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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045993
Ensembl Protein ID ENSP00000261942.6
UniProt Accession Q96CS3; O94963; Q8IUF2; Q9BRP2; Q9BVM7; FAF2_HUMAN
Genbank Protein ID BAC22491.1; AAH01069.2; AAH06145.2; AAH14001.2; BAA74910.1
Protein Name FAS-associated factor 2; Protein ETEA; UBX domain-containing protein 3B; UBX domain-containing protein 8
Genbank Nucleotide ID AB088120; BC001069; BC006145; BC014001; AB020694
Gene Name FAF2; ETEA; KIAA0887; UBXD8; UBXN3B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000113194.12 ENST00000510730.5 ENSP00000424146.1
ENSG00000113194.12 ENST00000261942.6 ENSP00000261942.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 18711132; 18775313; 23297223
ULD/UDP/UFD/UBX UBX 11243799; 22454508
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 1.60e-06 29.7 12 48
ULD/UDP/UFD/UBX 1.00e-16 62.9 358 439
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 2    ededkleqlve.MGF.dreealqaLraannnleaAve 36
           e+++kl q+++ +G+ + ++++  L+++n+n+eaAv 
   Q: 12   EQTEKLLQFQDlTGIeSMDQCRHTLEQHNWNIEAAVQ 48
           799********************************95 PP
   

   ULD/UDP/UFD/UBX
   S: 2    tteqatlqiRlpdGkrlvrkFpssttleqiyqfveyllvessdpFeLvspfPrrtlkpeehms.....tlqeagLvpsgsllv 79
           ++e++++ ++lp+++r++r+F+ s++l+ i++f+  +l+es ++F++ ++fPrr l +  +++     tlqeagL ++++l+v
   Q: 358  DPESVKIIFKLPNDSRVERRFHFSQSLTVIHDFLF-SLKESPEKFQIEANFPRRVLPCIPSEEwpnppTLQEAGLSHTEVLFV 439
           56799******************************.*************************99******************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223).
 Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223).
Protein Sequence
(Fasta)
MAAPEERDLT QEQTEKLLQF QDLTGIESMD QCRHTLEQHN WNIEAAVQDR LNEQEGVPSV 60
FNPPPSRPLQ VNTADHRIYS YVVSRPQPRG LLGWGYYLIM LPFRFTYYTI LDIFRFALRF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045993|UBD,UBA;ULD,UBX|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGCTAGTGC GGAGAGACAA GGCTCCAGGC ACGGAAAAGC AGATGCCGGG CCGGGGTTCC 60
AGCGCCGCAG TCACGGCGGT GGACGGCAAG CTGTGCGGAC GACTGGGGGC GCCATGAATG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045993|UBD,UBA;ULD,UBX|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0551--Lipid droplet
KW-1185--Reference proteome
KW-0834--Unfolded protein response
Interpro

IPR012336--Thioredoxin-like_fold
IPR006577--UAS
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom
IPR015943--WD40/YVTN_repeat-like_dom
PROSITE

PS50033--UBX
Pfam

PF00789--UBX
SMART

SM00594--UAS
Gene Ontology

GO:0035578--C:azurophil granule lumen
GO:0005783--C:endoplasmic reticulum
GO:0005576--C:extracellular region
GO:0005811--C:lipid particle
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0035473--F:lipase binding
GO:0055102--F:lipase inhibitor activity
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0034389--P:lipid particle organization
GO:0043312--P:neutrophil degranulation
GO:0006986--P:response to unfolded protein
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG hsa:23197
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000466 Aegilops tauschii 32.02 1.00e-21 97.80
IUUC-Aml-001491 Ailuropoda melanoleuca 97.29 0.00e+00 813.00
IUUC-Atr-002715 Amborella trichopoda 28.40 1.00e-28 120.00
IUUC-Apl-003340 Anas platyrhynchos 87.27 0.00e+00 752.00
IUUC-Aca-004296 Anolis carolinensis 91.26 0.00e+00 781.00
IUUC-Aly-006114 Arabidopsis lyrata 32.14 9.00e-17 81.60
IUUC-Ath-007354 Arabidopsis thaliana 31.21 4.00e-20 92.80
IUUC-Ago-007775 Ashbya gossypii 30.64 2.00e-12 67.40
IUUC-Acl-008096 Aspergillus clavatus 32.47 3.00e-26 113.00
IUUC-Afl-008447 Aspergillus flavus 32.16 2.00e-25 110.00
IUUC-Afu-008836 Aspergillus fumigatus 30.77 5.00e-25 109.00
IUUC-Ani-009247 Aspergillus nidulans 31.54 9.00e-25 108.00
IUUC-Ang-009721 Aspergillus niger 31.80 7.00e-26 112.00
IUUC-Aor-010080 Aspergillus oryzae 32.16 8.00e-25 108.00
IUUC-Ate-010379 Aspergillus terreus 33.46 1.00e-25 110.00
IUUC-Ame-010880 Astyanax mexicanus 78.60 0.00e+00 696.00
IUUC-Bgr-012032 Blumeria graminis 23.56 3.00e-20 93.20
IUUC-Bta-013187 Bos taurus 99.10 0.00e+00 840.00
IUUC-Bci-013871 Botrytis cinerea 28.62 1.00e-20 94.40
IUUC-Bdi-014964 Brachypodium distachyon 33.53 8.00e-21 95.10
IUUC-Bol-016064 Brassica oleracea 34.18 4.00e-21 96.30
IUUC-Bra-017693 Brassica rapa 32.56 5.00e-22 99.00
IUUC-Cel-018580 Caenorhabditis elegans 21.07 2.00e-04 40.80
IUUC-Cja-018867 Callithrix jacchus 93.24 0.00e+00 768.00
IUUC-Cfa-020467 Canis familiaris 99.78 0.00e+00 845.00
IUUC-Cpo-021987 Cavia porcellus 80.04 0.00e+00 714.00
IUUC-Cre-022908 Chlamydomonas reinhardtii 32.80 3.00e-17 83.20
IUUC-Csa-024081 Chlorocebus sabaeus 99.78 0.00e+00 845.00
IUUC-Cho-024488 Choloepus hoffmanni 99.10 0.00e+00 824.00
IUUC-Cin-025394 Ciona intestinalis 39.17 5.00e-61 228.00
IUUC-Csv-025919 Ciona savignyi 41.21 3.00e-66 245.00
IUUC-Cgl-026662 Colletotrichum gloeosporioides 29.44 3.00e-23 103.00
IUUC-Cne-027035 Cryptococcus neoformans 28.28 1.00e-06 48.50
IUUC-Cme-027217 Cyanidioschyzon merolae 24.01 2.00e-15 77.40
IUUC-Dre-028783 Danio rerio 83.60 0.00e+00 701.00
IUUC-Dno-029386 Dasypus novemcinctus 99.10 0.00e+00 832.00
IUUC-Dor-030740 Dipodomys ordii 75.58 1.00e-107 382.00
IUUC-Dse-031166 Dothistroma septosporum 30.56 1.00e-21 97.80
IUUC-Dme-031737 Drosophila melanogaster 42.86 9.00e-87 313.00
IUUC-Ete-033173 Echinops telfairi 98.65 0.00e+00 801.00
IUUC-Eca-033257 Equus caballus 98.88 0.00e+00 838.00
IUUC-Eeu-034927 Erinaceus europaeus 85.30 3.00e-148 518.00
IUUC-Fca-036165 Felis catus 99.78 0.00e+00 845.00
IUUC-Fal-037552 Ficedula albicollis 94.16 0.00e+00 807.00
IUUC-Fox-038042 Fusarium oxysporum 33.53 9.00e-23 101.00
IUUC-Fso-038157 Fusarium solani 29.61 6.00e-22 99.00
IUUC-Gmo-039281 Gadus morhua 84.27 0.00e+00 710.00
IUUC-Ggr-040025 Gaeumannomyces graminis 24.50 1.00e-16 81.30
IUUC-Gga-040656 Gallus gallus 94.38 0.00e+00 811.00
IUUC-Gac-041548 Gasterosteus aculeatus 83.82 0.00e+00 679.00
IUUC-Gma-043099 Glycine max 30.59 1.00e-19 90.90
IUUC-Ggo-044463 Gorilla gorilla 99.78 0.00e+00 845.00
IUUC-Hvu-047443 Hordeum vulgare 32.17 2.00e-16 79.70
IUUC-Itr-047969 Ictidomys tridecemlineatus 98.51 0.00e+00 726.00
IUUC-Kpa-049282 Komagataella pastoris 21.49 2.00e-17 84.00
IUUC-Lch-049899 Latimeria chalumnae 87.87 0.00e+00 728.00
IUUC-Lpe-050745 Leersia perrieri 35.76 9.00e-20 92.40
IUUC-Loc-052363 Lepisosteus oculatus 87.64 0.00e+00 762.00
IUUC-Lma-053279 Leptosphaeria maculans 29.79 5.00e-21 95.90
IUUC-Laf-054194 Loxodonta africana 96.79 0.00e+00 764.00
IUUC-Mcc-055811 Macaca mulatta 99.78 0.00e+00 845.00
IUUC-Meu-056391 Macropus eugenii 95.98 4.00e-99 355.00
IUUC-Mor-057016 Magnaporthe oryzae 25.95 9.00e-23 101.00
IUUC-Mpo-057383 Magnaporthe poae 30.06 2.00e-15 77.40
IUUC-Mtr-058297 Medicago truncatula 25.23 1.00e-26 114.00
IUUC-Mla-059091 Melampsora laricipopulina 29.39 3.00e-08 53.50
IUUC-Mga-059518 Meleagris gallopavo 94.35 0.00e+00 773.00
IUUC-Mvi-060414 Microbotryum violaceum 30.25 4.00e-10 60.50
IUUC-Mmr-061274 Microcebus murinus 99.33 0.00e+00 845.00
IUUC-Mdo-061873 Monodelphis domestica 94.68 0.00e+00 794.00
IUUC-Mmu-063992 Mus musculus 97.75 0.00e+00 832.00
IUUC-Mac-064544 Musa acuminata 32.50 2.00e-16 80.50
IUUC-Mpu-066089 Mustela putorius furo 99.55 0.00e+00 844.00
IUUC-Mlu-067041 Myotis lucifugus 99.10 0.00e+00 819.00
IUUC-Nfi-068382 Neosartorya fischeri 31.15 7.00e-25 108.00
IUUC-Ncr-068916 Neurospora crassa 31.14 1.00e-23 104.00
IUUC-Nle-069007 Nomascus leucogenys 99.53 0.00e+00 806.00
IUUC-Opr-070477 Ochotona princeps 88.09 0.00e+00 712.00
IUUC-Ont-072076 Oreochromis niloticus 87.42 0.00e+00 719.00
IUUC-Oan-073466 Ornithorhynchus anatinus 78.85 1.00e-164 572.00
IUUC-Ocu-073830 Oryctolagus cuniculus 99.33 0.00e+00 831.00
IUUC-Oba-075714 Oryza barthii 35.10 4.00e-19 90.50
IUUC-Obr-076861 Oryza brachyantha 33.53 9.00e-22 98.20
IUUC-Ogl-077668 Oryza glaberrima 26.44 5.00e-22 99.00
IUUC-Ogu-078916 Oryza glumaepatula 35.10 2.00e-19 90.50
IUUC-Oin-079308 Oryza indica 35.10 2.00e-19 90.10
IUUC-Olo-080935 Oryza longistaminata 35.34 3.00e-17 84.00
IUUC-Ome-081526 Oryza meridionalis 35.10 3.00e-19 89.70
IUUC-Oni-083120 Oryza nivara 35.10 2.00e-19 90.10
IUUC-Opu-084064 Oryza punctata 35.10 3.00e-19 90.10
IUUC-Oru-084948 Oryza rufipogon 35.10 2.00e-19 90.10
IUUC-Osa-086165 Oryza sativa 35.10 2.00e-19 90.10
IUUC-Ola-086916 Oryzias latipes 86.74 0.00e+00 714.00
IUUC-Olu-087751 Ostreococcus lucimarinus 26.39 1.00e-12 67.00
IUUC-Oga-088269 Otolemur garnettii 96.83 0.00e+00 790.00
IUUC-Oar-089219 Ovis aries 98.83 0.00e+00 805.00
IUUC-Ptr-090759 Pan troglodytes 99.78 0.00e+00 845.00
IUUC-Pan-092145 Papio anubis 99.78 0.00e+00 845.00
IUUC-Psi-093285 Pelodiscus sinensis 94.43 7.00e-163 566.00
IUUC-Pno-095142 Phaeosphaeria nodorum 32.40 8.00e-27 115.00
IUUC-Ppa-095784 Physcomitrella patens 24.10 7.00e-25 108.00
IUUC-Pfo-097425 Poecilia formosa 85.62 0.00e+00 719.00
IUUC-Pab-098443 Pongo abelii 99.78 0.00e+00 845.00
IUUC-Pop-099217 Populus trichocarpa 28.53 4.00e-35 142.00
IUUC-Pca-100699 Procavia capensis 79.21 1.00e-124 439.00
IUUC-Ppe-101800 Prunus persica 26.63 3.00e-26 112.00
IUUC-Pva-103145 Pteropus vampyrus 97.89 6.00e-142 497.00
IUUC-Pgr-103629 Puccinia graminis 28.39 3.00e-10 60.50
IUUC-Ptt-103793 Puccinia triticina 27.30 3.00e-14 73.90
IUUC-Pte-104225 Pyrenophora teres 33.95 1.00e-25 111.00
IUUC-Pyt-104700 Pyrenophora triticirepentis 33.76 1.00e-25 111.00
IUUC-Rno-106093 Rattus norvegicus 97.53 0.00e+00 830.00
IUUC-Sce-106313 Saccharomyces cerevisiae 29.48 2.00e-13 70.50
IUUC-Sha-106741 Sarcophilus harrisii 85.37 0.00e+00 646.00
IUUC-Sja-107815 Schizosaccharomyces japonicus 25.99 3.00e-15 76.30
IUUC-Spo-108055 Schizosaccharomyces pombe 25.72 1.00e-11 63.90
IUUC-Smo-109471 Selaginella moellendorffii 29.37 2.00e-20 94.00
IUUC-Sit-110718 Setaria italica 36.05 2.00e-20 93.60
IUUC-Sly-111335 Solanum lycopersicum 33.14 6.00e-23 102.00
IUUC-Stu-112406 Solanum tuberosum 34.39 1.00e-20 94.40
IUUC-Sar-113215 Sorex araneus 91.95 2.00e-180 624.00
IUUC-Sbi-114324 Sorghum bicolor 37.74 5.00e-23 102.00
IUUC-Sre-114905 Sporisorium reilianum 29.55 2.00e-12 67.80
IUUC-Ssc-116024 Sus scrofa 99.30 0.00e+00 809.00
IUUC-Tgu-117287 Taeniopygia guttata 94.61 0.00e+00 811.00
IUUC-Tru-118546 Takifugu rubripes 84.72 0.00e+00 686.00
IUUC-Tsy-119080 Tarsius syrichta 99.09 3.00e-133 468.00
IUUC-Tni-120327 Tetraodon nigroviridis 67.46 4.00e-159 554.00
IUUC-Tca-121139 Theobroma cacao 30.28 2.00e-20 94.00
IUUC-Tre-121891 Trichoderma reesei 32.26 5.00e-14 72.80
IUUC-Tvi-122596 Trichoderma virens 27.64 1.00e-21 98.20
IUUC-Tae-125206 Triticum aestivum 34.50 8.00e-23 101.00
IUUC-Tur-126427 Triticum urartu 33.33 9.00e-17 80.50
IUUC-Tme-126896 Tuber melanosporum 38.55 7.00e-26 112.00
IUUC-Tbe-127474 Tupaia belangeri 85.38 0.00e+00 714.00
IUUC-Ttr-128455 Tursiops truncatus 87.64 0.00e+00 746.00
IUUC-Uma-129503 Ustilago maydis 32.17 8.00e-09 55.50
IUUC-Vda-129700 Verticillium dahliae 28.25 2.00e-25 110.00
IUUC-Vpa-130516 Vicugna pacos 89.21 0.00e+00 708.00
IUUC-Vvi-131232 Vitis vinifera 31.32 1.00e-27 118.00
IUUC-Xtr-132664 Xenopus tropicalis 84.94 0.00e+00 705.00
IUUC-Xma-133998 Xiphophorus maculatus 86.29 0.00e+00 723.00
IUUC-Yli-134397 Yarrowia lipolytica 29.07 7.00e-24 105.00
IUUC-Zma-134832 Zea mays 36.42 2.00e-20 94.00
Created Date 25-Jun-2017

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