iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0266717	FBtr0331683	FBpp0304072
FBgn0266717	FBtr0082239	FBpp0081717
FBgn0266717	FBtr0331684	FBpp0304073
FBgn0266717	FBtr0331682	FBpp0304071
FBgn0266717	FBtr0331681	FBpp0304070

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Protein-protein Interaction
Mentha
Post-translational Modifications (PTMs)
CPLM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	15200957

Classification

Family	E-value	Score	Start	End
E2/UBC	1.40e-28	99.5	4536	4690

Active Site

Position(s)	Description	Evidence
4625	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdpp....egisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk.....ifhPnvyenGkvClsilk 87
           Rl++e+ +l+++ p    ++++++++++  l+ ++vli+Gp+dtpY++g+F++++ fp+dYP +P  ++++t+     +f+Pn+y++GkvCls+l+
   Q: 4536 RLAQEAVTLSTSLPlsfsSSVFVRCDTD-RLDIMKVLITGPADTPYANGCFEFDVFFPPDYPNQPMLINLETTgrhsvRFNPNLYNDGKVCLSVLN 4630
           8999*****9999977667778888888.5*****************************************************************7 PP
   S: 88   .....eeekWsp.alsvesvllsiqsll..aepnpesplneeaa...ellkknreeykkkv 137
                +eekW++ ++s+ +vl+siqsl+   ep++++p  e+++   + ++++re y++++
   Q: 4631 twhgrPEEKWNAqTSSFLQVLVSIQSLIlvPEPYFNEPGFERSRgspSGTNSSRE-YNSNI 4690
           788889*****97899***********98899*******9998866455555554.88776 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MATEQHHQQR VLKQDGYLDL GDCNSAPSRP FEMRNVVYHP QLNVLLLFDN GSTVKVLDAN 60
SGVILQTYHL SSNGDSIVHG RYMPLQDKIL FWDGHNLGLR GDYNGVLLLD TILQAPIGQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACATCTGTC AGAAGGTAGA AGAAGAAGGG GCAAAACGAA GAAGAAGAAG AAGCACAGAG 60
CTCTGTTTCG CAGCAATTAT TTTCCGAATT GAATTGCGAA AAAAACCCCT ACAGAGTATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001370--BIR_rpt
IPR022103--BIRC6
IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD
IPR015943--WD40/YVTN_repeat-like_dom

PROSITE

PS50143--BIR_REPEAT_2
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00653--BIR
PF12356--BIRC6
PF00179--UQ_con

SMART

SM00238--BIR

Gene Ontology

GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006915--P:apoptotic process
GO:0009267--P:cellular response to starvation
GO:0043066--P:negative regulation of apoptotic process
GO:0016242--P:negative regulation of macroautophagy
GO:0045849--P:negative regulation of nurse cell apoptotic process
GO:0048477--P:oogenesis
GO:0012501--P:programmed cell death
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032465--P:regulation of cytokinesis
GO:0007286--P:spermatid development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001583	Ailuropoda melanoleuca	52.34	0.00e+00	680.00
IUUC-Apl-004144	Anas platyrhynchos	51.32	0.00e+00	664.00
IUUC-Aca-005257	Anolis carolinensis	52.28	0.00e+00	678.00
IUUC-Ani-009463	Aspergillus nidulans	39.35	8.00e-26	110.00
IUUC-Ame-011337	Astyanax mexicanus	52.77	0.00e+00	688.00
IUUC-Bta-012501	Bos taurus	52.47	0.00e+00	681.00
IUUC-Bci-013596	Botrytis cinerea	32.94	2.00e-20	92.40
IUUC-Bol-016170	Brassica oleracea	40.41	7.00e-42	162.00
IUUC-Bra-016646	Brassica rapa	37.76	2.00e-43	168.00
IUUC-Cel-018661	Caenorhabditis elegans	34.36	1.00e-74	273.00
IUUC-Cja-018746	Callithrix jacchus	52.98	0.00e+00	685.00
IUUC-Cfa-020170	Canis familiaris	52.47	0.00e+00	682.00
IUUC-Cpo-022138	Cavia porcellus	52.47	0.00e+00	678.00
IUUC-Cre-022768	Chlamydomonas reinhardtii	42.33	2.00e-42	164.00
IUUC-Csa-023927	Chlorocebus sabaeus	52.85	0.00e+00	686.00
IUUC-Cho-024890	Choloepus hoffmanni	28.20	2.00e-103	372.00
IUUC-Cgl-026412	Colletotrichum gloeosporioides	36.24	2.00e-21	95.90
IUUC-Cne-026995	Cryptococcus neoformans	32.06	4.00e-43	169.00
IUUC-Dre-027941	Danio rerio	53.28	0.00e+00	720.00
IUUC-Dno-028913	Dasypus novemcinctus	52.22	0.00e+00	679.00
IUUC-Dor-030715	Dipodomys ordii	27.60	5.00e-82	300.00
IUUC-Dse-031232	Dothistroma septosporum	40.57	5.00e-39	155.00
IUUC-Ete-032587	Echinops telfairi	51.47	9.00e-125	442.00
IUUC-Eca-033819	Equus caballus	52.47	0.00e+00	672.00
IUUC-Eeu-034863	Erinaceus europaeus	30.41	2.00e-94	342.00
IUUC-Fca-035505	Felis catus	52.47	0.00e+00	679.00
IUUC-Fal-037318	Ficedula albicollis	52.57	0.00e+00	673.00
IUUC-Fox-037961	Fusarium oxysporum	33.73	4.00e-19	88.20
IUUC-Fso-038352	Fusarium solani	32.74	6.00e-18	84.30
IUUC-Gmo-039521	Gadus morhua	51.06	0.00e+00	658.00
IUUC-Ggr-040040	Gaeumannomyces graminis	43.68	8.00e-34	138.00
IUUC-Gga-040728	Gallus gallus	52.27	0.00e+00	676.00
IUUC-Gac-042251	Gasterosteus aculeatus	52.39	0.00e+00	696.00
IUUC-Gma-043461	Glycine max	38.87	1.00e-43	170.00
IUUC-Ggo-045562	Gorilla gorilla	37.13	5.00e-65	242.00
IUUC-Hsa-046339	Homo sapiens	52.85	0.00e+00	687.00
IUUC-Hvu-047441	Hordeum vulgare	41.77	1.00e-47	182.00
IUUC-Itr-048099	Ictidomys tridecemlineatus	28.67	4.00e-111	395.00
IUUC-Lch-050164	Latimeria chalumnae	52.66	0.00e+00	680.00
IUUC-Loc-052800	Lepisosteus oculatus	52.45	0.00e+00	667.00
IUUC-Lma-053044	Leptosphaeria maculans	38.93	1.00e-23	103.00
IUUC-Laf-054034	Loxodonta africana	52.72	0.00e+00	687.00
IUUC-Mcc-055267	Macaca mulatta	52.85	0.00e+00	686.00
IUUC-Meu-056461	Macropus eugenii	43.13	3.00e-81	298.00
IUUC-Mor-057074	Magnaporthe oryzae	36.24	2.00e-17	82.80
IUUC-Mpo-057396	Magnaporthe poae	44.77	5.00e-34	139.00
IUUC-Mtr-057797	Medicago truncatula	39.43	2.00e-46	179.00
IUUC-Mla-059114	Melampsora laricipopulina	40.78	6.00e-40	158.00
IUUC-Mga-059594	Meleagris gallopavo	49.70	9.00e-153	535.00
IUUC-Mmr-061179	Microcebus murinus	52.60	0.00e+00	680.00
IUUC-Mdo-062990	Monodelphis domestica	52.34	0.00e+00	676.00
IUUC-Mmu-063825	Mus musculus	52.20	0.00e+00	680.00
IUUC-Mpu-065908	Mustela putorius furo	52.47	0.00e+00	681.00
IUUC-Mlu-067106	Myotis lucifugus	51.71	0.00e+00	663.00
IUUC-Ncr-068852	Neurospora crassa	35.29	3.00e-16	79.00
IUUC-Nle-069347	Nomascus leucogenys	52.72	0.00e+00	685.00
IUUC-Opr-070799	Ochotona princeps	52.02	0.00e+00	669.00
IUUC-Ont-072046	Oreochromis niloticus	51.93	0.00e+00	678.00
IUUC-Oan-073289	Ornithorhynchus anatinus	52.46	2.00e-66	244.00
IUUC-Ocu-074556	Oryctolagus cuniculus	52.22	0.00e+00	680.00
IUUC-Ola-087459	Oryzias latipes	52.32	0.00e+00	698.00
IUUC-Oga-088251	Otolemur garnettii	49.31	2.00e-171	597.00
IUUC-Oar-090367	Ovis aries	52.72	0.00e+00	686.00
IUUC-Ptr-091512	Pan troglodytes	52.85	0.00e+00	686.00
IUUC-Pan-092222	Papio anubis	52.85	0.00e+00	687.00
IUUC-Pma-094574	Petromyzon marinus	29.83	3.00e-112	401.00
IUUC-Ppa-095592	Physcomitrella patens	31.07	4.00e-50	192.00
IUUC-Pfo-097086	Poecilia formosa	51.43	0.00e+00	689.00
IUUC-Pab-098390	Pongo abelii	52.85	0.00e+00	686.00
IUUC-Pca-101036	Procavia capensis	46.84	2.00e-69	259.00
IUUC-Pva-103053	Pteropus vampyrus	51.96	0.00e+00	674.00
IUUC-Pte-104333	Pyrenophora teres	43.41	7.00e-45	176.00
IUUC-Pyt-104498	Pyrenophora triticirepentis	30.92	1.00e-46	180.00
IUUC-Rno-106049	Rattus norvegicus	28.16	8.00e-126	446.00
IUUC-Sha-107483	Sarcophilus harrisii	52.34	0.00e+00	681.00
IUUC-Sit-110087	Setaria italica	40.00	8.00e-45	173.00
IUUC-Sar-112965	Sorex araneus	42.20	3.00e-65	245.00
IUUC-Ssc-115927	Sus scrofa	52.72	0.00e+00	683.00
IUUC-Tgu-117132	Taeniopygia guttata	51.18	0.00e+00	669.00
IUUC-Tru-118115	Takifugu rubripes	51.49	0.00e+00	697.00
IUUC-Tsy-118899	Tarsius syrichta	49.87	6.00e-176	612.00
IUUC-Tni-120891	Tetraodon nigroviridis	52.47	0.00e+00	694.00
IUUC-Tre-121946	Trichoderma reesei	33.77	5.00e-18	84.70
IUUC-Tvi-122513	Trichoderma virens	33.73	6.00e-20	90.90
IUUC-Tae-125407	Triticum aestivum	40.32	1.00e-47	183.00
IUUC-Tme-126930	Tuber melanosporum	40.96	3.00e-47	183.00
IUUC-Tbe-127630	Tupaia belangeri	31.88	2.00e-67	252.00
IUUC-Ttr-128629	Tursiops truncatus	52.27	0.00e+00	677.00
IUUC-Vda-129728	Verticillium dahliae	39.71	1.00e-17	83.60
IUUC-Vpa-130310	Vicugna pacos	52.67	0.00e+00	662.00
IUUC-Xtr-131861	Xenopus tropicalis	52.22	0.00e+00	689.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence