iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000114125.13	ENST00000273480.3	ENSP00000273480.3
ENSG00000114125.13	ENST00000480908.1	ENSP00000419084.1
ENSG00000114125.13	ENST00000393000.3	ENSP00000376725.3
ENSG00000114125.13	ENST00000477012.5	ENSP00000419339.1
ENSG00000114125.13	ENST00000477393.1	ENSP00000419979.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18258608; 20103673; 18258608; 19325126

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	9.90e-05	24.5	50	103

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..............kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+                 ++ ++ + C+H fh  C   w       +++ rCPlC+
   Q: 50   CAICRVQVmdaclrcqaenkqeDCVVVWGECNHSFHNCCMSLW------VKQNNRCPLCQ 103
           999966554444555555554333466688*************......**********7 PP

Organism

Homo sapiens

Functional Description
(View)

Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.

Protein Sequence
(Fasta)

MADVEDGEET CALASHSGSS GSKSGGDKMF SLKKWNAVAM WSWDVECDTC AICRVQVMDA 60
CLRCQAENKQ EDCVVVWGEC NHSFHNCCMS LWVKQNNRCP LCQQDWVVQR IGK 113

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCAGCCGG GGTCTAGGCA CCACGGTGGC TGGCGGCCTG CGGGCGGCGC TGTGGCCCGT 60
CGGGCGGCTC CACAGAGCCG CCCTAGCCTT CCGCCTTCCC CAAGCCAACG TCTCCGCCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR024766--Znf_RING_H2

PROSITE

PS50089--ZF_RING_2

Pfam

PF12678--zf-rbx1

Gene Ontology

GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005507--F:copper ion binding
GO:0097602--F:cullin family protein binding
GO:0019788--F:NEDD8 transferase activity
GO:0008270--F:zinc ion binding
GO:0045116--P:protein neddylation
GO:0016567--P:protein ubiquitination
GO:0051775--P:response to redox state

KEGG

hsa:9616

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001959	Ailuropoda melanoleuca	97.25	7.00e-50	188.00
IUUC-Apl-003554	Anas platyrhynchos	96.49	1.00e-28	117.00
IUUC-Aca-004651	Anolis carolinensis	84.48	2.00e-48	184.00
IUUC-Ame-010935	Astyanax mexicanus	100.00	7.00e-47	178.00
IUUC-Bta-013315	Bos taurus	97.35	5.00e-52	195.00
IUUC-Cel-018286	Caenorhabditis elegans	68.97	9.00e-34	134.00
IUUC-Cja-019230	Callithrix jacchus	98.23	8.00e-51	191.00
IUUC-Cfa-020188	Canis familiaris	96.46	1.00e-51	194.00
IUUC-Cpo-021681	Cavia porcellus	96.46	5.00e-52	195.00
IUUC-Csa-023305	Chlorocebus sabaeus	100.00	3.00e-53	199.00
IUUC-Cho-024539	Choloepus hoffmanni	94.69	7.00e-50	188.00
IUUC-Cin-025216	Ciona intestinalis	82.56	3.00e-40	155.00
IUUC-Csv-026356	Ciona savignyi	85.53	2.00e-36	143.00
IUUC-Dre-027952	Danio rerio	92.04	2.00e-48	183.00
IUUC-Dno-029920	Dasypus novemcinctus	95.58	4.00e-50	189.00
IUUC-Dme-031722	Drosophila melanogaster	81.52	1.00e-40	157.00
IUUC-Ete-033111	Echinops telfairi	74.34	1.00e-36	144.00
IUUC-Eca-034329	Equus caballus	96.51	1.00e-44	170.00
IUUC-Fal-037052	Ficedula albicollis	97.75	1.00e-47	180.00
IUUC-Gmo-038573	Gadus morhua	90.18	4.00e-48	182.00
IUUC-Gga-040409	Gallus gallus	85.96	2.00e-50	190.00
IUUC-Gac-041808	Gasterosteus aculeatus	89.29	4.00e-48	182.00
IUUC-Ggo-045314	Gorilla gorilla	100.00	3.00e-53	199.00
IUUC-Itr-048540	Ictidomys tridecemlineatus	95.58	2.00e-51	193.00
IUUC-Lch-049958	Latimeria chalumnae	91.15	4.00e-49	186.00
IUUC-Loc-052481	Lepisosteus oculatus	90.27	1.00e-48	184.00
IUUC-Laf-054260	Loxodonta africana	94.69	2.00e-49	187.00
IUUC-Mcc-055092	Macaca mulatta	85.84	2.00e-41	159.00
IUUC-Meu-056081	Macropus eugenii	91.89	3.00e-28	116.00
IUUC-Mga-059532	Meleagris gallopavo	91.80	1.00e-28	117.00
IUUC-Mmr-061775	Microcebus murinus	84.07	7.00e-39	151.00
IUUC-Mdo-062083	Monodelphis domestica	94.69	4.00e-50	189.00
IUUC-Mmu-063421	Mus musculus	96.46	2.00e-51	194.00
IUUC-Mpu-066010	Mustela putorius furo	97.35	5.00e-52	195.00
IUUC-Mlu-067975	Myotis lucifugus	96.49	1.00e-28	117.00
IUUC-Nle-069723	Nomascus leucogenys	100.00	3.00e-53	199.00
IUUC-Opr-070339	Ochotona princeps	96.46	6.00e-54	201.00
IUUC-Ont-072072	Oreochromis niloticus	90.18	2.00e-49	186.00
IUUC-Oan-073574	Ornithorhynchus anatinus	85.09	4.00e-47	179.00
IUUC-Ola-087260	Oryzias latipes	87.50	5.00e-49	185.00
IUUC-Oga-089038	Otolemur garnettii	96.46	8.00e-51	191.00
IUUC-Oar-089945	Ovis aries	97.35	5.00e-52	195.00
IUUC-Ptr-091040	Pan troglodytes	100.00	3.00e-53	199.00
IUUC-Pan-092693	Papio anubis	100.00	3.00e-53	199.00
IUUC-Psi-093633	Pelodiscus sinensis	100.00	3.00e-47	179.00
IUUC-Pfo-096440	Poecilia formosa	91.07	5.00e-48	182.00
IUUC-Pab-098277	Pongo abelii	100.00	3.00e-53	199.00
IUUC-Pva-102548	Pteropus vampyrus	96.46	1.00e-51	194.00
IUUC-Rno-105855	Rattus norvegicus	96.46	2.00e-51	194.00
IUUC-Sha-107430	Sarcophilus harrisii	94.69	4.00e-50	189.00
IUUC-Sar-112957	Sorex araneus	85.84	3.00e-47	179.00
IUUC-Ssc-115606	Sus scrofa	86.15	2.00e-18	83.60
IUUC-Tgu-116519	Taeniopygia guttata	90.32	4.00e-29	119.00
IUUC-Tru-117658	Takifugu rubripes	85.09	3.00e-48	182.00
IUUC-Tsy-119251	Tarsius syrichta	97.35	8.00e-51	191.00
IUUC-Tni-120364	Tetraodon nigroviridis	87.61	3.00e-48	183.00
IUUC-Tbe-127256	Tupaia belangeri	84.07	1.00e-38	150.00
IUUC-Ttr-129140	Tursiops truncatus	97.35	5.00e-52	195.00
IUUC-Vpa-130670	Vicugna pacos	96.55	4.00e-44	168.00
IUUC-Xtr-132382	Xenopus tropicalis	100.00	3.00e-46	176.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence