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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046265
UUCD1 version UUC-HoS-00049
Ensembl Protein ID ENSP00000226725.6
UniProt Accession O95198; A6NCM7; B2RD18; B4DFH7; F5H6M3; Q8N484; Q8TBH5; KLHL2_HUMAN
Genbank Protein ID AAC67502.1; BAG57438.1; BAG37765.1; AAH22503.1; AAH36468.1
Protein Name Kelch-like protein 2; Actin-binding protein Mayven
Genbank Nucleotide ID AF059569; AK294103; AK315372; AC012504; BC036468
Gene Name KLHL2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000109466.13 ENST00000226725.10 ENSP00000226725.6
ENSG00000109466.13 ENST00000511305.5 ENSP00000422113.1
ENSG00000109466.13 ENST00000514860.5 ENSP00000424198.1
ENSG00000109466.13 ENST00000506824.5 ENSP00000421844.1
ENSG00000109466.13 ENST00000421009.6 ENSP00000408974.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 21549840; 23838290
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 8.60e-21 75.7 56 123
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 7.20e-11 41.2 156 185
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +Dv++v ++ e++ah++vLaa+S++F+a+f++e++es+  ++v ik+v+   +r l++++Yt +++ +e
   Q: 56   CDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESR-AKRVRIKEVDGWTLRMLIDYVYTAEIQVTE 123
           8*************************************.*************************99765 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhF 31
            Nclgi++fAd++ c+dL  +a++++++hF
   Q: 156  VNCLGIRAFADMHACTDLLNKANTYAEQHF 185
           6****************************9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
 Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
Protein Sequence
(Fasta)
METPPLPPAC TKQGHQKPLD SKDDNTEKHC PVTVNPWHMK KAFKVMNELR SQNLLCDVTI 60
VAEDMEISAH RVVLAACSPY FHAMFTGEMS ESRAKRVRIK EVDGWTLRML IDYVYTAEIQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046265|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGCCCGCCG GTCCCGTCGC CGCCGCCCCG CACTCGGGCG AGCGCGGGAG CCGCGCAGTA 60
GACGGAGCGC GCCCGGCCGA GCGGGCCATG GCCGCGGGGG CCGCCGCCGC AGGTGGTGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046265|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030027--C:lamellipodium
GO:0001726--C:ruffle
GO:0003779--F:actin binding
GO:0042802--F:identical protein binding
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:11275
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002378 Ailuropoda melanoleuca 98.98 0.00e+00 1171.00
IUUC-Apl-003260 Anas platyrhynchos 93.15 0.00e+00 1102.00
IUUC-Aca-005143 Anolis carolinensis 88.76 0.00e+00 1095.00
IUUC-Cja-018942 Callithrix jacchus 98.98 0.00e+00 1170.00
IUUC-Cfa-020886 Canis familiaris 99.83 0.00e+00 1172.00
IUUC-Cpo-022543 Cavia porcellus 99.83 0.00e+00 1191.00
IUUC-Csa-023088 Chlorocebus sabaeus 99.66 0.00e+00 1191.00
IUUC-Dre-028082 Danio rerio 81.74 0.00e+00 978.00
IUUC-Dno-029873 Dasypus novemcinctus 97.28 0.00e+00 1145.00
IUUC-Dor-030460 Dipodomys ordii 79.11 0.00e+00 856.00
IUUC-Dse-031229 Dothistroma septosporum 37.14 4.00e-08 51.60
IUUC-Dme-032172 Drosophila melanogaster 62.08 0.00e+00 674.00
IUUC-Eca-033798 Equus caballus 99.14 0.00e+00 1166.00
IUUC-Eeu-034824 Erinaceus europaeus 91.53 0.00e+00 970.00
IUUC-Fca-036455 Felis catus 99.83 0.00e+00 1172.00
IUUC-Fal-037293 Ficedula albicollis 92.61 0.00e+00 1041.00
IUUC-Gmo-038811 Gadus morhua 78.85 0.00e+00 875.00
IUUC-Gga-040805 Gallus gallus 92.64 0.00e+00 1098.00
IUUC-Gac-041979 Gasterosteus aculeatus 81.29 0.00e+00 879.00
IUUC-Ggo-044620 Gorilla gorilla 94.55 0.00e+00 1110.00
IUUC-Lch-049939 Latimeria chalumnae 83.87 0.00e+00 979.00
IUUC-Loc-052780 Lepisosteus oculatus 86.29 0.00e+00 1035.00
IUUC-Laf-053800 Loxodonta africana 99.32 0.00e+00 1166.00
IUUC-Mcc-055732 Macaca mulatta 98.63 0.00e+00 1155.00
IUUC-Meu-056011 Macropus eugenii 96.13 0.00e+00 1051.00
IUUC-Mmr-061067 Microcebus murinus 97.46 0.00e+00 1154.00
IUUC-Mdo-062977 Monodelphis domestica 94.94 0.00e+00 1141.00
IUUC-Mmu-064035 Mus musculus 98.80 0.00e+00 1167.00
IUUC-Mpu-066726 Mustela putorius furo 99.66 0.00e+00 1171.00
IUUC-Mlu-067020 Myotis lucifugus 98.81 0.00e+00 1165.00
IUUC-Nle-069456 Nomascus leucogenys 99.15 0.00e+00 1174.00
IUUC-Opr-071130 Ochotona princeps 89.38 0.00e+00 1024.00
IUUC-Ont-072219 Oreochromis niloticus 82.87 0.00e+00 930.00
IUUC-Oan-073699 Ornithorhynchus anatinus 94.69 0.00e+00 961.00
IUUC-Ocu-074045 Oryctolagus cuniculus 99.16 0.00e+00 1183.00
IUUC-Oga-088494 Otolemur garnettii 98.15 0.00e+00 1166.00
IUUC-Oar-089645 Ovis aries 98.14 0.00e+00 1166.00
IUUC-Ptr-091063 Pan troglodytes 100.00 0.00e+00 1187.00
IUUC-Pan-092273 Papio anubis 99.59 0.00e+00 976.00
IUUC-Psi-093946 Pelodiscus sinensis 92.15 0.00e+00 1108.00
IUUC-Pma-094177 Petromyzon marinus 74.70 0.00e+00 796.00
IUUC-Pfo-096817 Poecilia formosa 81.82 0.00e+00 942.00
IUUC-Pab-097768 Pongo abelii 99.83 0.00e+00 1191.00
IUUC-Pca-100607 Procavia capensis 83.02 0.00e+00 852.00
IUUC-Pva-102218 Pteropus vampyrus 93.42 0.00e+00 1098.00
IUUC-Rno-105250 Rattus norvegicus 98.65 0.00e+00 1178.00
IUUC-Sar-113249 Sorex araneus 98.78 0.00e+00 1142.00
IUUC-Ssc-115423 Sus scrofa 98.64 0.00e+00 1167.00
IUUC-Tgu-117050 Taeniopygia guttata 91.45 0.00e+00 1085.00
IUUC-Tru-118239 Takifugu rubripes 82.02 0.00e+00 972.00
IUUC-Tsy-119377 Tarsius syrichta 85.27 0.00e+00 1004.00
IUUC-Tni-120122 Tetraodon nigroviridis 80.83 0.00e+00 877.00
IUUC-Ttr-128574 Tursiops truncatus 99.13 0.00e+00 717.00
IUUC-Vpa-130707 Vicugna pacos 95.28 0.00e+00 877.00
IUUC-Xtr-132035 Xenopus tropicalis 85.86 0.00e+00 1052.00
Created Date 25-Jun-2017

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