iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045801

UUCD1 version

UUC-HoS-00068

Ensembl Protein ID

ENSP00000231524.9

UniProt Accession

P36406; Q9BZY4; Q9BZY5; TRI23_HUMAN

Genbank Protein ID

AAA35940.1; AAG50176.1; AAG50177.1; AAG50178.1; AAH22510.1

Protein Name

E3 ubiquitin-protein ligase TRIM23; ADP-ribosylation factor domain-containing protein 1; GTP-binding protein ARD-1; RING finger protein 46; RING-type E3 ubiquitin transferase TRIM23; Tripartite motif-containing protein 23

Genbank Nucleotide ID

L04510; AF230397; AF230398; AF230399; BC022510

Gene Name

TRIM23; ARD1; ARFD1; RNF46

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000113595.14	ENST00000231524.13	ENSP00000231524.9
ENSG00000113595.14	ENST00000381018.7	ENSP00000370406.3
ENSG00000113595.14	ENST00000274327.11	ENSP00000274327.7
ENSG00000113595.14	ENST00000506400.1	ENSP00000427103.1
ENSG00000113595.14	ENST00000505205.1	ENSP00000424044.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID
DNA Methylation
MethyCancer
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	15684077; 18398435; 20724660; 25905670

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00041	22.5	31	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf....kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C + f    ++ p++l CgH+ ++dCl ++     +  +++rCP +r
   Q: 31   CGVCEDVFslqgDKVPRLLLCGHTVCHDCLTRL----PLHGRAIRCPFDR 76
           999*99889998888***************999....6678999***876 PP

Organism

Homo sapiens

Functional Description
(View)

Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.

Protein Sequence
(Fasta)

MATLVVNKLG AGVDSGRQGS RGTAVVKVLE CGVCEDVFSL QGDKVPRLLL CGHTVCHDCL 60
TRLPLHGRAI RCPFDRQVTD LGDSGVWGLK KNFALLELLE RLQNGPIGQY GAAEESIGIS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGACTACA TCATAATGGG AAGGATAAGG CGTTCCTCAA AATGGATGCC ATAAGTAAAG 60
TAAGCGCAAT TCAATTGAAC CCGAATGTTT ATTGAGCATT TCCTCAGCTC ATTCAAGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0342--GTP-binding
KW-0945--Host-virus interaction
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003649--Bbox_C
IPR027417--P-loop_NTPase
IPR005225--Small_GTP-bd_dom
IPR024156--Small_GTPase_ARF
IPR006689--Small_GTPase_ARF/SAR
IPR000315--Znf_B-box
IPR013087--Znf_C2H2_type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51417--ARF
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00025--Arf
PF00643--zf-B_box
PF14634--zf-RING_5

PRINTS

PR00328--SAR1GTPBP

SMART

SM00502--BBC
SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0000139--C:Golgi membrane
GO:0005765--C:lysosomal membrane
GO:0005634--C:nucleus
GO:0008047--F:enzyme activator activity
GO:0019003--F:GDP binding
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0042802--F:identical protein binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination
GO:0007264--P:small GTPase mediated signal transduction
GO:0016032--P:viral process

KEGG

hsa:373

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001685	Ailuropoda melanoleuca	97.74	0.00e+00	1125.00
IUUC-Apl-003280	Anas platyrhynchos	94.58	0.00e+00	1092.00
IUUC-Aca-004587	Anolis carolinensis	92.04	0.00e+00	1006.00
IUUC-Ame-010760	Astyanax mexicanus	88.31	0.00e+00	1048.00
IUUC-Bta-013139	Bos taurus	95.16	0.00e+00	1097.00
IUUC-Cel-018197	Caenorhabditis elegans	36.16	2.00e-95	342.00
IUUC-Cja-019407	Callithrix jacchus	99.65	0.00e+00	1144.00
IUUC-Cfa-020758	Canis familiaris	97.19	0.00e+00	1109.00
IUUC-Cpo-022050	Cavia porcellus	97.04	0.00e+00	1150.00
IUUC-Csa-023938	Chlorocebus sabaeus	100.00	0.00e+00	1147.00
IUUC-Cho-024793	Choloepus hoffmanni	76.02	0.00e+00	741.00
IUUC-Cin-025424	Ciona intestinalis	56.79	0.00e+00	635.00
IUUC-Csv-025949	Ciona savignyi	55.77	3.00e-179	621.00
IUUC-Dre-028835	Danio rerio	87.83	0.00e+00	1045.00
IUUC-Dno-029080	Dasypus novemcinctus	88.49	0.00e+00	1019.00
IUUC-Dor-031092	Dipodomys ordii	90.59	0.00e+00	1058.00
IUUC-Ete-033169	Echinops telfairi	83.97	0.00e+00	944.00
IUUC-Eca-033509	Equus caballus	98.08	0.00e+00	1129.00
IUUC-Eeu-034669	Erinaceus europaeus	99.12	6.00e-132	464.00
IUUC-Fca-035813	Felis catus	97.74	0.00e+00	1125.00
IUUC-Fal-037222	Ficedula albicollis	95.99	0.00e+00	1102.00
IUUC-Gmo-038996	Gadus morhua	87.65	0.00e+00	1040.00
IUUC-Gga-040181	Gallus gallus	93.43	0.00e+00	1114.00
IUUC-Gac-041763	Gasterosteus aculeatus	86.96	0.00e+00	1031.00
IUUC-Ggo-044808	Gorilla gorilla	94.10	0.00e+00	1081.00
IUUC-Itr-048568	Ictidomys tridecemlineatus	97.74	0.00e+00	1125.00
IUUC-Lch-049531	Latimeria chalumnae	91.32	0.00e+00	1058.00
IUUC-Loc-052929	Lepisosteus oculatus	90.21	0.00e+00	1053.00
IUUC-Laf-053593	Loxodonta africana	97.56	0.00e+00	1123.00
IUUC-Mcc-055065	Macaca mulatta	100.00	0.00e+00	1147.00
IUUC-Meu-056372	Macropus eugenii	98.67	1.00e-130	460.00
IUUC-Mga-059665	Meleagris gallopavo	94.35	0.00e+00	954.00
IUUC-Mmr-061643	Microcebus murinus	97.74	0.00e+00	1124.00
IUUC-Mdo-062624	Monodelphis domestica	92.97	0.00e+00	1107.00
IUUC-Mmu-064210	Mus musculus	97.74	0.00e+00	1156.00
IUUC-Mpu-066292	Mustela putorius furo	97.64	0.00e+00	1082.00
IUUC-Mlu-066952	Myotis lucifugus	97.56	0.00e+00	1123.00
IUUC-Nle-069002	Nomascus leucogenys	100.00	0.00e+00	1147.00
IUUC-Opr-070405	Ochotona princeps	87.28	0.00e+00	1019.00
IUUC-Ont-071487	Oreochromis niloticus	88.00	0.00e+00	1041.00
IUUC-Oan-073274	Ornithorhynchus anatinus	95.95	0.00e+00	987.00
IUUC-Ocu-074788	Oryctolagus cuniculus	97.39	0.00e+00	1119.00
IUUC-Ola-086339	Oryzias latipes	86.11	0.00e+00	1030.00
IUUC-Oga-089037	Otolemur garnettii	97.74	0.00e+00	1123.00
IUUC-Oar-089458	Ovis aries	97.32	0.00e+00	1096.00
IUUC-Pan-092120	Papio anubis	99.31	0.00e+00	1134.00
IUUC-Psi-093157	Pelodiscus sinensis	91.54	0.00e+00	1091.00
IUUC-Pfo-096904	Poecilia formosa	88.87	0.00e+00	1033.00
IUUC-Pab-098358	Pongo abelii	100.00	0.00e+00	1147.00
IUUC-Pva-102674	Pteropus vampyrus	95.82	0.00e+00	1100.00
IUUC-Rno-105352	Rattus norvegicus	97.74	0.00e+00	1156.00
IUUC-Sha-106532	Sarcophilus harrisii	86.89	1.00e-61	228.00
IUUC-Sar-113483	Sorex araneus	95.29	2.00e-149	522.00
IUUC-Ssc-116170	Sus scrofa	97.56	0.00e+00	1123.00
IUUC-Tgu-116968	Taeniopygia guttata	92.70	0.00e+00	1092.00
IUUC-Tru-118246	Takifugu rubripes	88.73	0.00e+00	1032.00
IUUC-Tni-120692	Tetraodon nigroviridis	89.25	0.00e+00	1028.00
IUUC-Ttr-128956	Tursiops truncatus	97.91	0.00e+00	1126.00
IUUC-Vpa-130291	Vicugna pacos	90.94	0.00e+00	1063.00
IUUC-Xtr-132331	Xenopus tropicalis	91.08	0.00e+00	916.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence