iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046820

Ensembl Protein ID

ENSP00000368745.5

UniProt Accession

Q14511; A8K9G7; A8MSJ9; G5E9Y9; Q5T9R4; Q5XKI0; CASL_HUMAN

Genbank Protein ID

AAA98770.1; AAB53696.1; BAF85371.1; CAI22676.1; CAI22676.1; CAI22677.1; CAI22677.1; CAI21579.1; CAI21579.1; CAI21580.1; CAI21580.1; EAW55299.1; EAW55301.1; AAH20686.1; AAH40207.1

Protein Name

Enhancer of filamentation 1; CRK-associated substrate-related protein; Cas scaffolding protein family member 2; Neural precursor cell expressed developmentally down-regulated protein 9; Renal carcinoma antigen NY-REN-12; p105; Enhancer of filamentation 1 p55

Genbank Nucleotide ID

L43821; U64317; AK292682; AL022098; AL139807; AL136139; AL139807; AL139807; AL136139; AL139807; AL136139; AL512382; CH471087; BC020686; BC040207

Gene Name

NEDD9; CASL; CASS2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000111859.16	ENST00000379446.9	ENSP00000368759.5
ENSG00000111859.16	ENST00000448183.6	ENSP00000395237.2
ENSG00000111859.16	ENST00000504387.5	ENSP00000422871.1
ENSG00000111859.16	ENST00000379433.5	ENSP00000368745.5
ENSG00000111859.16	ENST00000508546.5	ENSP00000424975.1
ENSG00000111859.16	ENST00000620854.4	ENSP00000478563.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB
Disease-associated Variation
GWASdb	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.30e-10	41.4	8	61

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlvi.ekeeqdegWlkgvkelegkrGlfPenFve 60
            ++lyd  ++  +eL ++kGd+++vi +++   egW+ +   l+g++G++P n v+
   Q: 8    ARALYDNVPECAEELAFRKGDILTVIeQNTGGLEGWWLC--SLHGRQGIVPGNRVK 61
           579***********************55566779*****..9**********9887 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts with BCAR3 and SH2D3C (By similarity). Homodimer. Can heterodimerize with HLH proteins ID2, E12, E47 and also with p130cas. Forms complexes in vivo with related adhesion focal tyrosine kinase (RAFTK), adapter protein CRKL and LYN kinase. Interacts with MICAL and TXNL4/DIM1.

Protein Sequence
(Fasta)

MKYKNLMARA LYDNVPECAE ELAFRKGDIL TVIEQNTGGL EGWWLCSLHG RQGIVPGNRV 60
KLLIGPMQET ASSHEQPASG LMQQTFGQQK LYQVPNPQAA PRDTIYQVPP SYQNQGIYQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACACATACAT ATGCCACTCA CATCCGACGT GTGTGGTTGC TCAGTAGGGA AATGCTTACA 60
GCTGCCTCTA GAAGCAAGTC CGCTCGCTGC ATGGAGAGGG AAACATGAGC ATGCAGCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-0131--Cell cycle
KW-0132--Cell division
KW-0965--Cell junction
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0333--Golgi apparatus
KW-0341--Growth regulation
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR021901--CAS_DUF3513
IPR014928--Serine_rich
IPR001452--SH3_domain
IPR015224--Talin_cent

PROSITE

PS50002--SH3

Pfam

PF12026--DUF3513
PF08824--Serine_rich
PF14604--SH3_9

SMART

SM00326--SH3

Gene Ontology

GO:0005938--C:cell cortex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0030027--C:lamellipodium
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005819--C:spindle
GO:0000922--C:spindle pole
GO:0051017--P:actin filament bundle assembly
GO:0007155--P:cell adhesion
GO:0051301--P:cell division
GO:0007010--P:cytoskeleton organization
GO:0007229--P:integrin-mediated signaling pathway
GO:0007067--P:mitotic nuclear division
GO:0040008--P:regulation of growth
GO:0007165--P:signal transduction

KEGG

hsa:4739

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Mcc-054944	Macaca mulatta	95.35	2.00e-95	341.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence