iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000114737.15	ENST00000443053.6	ENSP00000409346.2
ENSG00000114737.15	ENST00000348721.3	ENSP00000294173.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	miRTarBase	microRNA
TRANSFAC	miRWalk	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	19622774

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.10e-14	55.7	210	257

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           l++++++rs+ rSLqhLCRl+I+r++ +     +d+LPLP+++ dYL+++++q
   Q: 210  LVQPFVRRSSARSLQHLCRLVINRLVAD-----VDCLPLPRRMADYLRQYPFQ 257
           57999***********************.....8****************986 PP

Organism

Homo sapiens

Functional Description
(View)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Protein Sequence
(Fasta)

MVLCVQGPRP LLAVERTGQR PLWAPSLELP KPVMQPLPAG AFLEEVAEGT PAQTESEPKV 60
LDPEEDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP EGTFLVRDST HPSYLFTLSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGCTCGTC TGGCCCGCCC CCCTCGCCCT CGCAGGCGGT CCGCGCCACT GCCTCTCAGT 60
CCCTGTCCTG CGCCCGCGCG CCCCGGGAGC CTACCCAGCA CGCGCTCCGC GCCCACTGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR028425--CIS
IPR000980--SH2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0007205--P:protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016567--P:protein ubiquitination
GO:0001558--P:regulation of cell growth

KEGG

hsa:1154

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001189	Ailuropoda melanoleuca	90.51	3.00e-113	400.00
IUUC-Aca-004372	Anolis carolinensis	63.98	1.00e-87	316.00
IUUC-Ame-010787	Astyanax mexicanus	46.12	2.00e-51	194.00
IUUC-Bta-012826	Bos taurus	87.60	6.00e-120	422.00
IUUC-Cja-020004	Callithrix jacchus	94.82	7.00e-118	416.00
IUUC-Cfa-020150	Canis familiaris	89.24	1.00e-107	382.00
IUUC-Csa-023173	Chlorocebus sabaeus	96.02	9.00e-120	422.00
IUUC-Dre-028606	Danio rerio	37.66	7.00e-33	133.00
IUUC-Dno-028956	Dasypus novemcinctus	86.77	4.00e-114	403.00
IUUC-Dor-030148	Dipodomys ordii	73.64	2.00e-97	348.00
IUUC-Ete-032313	Echinops telfairi	83.20	2.00e-100	358.00
IUUC-Eca-033422	Equus caballus	90.31	6.00e-123	433.00
IUUC-Eeu-034806	Erinaceus europaeus	89.64	2.00e-110	392.00
IUUC-Fca-036374	Felis catus	89.92	3.00e-122	430.00
IUUC-Fal-036801	Ficedula albicollis	65.77	2.00e-87	315.00
IUUC-Gmo-038483	Gadus morhua	37.84	5.00e-36	144.00
IUUC-Gga-040891	Gallus gallus	66.15	2.00e-82	298.00
IUUC-Gac-042147	Gasterosteus aculeatus	39.62	3.00e-34	138.00
IUUC-Ggo-045511	Gorilla gorilla	98.80	2.00e-119	421.00
IUUC-Itr-048397	Ictidomys tridecemlineatus	83.39	2.00e-122	431.00
IUUC-Lch-050555	Latimeria chalumnae	55.73	2.00e-70	258.00
IUUC-Laf-054141	Loxodonta africana	86.87	5.00e-116	410.00
IUUC-Mcc-055401	Macaca mulatta	96.41	2.00e-119	421.00
IUUC-Meu-056592	Macropus eugenii	69.44	4.00e-93	333.00
IUUC-Mga-059515	Meleagris gallopavo	64.86	5.00e-78	283.00
IUUC-Mmr-060848	Microcebus murinus	91.24	7.00e-120	423.00
IUUC-Mdo-062720	Monodelphis domestica	67.83	5.00e-94	337.00
IUUC-Mmu-063348	Mus musculus	88.37	1.00e-126	445.00
IUUC-Mpu-065834	Mustela putorius furo	79.20	2.00e-115	407.00
IUUC-Mlu-067687	Myotis lucifugus	77.70	4.00e-97	347.00
IUUC-Nle-069277	Nomascus leucogenys	98.06	1.00e-125	442.00
IUUC-Ont-071890	Oreochromis niloticus	45.83	1.00e-35	142.00
IUUC-Oan-073672	Ornithorhynchus anatinus	65.38	3.00e-86	311.00
IUUC-Ocu-073875	Oryctolagus cuniculus	88.84	1.00e-112	399.00
IUUC-Ola-087140	Oryzias latipes	55.29	1.00e-23	102.00
IUUC-Oga-087943	Otolemur garnettii	89.15	4.00e-115	407.00
IUUC-Oar-090194	Ovis aries	87.75	3.00e-117	414.00
IUUC-Ptr-090934	Pan troglodytes	99.60	2.00e-120	424.00
IUUC-Pan-092121	Papio anubis	96.51	2.00e-124	437.00
IUUC-Psi-093733	Pelodiscus sinensis	62.45	1.00e-83	302.00
IUUC-Pfo-096313	Poecilia formosa	47.52	1.00e-42	166.00
IUUC-Pab-098439	Pongo abelii	98.84	9.00e-125	439.00
IUUC-Pca-101010	Procavia capensis	86.87	2.00e-114	404.00
IUUC-Pva-103112	Pteropus vampyrus	87.98	6.00e-125	439.00
IUUC-Rno-105917	Rattus norvegicus	82.66	5.00e-113	400.00
IUUC-Sha-106954	Sarcophilus harrisii	66.67	6.00e-93	333.00
IUUC-Smo-109292	Selaginella moellendorffii	31.15	2.30e-01	30.80
IUUC-Sar-113001	Sorex araneus	89.24	2.00e-109	388.00
IUUC-Ssc-115922	Sus scrofa	91.49	2.00e-65	241.00
IUUC-Tgu-117338	Taeniopygia guttata	65.22	1.00e-83	302.00
IUUC-Tru-118511	Takifugu rubripes	43.48	2.00e-31	129.00
IUUC-Tsy-119434	Tarsius syrichta	89.64	5.00e-115	406.00
IUUC-Tni-119837	Tetraodon nigroviridis	42.13	3.00e-28	118.00
IUUC-Tca-120923	Theobroma cacao	24.68	4.90e-02	30.40
IUUC-Ttr-128340	Tursiops truncatus	75.19	2.00e-78	284.00
IUUC-Vpa-130443	Vicugna pacos	89.53	1.00e-128	452.00
IUUC-Xtr-131784	Xenopus tropicalis	54.58	8.00e-68	249.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence