iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	2.40e-35	121.3	8	80

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 2    deeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLktL...vqkegWfrefl 73
           ++ +r l+s +++rv++ ++v++vld yl  fl++e ke+il+ + t gn +aaelLL+tL    + +gW++ f+
   Q: 8    EDSFRNLISIFRPRVKMNIQVEPVLD-YLV-FLPAETKEQILRKVTTCGNTSAAELLLSTLeqgQWPLGWTQMFV 80
           6889**********************.***.****************************************9885 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSTVCSAEDS FRNLISIFRP RVKMNIQVEP VLDYLVFLPA ETKEQILRKV TTCGNTSAAE 60
LLLSTLEQGQ WPLGWTQMFV EALEHSGNPL AARYVKPSLT DLPSPSSETA HDECLHLLNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCCGGCGG TGGCAGTGAG AGTAGTCCGG GGTCTATGAC CACCTGCTGC AGCGCATTCC 60
TGGCTCGTCT GCCACCTTCC GGGTGCCACC GATCAATCCG GTGCTCAGAG GCTACCCGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc

Interpro

IPR031964--CARD_dom
IPR011029--DEATH-like_dom
IPR006935--Helicase/UvrB_N
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR021673--RLR_CTR

PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51789--RLR_CTR

Pfam

PF16739--CARD_2
PF00271--Helicase_C
PF04851--ResIII
PF11648--RIG-I_C-RD

SMART

SM00487--DEXDc
SM00490--HELICc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0003725--F:double-stranded RNA binding
GO:0016817--F:hydrolase activity, acting on acid anhydrides
GO:0043021--F:ribonucleoprotein complex binding
GO:0003727--F:single-stranded RNA binding
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0039530--P:MDA-5 signaling pathway
GO:0032727--P:positive regulation of interferon-alpha production
GO:0032728--P:positive regulation of interferon-beta production
GO:0016925--P:protein sumoylation

KEGG

rno:499801

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001336	Ailuropoda melanoleuca	76.41	0.00e+00	1499.00
IUUC-Apl-003900	Anas platyrhynchos	59.65	0.00e+00	1162.00
IUUC-Aca-005329	Anolis carolinensis	58.16	0.00e+00	1024.00
IUUC-Ame-011305	Astyanax mexicanus	53.36	0.00e+00	758.00
IUUC-Bta-012361	Bos taurus	77.52	0.00e+00	1478.00
IUUC-Cel-018230	Caenorhabditis elegans	27.24	7.00e-61	229.00
IUUC-Cja-018760	Callithrix jacchus	78.19	0.00e+00	1483.00
IUUC-Cfa-020321	Canis familiaris	76.39	0.00e+00	1451.00
IUUC-Cpo-022450	Cavia porcellus	72.98	0.00e+00	1448.00
IUUC-Cre-022916	Chlamydomonas reinhardtii	33.33	3.00e-12	68.20
IUUC-Csa-024194	Chlorocebus sabaeus	80.23	0.00e+00	1491.00
IUUC-Cho-024364	Choloepus hoffmanni	69.16	0.00e+00	963.00
IUUC-Cin-025792	Ciona intestinalis	29.49	2.00e-67	249.00
IUUC-Cgl-026385	Colletotrichum gloeosporioides	30.60	2.00e-14	75.90
IUUC-Dre-028305	Danio rerio	46.15	0.00e+00	755.00
IUUC-Dno-029831	Dasypus novemcinctus	77.60	0.00e+00	1513.00
IUUC-Dor-030410	Dipodomys ordii	73.53	0.00e+00	1179.00
IUUC-Ete-032950	Echinops telfairi	71.33	8.00e-178	617.00
IUUC-Eca-034279	Equus caballus	77.63	0.00e+00	1479.00
IUUC-Eeu-034678	Erinaceus europaeus	73.74	0.00e+00	1467.00
IUUC-Fca-035618	Felis catus	80.14	0.00e+00	918.00
IUUC-Fal-037106	Ficedula albicollis	67.17	0.00e+00	959.00
IUUC-Fso-038398	Fusarium solani	31.68	6.00e-14	73.90
IUUC-Gmo-038598	Gadus morhua	47.84	0.00e+00	659.00
IUUC-Gga-040467	Gallus gallus	60.06	0.00e+00	1157.00
IUUC-Gac-042316	Gasterosteus aculeatus	46.80	0.00e+00	831.00
IUUC-Ggo-045461	Gorilla gorilla	79.65	0.00e+00	1477.00
IUUC-Hsa-045771	Homo sapiens	79.45	0.00e+00	1473.00
IUUC-Itr-048762	Ictidomys tridecemlineatus	77.90	0.00e+00	1491.00
IUUC-Lch-049913	Latimeria chalumnae	64.98	0.00e+00	911.00
IUUC-Loc-052768	Lepisosteus oculatus	52.22	0.00e+00	969.00
IUUC-Laf-053933	Loxodonta africana	77.28	0.00e+00	1471.00
IUUC-Mcc-054695	Macaca mulatta	80.33	0.00e+00	1494.00
IUUC-Meu-056829	Macropus eugenii	70.47	0.00e+00	1073.00
IUUC-Mga-059205	Meleagris gallopavo	59.57	0.00e+00	1143.00
IUUC-Mvi-060497	Microbotryum violaceum	33.96	4.00e-18	87.80
IUUC-Mmr-060703	Microcebus murinus	78.29	0.00e+00	1462.00
IUUC-Mdo-063079	Monodelphis domestica	68.38	0.00e+00	1374.00
IUUC-Mmu-064066	Mus musculus	93.18	0.00e+00	1908.00
IUUC-Mpu-066261	Mustela putorius furo	75.88	0.00e+00	1446.00
IUUC-Mlu-068196	Myotis lucifugus	76.85	0.00e+00	1462.00
IUUC-Nfi-068405	Neosartorya fischeri	25.12	3.00e-25	111.00
IUUC-Nle-069479	Nomascus leucogenys	77.51	0.00e+00	1446.00
IUUC-Opr-070717	Ochotona princeps	69.43	0.00e+00	1059.00
IUUC-Ont-071702	Oreochromis niloticus	46.26	0.00e+00	850.00
IUUC-Oan-073639	Ornithorhynchus anatinus	62.90	0.00e+00	1138.00
IUUC-Ocu-074521	Oryctolagus cuniculus	77.09	0.00e+00	1497.00
IUUC-Ola-086351	Oryzias latipes	45.07	0.00e+00	801.00
IUUC-Oga-088539	Otolemur garnettii	76.24	0.00e+00	1466.00
IUUC-Oar-090186	Ovis aries	77.20	0.00e+00	1439.00
IUUC-Ptr-090575	Pan troglodytes	77.60	0.00e+00	1447.00
IUUC-Pan-092371	Papio anubis	80.43	0.00e+00	1494.00
IUUC-Psi-093072	Pelodiscus sinensis	61.12	0.00e+00	1193.00
IUUC-Pma-094345	Petromyzon marinus	42.59	2.00e-93	336.00
IUUC-Pfo-096401	Poecilia formosa	51.25	0.00e+00	665.00
IUUC-Pab-097623	Pongo abelii	78.48	0.00e+00	1472.00
IUUC-Pca-100993	Procavia capensis	69.90	0.00e+00	1186.00
IUUC-Pva-102227	Pteropus vampyrus	72.76	0.00e+00	1355.00
IUUC-Pgr-103529	Puccinia graminis	39.34	3.00e-17	84.70
IUUC-Sha-107622	Sarcophilus harrisii	69.78	0.00e+00	1369.00
IUUC-Sar-113625	Sorex araneus	65.59	0.00e+00	677.00
IUUC-Tgu-117486	Taeniopygia guttata	58.67	0.00e+00	1098.00
IUUC-Tru-118445	Takifugu rubripes	44.57	0.00e+00	797.00
IUUC-Tsy-119512	Tarsius syrichta	77.12	0.00e+00	1417.00
IUUC-Tni-120711	Tetraodon nigroviridis	44.12	0.00e+00	818.00
IUUC-Tre-122194	Trichoderma reesei	35.00	5.00e-13	70.90
IUUC-Tbe-127644	Tupaia belangeri	70.40	0.00e+00	1312.00
IUUC-Ttr-128989	Tursiops truncatus	74.00	0.00e+00	1455.00
IUUC-Vpa-130587	Vicugna pacos	74.09	0.00e+00	1189.00
IUUC-Xtr-132127	Xenopus tropicalis	52.20	0.00e+00	977.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence