iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000111664.10	ENST00000229264.7	ENSP00000229264.3
ENSG00000111664.10	ENST00000435982.6	ENSP00000414734.2
ENSG00000111664.10	ENST00000539127.5	ENSP00000444325.1
ENSG00000111664.10	ENST00000537035.1	ENSP00000445967.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	miRNAMap	miRcode	RAID2
LncRNADisease
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-38	130.2	53	85
UBD/Beta-Prp	1.40e-51	177.1	46	267

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gH ++++++++ +d +llvs+s Dg++ vWD  
   Q: 53   GHLAKIYAMHWaTDsKLLVSASQDGKLIVWDSY 85
           899*********888***************965 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee... 131
            + r+l gh a+++a+ +  d+k+lv++s+D+ + vwd  t   vh++   ++ v+++++ psg++++ G+ d++  +++l++++   +   
   Q: 46   RTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKvsr 137
           55689*****************************************************************************9987777778 PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtd 223
            ls h+g  +c ++ + +n +v++s D+t+ lWd++tg+  + + g ht++  sl+++++ + ++sg++d + klwd+++g+c +t++gh++
   Q: 138  ELSAHTGYLSCCRFLD-DNNIVTSSGDTTCALWDIETGQQKTVFVG-HTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHES 227
           ***************9.566899**********************9.********************************************* PP
   S: 224  nvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlh 263
            ++ + f+pn+e + +gs+D s r++dlr ++ l +++++
   Q: 228  DINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHE 267
           *********************************9999984 PP

Organism

Homo sapiens

Functional Description
(View)

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2.

Protein Sequence
(Fasta)

MGEMEQLRQE AEQLKKQIAD ARKACADVTL AELVSGLEVV GRVQMRTRRT LRGHLAKIYA 60
MHWATDSKLL VSASQDGKLI VWDSYTTNKV HAIPLRSSWV MTCAYAPSGN FVACGGLDNM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCCTGGAG CCTGTGATTT GTCAGGGAAA TCTCAGCCAC CTGCTCCCCT CATGCAAATG 60
ACCCAAGCCC CTGGCAGCTG CTCCTTAGGC CTCCAAGTGT AAGCCCTGTC TTCCCTCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1014--Congenital stationary night blindness
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0807--Transducer
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR016346--Guanine_nucleotide-bd_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0044297--C:cell body
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0003924--F:GTPase activity
GO:0051020--F:GTPase binding
GO:0004871--F:signal transducer activity
GO:0071377--P:cellular response to glucagon stimulus
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006457--P:protein folding
GO:0008217--P:regulation of blood pressure

KEGG

hsa:2784

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000161	Aegilops tauschii	49.63	7.00e-76	277.00
IUUC-Aml-002370	Ailuropoda melanoleuca	97.06	0.00e+00	686.00
IUUC-Atr-002610	Amborella trichopoda	49.03	3.00e-86	311.00
IUUC-Apl-004079	Anas platyrhynchos	93.24	0.00e+00	674.00
IUUC-Aca-004539	Anolis carolinensis	90.00	0.00e+00	653.00
IUUC-Aly-006025	Arabidopsis lyrata	50.00	1.00e-83	303.00
IUUC-Ath-006617	Arabidopsis thaliana	50.65	2.00e-83	302.00
IUUC-Bgr-012079	Blumeria graminis	65.38	5.00e-132	464.00
IUUC-Bta-012810	Bos taurus	97.35	0.00e+00	686.00
IUUC-Bci-013621	Botrytis cinerea	66.67	7.00e-132	463.00
IUUC-Bdi-014785	Brachypodium distachyon	49.68	5.00e-87	314.00
IUUC-Bra-016695	Brassica rapa	51.28	2.00e-81	296.00
IUUC-Cja-019894	Callithrix jacchus	99.12	0.00e+00	699.00
IUUC-Cfa-020140	Canis familiaris	96.76	0.00e+00	685.00
IUUC-Cpo-021908	Cavia porcellus	96.76	0.00e+00	685.00
IUUC-Csa-023321	Chlorocebus sabaeus	100.00	0.00e+00	702.00
IUUC-Dno-029783	Dasypus novemcinctus	95.82	1.00e-180	625.00
IUUC-Dse-031388	Dothistroma septosporum	66.67	7.00e-138	483.00
IUUC-Ete-032435	Echinops telfairi	89.71	7.00e-178	616.00
IUUC-Eca-034169	Equus caballus	97.06	0.00e+00	685.00
IUUC-Eeu-034631	Erinaceus europaeus	90.91	9.00e-164	569.00
IUUC-Fca-035392	Felis catus	96.76	0.00e+00	689.00
IUUC-Fal-036902	Ficedula albicollis	91.18	0.00e+00	664.00
IUUC-Gga-040655	Gallus gallus	91.79	0.00e+00	658.00
IUUC-Ggo-045346	Gorilla gorilla	100.00	0.00e+00	702.00
IUUC-Hvu-047596	Hordeum vulgare	49.68	6.00e-86	310.00
IUUC-Itr-048501	Ictidomys tridecemlineatus	96.18	0.00e+00	681.00
IUUC-Lpe-051040	Leersia perrieri	49.36	1.00e-87	316.00
IUUC-Loc-052327	Lepisosteus oculatus	88.24	0.00e+00	642.00
IUUC-Laf-053616	Loxodonta africana	96.47	0.00e+00	684.00
IUUC-Mcc-055798	Macaca mulatta	100.00	0.00e+00	702.00
IUUC-Mga-059516	Meleagris gallopavo	93.24	0.00e+00	673.00
IUUC-Mmr-061701	Microcebus murinus	97.35	0.00e+00	688.00
IUUC-Mdo-061879	Monodelphis domestica	93.82	0.00e+00	671.00
IUUC-Mmu-063132	Mus musculus	97.06	0.00e+00	686.00
IUUC-Mac-064871	Musa acuminata	49.04	4.00e-84	305.00
IUUC-Mpu-066365	Mustela putorius furo	96.76	0.00e+00	687.00
IUUC-Mlu-067628	Myotis lucifugus	96.18	0.00e+00	681.00
IUUC-Ncr-068650	Neurospora crassa	64.62	4.00e-128	451.00
IUUC-Nle-069015	Nomascus leucogenys	98.53	0.00e+00	686.00
IUUC-Opr-070261	Ochotona princeps	97.65	0.00e+00	688.00
IUUC-Ocu-074255	Oryctolagus cuniculus	97.65	0.00e+00	688.00
IUUC-Oba-075818	Oryza barthii	47.69	1.00e-84	306.00
IUUC-Obr-076229	Oryza brachyantha	49.04	4.00e-84	305.00
IUUC-Ogl-077730	Oryza glaberrima	49.68	6.00e-88	317.00
IUUC-Ogu-078583	Oryza glumaepatula	49.23	2.00e-69	255.00
IUUC-Oin-079661	Oryza indica	49.04	4.00e-84	305.00
IUUC-Olo-080225	Oryza longistaminata	49.23	2.00e-69	255.00
IUUC-Oni-082161	Oryza nivara	49.36	1.00e-87	316.00
IUUC-Opu-084072	Oryza punctata	49.68	5.00e-88	318.00
IUUC-Oru-084316	Oryza rufipogon	49.04	4.00e-84	305.00
IUUC-Osa-085380	Oryza sativa	49.04	4.00e-84	305.00
IUUC-Oga-088685	Otolemur garnettii	97.65	0.00e+00	688.00
IUUC-Oar-089373	Ovis aries	94.13	0.00e+00	651.00
IUUC-Ptr-090627	Pan troglodytes	97.35	0.00e+00	682.00
IUUC-Pan-092347	Papio anubis	100.00	0.00e+00	701.00
IUUC-Psi-092965	Pelodiscus sinensis	93.24	0.00e+00	674.00
IUUC-Ppa-095726	Physcomitrella patens	45.05	5.00e-75	275.00
IUUC-Pab-098335	Pongo abelii	99.41	0.00e+00	700.00
IUUC-Pop-099370	Populus trichocarpa	49.35	5.00e-87	314.00
IUUC-Ppe-102016	Prunus persica	47.74	2.00e-84	305.00
IUUC-Pva-102666	Pteropus vampyrus	97.65	0.00e+00	689.00
IUUC-Pte-104053	Pyrenophora teres	65.49	1.00e-136	479.00
IUUC-Rno-105834	Rattus norvegicus	96.47	0.00e+00	649.00
IUUC-Sha-107128	Sarcophilus harrisii	93.82	0.00e+00	668.00
IUUC-Ssl-108539	Sclerotinia sclerotiorum	66.86	1.00e-131	462.00
IUUC-Smo-109652	Selaginella moellendorffii	43.89	2.00e-74	273.00
IUUC-Sit-110441	Setaria italica	49.36	2.00e-87	315.00
IUUC-Sly-111784	Solanum lycopersicum	49.35	2.00e-84	306.00
IUUC-Stu-112400	Solanum tuberosum	49.35	2.00e-84	306.00
IUUC-Sbi-114038	Sorghum bicolor	48.72	4.00e-86	311.00
IUUC-Ssc-115886	Sus scrofa	97.35	0.00e+00	686.00
IUUC-Tgu-116461	Taeniopygia guttata	91.76	0.00e+00	667.00
IUUC-Tca-121224	Theobroma cacao	49.68	7.00e-87	314.00
IUUC-Tae-125653	Triticum aestivum	50.00	4.00e-86	311.00
IUUC-Tur-126755	Triticum urartu	49.52	8.00e-87	315.00
IUUC-Tbe-127694	Tupaia belangeri	80.88	8.00e-148	516.00
IUUC-Vvi-131162	Vitis vinifera	49.68	1.00e-86	313.00
IUUC-Xtr-132928	Xenopus tropicalis	88.24	4.00e-179	620.00
IUUC-Zma-135893	Zea mays	48.72	4.00e-86	311.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence