iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.50e-09	38.1	33	96

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvg.geeffahkivLaasSsvFyalf.lmeleesksklmveikdvqpevfrallkFlYtgk 64
           aD ++v++ +++ +ahk+vLaa+S+  ++l+ +++l++   + +v + dv +++f+ ll+FlY+g+
   Q: 33   ADLTIVCEnKVKLHAHKLVLAAASPLIRNLLeDTHLSDC--STTVYFPDVNATYFKFLLDFLYSGQ 96
           688999999**********************55555566..79999*******************8 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Transcription factor required for terminalia development. Negative regulator of the JAK/STAT pathway: represses JAK/STAT-dependent expression of ventral veins lacking (vvl) in the posterior spiracles.

Protein Sequence
(Fasta)

MKEFQRMLML QYSKHGECIL KEIGAAFRGE HPADLTIVCE NKVKLHAHKL VLAAASPLIR 60
NLLEDTHLSD CSTTVYFPDV NATYFKFLLD FLYSGQTCIT SRDVNYLHDL LLLLQIKSDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCACAGTCAA AAAAAAAGGC TCCGAGTGAA CGGACGTGCG CGCGCGCAAA CTGAAAGTGT 60
AAGCACAAAC AGAGCGAAGC AAAGCAAGGC AAAAGCAAAA GCAGAAGCTG AAATCGAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0007620--P:copulation
GO:0045497--P:female analia development
GO:0030540--P:female genitalia development
GO:0007320--P:insemination
GO:0045496--P:male analia development
GO:0030539--P:male genitalia development
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006909--P:phagocytosis
GO:0046425--P:regulation of JAK-STAT cascade
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

dme:Dmel_CG5575

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001625	Ailuropoda melanoleuca	41.51	2.00e-14	73.60
IUUC-Afl-008695	Aspergillus flavus	33.85	1.30e-02	33.10
IUUC-Aor-010003	Aspergillus oryzae	33.85	5.00e-03	34.30
IUUC-Csa-023942	Chlorocebus sabaeus	41.51	3.00e-14	73.20
IUUC-Cho-024599	Choloepus hoffmanni	41.35	9.00e-15	74.30
IUUC-Cin-025470	Ciona intestinalis	40.43	7.00e-15	75.50
IUUC-Dre-027466	Danio rerio	34.19	4.00e-15	75.90
IUUC-Eca-034377	Equus caballus	41.35	4.00e-15	75.90
IUUC-Fox-037766	Fusarium oxysporum	41.94	4.00e-01	29.60
IUUC-Gmo-039515	Gadus morhua	41.35	8.00e-15	73.90
IUUC-Ggo-044500	Gorilla gorilla	41.51	3.00e-14	73.20
IUUC-Hsa-046648	Homo sapiens	41.35	4.00e-15	75.90
IUUC-Laf-053636	Loxodonta africana	41.51	1.00e-14	74.30
IUUC-Mcc-055290	Macaca mulatta	41.35	4.00e-15	75.90
IUUC-Mmu-063292	Mus musculus	41.35	4.00e-15	75.90
IUUC-Mlu-067370	Myotis lucifugus	41.35	4.00e-15	75.90
IUUC-Nle-069870	Nomascus leucogenys	41.35	4.00e-15	75.90
IUUC-Ocu-073970	Oryctolagus cuniculus	41.35	4.00e-15	75.90
IUUC-Ola-087102	Oryzias latipes	41.35	3.00e-15	76.30
IUUC-Oga-088873	Otolemur garnettii	41.51	3.00e-14	73.20
IUUC-Ptr-090628	Pan troglodytes	41.35	4.00e-15	75.90
IUUC-Pno-094901	Phaeosphaeria nodorum	27.45	1.90e-02	32.00
IUUC-Pab-098012	Pongo abelii	41.35	4.00e-15	75.90
IUUC-Pca-100127	Procavia capensis	41.35	3.00e-15	76.30
IUUC-Sha-107259	Sarcophilus harrisii	41.51	2.00e-14	73.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence