+00	1603.00
IUUC-Nle-069104	Nomascus leucogenys	98.64	0.00e+00	1682.00
IUUC-Opr-070233	Ochotona princeps	97.35	1.00e-87	318.00
IUUC-Ont-071969	Oreochromis niloticus	84.40	0.00e+00	874.00
IUUC-Oan-072914	Ornithorhynchus anatinus	71.90	0.00e+00	706.00
IUUC-Ocu-074943	Oryctolagus cuniculus	92.44	0.00e+00	1541.00
IUUC-Oga-088371	Otolemur garnettii	94.40	0.00e+00	1631.00
IUUC-Oar-090383	Ovis aries	93.16	0.00e+00	1527.00
IUUC-Ptr-091450	Pan troglodytes	99.69	0.00e+00	1726.00
IUUC-Pan-091800	Papio anubis	96.93	0.00e+00	1043.00
IUUC-Psi-093665	Pelodiscus sinensis	91.68	0.00e+00	902.00
IUUC-Pma-094559	Petromyzon marinus	83.19	0.00e+00	795.00
IUUC-Ppa-095483	Physcomitrella patens	42.34	6.00e-92	332.00
IUUC-Pfo-097163	Poecilia formosa	61.30	6.00e-136	478.00
IUUC-Pab-098742	Pongo abelii	99.58	0.00e+00	1683.00
IUUC-Pop-099648	Populus trichocarpa	31.39	1.00e-06	47.40
IUUC-Pca-100656	Procavia capensis	77.14	0.00e+00	741.00
IUUC-Ppe-101374	Prunus persica	31.82	1.00e-09	57.40
IUUC-Pva-103231	Pteropus vampyrus	83.87	0.00e+00	806.00
IUUC-Rno-105564	Rattus norvegicus	92.33	0.00e+00	1597.00
IUUC-Smo-109220	Selaginella moellendorffii	36.60	1.00e-87	317.00
IUUC-Sar-112934	Sorex araneus	86.37	0.00e+00	719.00
IUUC-Ssc-116278	Sus scrofa	91.20	0.00e+00	944.00
IUUC-Tgu-117396	Taeniopygia guttata	91.64	0.00e+00	944.00
IUUC-Tru-118296	Takifugu rubripes	75.61	0.00e+00	943.00
IUUC-Tsy-119188	Tarsius syrichta	87.67	0.00e+00	723.00
IUUC-Tni-120147	Tetraodon nigroviridis	73.88	0.00e+00	924.00
IUUC-Tbe-127682	Tupaia belangeri	87.62	0.00e+00	713.00
IUUC-Ttr-129176	Tursiops truncatus	99.09	0.00e+00	854.00
IUUC-Vpa-130336	Vicugna pacos	86.69	0.00e+00	1325.00
IUUC-Vvi-131514	Vitis vinifera	34.88	1.00e-07	50.80
IUUC-Xtr-132646	Xenopus tropicalis	66.80	0.00e+00	1070.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence