iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	HPRD
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	9.80e-11	43.5	18	81

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.d.vqpevfrallkFlYtgklde 67
           D +lv ++++f+ahk vLaa S++F++lf+++   +    +ve++ + + p+ ++++l+F+Yt+kl  
   Q: 18   DLVLVPQRSVFPAHKGVLAAYSQFFHSLFTQNKQLQ----RVELSlEaLAPGGLQQILNFIYTSKLLV 81
           5666779**********************9876654....57777656****************9965 PP

Organism

Homo sapiens

Functional Description
(View)

Belongs to the krueppel C2H2-type zinc-finger protein family.

Protein Sequence
(Fasta)

MGRLNEQRLF QPDLCDVDLV LVPQRSVFPA HKGVLAAYSQ FFHSLFTQNK QLQRVELSLE 60
ALAPGGLQQI LNFIYTSKLL VNAANVHEVL SAASLLQMAD IAASCQELLD ARSLGPPGPG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCAAGGGG GCCACTCAGC AGTGGTCAGG TCACACGGCT AGAGGGGCAC AGTGGGGCCT 60
GGGCCTCTGG TCCCTACTCC TCTGGTCCCT CTGTCTCCTG GCCCTGGGCC AGTCACCTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:92999

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001644	Ailuropoda melanoleuca	86.03	7.00e-163	567.00
IUUC-Apl-003792	Anas platyrhynchos	93.55	6.00e-164	570.00
IUUC-Ago-007832	Ashbya gossypii	29.76	5.70e+00	26.60
IUUC-Ame-011779	Astyanax mexicanus	88.78	6.00e-165	574.00
IUUC-Cfa-020980	Canis familiaris	100.00	3.00e-166	579.00
IUUC-Csa-023152	Chlorocebus sabaeus	97.93	0.00e+00	688.00
IUUC-Dre-027491	Danio rerio	76.92	7.00e-143	501.00
IUUC-Dno-029014	Dasypus novemcinctus	79.60	1.00e-76	280.00
IUUC-Eeu-034565	Erinaceus europaeus	88.45	6.00e-124	437.00
IUUC-Fca-035790	Felis catus	97.14	2.00e-170	592.00
IUUC-Fal-037386	Ficedula albicollis	83.08	6.00e-166	577.00
IUUC-Ggo-045280	Gorilla gorilla	100.00	5.00e-179	621.00
IUUC-Itr-048137	Ictidomys tridecemlineatus	95.55	1.00e-179	623.00
IUUC-Loc-052151	Lepisosteus oculatus	83.50	3.00e-162	565.00
IUUC-Laf-054550	Loxodonta africana	84.95	8.00e-141	494.00
IUUC-Mcc-054946	Macaca mulatta	98.19	0.00e+00	690.00
IUUC-Meu-056353	Macropus eugenii	97.69	2.00e-160	559.00
IUUC-Mmr-061799	Microcebus murinus	94.32	0.00e+00	672.00
IUUC-Mdo-062543	Monodelphis domestica	96.72	2.00e-167	582.00
IUUC-Mmu-064064	Mus musculus	88.18	0.00e+00	641.00
IUUC-Mpu-065849	Mustela putorius furo	92.76	3.00e-178	619.00
IUUC-Nle-070012	Nomascus leucogenys	99.27	4.00e-127	448.00
IUUC-Opr-070311	Ochotona princeps	94.51	8.00e-160	557.00
IUUC-Ocu-074253	Oryctolagus cuniculus	88.18	9.00e-149	520.00
IUUC-Oar-089279	Ovis aries	87.31	3.00e-171	595.00
IUUC-Ptr-090584	Pan troglodytes	97.78	2.00e-172	599.00
IUUC-Pan-092572	Papio anubis	98.19	0.00e+00	691.00
IUUC-Psi-093212	Pelodiscus sinensis	95.94	8.00e-166	577.00
IUUC-Pma-094713	Petromyzon marinus	70.59	3.00e-117	416.00
IUUC-Pfo-096165	Poecilia formosa	83.33	2.00e-160	559.00
IUUC-Pca-100825	Procavia capensis	90.51	4.00e-114	404.00
IUUC-Rno-105862	Rattus norvegicus	88.51	0.00e+00	644.00
IUUC-Sha-106960	Sarcophilus harrisii	97.30	2.00e-159	556.00
IUUC-Ssc-115649	Sus scrofa	95.87	2.00e-162	565.00
IUUC-Tgu-116570	Taeniopygia guttata	85.24	1.00e-140	493.00
IUUC-Tru-118636	Takifugu rubripes	92.72	6.00e-156	544.00
IUUC-Ttr-129151	Tursiops truncatus	95.64	6.00e-123	434.00
IUUC-Xtr-131974	Xenopus tropicalis	92.55	1.00e-152	533.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence