iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/Other	E3 activity/Other	17293853; 19176998; 21374733

Organism

Homo sapiens

Functional Description
(View)

Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.

Protein Sequence
(Fasta)

MSEAGGAGPG GCGAGAGAGA GPGALPPQPA ALPPAPPQGS PCAAAAGGSG ACGPATAVAA 60
AGTAEGPGGG GSARIAVKKA QLRSAPRAKK LEKLGVYSAC KAEESCKCNG WKNPNPSPTP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCGGGCAG CGGAAAAGAG GCCGTGGGGG GCCTCCCAGC GCTGGCAGAC ACCGTGAGGC 60
TGGCAGCCGC CGGCACGCAC ACCTAGTCCG CAGTCCCGAG GAACATGTCC GCAGCCAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0012--Acyltransferase
KW-0090--Biological rhythms
KW-0103--Bromodomain
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0945--Host-virus interaction
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase

Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR016376--GCN5/PCAF
IPR000182--GNAT_dom
IPR009464--PCAF_N

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51186--GNAT

Pfam

PF00583--Acetyltransf_1
PF00439--Bromodomain
PF06466--PCAF_N

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO

Gene Ontology

GO:0031672--C:A band
GO:0042641--C:actomyosin
GO:0005671--C:Ada2/Gcn5/Ada3 transcription activator complex
GO:0031674--C:I band
GO:0000776--C:kinetochore
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000125--C:PCAF complex
GO:0016407--F:acetyltransferase activity
GO:0003682--F:chromatin binding
GO:0004861--F:cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0004402--F:histone acetyltransferase activity
GO:0042826--F:histone deacetylase binding
GO:0004468--F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO:0032403--F:protein complex binding
GO:0019901--F:protein kinase binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003713--F:transcription coactivator activity
GO:0003712--F:transcription cofactor activity
GO:0008134--F:transcription factor binding
GO:0007050--P:cell cycle arrest
GO:0032869--P:cellular response to insulin stimulus
GO:0006338--P:chromatin remodeling
GO:0043966--P:histone H3 acetylation
GO:0043970--P:histone H3-K9 acetylation
GO:0018393--P:internal peptidyl-lysine acetylation
GO:0018076--P:N-terminal peptidyl-lysine acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007219--P:Notch signaling pathway
GO:0018394--P:peptidyl-lysine acetylation
GO:0045815--P:positive regulation of gene expression, epigenetic
GO:0035948--P:positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006473--P:protein acetylation
GO:0016579--P:protein deubiquitination
GO:0010835--P:regulation of protein ADP-ribosylation
GO:0048511--P:rhythmic process
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0016032--P:viral process

KEGG

hsa:8850

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001599	Ailuropoda melanoleuca	96.35	0.00e+00	1383.00
IUUC-Atr-003130	Amborella trichopoda	41.80	9.00e-88	317.00
IUUC-Apl-004026	Anas platyrhynchos	91.80	0.00e+00	1304.00
IUUC-Aly-006486	Arabidopsis lyrata	43.36	4.00e-76	279.00
IUUC-Ath-006763	Arabidopsis thaliana	43.51	1.00e-76	280.00
IUUC-Ago-007819	Ashbya gossypii	48.31	3.00e-87	315.00
IUUC-Acl-008194	Aspergillus clavatus	44.89	5.00e-81	295.00
IUUC-Afl-008546	Aspergillus flavus	44.60	2.00e-81	296.00
IUUC-Afu-009124	Aspergillus fumigatus	45.45	2.00e-82	299.00
IUUC-Ani-009432	Aspergillus nidulans	43.81	1.00e-76	280.00
IUUC-Ang-009824	Aspergillus niger	45.45	2.00e-82	299.00
IUUC-Aor-010076	Aspergillus oryzae	43.73	4.00e-79	288.00
IUUC-Bgr-012003	Blumeria graminis	42.60	3.00e-76	278.00
IUUC-Bta-012381	Bos taurus	95.03	0.00e+00	1416.00
IUUC-Bci-013974	Botrytis cinerea	45.95	6.00e-83	301.00
IUUC-Bdi-015016	Brachypodium distachyon	44.51	4.00e-84	305.00
IUUC-Cel-018633	Caenorhabditis elegans	48.09	1.00e-85	311.00
IUUC-Cja-019375	Callithrix jacchus	98.62	0.00e+00	1377.00
IUUC-Cfa-020400	Canis familiaris	92.03	0.00e+00	1292.00
IUUC-Cpo-021686	Cavia porcellus	98.36	0.00e+00	1441.00
IUUC-Cre-023019	Chlamydomonas reinhardtii	55.98	3.00e-53	202.00
IUUC-Csa-024252	Chlorocebus sabaeus	99.56	0.00e+00	1333.00
IUUC-Cho-024635	Choloepus hoffmanni	94.61	0.00e+00	996.00
IUUC-Cgl-026660	Colletotrichum gloeosporioides	44.60	7.00e-77	281.00
IUUC-Cne-027050	Cryptococcus neoformans	44.83	5.00e-71	262.00
IUUC-Dre-027468	Danio rerio	82.14	0.00e+00	1218.00
IUUC-Dno-029306	Dasypus novemcinctus	88.25	0.00e+00	1242.00
IUUC-Dor-030465	Dipodomys ordii	85.14	0.00e+00	651.00
IUUC-Dse-031386	Dothistroma septosporum	41.11	3.00e-71	262.00
IUUC-Eca-034212	Equus caballus	98.77	0.00e+00	1410.00
IUUC-Eeu-034605	Erinaceus europaeus	70.20	0.00e+00	724.00
IUUC-Fca-035972	Felis catus	98.07	0.00e+00	1318.00
IUUC-Fal-037223	Ficedula albicollis	90.98	0.00e+00	1317.00
IUUC-Fox-037874	Fusarium oxysporum	44.99	2.00e-77	282.00
IUUC-Fso-038286	Fusarium solani	45.17	1.00e-77	283.00
IUUC-Gmo-039102	Gadus morhua	81.07	0.00e+00	1207.00
IUUC-Ggr-039925	Gaeumannomyces graminis	45.71	2.00e-80	293.00
IUUC-Gga-041181	Gallus gallus	91.72	0.00e+00	1376.00
IUUC-Gac-041887	Gasterosteus aculeatus	81.73	0.00e+00	1205.00
IUUC-Gma-043540	Glycine max	43.68	3.00e-87	315.00
IUUC-Ggo-044607	Gorilla gorilla	100.00	0.00e+00	1513.00
IUUC-Hvu-047105	Hordeum vulgare	49.73	5.00e-52	198.00
IUUC-Kpa-049146	Komagataella pastoris	44.41	2.00e-83	302.00
IUUC-Lch-049478	Latimeria chalumnae	87.62	0.00e+00	1338.00
IUUC-Lpe-051678	Leersia perrieri	44.59	6.00e-77	281.00
IUUC-Loc-052255	Lepisosteus oculatus	85.07	0.00e+00	1309.00
IUUC-Laf-054575	Loxodonta africana	97.47	0.00e+00	1423.00
IUUC-Mcc-055161	Macaca mulatta	99.05	0.00e+00	1456.00
IUUC-Mor-057026	Magnaporthe oryzae	44.94	1.00e-81	296.00
IUUC-Mpo-057590	Magnaporthe poae	45.27	6.00e-81	294.00
IUUC-Mtr-057835	Medicago truncatula	46.53	1.00e-80	293.00
IUUC-Mla-058950	Melampsora laricipopulina	44.99	2.00e-76	279.00
IUUC-Mvi-060295	Microbotryum violaceum	46.15	2.00e-77	283.00
IUUC-Mmr-060643	Microcebus murinus	94.62	0.00e+00	1406.00
IUUC-Mdo-062732	Monodelphis domestica	93.96	0.00e+00	1409.00
IUUC-Mmu-064125	Mus musculus	94.33	0.00e+00	1398.00
IUUC-Mpu-066371	Mustela putorius furo	98.37	0.00e+00	1320.00
IUUC-Mlu-067447	Myotis lucifugus	95.76	0.00e+00	1372.00
IUUC-Nfi-068373	Neosartorya fischeri	45.45	4.00e-83	301.00
IUUC-Ncr-068652	Neurospora crassa	44.32	1.00e-77	283.00
IUUC-Nle-069659	Nomascus leucogenys	99.87	0.00e+00	1511.00
IUUC-Ont-071244	Oreochromis niloticus	82.74	0.00e+00	1221.00
IUUC-Oan-072794	Ornithorhynchus anatinus	93.34	0.00e+00	1256.00
IUUC-Ocu-074701	Oryctolagus cuniculus	95.52	0.00e+00	1341.00
IUUC-Oba-075479	Oryza barthii	42.71	4.00e-58	219.00
IUUC-Ogl-076970	Oryza glaberrima	44.15	2.00e-80	293.00
IUUC-Oin-079610	Oryza indica	42.71	7.00e-58	218.00
IUUC-Oni-083016	Oryza nivara	43.83	4.00e-79	288.00
IUUC-Opu-083976	Oryza punctata	44.30	6.00e-79	288.00
IUUC-Osa-085814	Oryza sativa	44.15	2.00e-80	293.00
IUUC-Ola-087071	Oryzias latipes	81.55	0.00e+00	1212.00
IUUC-Olu-087711	Ostreococcus lucimarinus	41.76	2.00e-77	283.00
IUUC-Oga-089043	Otolemur garnettii	98.95	0.00e+00	1469.00
IUUC-Oar-089893	Ovis aries	91.13	0.00e+00	1315.00
IUUC-Ptr-090629	Pan troglodytes	99.87	0.00e+00	1511.00
IUUC-Pan-092305	Papio anubis	99.34	0.00e+00	1502.00
IUUC-Psi-093574	Pelodiscus sinensis	88.81	0.00e+00	1293.00
IUUC-Pma-094160	Petromyzon marinus	76.61	0.00e+00	1127.00
IUUC-Ppa-095410	Physcomitrella patens	43.48	4.00e-79	288.00
IUUC-Pfo-097043	Poecilia formosa	82.47	0.00e+00	1211.00
IUUC-Pab-098748	Pongo abelii	100.00	0.00e+00	782.00
IUUC-Pca-100223	Procavia capensis	96.58	0.00e+00	1407.00
IUUC-Ppe-101832	Prunus persica	45.50	1.00e-87	317.00
IUUC-Pva-102122	Pteropus vampyrus	98.42	0.00e+00	1461.00
IUUC-Pte-104228	Pyrenophora teres	44.48	3.00e-83	301.00
IUUC-Pyt-104702	Pyrenophora triticirepentis	40.91	4.00e-83	301.00
IUUC-Sce-106432	Saccharomyces cerevisiae	47.06	2.00e-84	306.00
IUUC-Sha-107338	Sarcophilus harrisii	93.47	0.00e+00	1249.00
IUUC-Spo-108273	Schizosaccharomyces pombe	48.17	2.00e-93	336.00
IUUC-Ssl-108545	Sclerotinia sclerotiorum	44.92	3.00e-79	288.00
IUUC-Smo-109385	Selaginella moellendorffii	43.69	5.00e-80	291.00
IUUC-Sit-110222	Setaria italica	44.15	5.00e-80	291.00
IUUC-Sly-111498	Solanum lycopersicum	49.30	2.00e-54	206.00
IUUC-Sar-113574	Sorex araneus	97.67	0.00e+00	1391.00
IUUC-Sbi-114471	Sorghum bicolor	44.68	9.00e-82	297.00
IUUC-Sre-114915	Sporisorium reilianum	43.05	1.00e-82	300.00
IUUC-Ssc-116097	Sus scrofa	97.11	0.00e+00	1297.00
IUUC-Tgu-116699	Taeniopygia guttata	91.53	0.00e+00	1305.00
IUUC-Tru-118001	Takifugu rubripes	81.52	0.00e+00	1211.00
IUUC-Tsy-118910	Tarsius syrichta	82.48	0.00e+00	850.00
IUUC-Tni-119684	Tetraodon nigroviridis	82.13	0.00e+00	1217.00
IUUC-Tca-121066	Theobroma cacao	43.63	2.00e-85	310.00
IUUC-Tre-122112	Trichoderma reesei	45.17	1.00e-79	290.00
IUUC-Tvi-122355	Trichoderma virens	45.17	2.00e-79	289.00
IUUC-Tae-123931	Triticum aestivum	44.23	1.00e-77	283.00
IUUC-Tur-126587	Triticum urartu	44.84	1.00e-77	283.00
IUUC-Tme-126963	Tuber melanosporum	45.69	5.00e-86	311.00
IUUC-Tbe-127304	Tupaia belangeri	83.58	0.00e+00	1182.00
IUUC-Ttr-128536	Tursiops truncatus	96.99	0.00e+00	1389.00
IUUC-Uma-129538	Ustilago maydis	42.78	1.00e-81	298.00
IUUC-Vda-129860	Verticillium dahliae	44.76	4.00e-82	298.00
IUUC-Vpa-130239	Vicugna pacos	77.59	4.00e-161	561.00
IUUC-Vvi-130897	Vitis vinifera	44.29	2.00e-87	316.00
IUUC-Xtr-132300	Xenopus tropicalis	86.97	0.00e+00	1273.00
IUUC-Xma-134105	Xiphophorus maculatus	79.87	0.00e+00	1202.00
IUUC-Yli-134345	Yarrowia lipolytica	49.00	1.00e-87	316.00
IUUC-Zma-135384	Zea mays	44.90	3.00e-79	289.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence