iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdb	GWAS Central	OMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/JAMM	JAMM	20829789

Classification

Family	E-value	Score	Start	End
DUB/JAMM	1.50e-07	32.9	113	126

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/JAMM

   S: 1    HSHPgftcwlSsVD 14
           HSHPgf+cwlS+VD
   Q: 113  HSHPGFGCWLSGVD 126
           *************9 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.

Protein Sequence
(Fasta)

MDRLLRLGGG MPGLGQGPPT DAPAVDTAEQ VYISSLALLK MLKHGRAGVP MEVMGLMLGE 60
FVDDYTVRVI DVFAMPQSGT GVSVEAVDPV FQAKMLDMLK QTGRPEMVVG WYHSHPGFGC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATAACCAA GTTAAATCTA GCTCAAATGA ACCTTTTAGT TTTTGAGGAG GGCAATAATA 60
GTAGTGAACA CCAAAACGAA AGGGGATCTG GGCTTCAAAA TACTAACAGT TCTATTTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0597--Phosphoprotein
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR000555--JAMM/MPN+_dom
IPR024969--Rpn11/EIF3F_C

Pfam

PF01398--JAB
PF13012--MitMem_reg

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0005829--C:cytosol
GO:0031597--C:cytosolic proteasome complex
GO:0070062--C:extracellular exosome
GO:0005576--C:extracellular region
GO:1904813--C:ficolin-1-rich granule lumen
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0022624--C:proteasome accessory complex
GO:0000502--C:proteasome complex
GO:0008541--C:proteasome regulatory particle, lid subcomplex
GO:0034774--C:secretory granule lumen
GO:0061133--F:endopeptidase activator activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0070628--F:proteasome binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0000724--P:double-strand break repair via homologous recombination
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0000165--P:MAPK cascade
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0010972--P:negative regulation of G2/M transition of mitotic cell cycle
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0043312--P:neutrophil degranulation
GO:0038061--P:NIK/NF-kappaB signaling
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006521--P:regulation of cellular amino acid metabolic process
GO:0043488--P:regulation of mRNA stability
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0045471--P:response to ethanol
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway
GO:0055085--P:transmembrane transport
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0060071--P:Wnt signaling pathway, planar cell polarity pathway

KEGG

hsa:10213

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000544	Aegilops tauschii	81.72	1.00e-133	469.00
IUUC-Aml-001416	Ailuropoda melanoleuca	100.00	2.00e-174	604.00
IUUC-Atr-002629	Amborella trichopoda	83.99	1.00e-131	462.00
IUUC-Apl-004046	Anas platyrhynchos	99.33	7.00e-179	619.00
IUUC-Aca-005228	Anolis carolinensis	99.31	5.00e-173	600.00
IUUC-Aly-005457	Arabidopsis lyrata	82.35	4.00e-134	470.00
IUUC-Ath-007290	Arabidopsis thaliana	82.35	4.00e-134	470.00
IUUC-Ago-007866	Ashbya gossypii	65.98	3.00e-110	391.00
IUUC-Acl-008338	Aspergillus clavatus	70.59	6.00e-108	383.00
IUUC-Afl-008431	Aspergillus flavus	70.98	2.00e-121	428.00
IUUC-Afu-008909	Aspergillus fumigatus	70.98	5.00e-116	410.00
IUUC-Ani-009174	Aspergillus nidulans	70.98	4.00e-121	427.00
IUUC-Ang-009854	Aspergillus niger	71.17	2.00e-120	425.00
IUUC-Aor-009942	Aspergillus oryzae	70.98	7.00e-121	427.00
IUUC-Ate-010377	Aspergillus terreus	70.63	5.00e-121	427.00
IUUC-Ame-011628	Astyanax mexicanus	97.86	2.00e-153	535.00
IUUC-Bgr-012263	Blumeria graminis	69.04	3.00e-108	385.00
IUUC-Bta-012375	Bos taurus	100.00	2.00e-174	604.00
IUUC-Bci-013850	Botrytis cinerea	71.68	8.00e-112	396.00
IUUC-Bdi-014135	Brachypodium distachyon	83.27	2.00e-130	458.00
IUUC-Bol-016172	Brassica oleracea	82.35	4.00e-134	470.00
IUUC-Bra-017926	Brassica rapa	82.35	4.00e-134	470.00
IUUC-Cel-018247	Caenorhabditis elegans	76.90	8.00e-133	466.00
IUUC-Cja-019210	Callithrix jacchus	98.35	2.00e-178	617.00
IUUC-Cfa-020926	Canis familiaris	98.38	8.00e-170	589.00
IUUC-Cpo-021572	Cavia porcellus	100.00	2.00e-174	604.00
IUUC-Cre-022925	Chlamydomonas reinhardtii	76.90	1.00e-129	455.00
IUUC-Csa-023496	Chlorocebus sabaeus	100.00	2.00e-174	604.00
IUUC-Cho-024525	Choloepus hoffmanni	92.78	7.00e-160	556.00
IUUC-Cin-025492	Ciona intestinalis	90.00	2.00e-158	551.00
IUUC-Cgl-026493	Colletotrichum gloeosporioides	68.68	4.00e-101	361.00
IUUC-Cne-026785	Cryptococcus neoformans	69.93	4.00e-117	414.00
IUUC-Cme-027105	Cyanidioschyzon merolae	61.17	3.00e-101	361.00
IUUC-Dre-028788	Danio rerio	98.64	3.00e-175	607.00
IUUC-Dno-029058	Dasypus novemcinctus	100.00	2.00e-174	605.00
IUUC-Dor-031015	Dipodomys ordii	91.07	4.00e-153	533.00
IUUC-Dse-031242	Dothistroma septosporum	71.93	3.00e-123	434.00
IUUC-Dme-031668	Drosophila melanogaster	89.69	8.00e-159	552.00
IUUC-Ete-033146	Echinops telfairi	90.73	1.00e-137	482.00
IUUC-Eca-033734	Equus caballus	100.00	2.00e-174	604.00
IUUC-Eeu-035168	Erinaceus europaeus	71.85	1.00e-92	332.00
IUUC-Fca-036426	Felis catus	100.00	2.00e-174	604.00
IUUC-Fal-036954	Ficedula albicollis	99.31	5.00e-173	600.00
IUUC-Fox-037838	Fusarium oxysporum	71.28	3.00e-119	421.00
IUUC-Fso-038374	Fusarium solani	70.92	5.00e-119	420.00
IUUC-Gmo-038918	Gadus morhua	98.28	1.00e-171	595.00
IUUC-Ggr-039954	Gaeumannomyces graminis	70.82	1.00e-119	422.00
IUUC-Gga-040377	Gallus gallus	99.31	5.00e-173	600.00
IUUC-Gac-042386	Gasterosteus aculeatus	98.39	0.00e+00	635.00
IUUC-Gma-042811	Glycine max	82.70	2.00e-134	471.00
IUUC-Ggo-044916	Gorilla gorilla	100.00	6.00e-175	606.00
IUUC-Hvu-047188	Hordeum vulgare	81.72	5.00e-134	470.00
IUUC-Itr-048154	Ictidomys tridecemlineatus	98.90	1.00e-105	375.00
IUUC-Kpa-049128	Komagataella pastoris	73.31	1.00e-115	409.00
IUUC-Lch-050167	Latimeria chalumnae	93.17	5.00e-160	556.00
IUUC-Lpe-051086	Leersia perrieri	82.07	1.00e-133	469.00
IUUC-Loc-052888	Lepisosteus oculatus	98.63	2.00e-172	597.00
IUUC-Lma-052962	Leptosphaeria maculans	69.47	8.00e-120	423.00
IUUC-Laf-053949	Loxodonta africana	100.00	2.00e-174	604.00
IUUC-Mcc-055279	Macaca mulatta	98.03	2.00e-168	585.00
IUUC-Meu-055956	Macropus eugenii	91.07	1.00e-154	538.00
IUUC-Mor-057166	Magnaporthe oryzae	71.17	2.00e-111	395.00
IUUC-Mpo-057344	Magnaporthe poae	70.82	6.00e-120	423.00
IUUC-Mtr-057857	Medicago truncatula	83.04	3.00e-135	474.00
IUUC-Mla-058938	Melampsora laricipopulina	75.70	1.00e-131	462.00
IUUC-Mga-060093	Meleagris gallopavo	99.31	5.00e-173	600.00
IUUC-Mvi-060565	Microbotryum violaceum	72.98	1.00e-125	442.00
IUUC-Mmr-060899	Microcebus murinus	97.92	2.00e-167	582.00
IUUC-Mdo-062175	Monodelphis domestica	99.66	2.00e-173	601.00
IUUC-Mmu-063416	Mus musculus	100.00	2.00e-174	604.00
IUUC-Mac-065642	Musa acuminata	81.72	4.00e-133	467.00
IUUC-Mpu-065946	Mustela putorius furo	100.00	2.00e-174	604.00
IUUC-Mlu-067835	Myotis lucifugus	98.68	6.00e-178	616.00
IUUC-Nfi-068279	Neosartorya fischeri	70.98	6.00e-116	410.00
IUUC-Ncr-068821	Neurospora crassa	70.46	2.00e-109	388.00
IUUC-Nle-069212	Nomascus leucogenys	100.00	2.00e-174	604.00
IUUC-Opr-070928	Ochotona princeps	64.29	1.00e-79	289.00
IUUC-Ont-072135	Oreochromis niloticus	98.63	2.00e-172	597.00
IUUC-Oan-072755	Ornithorhynchus anatinus	99.66	2.00e-173	601.00
IUUC-Ocu-074433	Oryctolagus cuniculus	100.00	1.00e-158	551.00
IUUC-Oba-075678	Oryza barthii	82.07	7.00e-134	469.00
IUUC-Obr-076756	Oryza brachyantha	82.07	1.00e-133	469.00
IUUC-Ogl-077831	Oryza glaberrima	83.27	2.00e-130	458.00
IUUC-Ogu-078941	Oryza glumaepatula	82.07	7.00e-134	469.00
IUUC-Oin-080184	Oryza indica	82.07	7.00e-134	469.00
IUUC-Olo-080580	Oryza longistaminata	83.27	2.00e-130	457.00
IUUC-Ome-081739	Oryza meridionalis	80.69	3.00e-128	451.00
IUUC-Oni-082063	Oryza nivara	82.07	7.00e-134	469.00
IUUC-Opu-083207	Oryza punctata	82.07	1.00e-133	469.00
IUUC-Oru-085034	Oryza rufipogon	82.07	7.00e-134	469.00
IUUC-Osa-085486	Oryza sativa	82.07	7.00e-134	469.00
IUUC-Ola-087317	Oryzias latipes	98.63	2.00e-172	597.00
IUUC-Olu-087889	Ostreococcus lucimarinus	76.12	9.00e-132	462.00
IUUC-Oga-088032	Otolemur garnettii	100.00	4.00e-175	607.00
IUUC-Oar-090237	Ovis aries	100.00	3.00e-177	613.00
IUUC-Ptr-090881	Pan troglodytes	100.00	2.00e-174	604.00
IUUC-Pan-092658	Papio anubis	100.00	7.00e-175	605.00
IUUC-Psi-093672	Pelodiscus sinensis	99.66	2.00e-173	601.00
IUUC-Pma-094213	Petromyzon marinus	95.19	1.00e-166	578.00
IUUC-Pno-095038	Phaeosphaeria nodorum	69.47	1.00e-119	422.00
IUUC-Ppa-095467	Physcomitrella patens	85.12	1.00e-138	486.00
IUUC-Pfo-096322	Poecilia formosa	98.63	2.00e-172	597.00
IUUC-Pab-098484	Pongo abelii	100.00	2.00e-174	604.00
IUUC-Pop-099564	Populus trichocarpa	82.70	2.00e-134	471.00
IUUC-Pca-100785	Procavia capensis	93.05	4.00e-141	493.00
IUUC-Ppe-101727	Prunus persica	82.35	2.00e-133	468.00
IUUC-Pva-102569	Pteropus vampyrus	100.00	1.00e-176	612.00
IUUC-Pgr-103351	Puccinia graminis	75.35	6.00e-131	459.00
IUUC-Ptt-103763	Puccinia triticina	69.72	2.00e-117	415.00
IUUC-Pte-104088	Pyrenophora teres	69.82	1.00e-119	422.00
IUUC-Pyt-104597	Pyrenophora triticirepentis	70.19	5.00e-112	397.00
IUUC-Rno-105115	Rattus norvegicus	100.00	2.00e-174	604.00
IUUC-Sce-106353	Saccharomyces cerevisiae	67.59	3.00e-112	398.00
IUUC-Sha-107476	Sarcophilus harrisii	99.66	2.00e-173	601.00
IUUC-Sja-107807	Schizosaccharomyces japonicus	71.28	6.00e-124	436.00
IUUC-Spo-108255	Schizosaccharomyces pombe	70.59	3.00e-114	404.00
IUUC-Ssl-108392	Sclerotinia sclerotiorum	71.89	2.00e-111	395.00
IUUC-Smo-108824	Selaginella moellendorffii	83.04	3.00e-146	511.00
IUUC-Sit-110287	Setaria italica	82.07	1.00e-133	469.00
IUUC-Sly-111656	Solanum lycopersicum	82.01	3.00e-134	471.00
IUUC-Stu-112827	Solanum tuberosum	82.01	7.00e-134	469.00
IUUC-Sar-112979	Sorex araneus	83.51	3.00e-139	487.00
IUUC-Sbi-113841	Sorghum bicolor	82.07	1.00e-133	469.00
IUUC-Sre-114930	Sporisorium reilianum	77.06	1.00e-130	459.00
IUUC-Ssc-116058	Sus scrofa	100.00	4.00e-175	607.00
IUUC-Tgu-116499	Taeniopygia guttata	99.31	5.00e-173	600.00
IUUC-Tru-117576	Takifugu rubripes	98.63	2.00e-172	597.00
IUUC-Tsy-119371	Tarsius syrichta	91.41	7.00e-155	539.00
IUUC-Tni-120868	Tetraodon nigroviridis	98.39	6.00e-171	592.00
IUUC-Tca-121292	Theobroma cacao	82.70	3.00e-134	471.00
IUUC-Tre-122183	Trichoderma reesei	70.82	3.00e-115	407.00
IUUC-Tvi-122566	Trichoderma virens	70.82	2.00e-115	408.00
IUUC-Tae-125156	Triticum aestivum	81.72	1.00e-133	469.00
IUUC-Tur-126034	Triticum urartu	82.92	2.00e-130	458.00
IUUC-Tme-126903	Tuber melanosporum	71.93	2.00e-123	435.00
IUUC-Tbe-127525	Tupaia belangeri	91.11	5.00e-145	506.00
IUUC-Ttr-129072	Tursiops truncatus	100.00	2.00e-176	611.00
IUUC-Uma-129471	Ustilago maydis	77.42	2.00e-131	461.00
IUUC-Vda-129956	Verticillium dahliae	70.18	3.00e-110	391.00
IUUC-Vpa-130490	Vicugna pacos	100.00	2.00e-176	611.00
IUUC-Vvi-131302	Vitis vinifera	82.70	2.00e-134	471.00
IUUC-Xtr-132059	Xenopus tropicalis	98.97	1.00e-172	598.00
IUUC-Xma-133101	Xiphophorus maculatus	98.63	2.00e-172	597.00
IUUC-Yli-134638	Yarrowia lipolytica	71.02	4.00e-120	424.00
IUUC-Zma-135910	Zea mays	82.07	1.00e-133	469.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence