iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.50e-13	51.4	37	100

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +D++l+v++++f+ahk+ LaasS++F+ +f  e e +  ++ + ++++ ++ f  ll+F+Ytg l 
   Q: 37   CDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIG--QSIYMLEGMVADTFGILLEFIYTGYLH 100
           8*****************************7766665..57777888****************886 PP

Organism

Homo sapiens

Functional Description
(View)

May be involved in BMP2-induced transcription.

Protein Sequence
(Fasta)

MAETSPEPSG QLVVHSDAHS DTVLASFEDQ RKKGFLCDIT LIVENVHFRA HKALLAASSE 60
YFSMMFAEEG EIGQSIYMLE GMVADTFGIL LEFIYTGYLH ASEKSTEQIL ATAQFLKVYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGCTTCCG GGTTGGCTGT GGCTGTGGCT GCGGCGGCGG CGCAGGAGCA GAAACCGGTG 60
CGGCGCAGAA GCCCCAGAGG CGGGCGGGGC GGAGCGGAGG GCCAGCGGGC CCCGGCGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:9841

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001722	Ailuropoda melanoleuca	85.93	0.00e+00	1118.00
IUUC-Apl-003854	Anas platyrhynchos	73.98	0.00e+00	913.00
IUUC-Ame-011090	Astyanax mexicanus	50.30	2.00e-168	586.00
IUUC-Bta-013015	Bos taurus	89.90	0.00e+00	1196.00
IUUC-Cja-019537	Callithrix jacchus	96.56	0.00e+00	1273.00
IUUC-Cfa-021048	Canis familiaris	87.72	0.00e+00	1146.00
IUUC-Cpo-021818	Cavia porcellus	89.02	0.00e+00	1114.00
IUUC-Csa-023709	Chlorocebus sabaeus	97.43	0.00e+00	1293.00
IUUC-Cho-024967	Choloepus hoffmanni	82.09	0.00e+00	984.00
IUUC-Dre-028277	Danio rerio	46.61	1.00e-152	533.00
IUUC-Dno-029444	Dasypus novemcinctus	89.81	0.00e+00	1206.00
IUUC-Dor-030792	Dipodomys ordii	91.12	0.00e+00	1229.00
IUUC-Ete-032398	Echinops telfairi	80.46	0.00e+00	999.00
IUUC-Eca-034254	Equus caballus	91.69	0.00e+00	1201.00
IUUC-Fca-035831	Felis catus	87.83	0.00e+00	1098.00
IUUC-Fal-037055	Ficedula albicollis	71.16	0.00e+00	832.00
IUUC-Gmo-039469	Gadus morhua	46.37	2.00e-144	506.00
IUUC-Gga-040581	Gallus gallus	72.07	0.00e+00	906.00
IUUC-Gac-041537	Gasterosteus aculeatus	49.85	2.00e-154	538.00
IUUC-Ggo-045494	Gorilla gorilla	99.00	0.00e+00	1273.00
IUUC-Itr-048173	Ictidomys tridecemlineatus	92.39	0.00e+00	1159.00
IUUC-Lch-050497	Latimeria chalumnae	55.30	2.00e-132	466.00
IUUC-Loc-052654	Lepisosteus oculatus	59.08	7.00e-160	557.00
IUUC-Laf-053350	Loxodonta africana	89.60	0.00e+00	1123.00
IUUC-Mcc-055866	Macaca mulatta	98.28	0.00e+00	1267.00
IUUC-Meu-056118	Macropus eugenii	73.83	4.00e-123	435.00
IUUC-Mga-060047	Meleagris gallopavo	71.05	0.00e+00	886.00
IUUC-Mmr-060588	Microcebus murinus	89.67	0.00e+00	1141.00
IUUC-Mdo-062336	Monodelphis domestica	80.61	0.00e+00	993.00
IUUC-Mmu-063926	Mus musculus	85.06	0.00e+00	1121.00
IUUC-Mpu-066822	Mustela putorius furo	86.49	0.00e+00	1063.00
IUUC-Mlu-067720	Myotis lucifugus	90.17	0.00e+00	1149.00
IUUC-Nle-070056	Nomascus leucogenys	99.00	0.00e+00	1277.00
IUUC-Opr-070424	Ochotona princeps	78.22	0.00e+00	990.00
IUUC-Ont-072021	Oreochromis niloticus	47.80	6.00e-172	597.00
IUUC-Oan-073359	Ornithorhynchus anatinus	76.24	2.00e-88	320.00
IUUC-Ocu-074138	Oryctolagus cuniculus	87.07	0.00e+00	1119.00
IUUC-Oga-088106	Otolemur garnettii	91.87	0.00e+00	1182.00
IUUC-Oar-089235	Ovis aries	93.03	0.00e+00	1278.00
IUUC-Ptr-090645	Pan troglodytes	99.70	0.00e+00	1263.00
IUUC-Pan-092161	Papio anubis	97.44	0.00e+00	1253.00
IUUC-Psi-093172	Pelodiscus sinensis	74.74	0.00e+00	916.00
IUUC-Pfo-096250	Poecilia formosa	55.33	6.00e-129	454.00
IUUC-Pab-098359	Pongo abelii	98.71	0.00e+00	1271.00
IUUC-Pva-103156	Pteropus vampyrus	92.12	0.00e+00	1264.00
IUUC-Rno-105441	Rattus norvegicus	86.13	0.00e+00	1148.00
IUUC-Sha-107110	Sarcophilus harrisii	76.69	0.00e+00	966.00
IUUC-Sar-113684	Sorex araneus	87.70	0.00e+00	1166.00
IUUC-Ssc-115999	Sus scrofa	91.40	0.00e+00	1252.00
IUUC-Tgu-116975	Taeniopygia guttata	70.86	0.00e+00	835.00
IUUC-Tru-117553	Takifugu rubripes	46.51	1.00e-159	556.00
IUUC-Tsy-119107	Tarsius syrichta	92.61	0.00e+00	644.00
IUUC-Tni-120348	Tetraodon nigroviridis	46.46	1.00e-141	497.00
IUUC-Tbe-127729	Tupaia belangeri	89.26	0.00e+00	1199.00
IUUC-Ttr-129257	Tursiops truncatus	92.55	0.00e+00	1226.00
IUUC-Vpa-130203	Vicugna pacos	91.73	0.00e+00	1171.00
IUUC-Xtr-131980	Xenopus tropicalis	45.52	7.00e-121	427.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence