iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
iRefIndex	Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	22388039

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	4.00e-07	32.1	409	468

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..........kdgpl........vlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC+e++                       + +CgHv+h  Cl ++ + + ++ ++ +CP+C+
   Q: 409  CTICMERLtapsgykgpqP---TvkpdlvgkLSRCGHVYHIYCLVAM-YNNGNKDGSLQCPTCK 468
           9*******55555444320...222333333577**********555.56677**********6 PP

Organism

Homo sapiens

Functional Description
(View)

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.

Protein Sequence
(Fasta)

MLLASAVVVW EWLNEHGRWR PYSPAVSHHI EAVVRAGPRA GGSVVLGQVD SRLAPYIIDL 60
QSMNQFRQDT GTLRPVRRNY YDPSSAPGKG VVWEWENDNG SWTPYDMEVG ITIQHAYEKQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCGTCTTCC TGACTCTAGT ACGTTGAATC TGGCCAGAAA AACCACATTT GCTCTCTACG 60
TAGGTAATAT AAATCCATCA TTAGCGAAAT TGCTGCATCC CTTTGGACTG GGTCTCATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004170--WWE-dom
IPR018123--WWE-dom_subgr
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50918--WWE
PS50089--ZF_RING_2

Pfam

PF02825--WWE
PF00097--zf-C3HC4

SMART

SM00184--RING
SM00678--WWE

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007219--P:Notch signaling pathway
GO:0032479--P:regulation of type I interferon production

KEGG

hsa:23220

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001420	Ailuropoda melanoleuca	92.00	0.00e+00	945.00
IUUC-Apl-003314	Anas platyrhynchos	60.43	4.00e-170	591.00
IUUC-Aca-004282	Anolis carolinensis	83.57	0.00e+00	981.00
IUUC-Aly-006456	Arabidopsis lyrata	36.92	5.00e-07	48.90
IUUC-Bta-013541	Bos taurus	95.05	8.00e-169	587.00
IUUC-Cja-019164	Callithrix jacchus	96.28	0.00e+00	1038.00
IUUC-Cfa-020475	Canis familiaris	91.37	0.00e+00	964.00
IUUC-Cpo-021358	Cavia porcellus	91.57	0.00e+00	1046.00
IUUC-Csa-023895	Chlorocebus sabaeus	98.22	0.00e+00	1124.00
IUUC-Cho-024781	Choloepus hoffmanni	98.70	9.00e-172	596.00
IUUC-Cin-025512	Ciona intestinalis	52.27	7.00e-65	241.00
IUUC-Csv-026089	Ciona savignyi	51.58	3.00e-63	236.00
IUUC-Dre-028695	Danio rerio	81.76	1.00e-163	570.00
IUUC-Dno-029115	Dasypus novemcinctus	94.67	0.00e+00	1084.00
IUUC-Dor-030701	Dipodomys ordii	87.94	0.00e+00	775.00
IUUC-Dme-031724	Drosophila melanogaster	41.63	2.00e-48	187.00
IUUC-Eca-033784	Equus caballus	97.36	0.00e+00	689.00
IUUC-Eeu-035106	Erinaceus europaeus	74.68	0.00e+00	753.00
IUUC-Fca-035528	Felis catus	93.65	0.00e+00	1058.00
IUUC-Fal-037476	Ficedula albicollis	91.79	2.00e-175	608.00
IUUC-Gmo-039590	Gadus morhua	82.54	3.00e-145	508.00
IUUC-Gga-040618	Gallus gallus	82.10	0.00e+00	936.00
IUUC-Gac-041759	Gasterosteus aculeatus	67.47	0.00e+00	787.00
IUUC-Ggo-044787	Gorilla gorilla	99.35	0.00e+00	1134.00
IUUC-Itr-048056	Ictidomys tridecemlineatus	95.58	0.00e+00	1068.00
IUUC-Lch-049663	Latimeria chalumnae	60.28	0.00e+00	680.00
IUUC-Laf-054482	Loxodonta africana	93.86	0.00e+00	1091.00
IUUC-Mcc-055090	Macaca mulatta	98.03	0.00e+00	998.00
IUUC-Meu-056882	Macropus eugenii	84.29	4.00e-169	587.00
IUUC-Mga-060182	Meleagris gallopavo	89.47	3.00e-160	558.00
IUUC-Mdo-062755	Monodelphis domestica	85.97	0.00e+00	805.00
IUUC-Mmu-063394	Mus musculus	93.86	0.00e+00	1087.00
IUUC-Mac-064552	Musa acuminata	30.65	2.00e-04	40.40
IUUC-Mpu-066276	Mustela putorius furo	94.83	0.00e+00	1080.00
IUUC-Mlu-067664	Myotis lucifugus	88.64	0.00e+00	654.00
IUUC-Nle-069360	Nomascus leucogenys	98.22	0.00e+00	1106.00
IUUC-Opr-070345	Ochotona princeps	85.60	0.00e+00	753.00
IUUC-Ont-072400	Oreochromis niloticus	62.98	0.00e+00	776.00
IUUC-Oan-073373	Ornithorhynchus anatinus	93.19	7.00e-170	589.00
IUUC-Ocu-074185	Oryctolagus cuniculus	93.37	0.00e+00	847.00
IUUC-Ola-086644	Oryzias latipes	66.40	0.00e+00	749.00
IUUC-Oga-088147	Otolemur garnettii	95.95	0.00e+00	1054.00
IUUC-Oar-090311	Ovis aries	97.03	0.00e+00	646.00
IUUC-Ptr-091535	Pan troglodytes	99.68	0.00e+00	1140.00
IUUC-Pan-092233	Papio anubis	98.22	0.00e+00	1125.00
IUUC-Psi-093689	Pelodiscus sinensis	82.59	0.00e+00	863.00
IUUC-Pma-094460	Petromyzon marinus	72.88	1.00e-133	469.00
IUUC-Pfo-096557	Poecilia formosa	66.14	0.00e+00	773.00
IUUC-Pab-098027	Pongo abelii	98.87	0.00e+00	1130.00
IUUC-Pca-100457	Procavia capensis	100.00	2.00e-125	442.00
IUUC-Pva-102381	Pteropus vampyrus	82.85	0.00e+00	712.00
IUUC-Rno-105599	Rattus norvegicus	92.98	0.00e+00	874.00
IUUC-Ssc-116338	Sus scrofa	93.55	0.00e+00	1078.00
IUUC-Tgu-116484	Taeniopygia guttata	91.53	7.00e-164	569.00
IUUC-Tru-118590	Takifugu rubripes	82.57	4.00e-156	545.00
IUUC-Tsy-119110	Tarsius syrichta	94.15	0.00e+00	798.00
IUUC-Tni-120695	Tetraodon nigroviridis	68.40	0.00e+00	784.00
IUUC-Tbe-127393	Tupaia belangeri	86.86	0.00e+00	860.00
IUUC-Ttr-128524	Tursiops truncatus	80.62	0.00e+00	726.00
IUUC-Vpa-130723	Vicugna pacos	99.07	2.00e-61	229.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence