iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053636

Ensembl Protein ID

ENSLAFP00000010278.2

UniProt Accession

G3T952; G3T952_LOXAF

Protein Name

Uncharacterized protein

Gene Name

BCL6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000012300.2	ENSLAFT00000012295.2	ENSLAFP00000010278.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	4.10e-14	53.0	32	98

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.dvqpevfrallkFlYtgklden 68
           +Dv++vv +e+f+ahk vL+a+S  Fy+ f+ +l+ +   + ++++ ++ pe f  ll+F+Yt++l++ 
   Q: 32   TDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCN--LSVINLDpEINPEGFCILLDFMYTSRLNLR 98
           7**********************************76..699999988*****************9875 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI 60
FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCTCGC CGGCGGACAG TTGTATCCAG TTCACCCGCC ATGCCAGTGA TGTTCTTCTC 60
AACCTTAACC GCCTCCGGAG CCGTGACATC TTGACTGATG TTGTCATTGT GGTGAGCCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0005657--C:replication fork
GO:0031490--F:chromatin DNA binding
GO:0001161--F:intronic transcription regulatory region sequence-specific DNA binding
GO:0046872--F:metal ion binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0030036--P:actin cytoskeleton organization
GO:0030183--P:B cell differentiation
GO:0000902--P:cell morphogenesis
GO:0006974--P:cellular response to DNA damage stimulus
GO:0048821--P:erythrocyte development
GO:0002467--P:germinal center formation
GO:0043066--P:negative regulation of apoptotic process
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0001953--P:negative regulation of cell-matrix adhesion
GO:2000773--P:negative regulation of cellular senescence
GO:0048294--P:negative regulation of isotype switching to IgE isotypes
GO:0032764--P:negative regulation of mast cell cytokine production
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0045629--P:negative regulation of T-helper 2 cell differentiation
GO:0043065--P:positive regulation of apoptotic process
GO:0030890--P:positive regulation of B cell proliferation
GO:0051272--P:positive regulation of cellular component movement
GO:0031065--P:positive regulation of histone deacetylation
GO:0045666--P:positive regulation of neuron differentiation
GO:0000060--P:protein import into nucleus, translocation
GO:0043087--P:regulation of GTPase activity
GO:0050727--P:regulation of inflammatory response
GO:0043380--P:regulation of memory T cell differentiation
GO:0007266--P:Rho protein signal transduction
GO:0007283--P:spermatogenesis
GO:0042092--P:type 2 immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001625	Ailuropoda melanoleuca	95.48	0.00e+00	1366.00
IUUC-Apl-003263	Anas platyrhynchos	77.42	0.00e+00	1123.00
IUUC-Ame-010714	Astyanax mexicanus	58.79	0.00e+00	797.00
IUUC-Bta-012576	Bos taurus	95.76	0.00e+00	1343.00
IUUC-Cja-018906	Callithrix jacchus	94.63	0.00e+00	1364.00
IUUC-Cfa-021058	Canis familiaris	93.90	0.00e+00	1335.00
IUUC-Cpo-022328	Cavia porcellus	94.07	0.00e+00	1361.00
IUUC-Csa-023942	Chlorocebus sabaeus	95.34	0.00e+00	1380.00
IUUC-Cho-024599	Choloepus hoffmanni	91.38	0.00e+00	780.00
IUUC-Cin-025470	Ciona intestinalis	77.34	8.00e-60	225.00
IUUC-Csv-025860	Ciona savignyi	79.69	8.00e-60	225.00
IUUC-Dre-027605	Danio rerio	60.22	0.00e+00	819.00
IUUC-Dno-029476	Dasypus novemcinctus	88.89	0.00e+00	1301.00
IUUC-Dor-030724	Dipodomys ordii	93.79	0.00e+00	1324.00
IUUC-Dme-031902	Drosophila melanogaster	42.39	6.00e-14	72.40
IUUC-Ete-032678	Echinops telfairi	91.81	0.00e+00	1290.00
IUUC-Eca-034377	Equus caballus	95.62	0.00e+00	1367.00
IUUC-Eeu-034532	Erinaceus europaeus	85.92	0.00e+00	1235.00
IUUC-Fca-036465	Felis catus	95.76	0.00e+00	1367.00
IUUC-Fal-036977	Ficedula albicollis	77.73	0.00e+00	1145.00
IUUC-Gmo-039515	Gadus morhua	82.13	9.00e-112	396.00
IUUC-Gga-040505	Gallus gallus	77.70	0.00e+00	1129.00
IUUC-Gac-041393	Gasterosteus aculeatus	58.78	0.00e+00	795.00
IUUC-Gma-043945	Glycine max	32.58	8.00e-05	42.40
IUUC-Ggo-044500	Gorilla gorilla	95.48	0.00e+00	1384.00
IUUC-Hsa-046648	Homo sapiens	95.06	0.00e+00	1375.00
IUUC-Itr-048732	Ictidomys tridecemlineatus	91.24	0.00e+00	1305.00
IUUC-Lch-050387	Latimeria chalumnae	57.70	0.00e+00	747.00
IUUC-Loc-052103	Lepisosteus oculatus	61.79	0.00e+00	848.00
IUUC-Mcc-055290	Macaca mulatta	95.20	0.00e+00	1372.00
IUUC-Meu-055910	Macropus eugenii	79.55	0.00e+00	1162.00
IUUC-Mga-059925	Meleagris gallopavo	77.28	0.00e+00	1116.00
IUUC-Mmr-060855	Microcebus murinus	95.90	0.00e+00	1368.00
IUUC-Mmu-063292	Mus musculus	93.37	0.00e+00	1311.00
IUUC-Mpu-066598	Mustela putorius furo	95.34	0.00e+00	1340.00
IUUC-Mlu-067370	Myotis lucifugus	93.80	0.00e+00	1319.00
IUUC-Nle-069870	Nomascus leucogenys	95.06	0.00e+00	1373.00
IUUC-Opr-070986	Ochotona princeps	90.96	0.00e+00	1276.00
IUUC-Ont-072475	Oreochromis niloticus	59.39	0.00e+00	764.00
IUUC-Oan-073596	Ornithorhynchus anatinus	83.61	0.00e+00	1183.00
IUUC-Ocu-073970	Oryctolagus cuniculus	93.80	0.00e+00	1363.00
IUUC-Ola-087102	Oryzias latipes	59.53	0.00e+00	800.00
IUUC-Oga-088873	Otolemur garnettii	95.20	0.00e+00	1379.00
IUUC-Oar-090083	Ovis aries	90.40	0.00e+00	1246.00
IUUC-Ptr-090628	Pan troglodytes	95.34	0.00e+00	1378.00
IUUC-Pan-092324	Papio anubis	94.77	0.00e+00	1368.00
IUUC-Psi-093695	Pelodiscus sinensis	78.96	0.00e+00	1101.00
IUUC-Pfo-096460	Poecilia formosa	58.30	0.00e+00	786.00
IUUC-Pab-098012	Pongo abelii	95.20	0.00e+00	1377.00
IUUC-Pca-100127	Procavia capensis	95.16	0.00e+00	1274.00
IUUC-Pva-102830	Pteropus vampyrus	93.79	0.00e+00	1331.00
IUUC-Rno-105752	Rattus norvegicus	93.51	0.00e+00	1312.00
IUUC-Sha-107259	Sarcophilus harrisii	82.77	0.00e+00	1199.00
IUUC-Sar-113610	Sorex araneus	90.88	0.00e+00	1048.00
IUUC-Ssc-115327	Sus scrofa	94.77	0.00e+00	1353.00
IUUC-Tgu-116457	Taeniopygia guttata	78.40	0.00e+00	1154.00
IUUC-Tru-118520	Takifugu rubripes	58.92	0.00e+00	792.00
IUUC-Tni-119969	Tetraodon nigroviridis	59.14	0.00e+00	783.00
IUUC-Tbe-127327	Tupaia belangeri	89.12	0.00e+00	1259.00
IUUC-Ttr-129204	Tursiops truncatus	92.94	0.00e+00	1301.00
IUUC-Xtr-132937	Xenopus tropicalis	65.96	0.00e+00	889.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence