iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-054695

Ensembl Protein ID

ENSMMUP00000004277.2

UniProt Accession

Q0GBW6; Q0GBW6_MACMU

Genbank Protein ID

ABI33114.1; AFH29361.1; AFJ71053.1

Protein Name

Interferon-induced helicase C domain-containing protein 1; Melanoma differentiation associated protein-5

Genbank Nucleotide ID

JSUE03008994; JU472557; JV635713

Gene Name

IFIH1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000003202.3	ENSMMUT00000004537.3	ENSMMUP00000004277.2
ENSMMUG00000003202.3	ENSMMUT00000058655.1	ENSMMUP00000060886.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	1.40e-55	186.9	7	80

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 1    tdeeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLktL...vqkegWfrefl 73
           tde++r+l+s++++rv+++++v++vld yl+ fl++e+ke+i+++++t+gnmqa+elLL+tL   v+++gW+ref+
   Q: 7    TDENFRYLISCFRARVKMYIQVEPVLD-YLT-FLPAEVKEQIQRTVATSGNMQAVELLLSTLekgVWHLGWTREFV 80
           69*************************.***.*******************************************6 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MSNGYSTDEN FRYLISCFRA RVKMYIQVEP VLDYLTFLPA EVKEQIQRTV ATSGNMQAVE 60
LLLSTLEKGV WHLGWTREFV EALRRAGSPL AARYMNPELT DLPSPSFENA HDECLQLLNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGAATG GGTATTCCAC AGACGAGAAT TTCCGCTATC TCATCTCGTG CTTCAGGGCC 60
AGGGTGAAAA TGTACATCCA GGTGGAGCCT GTGCTGGACT ACCTGACCTT TCTGCCTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0862--Zinc

Interpro

IPR031964--CARD_dom
IPR011029--DEATH-like_dom
IPR006935--Helicase/UvrB_N
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR021673--RLR_CTR

PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51789--RLR_CTR

Pfam

PF16739--CARD_2
PF00271--Helicase_C
PF04851--ResIII
PF11648--RIG-I_C-RD

SMART

SM00487--DEXDc
SM00490--HELICc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0003725--F:double-stranded RNA binding
GO:0004386--F:helicase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0003727--F:single-stranded RNA binding
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0039530--P:MDA-5 signaling pathway
GO:0032727--P:positive regulation of interferon-alpha production
GO:0032728--P:positive regulation of interferon-beta production
GO:0016925--P:protein sumoylation

KEGG

mcc:702024

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001336	Ailuropoda melanoleuca	84.92	0.00e+00	1637.00
IUUC-Apl-003900	Anas platyrhynchos	61.83	0.00e+00	1208.00
IUUC-Aca-005329	Anolis carolinensis	59.48	0.00e+00	1029.00
IUUC-Aly-005838	Arabidopsis lyrata	31.46	2.10e-01	28.10
IUUC-Ame-011305	Astyanax mexicanus	48.02	0.00e+00	878.00
IUUC-Bta-012361	Bos taurus	84.49	0.00e+00	1597.00
IUUC-Cja-018760	Callithrix jacchus	93.37	0.00e+00	1758.00
IUUC-Cfa-020321	Canis familiaris	83.68	0.00e+00	1576.00
IUUC-Cpo-022450	Cavia porcellus	81.01	0.00e+00	1596.00
IUUC-Cre-022916	Chlamydomonas reinhardtii	33.33	2.00e-12	68.60
IUUC-Csa-024194	Chlorocebus sabaeus	99.61	0.00e+00	1830.00
IUUC-Cho-024364	Choloepus hoffmanni	77.42	0.00e+00	1055.00
IUUC-Dre-028305	Danio rerio	54.58	0.00e+00	717.00
IUUC-Dno-029831	Dasypus novemcinctus	87.41	0.00e+00	1682.00
IUUC-Dor-030410	Dipodomys ordii	78.72	0.00e+00	1271.00
IUUC-Ete-032950	Echinops telfairi	68.25	0.00e+00	781.00
IUUC-Eca-034279	Equus caballus	88.69	0.00e+00	1677.00
IUUC-Eeu-034678	Erinaceus europaeus	80.80	0.00e+00	1580.00
IUUC-Fca-035618	Felis catus	88.75	0.00e+00	993.00
IUUC-Fal-037106	Ficedula albicollis	59.48	0.00e+00	1106.00
IUUC-Gmo-038598	Gadus morhua	49.37	0.00e+00	674.00
IUUC-Gga-040467	Gallus gallus	61.31	0.00e+00	1186.00
IUUC-Gac-042316	Gasterosteus aculeatus	47.61	0.00e+00	840.00
IUUC-Ggo-045461	Gorilla gorilla	98.34	0.00e+00	1807.00
IUUC-Hsa-045771	Homo sapiens	98.44	0.00e+00	1807.00
IUUC-Itr-048762	Ictidomys tridecemlineatus	86.44	0.00e+00	1631.00
IUUC-Lch-049913	Latimeria chalumnae	66.26	0.00e+00	931.00
IUUC-Lpe-051697	Leersia perrieri	29.81	4.80e+00	26.90
IUUC-Loc-052768	Lepisosteus oculatus	53.68	0.00e+00	991.00
IUUC-Laf-053933	Loxodonta africana	85.41	0.00e+00	1625.00
IUUC-Meu-056829	Macropus eugenii	74.29	0.00e+00	1125.00
IUUC-Mga-059205	Meleagris gallopavo	62.02	0.00e+00	1187.00
IUUC-Mmr-060703	Microcebus murinus	89.32	0.00e+00	1653.00
IUUC-Mdo-063079	Monodelphis domestica	72.01	0.00e+00	1445.00
IUUC-Mmu-064066	Mus musculus	80.41	0.00e+00	1637.00
IUUC-Mpu-066261	Mustela putorius furo	84.50	0.00e+00	1597.00
IUUC-Mlu-068196	Myotis lucifugus	83.72	0.00e+00	1576.00
IUUC-Nle-069479	Nomascus leucogenys	93.95	0.00e+00	1733.00
IUUC-Opr-070717	Ochotona princeps	77.21	0.00e+00	1183.00
IUUC-Ont-071702	Oreochromis niloticus	47.70	0.00e+00	858.00
IUUC-Oan-073639	Ornithorhynchus anatinus	66.67	0.00e+00	1202.00
IUUC-Ocu-074521	Oryctolagus cuniculus	87.32	0.00e+00	1695.00
IUUC-Ola-086351	Oryzias latipes	46.47	0.00e+00	821.00
IUUC-Oga-088539	Otolemur garnettii	86.34	0.00e+00	1625.00
IUUC-Oar-090186	Ovis aries	84.39	0.00e+00	1583.00
IUUC-Ptr-090575	Pan troglodytes	93.76	0.00e+00	1725.00
IUUC-Pan-092371	Papio anubis	99.51	0.00e+00	1831.00
IUUC-Psi-093072	Pelodiscus sinensis	64.56	0.00e+00	1269.00
IUUC-Pma-094345	Petromyzon marinus	43.58	9.00e-97	347.00
IUUC-Pfo-096401	Poecilia formosa	51.94	0.00e+00	674.00
IUUC-Pab-097623	Pongo abelii	96.59	0.00e+00	1823.00
IUUC-Pca-100993	Procavia capensis	78.82	0.00e+00	1316.00
IUUC-Pva-102227	Pteropus vampyrus	80.70	0.00e+00	1496.00
IUUC-Rno-105198	Rattus norvegicus	80.33	0.00e+00	1630.00
IUUC-Sha-107622	Sarcophilus harrisii	73.38	0.00e+00	1432.00
IUUC-Sar-113625	Sorex araneus	70.58	0.00e+00	748.00
IUUC-Tgu-117486	Taeniopygia guttata	60.62	0.00e+00	1146.00
IUUC-Tru-118445	Takifugu rubripes	45.37	0.00e+00	822.00
IUUC-Tsy-119512	Tarsius syrichta	88.10	0.00e+00	1599.00
IUUC-Tni-120711	Tetraodon nigroviridis	45.76	0.00e+00	858.00
IUUC-Tbe-127644	Tupaia belangeri	76.59	0.00e+00	1416.00
IUUC-Ttr-128989	Tursiops truncatus	80.88	0.00e+00	1590.00
IUUC-Vpa-130587	Vicugna pacos	79.86	0.00e+00	1263.00
IUUC-Xtr-132127	Xenopus tropicalis	53.99	0.00e+00	1022.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence