iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000018548.15	ENSMUST00000041282.12	ENSMUSP00000049057.6
ENSMUSG00000018548.15	ENSMUST00000139532.1	ENSMUSP00000119269.1
ENSMUSG00000018548.15	ENSMUST00000154138.1	ENSMUSP00000118260.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	circBase	miRTarBase	microRNA
TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 activity/RING/RING	92.44	0.00e+00	1572.00	IUUC-Hsa-046400

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase required to prevent centriole reduplication (By similarity). Probably acts by ubiquitinating positive regulators of centriole reduplication (By similarity). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042).

Protein Sequence
(Fasta)

MDEQSVESIA EVFRCFICME KLRDARLCPH CSKLCCFSCI RRWLTEQRAQ CPHCRAPLQL 60
RELVNCRWAE EVTQQLDTLQ LCSLTKHEEN EKDKCENHHE KLSVFCWTCK KCICHQCALW 120

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Nucleotide Sequence
(Fasta)

CGCGCCTCTA GCTGCCCTGG TTACCGTTGG TGTTTGCGAA TTCTCTGTGG CGCCTGTTCC 60
GCCCCGGACG GGCCCCGCGG CGGTTTTCAC ACGCGCGCGC CGGCGTCACG TGGGCCAGGG 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0576--Peroxisome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003649--Bbox_C
IPR002083--MATH/TRAF_dom
IPR008974--TRAF-like
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50144--MATH
PS50119--ZF_BBOX
PS50089--ZF_RING_2

Pfam

PF00917--MATH
PF00643--zf-B_box

SMART

SM00502--BBC
SM00336--BBOX
SM00061--MATH

Gene Ontology

GO:0016235--C:aggresome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0035098--C:ESC/E(Z) complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0005777--C:peroxisome
GO:0003682--F:chromatin binding
GO:0042803--F:protein homodimerization activity
GO:0005164--F:tumor necrosis factor receptor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0070842--P:aggresome assembly
GO:0035518--P:histone H2A monoubiquitination
GO:0036353--P:histone H2A-K119 monoubiquitination
GO:0046600--P:negative regulation of centriole replication
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051865--P:protein autoubiquitination

KEGG

mmu:68729

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002402	Ailuropoda melanoleuca	93.04	0.00e+00	1599.00
IUUC-Apl-003421	Anas platyrhynchos	76.85	0.00e+00	1259.00
IUUC-Aca-004895	Anolis carolinensis	75.41	0.00e+00	1218.00
IUUC-Aly-005536	Arabidopsis lyrata	30.00	3.00e-08	53.10
IUUC-Ath-007082	Arabidopsis thaliana	29.46	1.00e-08	54.30
IUUC-Ame-011010	Astyanax mexicanus	71.43	0.00e+00	990.00
IUUC-Bta-012395	Bos taurus	90.97	0.00e+00	1454.00
IUUC-Bol-016312	Brassica oleracea	31.01	4.00e-08	52.80
IUUC-Cja-019077	Callithrix jacchus	91.51	0.00e+00	1566.00
IUUC-Cfa-020944	Canis familiaris	91.28	0.00e+00	1551.00
IUUC-Cpo-021701	Cavia porcellus	88.49	0.00e+00	1531.00
IUUC-Csa-023468	Chlorocebus sabaeus	92.12	0.00e+00	1583.00
IUUC-Cho-024941	Choloepus hoffmanni	85.12	0.00e+00	800.00
IUUC-Cin-025184	Ciona intestinalis	71.73	2.00e-171	595.00
IUUC-Csv-026304	Ciona savignyi	64.94	1.00e-59	221.00
IUUC-Dre-027580	Danio rerio	60.83	0.00e+00	993.00
IUUC-Dno-029665	Dasypus novemcinctus	88.78	0.00e+00	1428.00
IUUC-Dor-030509	Dipodomys ordii	68.06	0.00e+00	683.00
IUUC-Ete-032665	Echinops telfairi	74.20	2.00e-165	577.00
IUUC-Eca-034388	Equus caballus	92.00	0.00e+00	1585.00
IUUC-Eeu-034530	Erinaceus europaeus	59.62	3.00e-56	213.00
IUUC-Fca-035842	Felis catus	92.73	0.00e+00	1598.00
IUUC-Fal-037490	Ficedula albicollis	91.67	0.00e+00	944.00
IUUC-Gmo-039700	Gadus morhua	97.47	8.00e-94	337.00
IUUC-Gga-040199	Gallus gallus	76.71	0.00e+00	1245.00
IUUC-Gac-041724	Gasterosteus aculeatus	74.64	0.00e+00	923.00
IUUC-Ggo-045389	Gorilla gorilla	89.27	0.00e+00	1391.00
IUUC-Hsa-046400	Homo sapiens	92.44	0.00e+00	1579.00
IUUC-Itr-048382	Ictidomys tridecemlineatus	91.19	0.00e+00	1572.00
IUUC-Lch-049653	Latimeria chalumnae	68.01	0.00e+00	1080.00
IUUC-Loc-051900	Lepisosteus oculatus	62.17	0.00e+00	990.00
IUUC-Laf-053606	Loxodonta africana	93.06	0.00e+00	1578.00
IUUC-Mcc-054607	Macaca mulatta	92.33	0.00e+00	1590.00
IUUC-Meu-056746	Macropus eugenii	90.61	0.00e+00	793.00
IUUC-Mga-060028	Meleagris gallopavo	77.02	0.00e+00	1251.00
IUUC-Mmr-061345	Microcebus murinus	91.80	0.00e+00	1551.00
IUUC-Mdo-062615	Monodelphis domestica	81.33	0.00e+00	1363.00
IUUC-Mac-065602	Musa acuminata	28.26	3.00e-07	49.30
IUUC-Mpu-066437	Mustela putorius furo	92.43	0.00e+00	1575.00
IUUC-Mlu-068208	Myotis lucifugus	90.16	0.00e+00	1583.00
IUUC-Nle-069104	Nomascus leucogenys	91.42	0.00e+00	1541.00
IUUC-Opr-070233	Ochotona princeps	98.01	4.00e-89	323.00
IUUC-Ont-071969	Oreochromis niloticus	74.24	0.00e+00	942.00
IUUC-Oan-072914	Ornithorhynchus anatinus	69.29	0.00e+00	689.00
IUUC-Ocu-074943	Oryctolagus cuniculus	90.87	0.00e+00	1544.00
IUUC-Oga-088371	Otolemur garnettii	90.98	0.00e+00	1578.00
IUUC-Oar-090383	Ovis aries	91.07	0.00e+00	1493.00
IUUC-Ptr-091450	Pan troglodytes	92.23	0.00e+00	1586.00
IUUC-Pan-091800	Papio anubis	87.72	0.00e+00	931.00
IUUC-Psi-093665	Pelodiscus sinensis	92.61	0.00e+00	920.00
IUUC-Pma-094559	Petromyzon marinus	84.22	0.00e+00	798.00
IUUC-Ppa-095483	Physcomitrella patens	41.59	7.00e-92	332.00
IUUC-Pfo-097163	Poecilia formosa	60.18	1.00e-137	484.00
IUUC-Pab-098742	Pongo abelii	92.19	0.00e+00	1545.00
IUUC-Pop-099648	Populus trichocarpa	31.39	8.00e-07	47.80
IUUC-Pca-100656	Procavia capensis	77.14	0.00e+00	754.00
IUUC-Ppe-101374	Prunus persica	29.86	9.00e-10	57.80
IUUC-Pva-103231	Pteropus vampyrus	80.12	0.00e+00	1118.00
IUUC-Rno-105564	Rattus norvegicus	98.13	0.00e+00	1711.00
IUUC-Smo-109220	Selaginella moellendorffii	35.28	8.00e-88	318.00
IUUC-Sar-112934	Sorex araneus	81.71	0.00e+00	728.00
IUUC-Ssc-116278	Sus scrofa	88.44	0.00e+00	931.00
IUUC-Tgu-117396	Taeniopygia guttata	92.17	0.00e+00	959.00
IUUC-Tru-118296	Takifugu rubripes	75.68	0.00e+00	953.00
IUUC-Tsy-119188	Tarsius syrichta	87.90	0.00e+00	726.00
IUUC-Tni-120147	Tetraodon nigroviridis	74.19	0.00e+00	929.00
IUUC-Tbe-127682	Tupaia belangeri	88.08	0.00e+00	718.00
IUUC-Ttr-129176	Tursiops truncatus	99.32	0.00e+00	858.00
IUUC-Vpa-130336	Vicugna pacos	84.06	0.00e+00	1301.00
IUUC-Vvi-131514	Vitis vinifera	34.88	1.00e-07	50.80
IUUC-Xtr-132646	Xenopus tropicalis	66.80	0.00e+00	1080.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence